Expression profile of CYP1A1 and CYP1B1 enzymes in endometrial tumors

Tumor Biology

Volumn 35, Issue 10, 2014, Pages 9549-9556

  Spyrou, Ioannis ^a   Sifakis, Stavros ^b   Ploumidis, Achilles ^c   Papalampros, Alexandros E ^a   Felekouras, Evangellos ^a   Tsatsakis, Aristidis M ^b   Spandidos, Demetrios A ^b   Androutsopoulos, Vasilis P ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

^c Asklipeio Voulas ^*  (Greece)

Author keywords

Cancer; CYP1A1; CYP1B1; Metabolism; Tumor expression

Indexed keywords

CYP1A1 PROTEIN, HUMAN; CYP1B1 PROTEIN, HUMAN; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; TRANSCRIPTOME; TUMOR MARKER;

AGED; BIOSYNTHESIS; ENDOMETRIUM TUMOR; ENZYMOLOGY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; MIDDLE AGED; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGED; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1B1; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; MASS SPECTROMETRY; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84922394733     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13277-014-2240-2     Document Type: Article

References (24)

1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49:1374–403.
2. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007;18:581–92.
3. Shimada T, Fujii-Kuriyama Y. Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci. 2004;95:1–6.
4. Schwarz D, Kisselev P, Ericksen SS, Szklarz GD, Chernogolov A, Honeck H, et al. Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R), 18(S)-epoxyeicosatetraenoic acid. Biochem Pharmacol. 2004;67:1445–57.
5. Rodriguez M, Potter DA. CYP1A1 regulates breast cancer proliferation and survival. Mol Cancer Res. 2013;11:780–92.
6. Kasai S, Ishigaki T, Takumi R, Kamimura T, Kikuchi H. Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells. Biochim Biophys Acta. 1830;2013:2509–16.
7. Braeuning A, Kohle C, Buchmann A, Schwarz M. Coordinate regulation of cytochrome P450 1a1 expression in mouse liver by the aryl hydrocarbon receptor and the beta-catenin pathway. Toxicol Sci. 2011;122:16–25.
8. Murray GI, Taylor MC, McFadyen MC, McKay JA, Greenlee WF, Burke MD, et al. Tumor specific expression of Cytochrome P450 CYP1B1. Cancer Res. 1997;57:3026–31.
9. Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res. 2005;65:3726–34.
10. Cheung YL, Kerr AC, McFadyen MCE, Melvin WT, Murray GI. Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumors. Cancer Lett. 1999;139:199–205.
11. Spink DC, Spink BC, Cao JQ, DePasquale JA, Pentecost BT, Fasco MJ. Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis. 1998;19:291–8.
12. Bruno RD, Njar VC. Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem. 2007;15:5047–60.
13. Patterson LH, Murray GI. Tumor cytochrome P450 and drug activation. Curr Pharm Des. 2002;8:1335–47.
14. Androutsopoulos VP, Spyrou I, Ploumidis A, Papalampros AE, Kyriakakis M, Delakas D, et al. Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors. PLoS One. 2013;8:e82487.
15. Liehr JG, Ricci MJ. 4-Hydroxylation of estrogens as marker of human mammary tumors. Proc Natl Acad Sci. 1996;93:3294–6.
16. Androutsopoulos VP, Spandidos DA. The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and p53/p21 upregulation. J Nutr Biochem. 2013;24:496–504.
17. Saini S, Hinata H, Majid S, Dahiya R. Functional significance of cytochrome P450 CYP1B1 in endometrial carcinogenesis. Cancer Res. 2009;69:7038–45.
18. Hevir N, Sinkovec J, Rizner TL. Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: Lower levels of CYP1B1 and increased expression of S-COMT. Mol Cell Endocrinol. 2011;331:158–67.
19. Pradhan S, Nagashri MN, Gopinath KS, Kumar A. Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors. PLoS One. 2011;6:e27914.
20. Pavek P, Dvorak Z. Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr Drug Metab. 2008;9:129–43.
21. Liehr JC, Ricci MJ, Jefcoate CR, Hannigan EV, Hokanson JA, Zhu BT. 4-hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci. 1995;92:9220–4.
22. McFadyen MCE, Melvin WT, Murray GI. Cytochrome P450 CYP1B1 activity in renal cell carcinoma. Br J Cancer. 2004;91:966–71.
23. Fichtner I, Monks A, Hose C, Stevens MF, Bradshaw TD. The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models. Breast Cancer Res Treat. 2004;87:97–107.
24. Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, et al. Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Mol Cancer Ther. 2013;12:27–37.