메뉴 건너뛰기




Volumn 1, Issue 5, 2010, Pages

The interaction of gut microbes with host ABC transporters

Author keywords

ABC transporters; Cystic fibrosis transmembrane regulator (CFTR); Listeria monocytogenes; Multidrug resistance associated protein 2 (MRP2); P glycoprotein; Salmonella enterica serotype typhi; Salmonella enterica serotype typhimurium; Vibrio cholerae

Indexed keywords

ABC TRANSPORTER; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 2; TRANSMEMBRANE CONDUCTANCE REGULATOR;

EID: 77957654292     PISSN: 19490976     EISSN: 19490984     Source Type: Journal    
DOI: 10.4161/gmic.1.5.12925     Document Type: Review
Times cited : (34)

References (56)
  • 1
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2 and BCRP (ABCG2) in tissue defense
    • May 1
    • Leslie EM, Deeley RG, Cole SP. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2 and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol. May 1 2005; 204:216-37.
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 2
    • 34247623972 scopus 로고    scopus 로고
    • Regulation of drug transporters during infection and inflammation
    • Petrovic V, Teng S, Piquette-Miller M. Regulation of drug transporters during infection and inflammation. Mol Interv 2007; 7:99-111.
    • (2007) Mol Interv , vol.7 , pp. 99-111
    • Petrovic, V.1    Teng, S.2    Piquette-Miller, M.3
  • 3
    • 0344665555 scopus 로고    scopus 로고
    • ABC of oral bioavailability: Transporters as gatekeepers in the gut
    • Dietrich CG, Geier A, Oude Elferink RP. ABC of oral bioavailability: transporters as gatekeepers in the gut. Gut 2003; 52:1788-95.
    • (2003) Gut , vol.52 , pp. 1788-1795
    • Dietrich, C.G.1    Geier, A.2    Oude Elferink, R.P.3
  • 4
    • 21744441440 scopus 로고    scopus 로고
    • Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/-mice
    • Resta-Lenert S, Smitham J, Barrett KE. Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/-mice. Am J Physiol Gastrointest Liver Physiol 2005; 289:153-62.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289 , pp. 153-162
    • Resta-Lenert, S.1    Smitham, J.2    Barrett, K.E.3
  • 5
    • 0031437998 scopus 로고    scopus 로고
    • Review article: Intestinal permeability in Crohn's disease
    • Meddings JB. Review article: Intestinal permeability in Crohn's disease. Aliment Pharmacol Ther 1997; 11:47-53.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 47-53
    • Meddings, J.B.1
  • 6
    • 0033822405 scopus 로고    scopus 로고
    • Insights from mouse models of colitis
    • Boismenu R, Chen Y. Insights from mouse models of colitis. J Leukoc Biol 2000; 67:267-78.
    • (2000) J Leukoc Biol , vol.67 , pp. 267-278
    • Boismenu, R.1    Chen, Y.2
  • 7
    • 0038446554 scopus 로고    scopus 로고
    • Mechanisms of active intestinal inflammation and potential downregulation via lipoxins
    • Gewirtz AT, Neish AS, Madara JL. Mechanisms of active intestinal inflammation and potential downregulation via lipoxins. Adv Exp Med Biol 2002; 507:229-36.
    • (2002) Adv Exp Med Biol , vol.507 , pp. 229-236
    • Gewirtz, A.T.1    Neish, A.S.2    Madara, J.L.3
  • 8
    • 0035990093 scopus 로고    scopus 로고
    • Animal models of inflammatory bowel disease
    • Hibi T, Ogata H, Sakuraba A. Animal models of inflammatory bowel disease. J Gastroenterol 2002; 37:409-17.
    • (2002) J Gastroenterol , vol.37 , pp. 409-417
    • Hibi, T.1    Ogata, H.2    Sakuraba, A.3
  • 9
    • 0035870289 scopus 로고    scopus 로고
    • Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
    • Maliepaard M, Scheffer GL, Faneyte IF, et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 2001; 61:3458-64.
    • (2001) Cancer Res , vol.61 , pp. 3458-3464
    • Maliepaard, M.1    Scheffer, G.L.2    Faneyte, I.F.3
  • 10
    • 0034119967 scopus 로고    scopus 로고
    • Expression and localization of multidrug resistant protein mrp2 in rat small intestine
    • Mottino AD, Hoffman T, Jennes L, Vore M. Expression and localization of multidrug resistant protein mrp2 in rat small intestine. J Pharmacol Exp Ther 2000; 293:717-23.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 717-723
    • Mottino, A.D.1    Hoffman, T.2    Jennes, L.3    Vore, M.4
  • 12
    • 0029164287 scopus 로고
    • The ABC of channel regulation
    • Higgins CF. The ABC of channel regulation. Cell 1995; 82:693-6.
    • (1995) Cell , vol.82 , pp. 693-696
    • Higgins, C.F.1
  • 15
    • 0034953105 scopus 로고    scopus 로고
    • The human ATPbinding cassette (ABC) transporter superfamily
    • Dean M, Hamon Y, Chimini G. The human ATPbinding cassette (ABC) transporter superfamily. J Lipid Res 2001; 42:1007-17.
    • (2001) J Lipid Res , vol.42 , pp. 1007-1017
    • Dean, M.1    Hamon, Y.2    Chimini, G.3
  • 16
    • 3042647663 scopus 로고    scopus 로고
    • Intestinal P glycoprotein acts as a natural defense mechanism against Listeria monocytogenes
    • Neudeck BL, Loeb JM, Faith NG, Czuprynski CJ. Intestinal P glycoprotein acts as a natural defense mechanism against Listeria monocytogenes. Infect Immun 2004; 72:3849-54.
    • (2004) Infect Immun , vol.72 , pp. 3849-3854
    • Neudeck, B.L.1    Loeb, J.M.2    Faith, N.G.3    Czuprynski, C.J.4
  • 18
    • 0020698843 scopus 로고
    • Epidemic listeriosis-evidence for transmission by food
    • Schlech WF, 3rd, Lavigne PM, Bortolussi RA, et al. Epidemic listeriosis-evidence for transmission by food. N Engl J Med 1983; 308:203-6.
    • (1983) N Engl J Med , vol.308 , pp. 203-206
    • Schlech III, W.F.1    Lavigne, P.M.2    Bortolussi, R.A.3
  • 19
    • 0027428365 scopus 로고
    • Salmonella typhimurium attachment to human intestinal epithelial monolayers: Transcellular signalling to subepithelial neutrophils
    • McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol 1993; 123:895-907.
    • (1993) J Cell Biol , vol.123 , pp. 895-907
    • McCormick, B.A.1    Colgan, S.P.2    Delp-Archer, C.3    Miller, S.I.4    Madara, J.L.5
  • 20
    • 53449102658 scopus 로고    scopus 로고
    • Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif
    • Ye S, MacEachran DP, Hamilton JW, O'Toole GA, Stanton BA. Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif. Am J Physiol Cell Physiol 2008; 295:807-18.
    • (2008) Am J Physiol Cell Physiol , vol.295 , pp. 807-818
    • Ye, S.1    MacEachran, D.P.2    Hamilton, J.W.3    O'Toole, G.A.4    Stanton, B.A.5
  • 21
    • 73949118463 scopus 로고    scopus 로고
    • Reversing Agents for ATP-Binding Cassette Drug Transporters
    • Lee CH. Reversing Agents for ATP-Binding Cassette Drug Transporters. Methods Mol Biol 596:325-40.
    • Methods Mol Biol , vol.596 , pp. 325-340
    • Lee, C.H.1
  • 22
    • 73949155491 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: Clinical studies of p-glycoprotein inhibitors
    • Coley HM. Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitors. Methods Mol Biol 596:341-58.
    • Methods Mol Biol , vol.596 , pp. 341-358
    • Coley, H.M.1
  • 23
    • 0026645868 scopus 로고
    • Variable expression of P-glycoprotein in normal, inflamed and dysplastic areas in ulcerative colitis
    • Saclarides TJ, Jakate SM, Coon JS, et al. Variable expression of P-glycoprotein in normal, inflamed and dysplastic areas in ulcerative colitis. Dis Colon Rectum 1992; 35:747-52.
    • (1992) Dis Colon Rectum , vol.35 , pp. 747-752
    • Saclarides, T.J.1    Jakate, S.M.2    Coon, J.S.3
  • 24
    • 0037223561 scopus 로고    scopus 로고
    • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
    • Schwab M, Schaeffeler E, Marx C, et al. Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. Gastroenterology 2003; 124:26-33.
    • (2003) Gastroenterology , vol.124 , pp. 26-33
    • Schwab, M.1    Schaeffeler, E.2    Marx, C.3
  • 25
    • 0032776623 scopus 로고    scopus 로고
    • Differences in P-glycoprotein-170 expression and activity between Crohn's disease and ulcerative colitis
    • Yacyshyn B, Maksymowych W, Bowen-Yacyshyn MB. Differences in P-glycoprotein-170 expression and activity between Crohn's disease and ulcerative colitis. Hum Immunol 1999; 60:677-87.
    • (1999) Hum Immunol , vol.60 , pp. 677-687
    • Yacyshyn, B.1    Maksymowych, W.2    Bowen-Yacyshyn, M.B.3
  • 26
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
    • Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol 1998; 161:5733-44.
    • (1998) J Immunol , vol.161 , pp. 5733-5744
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 27
    • 0036169116 scopus 로고    scopus 로고
    • Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) mice
    • Maggio-Price L, Shows D, Waggie K, et al. Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) mice. Am J Pathol 2002; 160:739-51.
    • (2002) Am J Pathol , vol.160 , pp. 739-751
    • Maggio-Price, L.1    Shows, D.2    Waggie, K.3
  • 28
    • 0037624566 scopus 로고    scopus 로고
    • Multidrug resistance 1 gene (P-glycoprotein 170): An important determinant in gastrointestinal disease?
    • Ho GT, Moodie FM, Satsangi J. Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease? Gut 2003; 52:759-66.
    • (2003) Gut , vol.52 , pp. 759-766
    • Ho, G.T.1    Moodie, F.M.2    Satsangi, J.3
  • 29
    • 34247616480 scopus 로고    scopus 로고
    • Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels
    • Blokzijl H, Vander Borght S, Bok LI, et al. Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. Inflamm Bowel Dis 2007; 13:710-20.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 710-720
    • Blokzijl, H.1    Vander Borght, S.2    Bok, L.I.3
  • 30
    • 34249095800 scopus 로고    scopus 로고
    • Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel disease
    • Ardizzone S, Maconi G, Bianchi V, et al. Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel disease. Inflamm Bowel Dis 2007; 13:516-23.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 516-523
    • Ardizzone, S.1    Maconi, G.2    Bianchi, V.3
  • 32
    • 8844229534 scopus 로고    scopus 로고
    • Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis
    • Potocnik U, Ferkolj I, Glavac D, Dean M. Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Genes Immun 2004; 5:530-9.
    • (2004) Genes Immun , vol.5 , pp. 530-539
    • Potocnik, U.1    Ferkolj, I.2    Glavac, D.3    Dean, M.4
  • 33
    • 0344197096 scopus 로고    scopus 로고
    • Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent northern European populations
    • Croucher PJ, Mascheretti S, Foelsch UR, Hampe J, Schreiber S. Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent northern European populations. Gastroenterology 2003; 125:1919-20.
    • (2003) Gastroenterology , vol.125 , pp. 1919-1920
    • Croucher, P.J.1    Mascheretti, S.2    Foelsch, U.R.3    Hampe, J.4    Schreiber, S.5
  • 34
    • 2442717925 scopus 로고    scopus 로고
    • Inflammatory bowel disease: A complex group of genetic disorders
    • Hugot JP. Inflammatory bowel disease: a complex group of genetic disorders. Best Pract Res Clin Gastroenterol 2004; 18:451-62.
    • (2004) Best Pract Res Clin Gastroenterol , vol.18 , pp. 451-462
    • Hugot, J.P.1
  • 35
    • 0033713976 scopus 로고    scopus 로고
    • Multidrug resistance protein mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate
    • Van Aubel RA, Peters JG, Masereeuw R, Van Os CH, Russel FG. Multidrug resistance protein mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate. Am J Physiol Renal Physiol 2000; 279:713-7.
    • (2000) Am J Physiol Renal Physiol , vol.279 , pp. 713-717
    • Van Aubel, R.A.1    Peters, J.G.2    Masereeuw, R.3    Van Os, C.H.4    Russel, F.G.5
  • 36
    • 71849096364 scopus 로고    scopus 로고
    • Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3
    • Pazos M, Siccardi D, Mumy KL, et al. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. J Immunol 2008; 181:8044-52.
    • (2008) J Immunol , vol.181 , pp. 8044-8052
    • Pazos, M.1    Siccardi, D.2    Mumy, K.L.3
  • 37
    • 2442572098 scopus 로고    scopus 로고
    • Identification of hepoxilin A3 in inflammatory events: A required role in neutrophil migration across intestinal epithelia
    • Mrsny RJ, Gewirtz AT, Siccardi D, et al. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci USA 2004; 101:7421-6.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7421-7426
    • Mrsny, R.J.1    Gewirtz, A.T.2    Siccardi, D.3
  • 38
    • 0026573173 scopus 로고
    • Intestinal permeability in patients with Crohn's disease and their first degree relatives
    • Teahon K, Smethurst P, Levi AJ, Menzies IS, Bjarnason I. Intestinal permeability in patients with Crohn's disease and their first degree relatives. Gut 1992; 33:320-3.
    • (1992) Gut , vol.33 , pp. 320-323
    • Teahon, K.1    Smethurst, P.2    Levi, A.J.3    Menzies, I.S.4    Bjarnason, I.5
  • 39
    • 0026532999 scopus 로고
    • Increased pulmonary and intestinal permeability in Crohn's disease
    • Adenis A, Colombel JF, Lecouffe P, et al. Increased pulmonary and intestinal permeability in Crohn's disease. Gut 1992; 33:678-82.
    • (1992) Gut , vol.33 , pp. 678-682
    • Adenis, A.1    Colombel, J.F.2    Lecouffe, P.3
  • 40
    • 0030892062 scopus 로고    scopus 로고
    • Co-ordinate regulation of the cystic fibrosis and multidrug resistance genes in cystic fibrosis knockout mice
    • Trezise AE, Ratcliff R, Hawkins TE, et al. Co-ordinate regulation of the cystic fibrosis and multidrug resistance genes in cystic fibrosis knockout mice. Hum Mol Genet 1997; 6:527-37.
    • (1997) Hum Mol Genet , vol.6 , pp. 527-537
    • Trezise, A.E.1    Ratcliff, R.2    Hawkins, T.E.3
  • 41
    • 0027761180 scopus 로고
    • Induction of multidrug resistance downregulates the expression of CFTR in colon epithelial cells
    • Breuer W, Slotki IN, Ausiello DA, Cabantchik IZ. Induction of multidrug resistance downregulates the expression of CFTR in colon epithelial cells. Am J Physiol 1993; 265:1711-5.
    • (1993) Am J Physiol , vol.265 , pp. 1711-1715
    • Breuer, W.1    Slotki, I.N.2    Ausiello, D.A.3    Cabantchik, I.Z.4
  • 42
    • 0026451638 scopus 로고
    • The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression
    • Trezise AE, Romano PR, Gill DR, et al. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression. EMBO J 1992; 11:4291-303.
    • (1992) EMBO J , vol.11 , pp. 4291-4303
    • Trezise, A.E.1    Romano, P.R.2    Gill, D.R.3
  • 43
    • 0026763138 scopus 로고
    • Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation
    • Welsh MJ, Anderson MP, Rich DP, et al. Cystic fibrosis transmembrane conductance regulator: a chloride channel with novel regulation. Neuron 1992; 8:821-9.
    • (1992) Neuron , vol.8 , pp. 821-829
    • Welsh, M.J.1    Anderson, M.P.2    Rich, D.P.3
  • 44
    • 0032912589 scopus 로고    scopus 로고
    • Structure and function of the CFTR chloride channel
    • Sheppard DN, Welsh MJ. Structure and function of the CFTR chloride channel. Physiol Rev 1999; 79:23-45.
    • (1999) Physiol Rev , vol.79 , pp. 23-45
    • Sheppard, D.N.1    Welsh, M.J.2
  • 45
    • 0032492855 scopus 로고    scopus 로고
    • Salmonella typhi uses CFTR to enter intestinal epithelial cells
    • Pier GB, Grout M, Zaidi T, et al. Salmonella typhi uses CFTR to enter intestinal epithelial cells. Nature 1998; 393:79-82.
    • (1998) Nature , vol.393 , pp. 79-82
    • Pier, G.B.1    Grout, M.2    Zaidi, T.3
  • 46
    • 0030691027 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung
    • Pier GB, Grout M, Zaidi TS. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung. Proc Natl Acad Sci USA 1997; 94:12088-93.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12088-12093
    • Pier, G.B.1    Grout, M.2    Zaidi, T.S.3
  • 49
    • 0036841032 scopus 로고    scopus 로고
    • Salmonella enterica serovar typhi modulates cell surface expression of its receptor, the cystic fibrosis transmembrane conductance regulator, on the intestinal epithelium
    • Lyczak JB, Pier GB. Salmonella enterica serovar typhi modulates cell surface expression of its receptor, the cystic fibrosis transmembrane conductance regulator, on the intestinal epithelium. Infect Immun 2002; 70:6416-23.
    • (2002) Infect Immun , vol.70 , pp. 6416-6423
    • Lyczak, J.B.1    Pier, G.B.2
  • 50
    • 0242286532 scopus 로고    scopus 로고
    • Commensal bacteria increase invasion of intestinal epithelium by Salmonella enterica serovar Typhi
    • Lyczak JB. Commensal bacteria increase invasion of intestinal epithelium by Salmonella enterica serovar Typhi. Infect Immun 2003; 71:6610-4.
    • (2003) Infect Immun , vol.71 , pp. 6610-6614
    • Lyczak, J.B.1
  • 52
    • 0028853907 scopus 로고
    • Transcytosis of cholera toxin subunits across model human intestinal epithelia
    • Lencer WI, Moe S, Rufo PA, Madara JL. Transcytosis of cholera toxin subunits across model human intestinal epithelia. Proc Natl Acad Sci USA 1995; 92:10094-8.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10094-10098
    • Lencer, W.I.1    Moe, S.2    Rufo, P.A.3    Madara, J.L.4
  • 53
    • 0035026929 scopus 로고    scopus 로고
    • Microbes and microbial Toxins: Paradigms for microbial-mucosal toxins. V. Cholera: Invasion of the intestinal epithelial barrier by a stably folded protein toxin
    • Lencer WI. Microbes and microbial Toxins: paradigms for microbial-mucosal toxins. V. Cholera: invasion of the intestinal epithelial barrier by a stably folded protein toxin. Am J Physiol Gastrointest Liver Physiol 2001; 280:781-6.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280 , pp. 781-786
    • Lencer, W.I.1
  • 55
    • 0036896008 scopus 로고    scopus 로고
    • Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion
    • Ma T, Thiagarajah JR, Yang H, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest 2002; 110:1651-8.
    • (2002) J Clin Invest , vol.110 , pp. 1651-1658
    • Ma, T.1    Thiagarajah, J.R.2    Yang, H.3
  • 56
    • 3843066593 scopus 로고    scopus 로고
    • Discovery of glycine hydrazide pore-occluding CFTR inhibitors: Mechanism, structure-activity analysis and in vivo efficacy
    • Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis and in vivo efficacy. J Gen Physiol 2004; 124:125-37.
    • (2004) J Gen Physiol , vol.124 , pp. 125-137
    • Muanprasat, C.1    Sonawane, N.D.2    Salinas, D.3    Taddei, A.4    Galietta, L.J.5    Verkman, A.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.