Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells

Oncotarget

Volumn 6, Issue 29, 2015, Pages 27661-27673

  Rangarajan, Parthasarathy ^a   Subramaniam, Dharmalingam ^a   Paul, Santanu ^a   Kwatra, Deep ^a   Palaniyandi, Kanagaraj ^a   Islam, Shamima ^a   Harihar, Sitaram ^a   Ramalingam, Satish ^a   Gutheil, William ^b   Putty, Sandeep ^b   Pradhan, Rohan ^c   Padhye, Subhash ^c   Welch, Danny R ^a   Anant, Shrikant ^a   Dhar, Animesh ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c UNIVERSITY OF PUNE   (India)

Author keywords

Crocetin; DCLK 1; Gli transcription factor; Nude mice; Pancosphere

Indexed keywords

CAROTENOID; CROCETINIC ACID; DOUBLECORTIN; DOUBLECORTIN CALMODULIN DEPENDENT KINASE 1; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; CROCETIN; DCLK1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; PLANT EXTRACT; PROTEIN SERINE THREONINE KINASE; SHC SIGNALING ADAPTOR PROTEIN; SHC TRANSFORMING PROTEIN 2; SHC2 PROTEIN, HUMAN; SHH PROTEIN, HUMAN; SIGNAL PEPTIDE; SMO PROTEIN, HUMAN; SMOOTHENED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CELL MOTION; CHEMISTRY; CROCUS; DOSE RESPONSE; METABOLISM; MULTICELLULAR SPHEROID; NUDE MOUSE; PANCREAS TUMOR; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CAROTENOIDS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROCUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEDGEHOG PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; SMOOTHENED RECEPTOR; SPHEROIDS, CELLULAR; SRC HOMOLOGY 2 DOMAIN-CONTAINING, TRANSFORMING PROTEIN 2;

EID: 84944457140     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4871     Document Type: Article

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