A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Chiefari, Eusebio ^a   Ventura, Valeria ^a   Capula, Carmelo ^b   Randazzo, Giorgio ^a   Scorcia, Vincenzo ^a   Fedele, Monica ^c   Arcidiacono, Biagio ^a   Nevolo, Maria Teresa ^a   Bilotta, Francesco Luciano ^a   Vitiello, Michela ^c   Palmieri, Camillo ^a   Gulletta, Elio ^a   Fusco, Alfredo ^c,d   Foti, Daniela ^a   Vero, Raffaella ^b   Brunetti, Antonio ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b PUGLIESE CIACCIO HOSPITAL   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A1A PROTEIN; VASCULOTROPIN A;

ANIMAL; CELL PROLIFERATION; DIABETIC RETINOPATHY; DOWN REGULATION; GENETIC POLYMORPHISM; GENETICS; HEK293 CELL LINE; HEP-G2 CELL LINE; HUMAN; MALE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; RETINA; RETINA NEOVASCULARIZATION; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; DOWN-REGULATION; HEK293 CELLS; HEP G2 CELLS; HMGA1A PROTEIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; NEOVASCULARIZATION, PATHOLOGIC; POLYMORPHISM, GENETIC; RETINA; RETINAL NEOVASCULARIZATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 85006751753     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep39429     Document Type: Article

References (42)

1. Antonetti, D. A., Klein, R. & Gardner, T. W. Diabetic retinopathy. N. Engl. J. Med. 366, 1227-1239 (2012).
2. Yau, J. W. et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 35, 556-564 (2012).
3. Fong, D. S., Aiello, L. P., Ferris, F. L. 3rd. & Klein, R. Diabetic retinopathy. Diabetes Care 27, 2540-2553 (2004).
4. Crawford, T. N., Alfaro, D. V. 3rd., Kerrison, J. B. & Jablon, E. P. Diabetic retinopathy and angiogenesis. Curr. Diabetes Rev. 5, 8-13 (2009).
5. Ferrara, N., Gerber, H. P. & LeCouter, J. The biology of VEGF and its receptors. Nat. Med. 9, 669-676 (2003).
6. Mitamura, Y. et al. Vitreous levels of placenta growth factor and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Diabetes Care 25, 2352 (2002).
7. Stitt, A. W. et al. The progress in understanding and treatment of diabetic retinopathy. Prog. Retin. Eye Res. doi: 10.1016/j. preteyeres.2015.08.001 (2015).
8. Simó-Servat, O., Hernández, C. & Simó, R. Genetics in diabetic retinopathy: current concepts and new insights. Curr. Genomics 14, 289-299 (2013).
9. Arar, N. H. et al. Heritability of the severity of diabetic retinopathy: The FINDEye study. Invest. Ophthalmol. Vis. Sci. 49, 3839-3845 (2008).
10. Hietala, K., Forsblom, C., Summanen, P. & Groop, P. H. Heritability of proliferative diabetic retinopathy. Diabetes 57, 2176-2180 (2008)
11. Kuo, J. Z., Wong, T. Y. & Rotter, J. I.Challenges in elucidating the genetics of diabetic retinopathy. JAMA Ophthalmol. 132, 96-107 (2014).
12. Bustin, M. & Reeves, R. High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function. Prog. Nucleic Acid Res. Mol. Biol. 54, 35-100 (1996).
13. Foti, D. et al. Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat. Med. 11, 765-773 (2005).
14. Chiefari, E. et al. Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Nat. Commun. 1, 40 (2010).
15. Semple, R. K. From bending DNA to diabetes: The curious case of HMGA1. J. Biol. 8, 64 (2009).
16. Arce-Cerezo, A. et al. HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance. Sci. Rep. 5, 14487 (2015)
17. Bianco, A., Chiefari, E., Nobile, C. G. A., Foti, D. P., Pavia, M. & Brunetti, A. The association between HMGA1 rs146052672 variant and type 2 diabetes: A transethnic meta-Analysis. PLoS One 10, e0136077 (2015).
18. Ji, Y. S., Xu, Q. & Schmedtje, J. F. Jr. Hypoxia induces high-mobility-group protein I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium. Circ. Res. 83, 295-304 (1998).
19. Moussavi Nik, S. H., Newman, M. & Lardelli, M. The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Exp. Cell. Res. 317, 1503-1512 (2011).
20. Camós, S. et al. The high-mobility group I-Y transcription factor is involved in cerebral ischemia and modulates the expression of angiogenic proteins. Neuroscience 269, 112-130 (2014).
21. Carvajal, I. M., Baron, R. M. & Perrella, M. A. High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses. Crit. Care Med. 30, S36-S42 (2002).
22. Chau, K. Y. et al. The architectural transcription factor high mobility group I(Y) participates in photoreceptor-specific gene expression. J. Neurosci. 20, 7317-7324 (2000).
23. Choi, D. et al. Prediction of Cis-Regulatory Elements Controlling Genes Differentially Expressed by Retinal and Choroidal Vascular Endothelial Cells. J. Ocul. Biol. Dis. Infor. 1, 37-45 (2008).
24. Gaildrat, P., Killian, A., Martins, A., Tournier, I., Frébourg, T. & Tosi, M. Use of splicing reporter minigene assay to evaluate the effect on splicing of unclassified genetic variants. Methods Mol. Biol. 653, 249-257 (2010).
25. Chiefari, E. et al. Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA 305, 903-912 (2011).
26. Abcouwer, S. F. Angiogenic Factors and Cytokines in Diabetic Retinopathy. J. Clin. Cell. Immunol. Suppl 1 (2013).
27. Ozturk, B. T., Bozkurt, B., Kerimoglu, H., Okka, M., Kamis, U. & Gunduz, K. Effect of serum cytokines and VEGF levels on diabetic retinopathy and macular thickness. Mol. Vis. 15, 1906-1914 (2009).
28. Lee, J. H. et al. Cytokine profile of peripheral blood in type 2 diabetes mellitus patients with diabetic retinopathy. Ann. Clin. Lab. Sci. 38, 361-367 (2008).
29. Chiefari, E. et al. A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components. Sci. Rep. 3, 149 (2013).
30. Ford, K. M. & DAmore, P. A. Molecular regulation of vascular endothelial growth factor expression in the retinal pigment epithelium. Mol. Vis. 18, 519-527 (2012)
31. Namiki, A. et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J. Biol. Chem. 270, 31189-31195 (1995).
32. Messineo, S. et al. Cooperation between HMGA1 and HIF-1 contributes to hypoxia-induced VEGF and visfatin gene expression in 3T3-L1 adipocytes. Front. Endocrinol. 7, 73 doi: 10.3389/fendo.2016.00073 (2016).
33. Piret, J. P., Mottet, D., Raes, M. & Michiels, C. CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2. Ann. N. Y. Acad. Sci. 973, 443-447 (2002).
34. Tariq, K. et al. Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy. Mol. Vis. 19, 710-717 (2013).
35. Lee, S., Abecasis, G. R., Boehnke, M. & Lin, X. Rare-variant association analysis: study designs and statistical tests. Am. J. Hum. Genet. 95, 5-23 (2014).
36. Di Gaetano, C. et al. An Overview of the Genetic Structure within the Italian Population from Genome-Wide Data. PLoS One 7, e43759 (2012).
37. Wilkinson, C. P. et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110, 1677-1682 (2003).
38. Chiefari, E. et al. The cAMP-HMGA1-RBP4 system: A novel biochemical pathway for modulating glucose homeostasis. BMC Biol. 7, 24 (2009).
39. Chiefari, E. et al. HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway. Sci. Rep. 2, 251 (2012).
40. Foti, D., Iuliano, R., Chiefari, E. & Brunetti, A. A nucleoprotein complex containing Sp1, C/EBP beta, and HMGA1controls human insulin receptor gene transcription. Mol. Cell. Biol. 23, 2720-2732 (2003).
41. Paonessa, F. et al. Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer. Cancer Res. 66, 5085-5093 (2006).
42. Iiritano, S. et al. The HMGA1-IGF-I/IGFBP system: A novel pathway for modulating glucose uptake. Mol. Endocrinol. 26, 1578-1589 (2012).