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Volumn 112, Issue 4, 2010, Pages 317-327

Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study

Author keywords

Carcinogenesis; Chemoprevention; DMBA; Histology; Saffron; Tumorigenesis

Indexed keywords

ACETONE; CATALASE; CROCUS SATIVUS EXTRACT; CROTON OIL; DIMETHYLBENZ[A]ANTHRACENE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SAFFRON; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 77953536106     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2009.02.003     Document Type: Article
Times cited : (101)

References (54)
  • 1
    • 0027184894 scopus 로고
    • Biological effects of saffron
    • Abdullaev F.I. Biological effects of saffron. Biofactors 1993, 4:83-86.
    • (1993) Biofactors , vol.4 , pp. 83-86
    • Abdullaev, F.I.1
  • 2
    • 0036377909 scopus 로고    scopus 로고
    • Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.)
    • Abdullaev F.I. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp Biol Med (Maywood) 2002, 227:20-25.
    • (2002) Exp Biol Med (Maywood) , vol.227 , pp. 20-25
    • Abdullaev, F.I.1
  • 3
    • 9644268896 scopus 로고    scopus 로고
    • Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials
    • Abdullaev F.I., Espinosa-Aguirre J.J. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev 2004, 28:426-432.
    • (2004) Cancer Detect Prev , vol.28 , pp. 426-432
    • Abdullaev, F.I.1    Espinosa-Aguirre, J.J.2
  • 4
    • 0027103979 scopus 로고
    • The effect of saffron on intracellular DNA, RNA and protein synthesis in malignant and non-malignant human cells
    • Abdullaev F.I., Frenkel G.D. The effect of saffron on intracellular DNA, RNA and protein synthesis in malignant and non-malignant human cells. Biofactors 1992, 4:43-45.
    • (1992) Biofactors , vol.4 , pp. 43-45
    • Abdullaev, F.I.1    Frenkel, G.D.2
  • 5
    • 0029548374 scopus 로고
    • Inhibition of colony formation of Hela cells by naturally occurring and synthetic agents
    • Abdullaev F.I., Gonzalez de Mejia E. Inhibition of colony formation of Hela cells by naturally occurring and synthetic agents. Biofactors 1995, 5:133-138.
    • (1995) Biofactors , vol.5 , pp. 133-138
    • Abdullaev, F.I.1    Gonzalez de Mejia, E.2
  • 6
    • 0031216857 scopus 로고    scopus 로고
    • Antitumor activity of natural substances: lectins and saffron
    • Abdullaev F.I., Gonzalez de Mejia E. Antitumor activity of natural substances: lectins and saffron. Arch Latinoam Nutr 1997, 47:195-202.
    • (1997) Arch Latinoam Nutr , vol.47 , pp. 195-202
    • Abdullaev, F.I.1    Gonzalez de Mejia, E.2
  • 7
    • 77953536250 scopus 로고    scopus 로고
    • Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines
    • Afshari J.T., Brook A., Mousavi S.H. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol 2008, 28:28.
    • (2008) Food Chem Toxicol , vol.28 , pp. 28
    • Afshari, J.T.1    Brook, A.2    Mousavi, S.H.3
  • 8
    • 0025299572 scopus 로고
    • Increased levels of lipid peroxides in aged rat brain as revealed by direct assay of peroxide values
    • Ando S., Kon K., Aino K., Totani Y. Increased levels of lipid peroxides in aged rat brain as revealed by direct assay of peroxide values. Neurosci Lett 1990, 113:199-204.
    • (1990) Neurosci Lett , vol.113 , pp. 199-204
    • Ando, S.1    Kon, K.2    Aino, K.3    Totani, Y.4
  • 9
    • 77951504705 scopus 로고
    • The use of saffron
    • Basker D., Negbi M. The use of saffron. Econ. Bot. 1983, 37:228-236.
    • (1983) Econ. Bot. , vol.37 , pp. 228-236
    • Basker, D.1    Negbi, M.2
  • 10
    • 0011030944 scopus 로고
    • Riboflavine and thiamine contents of saffron, Crocus sativus Linn
    • Bhat J.V., Broker R. Riboflavine and thiamine contents of saffron, Crocus sativus Linn. Nature 1953, 172:544.
    • (1953) Nature , vol.172 , pp. 544
    • Bhat, J.V.1    Broker, R.2
  • 11
    • 0017065770 scopus 로고
    • The biochemistry of preneoplasia in mouse skin
    • Boutwell R.K. The biochemistry of preneoplasia in mouse skin. Cancer Res 1976, 36:2631-2635.
    • (1976) Cancer Res , vol.36 , pp. 2631-2635
    • Boutwell, R.K.1
  • 12
    • 2542554241 scopus 로고    scopus 로고
    • Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice
    • Das I., Chakrabarty R.N., Das S. Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev 2004, 5:70-76.
    • (2004) Asian Pac J Cancer Prev , vol.5 , pp. 70-76
    • Das, I.1    Chakrabarty, R.N.2    Das, S.3
  • 13
    • 60749085613 scopus 로고    scopus 로고
    • Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA induced skin carcinoma
    • Das I, Saha T. Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA induced skin carcinoma. Nutrition 2009;25:459-471.
    • (2009) Nutrition , vol.25 , pp. 459-471
    • Das, I.1    Saha, T.2
  • 14
    • 0037220250 scopus 로고    scopus 로고
    • Dealing with variability in food production chains: a tool to enhance the sensitivity of epidemiological studies on phytochemicals
    • Dekker M., Verkerk R. Dealing with variability in food production chains: a tool to enhance the sensitivity of epidemiological studies on phytochemicals. Eur J Nutr 2003, 42:67-72.
    • (2003) Eur J Nutr , vol.42 , pp. 67-72
    • Dekker, M.1    Verkerk, R.2
  • 15
    • 0642339654 scopus 로고    scopus 로고
    • Studies on the pharmacological effects of saffron (Crocus sativus L.) - a review
    • Deng Y., Guo Z.G., Zeng Z.L., Wang Z. Studies on the pharmacological effects of saffron (Crocus sativus L.) - a review. Zhongguo Zhong Yao Za Zhi 2002, 27:565-568.
    • (2002) Zhongguo Zhong Yao Za Zhi , vol.27 , pp. 565-568
    • Deng, Y.1    Guo, Z.G.2    Zeng, Z.L.3    Wang, Z.4
  • 16
    • 0030901888 scopus 로고    scopus 로고
    • In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract
    • Dufresne C., Cormier F., Dorion S. In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract. Planta Med 1997, 63:150-153.
    • (1997) Planta Med , vol.63 , pp. 150-153
    • Dufresne, C.1    Cormier, F.2    Dorion, S.3
  • 17
    • 0034105343 scopus 로고    scopus 로고
    • The cytolytic effect of a glycoconjugate extracted from corms of saffron plant (Crocus sativus) on human cell lines in culture
    • Escribano J., Diaz-Guerra M.J., Riese H.H., Alvarez A., Proenza R., Fernandez J.A. The cytolytic effect of a glycoconjugate extracted from corms of saffron plant (Crocus sativus) on human cell lines in culture. Planta Med 2000, 66:157-162.
    • (2000) Planta Med , vol.66 , pp. 157-162
    • Escribano, J.1    Diaz-Guerra, M.J.2    Riese, H.H.3    Alvarez, A.4    Proenza, R.5    Fernandez, J.A.6
  • 18
    • 0028982360 scopus 로고
    • 7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo
    • Frenkel K., Wei L., Wei H. 7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo. Free Radic Biol Med 1995, 19:373-380.
    • (1995) Free Radic Biol Med , vol.19 , pp. 373-380
    • Frenkel, K.1    Wei, L.2    Wei, H.3
  • 19
    • 2942615338 scopus 로고    scopus 로고
    • Crocetin from saffron: an active component of an ancient spice
    • Giaccio M. Crocetin from saffron: an active component of an ancient spice. Crit Rev Food Sci Nutr 2004, 44:155-172.
    • (2004) Crit Rev Food Sci Nutr , vol.44 , pp. 155-172
    • Giaccio, M.1
  • 20
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 21
    • 0031750787 scopus 로고    scopus 로고
    • Chemoprevention of cancer
    • Hakama M. Chemoprevention of cancer. Acta Oncol 1998, 37:227-230.
    • (1998) Acta Oncol , vol.37 , pp. 227-230
    • Hakama, M.1
  • 22
    • 34548408192 scopus 로고    scopus 로고
    • Molecular targets of cancer chemoprevention by garlic-derived organosulfides
    • Herman-Antosiewicz A., Powolny A.A., Singh S.V. Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta Pharmacol Sin 2007, 28:1355-1364.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1355-1364
    • Herman-Antosiewicz, A.1    Powolny, A.A.2    Singh, S.V.3
  • 23
    • 0033387944 scopus 로고    scopus 로고
    • Chemoprevention of cancer: an ongoing saga
    • Kellen J.A. Chemoprevention of cancer: an ongoing saga. In Vivo 1999, 13:423-426.
    • (1999) In Vivo , vol.13 , pp. 423-426
    • Kellen, J.A.1
  • 25
    • 0002191974 scopus 로고
    • A spectrophotometric method for the measurement of catalase
    • Luck H. A spectrophotometric method for the measurement of catalase. Meth. Enzym. Anal. 1963, 27:885-895.
    • (1963) Meth. Enzym. Anal. , vol.27 , pp. 885-895
    • Luck, H.1
  • 26
    • 0036383954 scopus 로고    scopus 로고
    • Gene p53 mutations, protein p53, and anti-p53 antibodies as biomarkers of cancer process
    • Lutz W., Nowakowska-Swirta E. Gene p53 mutations, protein p53, and anti-p53 antibodies as biomarkers of cancer process. Int J Occup Med Environ Health 2002, 15:209-218.
    • (2002) Int J Occup Med Environ Health , vol.15 , pp. 209-218
    • Lutz, W.1    Nowakowska-Swirta, E.2
  • 27
    • 0016272750 scopus 로고
    • Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
    • Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974, 47:469-474.
    • (1974) Eur J Biochem , vol.47 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 28
    • 0014691242 scopus 로고
    • Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
    • McCord J.M., Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969, 244:6049-6055.
    • (1969) J Biol Chem , vol.244 , pp. 6049-6055
    • McCord, J.M.1    Fridovich, I.2
  • 29
    • 0034053334 scopus 로고    scopus 로고
    • Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates
    • Molnar J., Szabo D., Pusztai R., Mucsi I., Berek L., Ocsovszki I., et al. Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates. Anticancer Res 2000, 20:861-867.
    • (2000) Anticancer Res , vol.20 , pp. 861-867
    • Molnar, J.1    Szabo, D.2    Pusztai, R.3    Mucsi, I.4    Berek, L.5    Ocsovszki, I.6
  • 30
    • 0017654331 scopus 로고
    • Metabolic activation of the carcinogen 7,12-dimethylbenz[a]anthracene for DNA binding
    • Moschel R.C., Baird W.M., Dipple A. Metabolic activation of the carcinogen 7,12-dimethylbenz[a]anthracene for DNA binding. Biochem Biophys Res Commun 1977, 76:1092-1098.
    • (1977) Biochem Biophys Res Commun , vol.76 , pp. 1092-1098
    • Moschel, R.C.1    Baird, W.M.2    Dipple, A.3
  • 31
    • 0028834324 scopus 로고
    • Saffron chemoprevention in biology and medicine: a review
    • Nair S.C., Kurumboor S.K., Hasegawa J.H. Saffron chemoprevention in biology and medicine: a review. Cancer Biother 1995, 10:257-264.
    • (1995) Cancer Biother , vol.10 , pp. 257-264
    • Nair, S.C.1    Kurumboor, S.K.2    Hasegawa, J.H.3
  • 32
    • 0025809643 scopus 로고
    • Antitumour activity of saffron (Crocus sativus)
    • Nair S.C., Pannikar B., Panikkar K.R. Antitumour activity of saffron (Crocus sativus). Cancer Lett 1991, 57:109-114.
    • (1991) Cancer Lett , vol.57 , pp. 109-114
    • Nair, S.C.1    Pannikar, B.2    Panikkar, K.R.3
  • 33
  • 35
    • 0027426373 scopus 로고
    • New lectins from bulbs of Crocus sativum
    • Oda Y., Tatsumi Y. New lectins from bulbs of Crocus sativum. Biol Pharm Bull 1993, 16:978-981.
    • (1993) Biol Pharm Bull , vol.16 , pp. 978-981
    • Oda, Y.1    Tatsumi, Y.2
  • 36
    • 0023078113 scopus 로고
    • Assay for lipid peroxide content in mitochondria by the thiobarbituric acid reaction
    • Ogura R., Sakanashi T., Nagata O., Sugiyama M., Kajiyama K., Nakagawa T., et al. Assay for lipid peroxide content in mitochondria by the thiobarbituric acid reaction. Kurume Med J 1987, 34:53-58.
    • (1987) Kurume Med J , vol.34 , pp. 53-58
    • Ogura, R.1    Sakanashi, T.2    Nagata, O.3    Sugiyama, M.4    Kajiyama, K.5    Nakagawa, T.6
  • 37
    • 34748858784 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis: impact on cancer therapy
    • Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 2007, 96:2181-2196.
    • (2007) J Pharm Sci , vol.96 , pp. 2181-2196
    • Ozben, T.1
  • 38
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967, 70:158-169.
    • (1967) J Lab Clin Med , vol.70 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 39
    • 0026676309 scopus 로고
    • Antioxidant effects of carotenoids in vivo and in vitro: an overview
    • Palozza P., Krinsky N.I. Antioxidant effects of carotenoids in vivo and in vitro: an overview. Methods Enzymol 1992, 213:403-420.
    • (1992) Methods Enzymol , vol.213 , pp. 403-420
    • Palozza, P.1    Krinsky, N.I.2
  • 40
    • 0038125510 scopus 로고    scopus 로고
    • Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice
    • Premkumar K., Abraham S.K., Santhiya S.T., Ramesh A. Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytother Res 2003, 17:614-617.
    • (2003) Phytother Res , vol.17 , pp. 614-617
    • Premkumar, K.1    Abraham, S.K.2    Santhiya, S.T.3    Ramesh, A.4
  • 41
    • 33644778804 scopus 로고    scopus 로고
    • Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice
    • Premkumar K., Thirunavukkarasu C., Abraham S.K., Santhiya S.T., Ramesh A. Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Hum Exp Toxicol 2006, 25:79-84.
    • (2006) Hum Exp Toxicol , vol.25 , pp. 79-84
    • Premkumar, K.1    Thirunavukkarasu, C.2    Abraham, S.K.3    Santhiya, S.T.4    Ramesh, A.5
  • 42
    • 34548445132 scopus 로고    scopus 로고
    • Saffron in phytotherapy: pharmacology and clinical uses
    • Schmidt M., Betti G., Hensel A. Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr 2007, 157:315-319.
    • (2007) Wien Med Wochenschr , vol.157 , pp. 315-319
    • Schmidt, M.1    Betti, G.2    Hensel, A.3
  • 43
    • 0017905104 scopus 로고
    • Tumor initiation and promotion
    • Scribner J.D., Suss R. Tumor initiation and promotion. Int Rev Exp Pathol 1978, 18:137-198.
    • (1978) Int Rev Exp Pathol , vol.18 , pp. 137-198
    • Scribner, J.D.1    Suss, R.2
  • 44
    • 4344626474 scopus 로고    scopus 로고
    • Indian food ingredients and cancer prevention-an experimental evaluation of anticarcinogenic effects of garlic in rat colon
    • Sengupta A., Ghosh S., Bhattacharjee S., Das S. Indian food ingredients and cancer prevention-an experimental evaluation of anticarcinogenic effects of garlic in rat colon. Asian Pac J Cancer Prev 2004, 5:126-132.
    • (2004) Asian Pac J Cancer Prev , vol.5 , pp. 126-132
    • Sengupta, A.1    Ghosh, S.2    Bhattacharjee, S.3    Das, S.4
  • 45
    • 0032449901 scopus 로고    scopus 로고
    • Carotenoids and cancer: prevention and potential therapy
    • Smith T.A. Carotenoids and cancer: prevention and potential therapy. Br J Biomed Sci 1998, 55:268-275.
    • (1998) Br J Biomed Sci , vol.55 , pp. 268-275
    • Smith, T.A.1
  • 46
    • 0001318080 scopus 로고    scopus 로고
    • Mechanisms of induction of skin cancer by UV radiation
    • Soehnge H., Ouhtit A., Ananthaswamy O.N. Mechanisms of induction of skin cancer by UV radiation. Front Biosci 1997, 2:d538-d551.
    • (1997) Front Biosci , vol.2
    • Soehnge, H.1    Ouhtit, A.2    Ananthaswamy, O.N.3
  • 47
    • 0034011263 scopus 로고    scopus 로고
    • Chemoprevention of cancer
    • Sporn M.B., Suh N. Chemoprevention of cancer. Carcinogenesis 2000, 21:525-530.
    • (2000) Carcinogenesis , vol.21 , pp. 525-530
    • Sporn, M.B.1    Suh, N.2
  • 48
    • 0028567256 scopus 로고
    • Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L
    • Tarantilis P.A., Morjani H., Polissiou M., Manfait M. Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. Anticancer Res 1994, 14:1913-1918.
    • (1994) Anticancer Res , vol.14 , pp. 1913-1918
    • Tarantilis, P.A.1    Morjani, H.2    Polissiou, M.3    Manfait, M.4
  • 49
    • 0028892819 scopus 로고
    • Crocetin protects against oxidative damage in rat primary hepatocytes
    • Tseng T.H., Chu C.Y., Huang J.M., Shiow S.J., Wang C.J. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett 1995, 97:61-67.
    • (1995) Cancer Lett , vol.97 , pp. 61-67
    • Tseng, T.H.1    Chu, C.Y.2    Huang, J.M.3    Shiow, S.J.4    Wang, C.J.5
  • 50
    • 0035837659 scopus 로고    scopus 로고
    • Ras gene mutations in 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat sarcomas
    • Walentinsson A., Levan G. Ras gene mutations in 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat sarcomas. Cancer Lett 2001, 166:47-53.
    • (2001) Cancer Lett , vol.166 , pp. 47-53
    • Walentinsson, A.1    Levan, G.2
  • 51
    • 0026590679 scopus 로고
    • Inhibition of carcinogenesis by minor dietary constituents
    • Wattenberg L.W. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res 1992, 52:2085s-2091s.
    • (1992) Cancer Res , vol.52
    • Wattenberg, L.W.1
  • 53
    • 32644434107 scopus 로고    scopus 로고
    • Study of the effect of crocin on rat experimental hyperlipemia and the underlying mechanisms
    • Xu G.L., Yu S.Q., Gong Z.N., Zhang S.Q. Study of the effect of crocin on rat experimental hyperlipemia and the underlying mechanisms. Zhongguo Zhong Yao Za Zhi 2005, 30:369-372.
    • (2005) Zhongguo Zhong Yao Za Zhi , vol.30 , pp. 369-372
    • Xu, G.L.1    Yu, S.Q.2    Gong, Z.N.3    Zhang, S.Q.4
  • 54
    • 33847190347 scopus 로고    scopus 로고
    • Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia
    • Zheng Y.Q., Liu J.X., Wang J.N., Xu L. Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007, 1138:86-94.
    • (2007) Brain Res , vol.1138 , pp. 86-94
    • Zheng, Y.Q.1    Liu, J.X.2    Wang, J.N.3    Xu, L.4


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