Opioids and the immune system: What is their mechanism of action?

British Journal of Pharmacology

Volumn 164, Issue 7, 2011, Pages 1826-1828

  Eisenstein, Toby K ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

immune responses; immunomodulation; immunosuppression; morphine; opioids

Indexed keywords

FAS ANTIGEN; FAS LIGAND; GLUCOCORTICOID; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NARCOTIC ANALGESIC AGENT; T LYMPHOCYTE RECEPTOR BETA CHAIN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC DRUG ADMINISTRATION; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; LEUKOCYTE; LYMPHOCYTE DEPLETION; MACROPHAGE; MONOCYTE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN; THYMUS;

ANALGESICS, OPIOID; ANIMALS; B-LYMPHOCYTES; MALE; MORPHINE; NARCOTICS; T-LYMPHOCYTES;

EID: 81355134425     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01513.x     Document Type: Article

References (25)

1. Carr DJJ, Mayo S, Gebhardt BM, Porter J, (1994). Central α-adrenergic involvement in morphine-mediated suppression of splenic natural killer cell activity. J Neuroimmunol 53: 53-63.
2. Eisenstein TK, Meissler JJ, Rogers TJ, Geller EB, Adler MW, (1995). Mouse strain differences in immunosuppression by opioids in vitro. J Pharmacol Exp Ther 275: 1484-1489. (Pubitemid 26129940)
3. Felten SY, Olschowka J, (1987). Noradrenergic sympathetic innervation of the spleen: II. Tyrosine hydroxylase (TH)-positive nerve terminal form synapticlike contacts on lymphocytes in the splenic white pulp. J Neurosci Res 18: 37-48.
4. Flores LR, Hernandez MC, Bayer BM, (1994). Acute immunosuppressive effects of morphine: lack of involvement of pituitary and adrenal factors. J Pharmacol Exp Ther 268: 1129-1134. (Pubitemid 24100324)
5. Guo CJ, Li Y, Tian S, Wang X, Douglas SD, Ho WZ, (2002). Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor. J Invest Med 50: 435-442. (Pubitemid 35278684)
6. Mellon RD, Bayer BM, (2001). Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine. Drug Alcohol Depend 62: 141-147. (Pubitemid 32195504)
7. Nair MP, Schwartz SA, Polasani R, Hou J, Sweet A, Chadha KC, (1997). Immunoregulatory effects of morphine on human lymphocytes. Clin Diag Lab Immunol 4: 127-132. (Pubitemid 27130222)
8. Peterson PK, Sharp BM, Gekker G, Portoghese PS, Sannerud K, Balfour HH Jr, (1990). Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures. AIDS 4: 869-873. (Pubitemid 20342117)
9. Roy S, Ramakrishnan S, Loh HH, Lee NM, (1991). Chronic morphine treatment selectively suppresses macrophage colony formation in bone marrow. Eur J Pharmacol 195: 359-363.
10. h2 differentiation. Surgery 130: 304-309. (Pubitemid 32721684)
11. 1 receptors mediate morphine-induced reductions of natural killer cell activity. J Neuroimmunol 177: 18-26. (Pubitemid 44108233)
12. Sharp BM, (2004). Opioid receptor expression and function. J Neuroimmunol 147: 3-5. (Pubitemid 38114935)
13. Shavit Y, Depaulis A, Martin FC, Terman GW, Pechnick RN, Zane CJ, et al,. (1986). Involvement of brain opiate receptors in the immune-suppressive effect of morphine. Proc Natl Acad Sci U S A 83: 7114-7117. (Pubitemid 17172840)
14. Singhal PC, Sharma P, Kapasi AA, Reddy K, Franki N, Gibbons N, (1998). Morphine enhances macrophage apoptosis. J Immunol 160: 1886-1893. (Pubitemid 28106477)
15. Singhal PC, Bhaskaran M, Patel J, Patel K, Kasinath BS, Franki N, et al,. (2002). Role of P38 MAPK phosphorylation and FasL in morphine-induced macrophage apoptosis. J Immunol 168: 4025-4033.
16. Steele AD, Henderson EE, Rogers TJ, (2003). μ-Opioid modulation of HIV-1 coreceptor expression and HIV-1 replication. Virology 309: 99-107. (Pubitemid 36506593)
17. Szabo I, Rojavin M, Bussiere JL, Eisenstein TK, Adler MW, Rogers TJ, (1993). Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids. J Pharmacol Exp Ther 267: 703-706. (Pubitemid 23352527)
18. Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, et al,. (2003). Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. J Leukoc Biol 74: 1074-1082. (Pubitemid 38040329)
19. Tomassini N, Renaud FL, Roy S, Loh HH, (2003). Mu and delta receptors mediate morphine effects on phagocytosis by murine peritoneal macrophages. J Neuroimmunol 136: 9-16. (Pubitemid 36298839)
20. Vassou D, Badogeorgou E, Kampa M, Dimitriou H, Hatzoglou A, Castanas E, (2008). Opioids modulate constitutive B-lymphocyte secretion. Int Immunopharm 8: 634-644.
21. Wang J, Barke RA, Charboneau R, Schwendener R, Roy S, (2008). Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NFκB signaling. J Immunol 180: 3594-3600.
22. Weber RJ, Pert A, (1989). The periaqueductal gray matter mediates opiate-induced immunosuppression. Science 245: 188-190. (Pubitemid 19193937)
23. Wetzel MA, Steele AD, Eisenstein TK, Adler MW, Henderson EE, Rogers TJ, (2000). μ-Opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-γ-inducible protein-10 expression in human peripheral blood mononuclear cells. J Immunol 165: 6519-6524.
24. Yin D, Mufson A, Wang R, Shi Y, (1999). Fas-mediated cell death promoted by opioids. Nature 397: 218.
25. Zhang EY, Xiong J, Parker BL, Chen AY, Fields PE, Ma X, et al,. (2011). Depletion and recovery of lymphoid subsets following morphine administration. Br J Pharmacol 164: 1829-1844.