Identification of novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides in camel milk protein hydrolysates

Food Chemistry

Volumn 244, Issue , 2018, Pages 340-348

  Nongonierma, Alice B ^a   Paolella, Sara ^a   Mudgil, Priti ^b   Maqsood, Sajid ^b   FitzGerald, Richard J ^a  

^a UNIVERSITY OF LIMERICK   (Ireland)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Bioactive peptides; Camel milk proteins; Dipeptidyl peptidase IV inhibition; Homologous peptides; Quantitative structure activity relationship (QSAR); Trypsin

Indexed keywords

ANTIBODIES; COMPUTATIONAL CHEMISTRY; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; STRUCTURES (BUILT OBJECTS);

BIOACTIVE PEPTIDES; CAMEL MILKS; DIPEPTIDYL PEPTIDASE IV; HOMOLOGOUS PEPTIDE; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS (QSAR); TRYPSIN;

PEPTIDES;

DIPEPTIDYL PEPTIDASE IV INHIBITOR; MILK PROTEIN; PROTEIN HYDROLYSATE; DIPEPTIDYL PEPTIDASE IV; PEPTIDE; TRYPSIN;

AMINO ACID SEQUENCE; ARTICLE; CAMEL MILK; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IC50; IN VITRO STUDY; MOLECULAR WEIGHT; NONHUMAN; PROTEIN STABILITY; QUALITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; ANIMAL; BOVINE; CAMEL; CHEMISTRY; COMPUTER SIMULATION; LIQUID CHROMATOGRAPHY; METABOLISM; MILK; PRECLINICAL STUDY; PROCEDURES;

AMINO ACID SEQUENCE; ANIMALS; CAMELUS; CATTLE; CHROMATOGRAPHY, LIQUID; COMPUTER SIMULATION; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG EVALUATION, PRECLINICAL; MILK; MILK PROTEINS; PEPTIDES; PROTEIN HYDROLYSATES; TRYPSIN;

EID: 85031811515     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2017.10.033     Document Type: Article

References (40)

1. Abdel Gader, G.M.A., Alhaider, A.A., The unique medicinal properties of camel products: a review of the scientific evidence. Journal of Taibah University Medical Sciences 11 (2016), 98–103.
2. Agarwal, R.P., Swami, S.C., Beniwal, R., Kochar, D.K., Sahani, M.S., Tuteja, F.C., Ghouri, S.K., Effect of camel milk on glycemic control, risk factors and diabetes quality of life in type-1 diabetes: a randomized prospective controlled study. Journal of Camel Practice and Research 10 (2003), 45–50.
3. Agyei, D., Ongkudon, C.M., Wei, C.Y., Chan, A.S., Danquah, M.K., Bioprocess challenges to the isolation and purification of bioactive peptides. Food and Bioproducts Processing 98 (2016), 244–256.
4. Andersen, E.S., Deacon, C.F., Holst, J.J., Do we know the true mechanism of action of the DPP-4 inhibitors?. Diabetes, Obesity and Metabolism, In press, 2017, 10.1111/dom.13018.
5. Bode, W., Meyer, E. Jr, Powers, J.C., Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors. Biochemistry 28 (1989), 1951–1963.
6. Erhardt, G., Shuiep, E.T.S., Lisson, M., Weimann, C., Wang, Z., El Zubeir, I.E.Y.M., Pauciullo, A., Alpha S1-casein polymorphisms in camel (Camelus dromedarius) and descriptions of biological active peptides and allergenic epitopes. Tropical Animal Health and Production 48 (2016), 879–887.
7. Godfrey, T., Protein modification. Godfrey, T., West, S., (eds.) Industrial enzymology, 2nd ed., 1996, Macmillan Press, London, 303–325.
8. Hailu, Y., Hansen, E.B., Seifu, E., Eshetu, M., Ipsen, R., Kappeler, S., Functional and technological properties of camel milk proteins: a review. Journal of Dairy Research 83 (2016), 422–429.
9. Hatanaka, T., Inoue, Y., Arima, J., Kumagai, Y., Usuki, H., Kawakami, K., Mukaihara, T., Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran. Food Chemistry 134 (2012), 797–802.
10. Jin, Y., Yan, J., Yu, Y., Qi, Y., Screening and identification of DPP-IV inhibitory peptides from deer skin hydrolysates by an integrated approach of LC–MS/MS and in silico analysis. Journal of Functional Foods 18 (2015), 344–357.
11. Lacroix, I.M.E., Li-Chan, E.C.Y., Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins. Peptides 54 (2014), 39–48.
12. Lacroix, I.M.E., Li-Chan, E.C.Y., Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations. Trends in Food Science & Technology 54 (2016), 1–16.
13. Lacroix, I.M.E., Meng, G., Cheung, I.W.Y., Li-Chan, E.C.Y., Do whey protein-derived peptides have dual dipeptidyl-peptidase IV and angiotensin I-converting enzyme inhibitory activities?. Journal of Functional Foods 21 (2016), 87–96.
14. Lan, V.T.T., Ito, K., Ohno, M., Motoyama, T., Ito, S., Kawarasaki, Y., Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175 (2015), 66–73.
15. Le Maux, S., Nongonierma, A.B., FitzGerald, R.J., Peptide composition and dipeptidyl peptidase IV inhibitory properties of β-lactoglobulin hydrolysates having similar extents of hydrolysis while generated using different enzyme-to-substrate ratios. Food Research International 99 (2017), 84–90.
16. Lin, Z.H., Long, H.X., Bo, Z., Wang, Y.Q., Wu, Y.Z., New descriptors of amino acids and their application to peptide QSAR study. Peptides 29 (2008), 1798–1805.
17. Mati, A., Senoussi-Ghezali, C., Ahmed Zennia, S.S., Almi-Sebbane, D., El-Hatmi, H., Girardet, J.-M., Dromedary camel milk proteins, a source of peptides having biological activities – a review. International Dairy Journal 73 (2016), 25–37.
18. Mullally, M.M., O'Callaghan, D.M., FitzGerald, R.J., Donnelly, W., Dalton, J.P., Proteolytic and peptidolytic activities in commercial pancreatic protease preparations and their relationship to some whey protein hydrolyzate characteristics. Journal of Agricultural and Food Chemistry 42 (1994), 2973–2981.
19. Nongonierma, A.B., FitzGerald, R.J., Dipeptidyl peptidase IV inhibitory and antioxidative properties of milk-derived dipeptides and hydrolysates. Peptides 39 (2013), 157–163.
20. Nongonierma, A.B., FitzGerald, R.J., Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing peptides. Journal of Functional Foods 5 (2013), 1909–1917.
21. Nongonierma, A.B., FitzGerald, R.J., Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides. Food & Function 4 (2013), 1843–1849.
22. Nongonierma, A.B., FitzGerald, R.J., An in silico model to predict the potential of dietary proteins as sources of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides. Food Chemistry 165 (2014), 489–498.
23. Nongonierma, A.B., FitzGerald, R.J., Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chemistry 145 (2014), 845–852.
24. Nongonierma, A.B., FitzGerald, R.J., Utilisation of the isobole methodology to study dietary peptide–drug and peptide–peptide interactive effects on dipeptidyl peptidase IV (DPP-IV) inhibition. Food & Function 6 (2015), 312–319.
25. Nongonierma, A.B., FitzGerald, R.J., Learnings from quantitative structure-activity relationship (QSAR) studies with respect to food protein-derived bioactive peptides: a review. RSC Advances 6 (2016), 75400–75413.
26. Nongonierma, A.B., FitzGerald, R.J., Prospects for the management of type 2 diabetes using food protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity. Current Opinion in Food Science 8 (2016), 19–24.
27. Nongonierma, A.B., FitzGerald, R.J., Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity. Peptides 79 (2016), 1–7.
28. Nongonierma, A.B., Le Maux, S., Hamayon, J., FitzGerald, R.J., Strategies for the release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides in an enzymatic hydrolyzate of α-lactalbumin. Food & Function 7 (2016), 3437–3443.
29. Nongonierma, A.B., Paolella, S., Mudgil, P., Maqsood, S., FitzGerald, R.J., Dipeptidyl peptidase IV (DPP-IV) inhibitory properties of camel milk protein hydrolysates generated with trypsin. Journal of Functional Foods 34 (2017), 49–58.
30. Panchaud, A., Affolter, M., Kussmann, M., Mass spectrometry for nutritional peptidomics: How to analyze food bioactives and their health effects. Journal of Proteomics 75 (2012), 3546–3559.
31. Rahfeld, J., Schierborn, M., Hartrodt, B., Neubert, K., Heins, J., Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV?. Biochimica et Biophysica Acta (BBA) 1076 (1991), 314–316.
32. Sagardia, I., Iloro, I., Elortza, F., Bald, C., Quantitative structure–activity relationship based screening of bioactive peptides identified in ripened cheese. International Dairy Journal 33 (2013), 184–190.
33. Salami, M., Yousefi, R., Ehsani, M.R., Dalgalarrondo, M., Chobert, J.-M., Haertlé, T., Moosavi-Movahedi, A.A., Kinetic characterization of hydrolysis of camel and bovine milk proteins by pancreatic enzymes. International Dairy Journal 18 (2008), 1097–1102.
34. Sanchón, J., Fernández-Tomé, S., Miralles, B., Hernández-Ledesma, B., Tomé, D., Gaudichon, C., Recio, I., Protein degradation and peptide release from milk proteins in human jejunum. Comparison with in vitro gastrointestinal simulation. Food Chemistry 239 (2018), 486–494.
35. Silveira, S.T., Martínez-Maqueda, D., Recio, I., Hernández-Ledesma, B., Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin. Food Chemistry 141 (2013), 1072–1077.
36. Tagliazucchi, D., Shamsia, S., Conte, A., Release of angiotensin converting enzyme-inhibitory peptides during in vitro gastro-intestinal digestion of camel milk. International Dairy Journal 56 (2016), 119–128.
37. Tulipano, G., Faggi, L., Nardone, A., Cocchi, D., Caroli, A.M., Characterisation of the potential of β-lactoglobulin and α-lactalbumin as sources of bioactive peptides affecting incretin function: in silico and in vitro comparative studies. International Dairy Journal 48 (2015), 62–72.
38. Uenishi, H., Kabuki, T., Seto, Y., Serizawa, A., Nakajima, H., Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. International Dairy Journal 22 (2012), 24–30.
39. Umezawa, H., Aoyagi, T., Ogawa, K., Naganawa, H., Hamada, M., Takeuchi, T., Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. Journal of Antibiotics 37 (1984), 422–425.
40. Walsh, D.J., Bernard, H., Murray, B.A., MacDonald, J., Pentzien, A.K., Wright, G.A., FitzGerald, R.J., In vitro generation and stability of the lactokinin β-lactoglobulin fragment (142–148). Journal of Dairy Science 87 (2004), 3845–3857.