Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells

Food and Chemical Toxicology

Volumn 110, Issue , 2017, Pages 383-394

  Wilsher, Nicola E ^a   Arroo, Randolph R ^a   Matsoukas, Minos Timotheos ^b   Tsatsakis, Aristidis M ^c   Spandidos, Demetrios A ^c   Androutsopoulos, Vasilis P ^c  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF CRETE   (Greece)

Author keywords

Antiproliferation; Apigenin; Breast cancer; Cytochrome P450 CYP1 enzymes; Flavonoids; Kaempferol; Luteolin; Quercetin

Indexed keywords

6 HYDROXYLUTEOLIN; ACACETIN; ALPHA NAPTHOFLAVONE DERIVATIVE; APIGENIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 FAMILY 1; KAEMPFEROL; LUTEOLIN; QUERCETIN; SCUTELLAREIN; UNCLASSIFIED DRUG; CYP1A1 PROTEIN, HUMAN; CYP1A2 PROTEIN, HUMAN; CYP1B1 PROTEIN, HUMAN; CYTOCHROME P450 1B1; FLAVONE DERIVATIVE; FLAVONOL DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CONTROLLED STUDY; DRUG POTENCY; ENZYME METABOLISM; HUMAN; HUMAN CELL; IC50; MCF-10A CELL LINE; MCF-7 CELL LINE; MDA-MB-468 CELL LINE; MOLECULAR MODEL; BREAST TUMOR; CHEMISTRY; ENZYMOLOGY; FEMALE; GENETICS; HYDROXYLATION; METABOLISM;

BREAST NEOPLASMS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP1B1; FEMALE; FLAVONES; FLAVONOLS; HUMANS; HYDROXYLATION; LUTEOLIN; MCF-7 CELLS;

EID: 85032711293     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2017.10.051     Document Type: Article

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