The effects of aqueous extract of garlic (Allium sativum L.) on laryngeal cancer cells (Hep-2) and L929 cells in vitro

Journal of Medicinal Plants

Volumn 5, Issue 18, 2006, Pages 41-48

  Hadjzadeh, M A I R ^a,c   Tavakol Afshari, J ^b   Ghorbani, A ^a   Shakeri, M T ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Allium sativum L.; Aqueous extract; Cytotoxic; Garlic; Hep 2 cells; L929 cells; SCC

Indexed keywords

AJOENE; ALLIIN; CYTARABINE; FLUDARABINE;

APOPTOSIS; ARTICLE; CELL LINE; CELL VIABILITY; GARLIC; HEP 2 CELL; HUMAN; MYELOID LEUKEMIA; SQUAMOUS CELL CARCINOMA;

ALLIUM SATIVUM;

EID: 33845294078     PISSN: 2717204X     EISSN: 27172058     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ghazanfari T, Hassan ZM and Ebrahimi M. Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity. Int. Immunopharmacol. 2002; 2: 1541-1549.
2. Augusti KT. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian J. Exp. 1996; 34: 634-640.
3. Chiba K, Kawakami K and Tohyama K. Simultaneous evaluation of viability by neutral red, MTT and crystal violet staining assays of the same cells. Toxicology in vitro. 1998; 12: 251-258.
4. Milner JA. A historical perspective on garlic and cancer. J. Nutr. 2001; 131: 1027-1031.
5. Colic M, Vucevic D, Kilibarda V, Radicevic N and Savic M. Modulatory effects of garlic extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A. Phytomed. 2002; 9: 117-125.
6. Bianchini F and Vainio H. Alium vegetable and organosulfur compounds: Do they help prevent cancer?. Environmental Health Perspectives. 2001; 109: 893-902.
7. Ahmed N, Laverick J, Sammons J, Zhang H, Maslin DJ and Hassan HT. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res. 2001; 21: 3519-3524.
8. Whelan LC and Ryan MF. Ethanolic extracts of euphorbia and other ethnobotanical species as inhibitors of human tumour cell growth. Phytomed. 2003; 10: 53-58.
9. Durmaz R, Deliorman S, Isiksoy S, Uyar R, Erol K and Tel E. Antiproliferative properties of the Lazaroids U-83836E and U-74389G on Glioma Cells in vitro. Pathol. Oncology Res. 1999; 5: 223-228.
10. th ed. Wiley_Liss. USA. 2000.
11. Robert V, Mouille B, Mayeur C, Michaud M and Blachier F. Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: evidence of sensitive and resistant sub-populations. Carcinogenesis. 2001; 22: 1155-1161.
12. Sundaram SG and Milner JA. Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett. 1993; 74: 85-90.
13. Pinheiro ALB, Nascimento SCD, Vieira ALDB, Rolim AB, Silva PSD and Brugnera JRA. Does LLLT stimulate laryngeal carcinoma cells? An "in vitro" study. Braz. Dent. J. 2002; 13: 109-112.
14. Klucar J and Al-Rubeai M. G2 cell cycle arrest and apoptosis are induced in Burkitt's lymphoma cells by the anticancer agent oracin. FEBS Lette. 1997; 400: 127-130.
15. Thonemann B, Schmalz G, Hiller KA and Schweikl H. Responses of L929 mouse fibroblast, primary and immortalized bovine dental papilla-derived cell line to dental resin components. dental materials. 2002; 18: 318-323.
16. Abe K and Matsuki N. Measurment of cellular 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT. Neuroscience Res. 2000; 38: 325-329.
17. Li M, Ciu JR, Ye Y, Min JM, Zhang LH, Wang K, Gares M, Cros J, Wright M and Leung-Tack J. Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule - interaction properties. Carcinogenesis. 2002; 23: 573-579.
18. Nakagawa H, Tsuta K, Kiuchi K, Senzaki H, Tanaka K, Hioki K and Tsubura A. Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. Carcinogenesis. 2001; 22: 891-7.
19. Hofbauer R, Frass M, Gmeiner B, Kaye AD and Frost EAM. Effects of garlic extract (Allium sativum) on neutrophil migration at the cellular level. Heart Dis. 2001; 3: 14-17.
20. Sengupta A, Ghosh S and Das S. Administration of garlic and tomato can protect from carcinogen induced clastogenicity. Nut. Res. 2002; 22: 859-866.