-
1
-
-
38849190556
-
Gut microbiota: a potential new territory for drug targeting
-
Jia, W., Li, H., Zhao, L., Nicholson, J.K., Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov 7:2 (2008), 123–129.
-
(2008)
Nat Rev Drug Discov
, vol.7
, Issue.2
, pp. 123-129
-
-
Jia, W.1
Li, H.2
Zhao, L.3
Nicholson, J.K.4
-
2
-
-
33845874101
-
An obesity-associated gut microbiome with increased capacity for energy harvest
-
Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., Gordon, J.I., An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444 (2006), 1027–1031.
-
(2006)
Nature
, vol.444
, pp. 1027-1031
-
-
Turnbaugh, P.J.1
Ley, R.E.2
Mahowald, M.A.3
Magrini, V.4
Mardis, E.R.5
Gordon, J.I.6
-
3
-
-
84880155188
-
Ecology and physiology of the intestinal tract
-
Blaut, M., Ecology and physiology of the intestinal tract. Curr Top Microbiol Immunol 358 (2013), 247–272.
-
(2013)
Curr Top Microbiol Immunol
, vol.358
, pp. 247-272
-
-
Blaut, M.1
-
4
-
-
33750719994
-
Global systems biology, personalized medicine and molecular epidemiology
-
Nicholson, J.K., Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol, 2, 2006, 52.
-
(2006)
Mol Syst Biol
, vol.2
, pp. 52
-
-
Nicholson, J.K.1
-
5
-
-
84884770604
-
A small volatile bacterial molecule triggers mitocondrial dysfunction in murine skeletal muscle
-
Tzika, A.A., Constantinou, C., Bandyopadhaya, A., et al. A small volatile bacterial molecule triggers mitocondrial dysfunction in murine skeletal muscle. PLoS One, 8(9), 2013, e74528.
-
(2013)
PLoS One
, vol.8
, Issue.9
, pp. e74528
-
-
Tzika, A.A.1
Constantinou, C.2
Bandyopadhaya, A.3
-
6
-
-
79953647671
-
The gut microbiome as therapeutic target
-
Cani, P.D., Delzenne, N.M., The gut microbiome as therapeutic target. Pharmacol Ther 130:2 (2011), 202–212.
-
(2011)
Pharmacol Ther
, vol.130
, Issue.2
, pp. 202-212
-
-
Cani, P.D.1
Delzenne, N.M.2
-
7
-
-
50849084986
-
The gastrointestinal microbiota as a site for the biotransformation of drugs
-
Sousa, T., Paterson, R., Moore, V., Carlsson, A., Abrahamsson, B., Basit, A.W., The gastrointestinal microbiota as a site for the biotransformation of drugs. Int J Pharm 363:1-2 (2008), 1–25.
-
(2008)
Int J Pharm
, vol.363
, Issue.1-2
, pp. 1-25
-
-
Sousa, T.1
Paterson, R.2
Moore, V.3
Carlsson, A.4
Abrahamsson, B.5
Basit, A.W.6
-
8
-
-
67650595188
-
The role of gut microbiota in drug response
-
Wilson, I.D., Nicholson, J.K., The role of gut microbiota in drug response. Curr Pharm Des 15 (2009), 1519–1523.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 1519-1523
-
-
Wilson, I.D.1
Nicholson, J.K.2
-
9
-
-
84907487928
-
Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics
-
Carmody, R.N., Turnbaugh, P.J., Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics. J Clin Invest 124:10 (2014), 4173–4181.
-
(2014)
J Clin Invest
, vol.124
, Issue.10
, pp. 4173-4181
-
-
Carmody, R.N.1
Turnbaugh, P.J.2
-
10
-
-
33744804299
-
Metagenomic analysis of the human distal gut microbiome
-
Gill, S.R., Pop, M., Deboy, R.T., et al. Metagenomic analysis of the human distal gut microbiome. Science 312:5778 (2006), 1355–1359.
-
(2006)
Science
, vol.312
, Issue.5778
, pp. 1355-1359
-
-
Gill, S.R.1
Pop, M.2
Deboy, R.T.3
-
11
-
-
0024383615
-
Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora
-
Mathan, V.I., Wiederman, J., Dobkin, J.F., Lindenbaum, J., Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora. Gut 30:7 (1989), 971–977.
-
(1989)
Gut
, vol.30
, Issue.7
, pp. 971-977
-
-
Mathan, V.I.1
Wiederman, J.2
Dobkin, J.F.3
Lindenbaum, J.4
-
12
-
-
70349108406
-
Intestinal microbiota regulate xenobiotic metabolism in the liver
-
Björkholm, B., Bok, C.M., Lundin, A., et al. Intestinal microbiota regulate xenobiotic metabolism in the liver. PLoS One, 4(9), 2009, e6958.
-
(2009)
PLoS One
, vol.4
, Issue.9
, pp. e6958
-
-
Björkholm, B.1
Bok, C.M.2
Lundin, A.3
-
13
-
-
84859648364
-
Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters
-
Davey, K.J., O'Mahony, S.M., Schellekens, H., et al. Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters. Psychopharmacology (Berl) 221:1 (2012), 155–169.
-
(2012)
Psychopharmacology (Berl)
, vol.221
, Issue.1
, pp. 155-169
-
-
Davey, K.J.1
O'Mahony, S.M.2
Schellekens, H.3
-
14
-
-
44649176941
-
Gut microbiota: a new aspect that should be taken into more consideration when assessing the toxicity of chemicals or the adverse effects and efficacy of drugs
-
Qin, X., Gut microbiota: a new aspect that should be taken into more consideration when assessing the toxicity of chemicals or the adverse effects and efficacy of drugs. Regul Toxicol Pharmacol, 51(2), 2008, 251.
-
(2008)
Regul Toxicol Pharmacol
, vol.51
, Issue.2
, pp. 251
-
-
Qin, X.1
-
15
-
-
84954379199
-
The influence of gut microbiota on drug metabolism and toxicity
-
Li, H., He, J., Jia, W., The influence of gut microbiota on drug metabolism and toxicity. Expert Opin Drug Metab Toxicol 12:1 (2016), 31–40.
-
(2016)
Expert Opin Drug Metab Toxicol
, vol.12
, Issue.1
, pp. 31-40
-
-
Li, H.1
He, J.2
Jia, W.3
-
16
-
-
84946218737
-
Gut microbiota-mediated drug-antibiotic interactions
-
Kim, D.H., Gut microbiota-mediated drug-antibiotic interactions. Drug Metab Dispos 43:10 (2015), 1581–1589.
-
(2015)
Drug Metab Dispos
, vol.43
, Issue.10
, pp. 1581-1589
-
-
Kim, D.H.1
-
17
-
-
66649100229
-
Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in rat
-
Meini, W., Sczesny, S., Brigelius-Flohé, R., Blaut, M., Glatt, H., Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in rat. Drug Metab Dispos 37:6 (2009), 1179–1186.
-
(2009)
Drug Metab Dispos
, vol.37
, Issue.6
, pp. 1179-1186
-
-
Meini, W.1
Sczesny, S.2
Brigelius-Flohé, R.3
Blaut, M.4
Glatt, H.5
-
18
-
-
83055184684
-
Epithelial barrier biology; Good fences make good neighbours
-
Moens, E., Veldhoen, M., Epithelial barrier biology; Good fences make good neighbours. Immunology 135:1 (2012), 1–8.
-
(2012)
Immunology
, vol.135
, Issue.1
, pp. 1-8
-
-
Moens, E.1
Veldhoen, M.2
-
19
-
-
65249119418
-
The human intestinal microbiome: a new frontier of human biology
-
Hattori, M., Taylor, T.D., The human intestinal microbiome: a new frontier of human biology. DNA Res 16:1 (2009), 1–12.
-
(2009)
DNA Res
, vol.16
, Issue.1
, pp. 1-12
-
-
Hattori, M.1
Taylor, T.D.2
-
20
-
-
84977507546
-
Genome medicine, microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions
-
Zhang, L.S., Davies, S.S., Genome medicine, microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions. Genome Med, 8(1), 2016, 46.
-
(2016)
Genome Med
, vol.8
, Issue.1
, pp. 46
-
-
Zhang, L.S.1
Davies, S.S.2
-
21
-
-
84960173068
-
Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction
-
Zhou, S.S., Xu, J., Zhu, H., et al. Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction. Sci Rep, 6, 2016, 22474.
-
(2016)
Sci Rep
, vol.6
, pp. 22474
-
-
Zhou, S.S.1
Xu, J.2
Zhu, H.3
-
22
-
-
54949089595
-
Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats
-
Yamamoto, M., Kurita, A., Asahara, T., et al. Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats. Oncol Rep 20:4 (2008), 727–730.
-
(2008)
Oncol Rep
, vol.20
, Issue.4
, pp. 727-730
-
-
Yamamoto, M.1
Kurita, A.2
Asahara, T.3
-
23
-
-
80052895923
-
Variation of glucoraphanin metabolism in vivo and ex vivo by human gut bacteria
-
Li, F., Hullar, M.A., Beresford, S.A., Lampe, J.W., Variation of glucoraphanin metabolism in vivo and ex vivo by human gut bacteria. Br J Nutr 106 (2011), 408–416.
-
(2011)
Br J Nutr
, vol.106
, pp. 408-416
-
-
Li, F.1
Hullar, M.A.2
Beresford, S.A.3
Lampe, J.W.4
-
24
-
-
77955647582
-
Gut microbiota in health and disease
-
Sekirov, I., Russell, S.L., Antunes, L.C.M., Finlay, B.F., Gut microbiota in health and disease. Physiol Rev 90:3 (2010), 859–904.
-
(2010)
Physiol Rev
, vol.90
, Issue.3
, pp. 859-904
-
-
Sekirov, I.1
Russell, S.L.2
Antunes, L.C.M.3
Finlay, B.F.4
-
25
-
-
0019127339
-
Role of the intestinal flora in the metabolism of misonidazole
-
Koch, R.L., Beaulieu, B.B. Jr., Goldman, P., Role of the intestinal flora in the metabolism of misonidazole. Biochem Pharmacol 29:24 (1980), 3281–3284.
-
(1980)
Biochem Pharmacol
, vol.29
, Issue.24
, pp. 3281-3284
-
-
Koch, R.L.1
Beaulieu, B.B.2
Goldman, P.3
-
26
-
-
0023234065
-
The reduction of sulphinpyrazone and sulindac by intestinal bacteria
-
Strong, H.A., Renwick, A.G., George, C.F., Liu, Y.F., Hill, M.J., The reduction of sulphinpyrazone and sulindac by intestinal bacteria. Xenobiotica 17:6 (1987), 685–696.
-
(1987)
Xenobiotica
, vol.17
, Issue.6
, pp. 685-696
-
-
Strong, H.A.1
Renwick, A.G.2
George, C.F.3
Liu, Y.F.4
Hill, M.J.5
-
27
-
-
0021738040
-
The site of reduction of sulphinpyrazone in the rabbit
-
Strong, H.A., Renwick, A.G., George, C.F., The site of reduction of sulphinpyrazone in the rabbit. Xenobiotica 14:10 (1984), 815–826.
-
(1984)
Xenobiotica
, vol.14
, Issue.10
, pp. 815-826
-
-
Strong, H.A.1
Renwick, A.G.2
George, C.F.3
-
28
-
-
77954960284
-
Biotransformation of valdecoxib by microbial cultures
-
Keshetti, S., Ciddi, V., Biotransformation of valdecoxib by microbial cultures. J Microbiol Biotechnol 20:4 (2010), 809–816.
-
(2010)
J Microbiol Biotechnol
, vol.20
, Issue.4
, pp. 809-816
-
-
Keshetti, S.1
Ciddi, V.2
-
29
-
-
0019174126
-
Relationship between metronidazole metabolism and bactericidal activity
-
Chrystal, E.J., Koch, R.L., McLafferty, M.A., Goldman, P., Relationship between metronidazole metabolism and bactericidal activity. Antimicrob Agents Chemother 18:4 (1980), 566–573.
-
(1980)
Antimicrob Agents Chemother
, vol.18
, Issue.4
, pp. 566-573
-
-
Chrystal, E.J.1
Koch, R.L.2
McLafferty, M.A.3
Goldman, P.4
-
30
-
-
0030964923
-
The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide
-
Kitamura, S., Sugihara, K., Kuwasako, M., Tatsumi, K., The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide. J Pharm Pharmacol 49:3 (1997), 253–256.
-
(1997)
J Pharm Pharmacol
, vol.49
, Issue.3
, pp. 253-256
-
-
Kitamura, S.1
Sugihara, K.2
Kuwasako, M.3
Tatsumi, K.4
-
31
-
-
0021677458
-
Role of intestinal microflora in clonazepam metabolism in the rat
-
Elmer, G.W., Remmel, R.P., Role of intestinal microflora in clonazepam metabolism in the rat. Xenobiotica 14 (1984), 829–840.
-
(1984)
Xenobiotica
, vol.14
, pp. 829-840
-
-
Elmer, G.W.1
Remmel, R.P.2
-
32
-
-
0025912777
-
Involvement of the intestinal microflora in nitrazepam-induced teratogenicity in rats and its relationship to nitroreduction
-
Takeno, S., Sakai, T., Involvement of the intestinal microflora in nitrazepam-induced teratogenicity in rats and its relationship to nitroreduction. Teratology 44:2 (1991), 209–214.
-
(1991)
Teratology
, vol.44
, Issue.2
, pp. 209-214
-
-
Takeno, S.1
Sakai, T.2
-
33
-
-
84863675297
-
The influence of probiotic treatment on sulfasalazine metabolism in rat
-
Lee, H.J., Zhang, H., Orlovich, D.A., Fawcett, J.P., The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica 42:8 (2012), 791–797.
-
(2012)
Xenobiotica
, vol.42
, Issue.8
, pp. 791-797
-
-
Lee, H.J.1
Zhang, H.2
Orlovich, D.A.3
Fawcett, J.P.4
-
34
-
-
0025728830
-
Sulphasalazine in ulcerative colitis: in memoriam?
-
Hayllar, J., Bjarnason, I., Sulphasalazine in ulcerative colitis: in memoriam?. Gut 32:5 (1991), 462–463.
-
(1991)
Gut
, vol.32
, Issue.5
, pp. 462-463
-
-
Hayllar, J.1
Bjarnason, I.2
-
35
-
-
0017576716
-
Development of germ-free animal characteristics in conventional rats in antibiotics
-
Gustafsson, B.E., Norin, K.E., Development of germ-free animal characteristics in conventional rats in antibiotics. Acta Pathol Microbiol Scand B 85B:1 (1977), 1–8.
-
(1977)
Acta Pathol Microbiol Scand B
, vol.85B
, Issue.1
, pp. 1-8
-
-
Gustafsson, B.E.1
Norin, K.E.2
-
36
-
-
0742269696
-
The use of formulation technology to assess regional gastrointestinal drug absorption in humans
-
Basit, A.W., Podczeck, F., Newton, J.M., et al. The use of formulation technology to assess regional gastrointestinal drug absorption in humans. Eur J Pharm Sci 21:2-3 (2004), 179–189.
-
(2004)
Eur J Pharm Sci
, vol.21
, Issue.2-3
, pp. 179-189
-
-
Basit, A.W.1
Podczeck, F.2
Newton, J.M.3
-
37
-
-
0028231334
-
Site-dependent small intestinal absorption of ranitidine
-
Gramatté, T., el Desoky, E., Klotz, U., Site-dependent small intestinal absorption of ranitidine. Eur J Clin Pharmacol 46:3 (1994), 253–259.
-
(1994)
Eur J Clin Pharmacol
, vol.46
, Issue.3
, pp. 253-259
-
-
Gramatté, T.1
el Desoky, E.2
Klotz, U.3
-
38
-
-
0028914209
-
Metabolism of omeprazole by gut flora in rats
-
Watanabe, K., Yamashita, S., Furuno, K., Kawasaki, H., Gomita, Y., Metabolism of omeprazole by gut flora in rats. J Pharm Sci 84:4 (1995), 516–517.
-
(1995)
J Pharm Sci
, vol.84
, Issue.4
, pp. 516-517
-
-
Watanabe, K.1
Yamashita, S.2
Furuno, K.3
Kawasaki, H.4
Gomita, Y.5
-
39
-
-
80053596796
-
Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis
-
Wallace, J.L., Syer, S., Denou, E., et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology 141:4 (2011), 1314–1322.
-
(2011)
Gastroenterology
, vol.141
, Issue.4
, pp. 1314-1322
-
-
Wallace, J.L.1
Syer, S.2
Denou, E.3
-
40
-
-
0032498318
-
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine
-
Ogura, K., Nishiyama, T., Takubo, H., et al. Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine. Cancer Lett 122:1-2 (1998), 107–113.
-
(1998)
Cancer Lett
, vol.122
, Issue.1-2
, pp. 107-113
-
-
Ogura, K.1
Nishiyama, T.2
Takubo, H.3
-
41
-
-
0030985696
-
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil
-
Nakayama, H., Kinouchi, T., Kataoka, K., et al. Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil. Pharmacogenetics 7:1 (1997), 35–43.
-
(1997)
Pharmacogenetics
, vol.7
, Issue.1
, pp. 35-43
-
-
Nakayama, H.1
Kinouchi, T.2
Kataoka, K.3
-
42
-
-
84948451779
-
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
-
Sivan, A., Corrales, L., Hubert, N., et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science 350:6264 (2015), 1084–1089.
-
(2015)
Science
, vol.350
, Issue.6264
, pp. 1084-1089
-
-
Sivan, A.1
Corrales, L.2
Hubert, N.3
-
43
-
-
85014509216
-
Gut microbiota modulation of chemotherapy efficacy and toxicity
-
Alexander, J.L., Wilson, I.D., Teare, J., et al. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol 14:6 (2017), 356–365.
-
(2017)
Nat Rev Gastroenterol Hepatol
, vol.14
, Issue.6
, pp. 356-365
-
-
Alexander, J.L.1
Wilson, I.D.2
Teare, J.3
-
44
-
-
33746102877
-
Pro-antibiotic substrates for the identification of enantioselective hydrolases
-
Hwang, B.Y., Oh, J.M., Kim, J., Kim, B.G., Pro-antibiotic substrates for the identification of enantioselective hydrolases. Biotechnol Lett 28:15 (2006), 1181–1185.
-
(2006)
Biotechnol Lett
, vol.28
, Issue.15
, pp. 1181-1185
-
-
Hwang, B.Y.1
Oh, J.M.2
Kim, J.3
Kim, B.G.4
-
45
-
-
84858596741
-
Antibiotic susceptibility of different lactic acid bacteria strains
-
Karapetkov, N., Georgieva, R., Rumyan, N., Karaivanova, E., Antibiotic susceptibility of different lactic acid bacteria strains. Benef Microbes 2:4 (2011), 335–339.
-
(2011)
Benef Microbes
, vol.2
, Issue.4
, pp. 335-339
-
-
Karapetkov, N.1
Georgieva, R.2
Rumyan, N.3
Karaivanova, E.4
-
46
-
-
0027240704
-
The role of gastrointestinal microflora in the metabolism of drugs
-
Abu Shamat, M., The role of gastrointestinal microflora in the metabolism of drugs. Int J Pharm 97 (1993), 1–13.
-
(1993)
Int J Pharm
, vol.97
, pp. 1-13
-
-
Abu Shamat, M.1
-
47
-
-
0030731165
-
Regioselectivity of nitroglycerin denitration by flavoprotein nitroester reductases purified from two Pseudomonas species
-
Blehert, D.S., Knoke, K.L., Fox, B.G., Chambliss, G.H., Regioselectivity of nitroglycerin denitration by flavoprotein nitroester reductases purified from two Pseudomonas species. J Bacteriol 179 (1997), 6912–6920.
-
(1997)
J Bacteriol
, vol.179
, pp. 6912-6920
-
-
Blehert, D.S.1
Knoke, K.L.2
Fox, B.G.3
Chambliss, G.H.4
-
48
-
-
0031663816
-
Aerobic growth on nitroglycerin as the sole carbon, nitrogen, and energy source by a mixed bacterial culture
-
Accashian, J.V., Vinopal, R.T., Kim, B.J., Smets, B.F., Aerobic growth on nitroglycerin as the sole carbon, nitrogen, and energy source by a mixed bacterial culture. Appl Environ Microbiol 64:9 (1998), 3300–3304.
-
(1998)
Appl Environ Microbiol
, vol.64
, Issue.9
, pp. 3300-3304
-
-
Accashian, J.V.1
Vinopal, R.T.2
Kim, B.J.3
Smets, B.F.4
-
49
-
-
78149377371
-
The first global screening of protein substrates bearing protein-bound 3,4-Dihydroxyphenylalanine in Escherichia coli and human mitochondria
-
Lee, S., Chen, Y., Luo, H., et al. The first global screening of protein substrates bearing protein-bound 3,4-Dihydroxyphenylalanine in Escherichia coli and human mitochondria. J Proteome Res 9:11 (2010), 5705–5714.
-
(2010)
J Proteome Res
, vol.9
, Issue.11
, pp. 5705-5714
-
-
Lee, S.1
Chen, Y.2
Luo, H.3
-
50
-
-
0041851676
-
Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid
-
Deloménie, C., Fouix, S., Longuemaux, S., et al. Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol 183:11 (2001), 3417–3427.
-
(2001)
J Bacteriol
, vol.183
, Issue.11
, pp. 3417-3427
-
-
Deloménie, C.1
Fouix, S.2
Longuemaux, S.3
-
51
-
-
0021058255
-
The synthesis and mutagenicity of the N-formyl analog of N-hydroxyphenacetin
-
Corbett, M.D., Wei, C.I., Fernando, S.Y., Doerge, D.R., Corbett, B.R., The synthesis and mutagenicity of the N-formyl analog of N-hydroxyphenacetin. Carcinogenesis 4:12 (1983), 1615–1618.
-
(1983)
Carcinogenesis
, vol.4
, Issue.12
, pp. 1615-1618
-
-
Corbett, M.D.1
Wei, C.I.2
Fernando, S.Y.3
Doerge, D.R.4
Corbett, B.R.5
-
52
-
-
0015621623
-
The demethylation of methamphetamine by intestinal microflora
-
Caldwell, J., Hawksworth, G.M., The demethylation of methamphetamine by intestinal microflora. J Pharm Pharmacol 25:5 (1973), 422–424.
-
(1973)
J Pharm Pharmacol
, vol.25
, Issue.5
, pp. 422-424
-
-
Caldwell, J.1
Hawksworth, G.M.2
-
53
-
-
0025879859
-
Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria
-
Shu, Y.Z., Kingston, D.G., Van Tassell, R.L., Wilkins, T.D., Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria. Xenobiotica 21:6 (1991), 737–750.
-
(1991)
Xenobiotica
, vol.21
, Issue.6
, pp. 737-750
-
-
Shu, Y.Z.1
Kingston, D.G.2
Van Tassell, R.L.3
Wilkins, T.D.4
-
54
-
-
0028147301
-
The metabolism and excretion of risperidone after oral administration in rats and dogs
-
Meuldermans, W., Hendrickx, J., Mannens, G., et al. The metabolism and excretion of risperidone after oral administration in rats and dogs. Drug Metab Dispos 22:1 (1994), 129–138.
-
(1994)
Drug Metab Dispos
, vol.22
, Issue.1
, pp. 129-138
-
-
Meuldermans, W.1
Hendrickx, J.2
Mannens, G.3
-
55
-
-
37849014547
-
Evaluation of small bowel bacterial overgrowth
-
Schiller, L.R., Evaluation of small bowel bacterial overgrowth. Curr Gastroenterol Rep 9:5 (2007), 373–377.
-
(2007)
Curr Gastroenterol Rep
, vol.9
, Issue.5
, pp. 373-377
-
-
Schiller, L.R.1
-
56
-
-
79956075540
-
Colonization-induced host-gut microbial metabolic interaction
-
Claus, S.P., Ellero, S.L., Berger, B., et al. Colonization-induced host-gut microbial metabolic interaction. MBio 2:2 (2011), e00271–e002710.
-
(2011)
MBio
, vol.2
, Issue.2
, pp. e00271-e002710
-
-
Claus, S.P.1
Ellero, S.L.2
Berger, B.3
-
57
-
-
0031827877
-
Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats
-
Takasuna, K., Hagiwara, T., Hirohashi, M., et al. Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats. Cancer Chemother Pharmacol 42:4 (1998), 280–286.
-
(1998)
Cancer Chemother Pharmacol
, vol.42
, Issue.4
, pp. 280-286
-
-
Takasuna, K.1
Hagiwara, T.2
Hirohashi, M.3
-
58
-
-
0020559929
-
Metabolism and cardiac actions of a polar aminocardenolide and digoxin in the conscious dog
-
Songu-Mize, E., Nash, C.B., Elam, J.T., Caldwell, R.W., Metabolism and cardiac actions of a polar aminocardenolide and digoxin in the conscious dog. J Pharmacol Exp Ther 226:1 (1983), 65–70.
-
(1983)
J Pharmacol Exp Ther
, vol.226
, Issue.1
, pp. 65-70
-
-
Songu-Mize, E.1
Nash, C.B.2
Elam, J.T.3
Caldwell, R.W.4
-
59
-
-
0029840531
-
Main ginseng saponin metabolites formed by intestinal bacteria
-
Hasegawa, H., Sung, J.H., Matsumiya, S., Uchiyama, M., Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 62:5 (1996), 453–457.
-
(1996)
Planta Med
, vol.62
, Issue.5
, pp. 453-457
-
-
Hasegawa, H.1
Sung, J.H.2
Matsumiya, S.3
Uchiyama, M.4
-
60
-
-
0042526129
-
Degradation of ginsenosides in humans after oral administration
-
Tawab, M.A., Bahr, U., Karas, M., Wurglics, M., Schubert-Zsilavecz, M., Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 31:8 (2003), 1065–1071.
-
(2003)
Drug Metab Dispos
, vol.31
, Issue.8
, pp. 1065-1071
-
-
Tawab, M.A.1
Bahr, U.2
Karas, M.3
Wurglics, M.4
Schubert-Zsilavecz, M.5
-
61
-
-
0034534704
-
Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form
-
Akao, T., Kawabata, K., Yanagisawa, E., et al. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J Pharm Pharmacol 52:12 (2000), 1563–1568.
-
(2000)
J Pharm Pharmacol
, vol.52
, Issue.12
, pp. 1563-1568
-
-
Akao, T.1
Kawabata, K.2
Yanagisawa, E.3
-
62
-
-
0027278725
-
Extent and implications of interspecies differences in the intestinal hydrolysis of certain glucuronideconjugates
-
Kenyon, E.M., Calabrese, E.J., Extent and implications of interspecies differences in the intestinal hydrolysis of certain glucuronideconjugates. Xenobiotica 23:4 (1993), 373–381.
-
(1993)
Xenobiotica
, vol.23
, Issue.4
, pp. 373-381
-
-
Kenyon, E.M.1
Calabrese, E.J.2
-
63
-
-
84857422388
-
Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats
-
Matuskova, Z., Siller, M., Tunkova, A., et al. Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats. Neuro Endocrinol Lett, 32, 2011, S1.
-
(2011)
Neuro Endocrinol Lett
, vol.32
, pp. S1
-
-
Matuskova, Z.1
Siller, M.2
Tunkova, A.3
-
64
-
-
84946203976
-
RNA-seq quantification of hepatic drug processing genes in germ-free mice
-
Selwyn, F.P., Cui, J.Y., Klaassen, C.D., RNA-seq quantification of hepatic drug processing genes in germ-free mice. Drug Metab Dispos 43 (2015), 1572–1580.
-
(2015)
Drug Metab Dispos
, vol.43
, pp. 1572-1580
-
-
Selwyn, F.P.1
Cui, J.Y.2
Klaassen, C.D.3
-
65
-
-
0025301495
-
Mutagen excretion and cytochrome P-450 dependant activity in germ free and conventional rats fed a diet containing fried meat
-
Overvik, E., Lindeskop, P., Midtvedt, T., Gustafsson, J.A., Mutagen excretion and cytochrome P-450 dependant activity in germ free and conventional rats fed a diet containing fried meat. Food Chem Toxicol 28 (1990), 253–261.
-
(1990)
Food Chem Toxicol
, vol.28
, pp. 253-261
-
-
Overvik, E.1
Lindeskop, P.2
Midtvedt, T.3
Gustafsson, J.A.4
-
66
-
-
0023063109
-
Mutagen activation by hepatic fractions from conventional, germ free and monoassociated rats
-
Rowland, I.R., Mallett, A.K., Cole, C.B., Fuller, R., Mutagen activation by hepatic fractions from conventional, germ free and monoassociated rats. Arch Toxicol S11 (1987), 261–263.
-
(1987)
Arch Toxicol
, vol.S11
, pp. 261-263
-
-
Rowland, I.R.1
Mallett, A.K.2
Cole, C.B.3
Fuller, R.4
-
67
-
-
77955153069
-
The endocannabinoid system links gut microbiota to adipogenesis
-
Muccioli, G.G., Naslain, D., Bäckhed, F., et al. The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol, 6, 2010, 392.
-
(2010)
Mol Syst Biol
, vol.6
, pp. 392
-
-
Muccioli, G.G.1
Naslain, D.2
Bäckhed, F.3
-
68
-
-
84856516709
-
The cannabinoid agonist WIN55212-2 decreases l-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats
-
Martinez, A., Macheda, T., Morgese, M.G., Trabace, L., Giuffrida, A., The cannabinoid agonist WIN55212-2 decreases l-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats. Neurosci Res 72:3 (2012), 236–242.
-
(2012)
Neurosci Res
, vol.72
, Issue.3
, pp. 236-242
-
-
Martinez, A.1
Macheda, T.2
Morgese, M.G.3
Trabace, L.4
Giuffrida, A.5
-
69
-
-
85026818617
-
The role of CB1 in intestinal permeability and inflammation
-
Karwad, M.A., Couch, D.G., Theophilidou, E., et al. The role of CB1 in intestinal permeability and inflammation. FASEB J 31:8 (2017), 3267–3277.
-
(2017)
FASEB J
, vol.31
, Issue.8
, pp. 3267-3277
-
-
Karwad, M.A.1
Couch, D.G.2
Theophilidou, E.3
-
70
-
-
77957654292
-
The interaction of gut microbes with host ABC transporters
-
Mercado-Lubo, R., McCormick, B.A., The interaction of gut microbes with host ABC transporters. Gut Microbes 1:5 (2010), 301–306.
-
(2010)
Gut Microbes
, vol.1
, Issue.5
, pp. 301-306
-
-
Mercado-Lubo, R.1
McCormick, B.A.2
-
71
-
-
79952749581
-
Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways
-
Van Baarlen, P., Troost, F., van der Meer, C., et al. Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways. Proc Natl Acad Sci U S A 108 (2011), 4562–4569.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4562-4569
-
-
Van Baarlen, P.1
Troost, F.2
van der Meer, C.3
-
72
-
-
5044229817
-
The challenges of modeling mammalian biocomplexity
-
Nicholson, J.K., Holmes, E., Lindon, J.C., Wilson, I.D., The challenges of modeling mammalian biocomplexity. Nat Biotechnol 22:10 (2004), 1268–1274.
-
(2004)
Nat Biotechnol
, vol.22
, Issue.10
, pp. 1268-1274
-
-
Nicholson, J.K.1
Holmes, E.2
Lindon, J.C.3
Wilson, I.D.4
-
73
-
-
79960007110
-
Mesalazine (5-aminosalicylic acid) alters faecal bacterial profiles, but not mucosal proteolytic activity in diarrhoea-predominant irritable bowel syndrome
-
Andrews, C.N., Griffiths, T.A., Kaufman, J., et al. Mesalazine (5-aminosalicylic acid) alters faecal bacterial profiles, but not mucosal proteolytic activity in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 34:3 (2011), 374–383.
-
(2011)
Aliment Pharmacol Ther
, vol.34
, Issue.3
, pp. 374-383
-
-
Andrews, C.N.1
Griffiths, T.A.2
Kaufman, J.3
-
74
-
-
79953203529
-
Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling
-
Wang, J., Ma, J., Charboneau, R., Barke, R., Roy, S., Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling. J Biol Chem 286:12 (2011), 10225–10232.
-
(2011)
J Biol Chem
, vol.286
, Issue.12
, pp. 10225-10232
-
-
Wang, J.1
Ma, J.2
Charboneau, R.3
Barke, R.4
Roy, S.5
-
75
-
-
81355134425
-
Opioids and the immune system: what is their mechanism of action?
-
Eisenstein, T.K., Opioids and the immune system: what is their mechanism of action?. Br J Pharmacol 164:7 (2011), 1826–1828.
-
(2011)
Br J Pharmacol
, vol.164
, Issue.7
, pp. 1826-1828
-
-
Eisenstein, T.K.1
-
76
-
-
0034672109
-
Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats
-
Koller, M.M., Purushotham, K.R., Maeda, N., Scarpace, P.J., Humphreys-Beher, M.G., Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats. Life Sci 68:4 (2000), 445–455.
-
(2000)
Life Sci
, vol.68
, Issue.4
, pp. 445-455
-
-
Koller, M.M.1
Purushotham, K.R.2
Maeda, N.3
Scarpace, P.J.4
Humphreys-Beher, M.G.5
-
77
-
-
84991696768
-
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness
-
Macedo, D., Filho, A.J., Soares de Sousa, C.N., et al. Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness. J Affect Disord 208 (2016), 22–32.
-
(2016)
J Affect Disord
, vol.208
, pp. 22-32
-
-
Macedo, D.1
Filho, A.J.2
Soares de Sousa, C.N.3
-
78
-
-
81355143314
-
Depletion and recovery of lymphoid subsets following morphine administration
-
Zhang, E.Y., Xiong, J., Parker, B.L., et al. Depletion and recovery of lymphoid subsets following morphine administration. Br J Pharmacol 164 (2001), 1829–1844.
-
(2001)
Br J Pharmacol
, vol.164
, pp. 1829-1844
-
-
Zhang, E.Y.1
Xiong, J.2
Parker, B.L.3
-
79
-
-
84930656532
-
Opioid exacerbation of grampositive sepsis, induced by gut microbial modulation, is rescued by IL-17A neutralization
-
Meng, J., Banerjee, S., Li, D., et al. Opioid exacerbation of grampositive sepsis, induced by gut microbial modulation, is rescued by IL-17A neutralization. Sci Rep, 5, 2015, 10918.
-
(2015)
Sci Rep
, vol.5
, pp. 10918
-
-
Meng, J.1
Banerjee, S.2
Li, D.3
-
80
-
-
84937109454
-
Disruption of gut homeostasis by opioids accelerates HIV disease progression
-
Meng, J., Sindberg, G.M., Roy, S., Disruption of gut homeostasis by opioids accelerates HIV disease progression. Front Microbiol 6 (2015), 643–654.
-
(2015)
Front Microbiol
, vol.6
, pp. 643-654
-
-
Meng, J.1
Sindberg, G.M.2
Roy, S.3
-
81
-
-
79951995822
-
Whole-genome sequencing and social-network analysis of a tuberculosis outbreak
-
Gardy, J.L., Johnston, J.C., Ho Sui, S.J., et al. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N Engl J Med 364:8 (2011), 730–739.
-
(2011)
N Engl J Med
, vol.364
, Issue.8
, pp. 730-739
-
-
Gardy, J.L.1
Johnston, J.C.2
Ho Sui, S.J.3
-
82
-
-
84856736136
-
Impact of cigarette smoke exposure on host-bacterial pathogen interactions
-
Garmendia, J., Morey, P., Bengoechea, J.A., Impact of cigarette smoke exposure on host-bacterial pathogen interactions. Eur Respir J 39:2 (2012), 467–477.
-
(2012)
Eur Respir J
, vol.39
, Issue.2
, pp. 467-477
-
-
Garmendia, J.1
Morey, P.2
Bengoechea, J.A.3
-
83
-
-
70349335851
-
Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
-
Mutlu, E., Keshavarzian, A., Engen, P., Forsyth, C.B., Sikaroodi, M., Gillevet, P., Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol Clin Exp Res 33 (2009), 1836–1846.
-
(2009)
Alcohol Clin Exp Res
, vol.33
, pp. 1836-1846
-
-
Mutlu, E.1
Keshavarzian, A.2
Engen, P.3
Forsyth, C.B.4
Sikaroodi, M.5
Gillevet, P.6
-
84
-
-
84946214404
-
Combined contribution of increased intestinal permeability and inhibited deglycosylation of ginsenoside Rb1 in the intestinal tract to the Enhancement of ginsenoside Rb1 exposure in diabetic rats after oral administration
-
Liu, C., Hu, M., Guo, H., et al. Combined contribution of increased intestinal permeability and inhibited deglycosylation of ginsenoside Rb1 in the intestinal tract to the Enhancement of ginsenoside Rb1 exposure in diabetic rats after oral administration. Drug Metab Dispos 43:11 (2015), 1702–1710.
-
(2015)
Drug Metab Dispos
, vol.43
, Issue.11
, pp. 1702-1710
-
-
Liu, C.1
Hu, M.2
Guo, H.3
-
85
-
-
84962174338
-
American diabetes association and JDRF research symposium: diabetes and the microbiome
-
Semenkovich, C.F., Danska, J., Darsow, T., et al. American diabetes association and JDRF research symposium: diabetes and the microbiome. Diabetes 64:12 (2015), 3967–3977.
-
(2015)
Diabetes
, vol.64
, Issue.12
, pp. 3967-3977
-
-
Semenkovich, C.F.1
Danska, J.2
Darsow, T.3
|