MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1863, Issue 12, 2017, Pages 3254-3264

  Lemma, Silvia ^a,b   Di Pompo, Gemma ^a,b   Porporato, Paolo E ^c,e   Sboarina, Martina ^c   Russell, Shonagh ^d   Gillies, Robert J ^d   Baldini, Nicola ^a,b   Sonveaux, Pierre ^c   Avnet, Sofia ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF TURIN   (Italy)

Author keywords

Bone metastases; Breast cancer; Lactate; Osteoclast; Tumor metabolism

Indexed keywords

CATHEPSIN K; COLLAGEN TYPE 1; GLUCOSE TRANSPORTER 1; LACTIC ACID; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 4; TATA BINDING PROTEIN; 7-(N-BENZYL-N-METHYLAMINO)-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID; COTRANSPORTER; COUMARIN DERIVATIVE; GLUCOSE; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; SLC16A4 PROTEIN, HUMAN; SLC16A4 PROTEIN, MOUSE;

ACIDIFICATION; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MATRIX; BONE METASTASIS; CELL HYPOXIA; CELL MEMBRANE; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MCF-7 CELL LINE; MDA-MB-231 CELL LINE; MICROENVIRONMENT; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OXYGEN CONSUMPTION; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE TUMOR; BREAST TUMOR; METABOLISM; PATHOLOGY; SECONDARY; STROMA CELL; TUMOR CELL LINE;

ANIMALS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL LINE, TUMOR; COUMARINS; FEMALE; GLUCOSE; GLYCOLYSIS; HUMANS; LACTATES; MCF-7 CELLS; MICE; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; OSTEOCLASTS; STROMAL CELLS; SYMPORTERS;

EID: 85032865202     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2017.08.030     Document Type: Article

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