Crocin and crocetin derivatives inhibit skin tumour promotion in mice

Phytotherapy Research

Volumn 12, Issue 6, 1998, Pages 400-404

  Konoshima, T ^a   Takasaki, M ^a   Tokuda, H ^b   Morimoto, S ^c   Tanaka, H ^c   Kawata, E ^c   Xuan, L J ^c   Saito, H ^d   Sugiura, M ^d   Molnar, J ^e   Shoyama, Y ^c  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Crocin; Crocus sativus; EBV EA induction; Mouse skin papilloma; Two stage carcinogenesis

Indexed keywords

ANTINEOPLASTIC AGENT; CROCETIN; CROCETIN DERIVATIVE; CROCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; FEMALE; HUMAN; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; SKIN CARCINOGENESIS; SKIN PAPILLOMA;

CROCUS SATIVUS;

EID: 7344261828     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199809)12:6<400::AID-PTR321>3.0.CO;2-4     Document Type: Article

References (24)

1. Escribano, J., Alonso, G. L., Coca-Prados, M., and Fernandas, J. A. (1996). Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett. 100, 23-30.
2. Gainer, J., and Jones, J. R. (1975), The use of crocetin in experimental atherosclerosis. Experientia 31, 548-549.
3. Gainer, J. L., Wallis, D. A., and Jones, J. R. (1976), The effect of crocetin on skin papilomas and rous sarcoma. Oncology 33, 222-224.
4. Inada, A., Nakanishi, T., and Konoshima, T. et al. (1993). Anti-tumor-promoting activities of natural products II. Biol. Pharm. Bull. 16, 930-931.
5. Konoshima, T., Kozuka, M., Koyama, J., Okatani, T., Tagahra, K., and Tokuda, H. (1989), Studies on inhibitors of skin tumor promotion VI. J. Nat. Prod. 52, 987-995.
6. Konoshima, T., Kokumai, M., Kozuka, M., Tokuda, H., Nishino, H., and Iwashima, A. (1992). Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys. J. Nat. Prod. 55, 1776-1778.
7. Konoshima, T., Takasaki, M., Kozuka, M., and Tokuda, H. (1994). Anti-tumor-promoting activities of Kampo prescriptions, II. Yakugaku Zasshi 114, 248-256.
8. Konoshima, T., Takasaki, M., Tokuda, H., Masuda, K., Arai, Y., Shiogima, H., and Ageta, H. (1996b). Anti-tumor-promoting activities of triterpenoids from fern (1), Biol. Pharm. Bull., 19, 962-965. and references cited therein.
9. Konoshima, T. (1996). Anti-tumor-promoting activities of triterpenoid glycosides; Cancer chemoprevention by saponins. In, Advances in Experimental Medicine and Biology Vol. 404, Saponins Used in Traditional and Modern Medicine, ed. by G. R. Waller and K. Yamasaki, pp. 87-100 Plenum Press, New York.
10. Konoshima, T., Takasaki, M., and Tokuda, H. (1996a), Anti-tumor-promoting activities of the roots of Panax notoginseng (1). Nat Med., 50, 158-162.
11. Miwa, T. (1954). Study on Gardenia florida L. (Fructus Gardeniae) as a remedy for icterus. Report IV, On the effect of the active principle and extract of Fructus Gardeniae on the bile secretion of rabbits, blood bilirubin and peripheral lymph bilirubin of common bile-duct ligated rabbits. Jpn. J. Pharmacol., 4, 69-81.
12. Nair, S. C., Pannikar, B., and Panikkar, K. R. (1991). Antitumour activity of saffron (Crocus sativus). Cancer Lett. 57, 109-114.
13. Salomi, M. J., Nair, S. C., and Panikkar, K. R. (1991). Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nut. Cancer 16, 67-72.
14. Sugiura, M., Shoyama, Y., Saito, H., and Abe, K. (1994). Crocin (crocetin di-gentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo. J. Pharmacol. Exp. Ther. 271, 703-707.
15. Ohigashi, H., Takamura, H., Koshimizu, K., Tokuda, H., and Ito, Y. (1986). Search for possible antitumor promoters by inhibition of TPA-induced Epstein-Barr virus activation. Cancer Lett. 30, 143-151.
16. Pfander, H., and Wittwer, F. (1975). Carotinoid-Glykoside. Untersuchungen zur Carotinoid-Zusammensetzung im Safran. Helv. Chim. Acta 58, 1608-1620.
17. Pfander, H., and Wittwer, F. (1979). Carotinoid-Glycosylester. Die Synthese von Crocetin-di-(β-D-glucosyl)-ester. Eine new Methode zur Selektiven Veresterung von Ungeschützter β-D-Glucose. Helv. Chim. Acta 62, 1944-1951.
18. Sugiura, M., Shoyama, Y., Saito, H., and Nishiyama, N. (1995c). Crocin improves the ethanol-induced impairment of learning behaviour and mice in passive avoidance tests. Proc. Jpn. Acad. 71, Ser.B, 319-324.
19. Sugiura, M., Shoyama, Y., Saito, H., and Abe, K. (1995b). The effects of ethanol and crocin on the induction of long-term potentiation in the CA1 region of rat hippocampal slices. Jpn J. Pharmacol. 67, 395-397.
20. Sugiura, M., Saito, H., Abe, K., and Shoyama, Y. (1995a). Ethanol extract of Crocus sativus L. antagonizes the inhibitory action of ethanol on hippocampal long-term potentiation in vivo. Phytother. Res. 91, 100-104.
21. Sugiura, M., Shoyama, Y., Zhang, Y., Saito, H., and Abe, K. (1996). Effect of ethanol extract of Crocus sativus L. and its purified chemicals on learning behavior and long-term potentiation. In: Preclinical and clinical strategies for the treatment of neurodegenerative, cerebrovascular and mental disorders. pp. 270-276, Int. Acad. Biomed. Drug Res., Basel.
22. Takagi, Y., Sekiguchi, M., and Okubo, S. et al. (1968). Nucleases specific for ultraviolet light-irradiated DNA and their possible role in dark repair. Cold Spring Harbor Symp. Quant. Biol. 33, 219-227.
23. Takasaki, M., Konoshima, T., Kozuka, M., and Tokuda, H. (1995). Antitumor-promoting activities of euglobals from eucalyptus plants. Biol. Pharm. Bull. 18, 435-438.
24. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. (1994). Effect of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol. Pharm. Bull. 17, 217-221.