Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment

Experimental Cell Research

Volumn 318, Issue 4, 2012, Pages 326-335

  Rattigan, Yanique I ^a,b,d   Patel, Brijesh B ^a,b   Ackerstaff, Ellen ^c   Sukenick, George ^c   Koutcher, Jason A ^c   Glod, John W ^a,b   Banerjee, Debabrata ^a,b  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glycolytic tumor cells; Lactate metabolism; Stromal carcinoma associated fibroblasts (CAFs)

Indexed keywords

2 OXOGLUTARIC ACID; CARBON 13; LACTIC ACID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2; MONOCARBOXYLATE TRANSPORTER 4; STAT3 PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL HYPOXIA; CELL INTERACTION; CELL METABOLISM; CONTROLLED STUDY; ENERGY RESOURCE; ENZYME ACTIVATION; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ISOTOPE LABELING; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STROMAL CARCINOMA ASSOCIATED FIBROBLAST; TRANSCRIPTION REGULATION; TUMOR MICROENVIRONMENT;

EID: 84856103868     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.11.014     Document Type: Article

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