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Volumn 60, Issue 1, 2018, Pages 56-64

HMGA1 is a novel transcriptional regulator of the FoxO1 gene

Author keywords

DNA chromatin interaction; FoxO1; Gene transcription; HMGA1; Insulin signaling

Indexed keywords

HIGH MOBILITY GROUP A1A PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR;

EID: 85031810281     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-017-1445-8     Document Type: Article
Times cited : (20)

References (50)
  • 1
    • 79959961108 scopus 로고    scopus 로고
    • The complex biology of FOXO
    • COI: 1:CAS:528:DC%2BC3MXpvVyjsL8%3D, PID: 21443460
    • M. Monsalve, Y. Olmos, The complex biology of FOXO. Curr. Drug Targets 12, 1322–1350 (2011)
    • (2011) Curr. Drug Targets , vol.12 , pp. 1322-1350
    • Monsalve, M.1    Olmos, Y.2
  • 2
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • COI: 1:CAS:528:DC%2BD2cXktlCqtrw%3D, PID: 15137936
    • D. Accili, K.C. Arden, FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421–426 (2004)
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 3
    • 0042477748 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors
    • COI: 1:CAS:528:DC%2BD3sXms1Sqtr8%3D, PID: 12925703
    • M.L. Hribal, J. Nakae, T. Kitamura, J.R. Shutter, D. Accili, Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J. Cell Biol. 162, 535–541 (2003)
    • (2003) J. Cell Biol. , vol.162 , pp. 535-541
    • Hribal, M.L.1    Nakae, J.2    Kitamura, T.3    Shutter, J.R.4    Accili, D.5
  • 4
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    • COI: 1:CAS:528:DC%2BD3sXntVyqsw%3D%3D, PID: 12530968
    • J. Nakae, T. Kitamura, Y. Kitamura, W.H. Biggs 3rd, K.C. Arden, D. Accili, The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4, 119–129 (2003)
    • (2003) Dev. Cell , vol.4 , pp. 119-129
    • Nakae, J.1    Kitamura, T.2    Kitamura, Y.3    Biggs, W.H.4    Arden, K.C.5    Accili, D.6
  • 5
    • 84855868834 scopus 로고    scopus 로고
    • FoxO1, the transcriptional chief of staff of energy metabolism
    • COI: 1:CAS:528:DC%2BC38Xos12ntg%3D%3D, PID: 21816244
    • S. Kousteni, FoxO1, the transcriptional chief of staff of energy metabolism. Bone 50, 437–443 (2012)
    • (2012) Bone , vol.50 , pp. 437-443
    • Kousteni, S.1
  • 8
    • 27744518040 scopus 로고    scopus 로고
    • FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    • COI: 1:CAS:528:DC%2BD2MXhtVygs7jP, PID: 16154098
    • Y.I. Kitamura, T. Kitamura, J.P. Kruse, J.C. Raum, R. Stein, W. Gu, D. Accili, FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2, 153–163 (2005)
    • (2005) Cell Metab. , vol.2 , pp. 153-163
    • Kitamura, Y.I.1    Kitamura, T.2    Kruse, J.P.3    Raum, J.C.4    Stein, R.5    Gu, W.6    Accili, D.7
  • 9
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver
    • COI: 1:CAS:528:DC%2BD2sXhtV2gt7vL, PID: 17767907
    • M. Matsumoto, A. Pocai, L. Rossetti, R.A. Depinho, D. Accili, Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver. Cell. Metab. 6, 208–216 (2007)
    • (2007) Cell. Metab. , vol.6 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    Depinho, R.A.4    Accili, D.5
  • 10
    • 0027320012 scopus 로고
    • Regulation and function of insulinlike growth factor-binding protein-1
    • COI: 1:CAS:528:DyaK3sXmsVWnt7g%3D, PID: 7690486
    • P.D.K. Lee, C.A. Conover, D.R. Powell, Regulation and function of insulinlike growth factor-binding protein-1. Proc. Soc. Exp. Biol. Med. 204, 4–29 (1993)
    • (1993) Proc. Soc. Exp. Biol. Med. , vol.204 , pp. 4-29
    • Lee, P.D.K.1    Conover, C.A.2    Powell, D.R.3
  • 12
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • COI: 1:CAS:528:DyaK1MXltVOqsrY%3D, PID: 10377430
    • W.H. Biggs 3rd, J. Meisenhelder, T. Hunter, W.K. Cavenee, K.C. Arden, Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA 96, 7421–7426 (1999)
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7421-7426
    • Biggs, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 13
    • 0141706357 scopus 로고    scopus 로고
    • Insulin-induced phosphorylation of FKHR (FOXO1) targets to proteosomal degradation
    • COI: 1:CAS:528:DC%2BD3sXotFKmsr4%3D, PID: 13679577
    • H. Matsuzaki, H. Daitoku, M. Hatta, K. Tanaka, A. Fukamizu, Insulin-induced phosphorylation of FKHR (FOXO1) targets to proteosomal degradation. Proc. Natl. Acad. Sci. USA 100, 11285–11290 (2003)
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11285-11290
    • Matsuzaki, H.1    Daitoku, H.2    Hatta, M.3    Tanaka, K.4    Fukamizu, A.5
  • 14
    • 0035868368 scopus 로고    scopus 로고
    • Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting
    • COI: 1:CAS:528:DC%2BD3MXisFaksLc%3D, PID: 11237865
    • G. Rena, A.R. Prescott, S. Guo, P. Cohen, T.G. Unterman, Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting. Biochem. J. 354, 605–612 (2001)
    • (2001) Biochem. J. , vol.354 , pp. 605-612
    • Rena, G.1    Prescott, A.R.2    Guo, S.3    Cohen, P.4    Unterman, T.G.5
  • 15
    • 0037160050 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding
    • COI: 1:CAS:528:DC%2BD38Xosl2ltro%3D, PID: 12228231
    • X. Zhang, L. Gan, H. Pan, S. Guo, X. He, S.T. Olson, A. Mesecar, S. Adam, T.G. Unterman, Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 277, 45276–45284 (2002)
    • (2002) J. Biol. Chem. , vol.277 , pp. 45276-45284
    • Zhang, X.1    Gan, L.2    Pan, H.3    Guo, S.4    He, X.5    Olson, S.T.6    Mesecar, A.7    Adam, S.8    Unterman, T.G.9
  • 16
    • 84942990707 scopus 로고    scopus 로고
    • The new biology of diabetes
    • COI: 1:CAS:528:DC%2BC2MXhtlWmu7nL, PID: 26248647
    • U.B. Pajvani, D. Accili, The new biology of diabetes. Diabetologia 58, 2459–2468 (2015)
    • (2015) Diabetologia , vol.58 , pp. 2459-2468
    • Pajvani, U.B.1    Accili, D.2
  • 17
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • COI: 1:CAS:528:DC%2BD1cXotlymsr0%3D, PID: 18590693
    • X.C. Dong, K.D. Copps, S. Guo, Y. Li, R. Kollipara, R.A. DePinho, M.F. White, Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 8, 65–76 (2008)
    • (2008) Cell Metab. , vol.8 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    DePinho, R.A.6    White, M.F.7
  • 19
    • 34247898772 scopus 로고    scopus 로고
    • E2F-1 regulates expression of FOXO1 and FOXO3a
    • COI: 1:CAS:528:DC%2BD2sXltF2ltbY%3D, PID: 17482685
    • K. Nowak, K. Killmer, C. Gessner, W. Lutz, E2F-1 regulates expression of FOXO1 and FOXO3a. Biochim. Biophys. Acta 1769, 244–252 (2007)
    • (2007) Biochim. Biophys. Acta , vol.1769 , pp. 244-252
    • Nowak, K.1    Killmer, K.2    Gessner, C.3    Lutz, W.4
  • 20
    • 85016779867 scopus 로고    scopus 로고
    • Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy
    • PID: 28341857
    • P. García-Sanz, M. Mirasierra, R. Moratalla, M. Vallejo, Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy. Sci. Rep. 7, 389 (2017)
    • (2017) Sci. Rep. , vol.7
    • García-Sanz, P.1    Mirasierra, M.2    Moratalla, R.3    Vallejo, M.4
  • 21
    • 38849094466 scopus 로고    scopus 로고
    • FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A
    • COI: 1:CAS:528:DC%2BD1cXhsVSntLk%3D, PID: 17993506
    • F.B. Berry, J.M. Skarie, F. Mirzayans, Y. Fortin, T.J. Hudson, V. Raymond, B.A. Link, M.A. Walter, FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. Hum. Mol. Genet. 17, 490–505 (2008)
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 490-505
    • Berry, F.B.1    Skarie, J.M.2    Mirzayans, F.3    Fortin, Y.4    Hudson, T.J.5    Raymond, V.6    Link, B.A.7    Walter, M.A.8
  • 22
    • 67449100489 scopus 로고    scopus 로고
    • The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors
    • COI: 1:CAS:528:DC%2BD1MXktlGks7g%3D, PID: 19244250
    • A. Essaghir, N. Dif, C.Y. Marbehant, P.J. Coffer, J.B. Demoulin, The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J. Biol. Chem. 284, 10334–10342 (2009)
    • (2009) J. Biol. Chem. , vol.284 , pp. 10334-10342
    • Essaghir, A.1    Dif, N.2    Marbehant, C.Y.3    Coffer, P.J.4    Demoulin, J.B.5
  • 23
    • 0037112090 scopus 로고    scopus 로고
    • Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles
    • COI: 1:CAS:528:DC%2BD38XpsVWju78%3D, PID: 12424797
    • T. Furuyama, H. Yamashita, K. Kitayama, Y. Higami, I. Shimokawa, N. Mori, Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles. Microsc. Res. Tech. 59, 331–334 (2002)
    • (2002) Microsc. Res. Tech. , vol.59 , pp. 331-334
    • Furuyama, T.1    Yamashita, H.2    Kitayama, K.3    Higami, Y.4    Shimokawa, I.5    Mori, N.6
  • 24
    • 0038363836 scopus 로고    scopus 로고
    • Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16
    • COI: 1:CAS:528:DC%2BD3sXjs1eisrg%3D, PID: 12683947
    • M. Imae, Z. Fu, A. Yoshida, T. Noguchi, H. Kato, Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. J. Mol. Endocrinol. 30, 253–262 (2003)
    • (2003) J. Mol. Endocrinol. , vol.30 , pp. 253-262
    • Imae, M.1    Fu, Z.2    Yoshida, A.3    Noguchi, T.4    Kato, H.5
  • 25
    • 0035904395 scopus 로고    scopus 로고
    • Molecular biology of HMGA proteins: hubs of nuclear function
    • COI: 1:CAS:528:DC%2BD3MXnsFGgtb4%3D, PID: 11602345
    • R. Reeves, Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277, 63–81 (2001)
    • (2001) Gene , vol.277 , pp. 63-81
    • Reeves, R.1
  • 27
    • 0037385239 scopus 로고    scopus 로고
    • A nucleoprotein complex containing Sp1, C/EBPβ, and HMGI-Y controls human insulin receptor gene transcription
    • COI: 1:CAS:528:DC%2BD3sXktV2lsbY%3D, PID: 12665574
    • D. Foti, R. Iuliano, E. Chiefari, A. Brunetti, A nucleoprotein complex containing Sp1, C/EBPβ, and HMGI-Y controls human insulin receptor gene transcription. Mol. Cell Biol. 23, 2720–2732 (2003)
    • (2003) Mol. Cell Biol. , vol.23 , pp. 2720-2732
    • Foti, D.1    Iuliano, R.2    Chiefari, E.3    Brunetti, A.4
  • 28
    • 84920122824 scopus 로고    scopus 로고
    • Cooperation between HMGA1, PDX-1 and MafA is essential for glucose-induced insulin transcription in pancreatic beta cells
    • B. Arcidiacono, S. Iiritano, E. Chiefari, F.S. Brunetti, G. Gu, D.P. Foti, A. Brunetti, Cooperation between HMGA1, PDX-1 and MafA is essential for glucose-induced insulin transcription in pancreatic beta cells. Front. Endocrinol. 5, 237 (2015). https://doi.org/10.3389/fendo.2014.00237
    • (2015) Front. Endocrinol. , vol.5 , pp. 237
    • Arcidiacono, B.1    Iiritano, S.2    Chiefari, E.3    Brunetti, F.S.4    Gu, G.5    Foti, D.P.6    Brunetti, A.7
  • 29
    • 0035128347 scopus 로고    scopus 로고
    • Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y)
    • COI: 1:CAS:528:DC%2BD3MXhsFemsrc%3D, PID: 11156965
    • A. Brunetti, G. Manfioletti, E. Chiefari, I.D. Goldfine, D. Foti, Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y). FASEB J. 15, 492–500 (2001)
    • (2001) FASEB J. , vol.15 , pp. 492-500
    • Brunetti, A.1    Manfioletti, G.2    Chiefari, E.3    Goldfine, I.D.4    Foti, D.5
  • 33
    • 70349269113 scopus 로고    scopus 로고
    • Transcriptional activity of the murine retinol-binding protein gene is regulated by a multiprotein complex containing HMGA1, p54 nrb/NonO, protein-associated splicing factor (PSF) and steroidogenic factor 1 (SF1)/liver receptor homologue 1 (LRH-1)
    • COI: 1:CAS:528:DC%2BD1MXhtFyntLrM, PID: 19389484
    • A. Bianconcini, A. Lupo, S. Capone, L. Quadro, M. Monti, D. Zurlo, A. Fucci, L. Sabatino, A. Brunetti, E. Chiefari, M.E. Gottesman, W.S. Blaner, V. Colantuoni, Transcriptional activity of the murine retinol-binding protein gene is regulated by a multiprotein complex containing HMGA1, p54 nrb/NonO, protein-associated splicing factor (PSF) and steroidogenic factor 1 (SF1)/liver receptor homologue 1 (LRH-1). Int. J. Biochem. Cell Biol. 41, 2189–2203 (2009)
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 2189-2203
    • Bianconcini, A.1    Lupo, A.2    Capone, S.3    Quadro, L.4    Monti, M.5    Zurlo, D.6    Fucci, A.7    Sabatino, L.8    Brunetti, A.9    Chiefari, E.10    Gottesman, M.E.11    Blaner, W.S.12    Colantuoni, V.13
  • 37
    • 84943170617 scopus 로고    scopus 로고
    • The association between HMGA1 rs146052672 variant and type 2 diabetes: a transethnic meta-analysis
    • PID: 26296198
    • A. Bianco, E. Chiefari, C.G.A. Nobile, D.P. Foti, M. Pavia, A. Brunetti, The association between HMGA1 rs146052672 variant and type 2 diabetes: a transethnic meta-analysis. PLoS One 10, e0136077 (2015). https://doi.org/10.1371/journal.pone.0136077
    • (2015) PLoS One , vol.10
    • Bianco, A.1    Chiefari, E.2    Nobile, C.G.A.3    Foti, D.P.4    Pavia, M.5    Brunetti, A.6
  • 40
    • 0030048931 scopus 로고    scopus 로고
    • Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene
    • COI: 1:CAS:528:DyaK28Xhtlais78%3D, PID: 8550844
    • A. Brunetti, L. Brunetti, D. Foti, D. Accili, I.D. Goldfine, Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene. J. Clin. Invest. 97, 258–262 (1996)
    • (1996) J. Clin. Invest. , vol.97 , pp. 258-262
    • Brunetti, A.1    Brunetti, L.2    Foti, D.3    Accili, D.4    Goldfine, I.D.5
  • 42
    • 84980343910 scopus 로고    scopus 로고
    • Cooperation between HMGA1 and HIF-1 contributes to hypoxia-induced VEGF and Visfatin gene expression in 3T3-L1 adipocytes
    • S. Messineo, A.E. Laria, B. Arcidiacono, E. Chiefari, R.M. Luque Huertas, D.P. Foti, A. Brunetti, Cooperation between HMGA1 and HIF-1 contributes to hypoxia-induced VEGF and Visfatin gene expression in 3T3-L1 adipocytes. Front. Endocrinol. 7, 73 (2016). https://doi.org/10.3389/fendo.2016.00073
    • (2016) Front. Endocrinol. , vol.7 , pp. 73
    • Messineo, S.1    Laria, A.E.2    Arcidiacono, B.3    Chiefari, E.4    Luque Huertas, R.M.5    Foti, D.P.6    Brunetti, A.7
  • 43
    • 41349116750 scopus 로고    scopus 로고
    • The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-γ (PPARγ) and thiazolidinedione-PPARγ agonists
    • COI: 1:CAS:528:DC%2BD1cXkslKnu7Y%3D, PID: 18310298
    • V. Costa, D. Foti, F. Paonessa, E. Chiefari, L. Palaia, G. Brunetti, E. Gulletta, A. Fusco, A. Brunetti, The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-γ (PPARγ) and thiazolidinedione-PPARγ agonists. Endocr. Relat. Cancer 15, 325–335 (2008)
    • (2008) Endocr. Relat. Cancer , vol.15 , pp. 325-335
    • Costa, V.1    Foti, D.2    Paonessa, F.3    Chiefari, E.4    Palaia, L.5    Brunetti, G.6    Gulletta, E.7    Fusco, A.8    Brunetti, A.9
  • 44
    • 0035930629 scopus 로고    scopus 로고
    • The role of hepatic nuclear factor 1a and PDX-1 in transcriptional regulation of the pdx-1 gene
    • COI: 1:CAS:528:DC%2BD38XkvFWr, PID: 11590182
    • K. Gerrish, M.A. Cissell, R. Stein, The role of hepatic nuclear factor 1a and PDX-1 in transcriptional regulation of the pdx-1 gene. J. Biol. Chem. 276, 47775–47784 (2001)
    • (2001) J. Biol. Chem. , vol.276 , pp. 47775-47784
    • Gerrish, K.1    Cissell, M.A.2    Stein, R.3
  • 45
    • 33645863768 scopus 로고    scopus 로고
    • Transcriptional regulation of metabolism
    • COI: 1:CAS:528:DC%2BD28Xktlylu7o%3D, PID: 16601267
    • B. Desvergne, L. Michalik, W. Wahli, Transcriptional regulation of metabolism. Physiol. Rev. 86, 465–514 (2006)
    • (2006) Physiol. Rev. , vol.86 , pp. 465-514
    • Desvergne, B.1    Michalik, L.2    Wahli, W.3
  • 46
    • 0141817720 scopus 로고    scopus 로고
    • Insulin’s expanding control of forkheads
    • COI: 1:CAS:528:DC%2BD3sXotFKnuro%3D, PID: 14506300
    • M.P. Czech, Insulin’s expanding control of forkheads. Proc. Natl. Acad. Sci. USA 100, 11198–11200 (2003)
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11198-11200
    • Czech, M.P.1
  • 47
    • 26944461217 scopus 로고    scopus 로고
    • Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
    • COI: 1:CAS:528:DC%2BD2MXhtFOntLrL, PID: 16230533
    • O. Puig, R. Tjian, Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19, 2435–2446 (2005)
    • (2005) Genes Dev. , vol.19 , pp. 2435-2446
    • Puig, O.1    Tjian, R.2
  • 49
    • 84858322507 scopus 로고    scopus 로고
    • Role of forkhead transcription factors in diabetes-induced oxidative stress
    • PID: 22454632
    • B. Ponugoti, G. Dong, D.T. Graves, Role of forkhead transcription factors in diabetes-induced oxidative stress. Exp. Diabetes Res. 2012, 939751 (2012). https://doi.org/10.1155/2012/939751
    • (2012) Exp. Diabetes Res. , vol.2012 , pp. 939751
    • Ponugoti, B.1    Dong, G.2    Graves, D.T.3
  • 50
    • 64649104157 scopus 로고    scopus 로고
    • FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats
    • COI: 1:CAS:528:DC%2BD1MXktleiurY%3D, PID: 19168598
    • Y. Behl, P. Krothapalli, T. Desta, S. Roy, D.T. Graves, FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes 58, 917–925 (2009)
    • (2009) Diabetes , vol.58 , pp. 917-925
    • Behl, Y.1    Krothapalli, P.2    Desta, T.3    Roy, S.4    Graves, D.T.5


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