Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y)

FASEB Journal

Volumn 15, Issue 2, 2001, Pages 492-500

  Brunetti, A ^a   Manfioletti, G ^a   Chiefari, E ^a   Goldfine, I D ^a   Foti, D ^a  

^a Policlinico Mater Domini   (Italy)

Author keywords

CAT reporter gene; Insulin receptor promoter; Transcription factors

Indexed keywords

HIGH MOBILITY GROUP PROTEIN; INSULIN RECEPTOR;

ADIPOCYTE; ARTICLE; HUMAN; HUMAN CELL; INSULIN METABOLISM; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

5' UNTRANSLATED REGIONS; ANIMALS; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, REPORTER; HIGH MOBILITY GROUP PROTEINS; HMGA1A PROTEIN; HUMANS; LYMPHOCYTES; PROMOTER REGIONS (GENETICS); RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS; RNA, ANTISENSE; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0035128347     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0190com     Document Type: Article

References (62)

1. The molecular mechanisms of insulin action
2. The insulin receptor: Molecular biology and transmembrane signalling
3. The insulin signaling system
4. Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels
5. Differential effects of fibroblast growth factor on insulin receptor and muscle specific protein gene expression in BC3H-1 myocytes
6. Regulating insulin-receptor-gene expression by differentiation and hormones
7. Glucocorticoid regulation of insulin receptor gene transcription in IM-9 cultured lymphocytes
8. Induction of the insulin proreceptor by hydrocortisone in cultured lymphocytes (IM-9 line)
9. Characterization of the mouse insulin receptor gene promoter
10. The development of insulin receptors and responses in the differentiating nonfusing muscle cell line BC3H-1
11. Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody
12. Insulin resistance and insulin action. An in vitro and in vivo perspective
13. Lilly lecture: Molecular mechanisms of insulin resistance. Lesson from patients with mutations in the insulin-receptor gene
14. Non-insulin-dependent diabetes mellitus: A genetically programmed failure of the beta cell to compensate for insulin resistance
15. Deconstructing type 2 diabetes
16. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
17. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells
18. Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy, brain metabolism and in behavior in adult rats
19. Elevated insulin receptor content in human breast cancer
20. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: A possible mechanism for receptor overexpression in breast cancer
21. Increased expression of insulin receptor substrate-1 in human pancreatic cancer
22. Frequent deletion of chromosome 19 and a rare rearrangement of 19p13.3 involving the insulin receptor gene in human ovarian cancer
23. Steroid receptor regulated transcription of specific genes and gene networks
24. DNA binding by proteins
25. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
26. Characterization of the promoter region of the human insulin receptor gene
27. Sequence and analysis of promoter region of human insulin-receptor gene
28. Structure of the human insulin receptor gene and characterization of its promoter
29. Characterization of the promoter region and 3′-end of the human insulin receptor gene
30. Structural and functional analysis of the insulin receptor promoter
31. Identification of cis- and trans-acting factors regulating the expression of the human insulin receptor gene
32. Identification of unique nuclear regulatory proteins for the insulin receptor gene, which appear during myocyte and adipocyte differentiation
33. Nuclear protein-binding analysis of a GC-rich insulin-receptor promoter regulatory, region
34. An upstream element from the human insulin receptor gene promoter contains binding sites for C/EBPb and NF-1
35. High-mobility group proteins: Architectural components that facilitates chromatin function
36. Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1β in vascular smooth muscle cells
37. Accurate transcription by RNA polymerase II in a soluble extract from isolated mammalian nuclei
38. Insulin receptors and bioresponses in a human liver cell line (HepG2)
39. Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase
40. Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor β-subunit mutants
41. NF-κB mediated transcriptional activation is enhanced by the architectural factor HMGI-C
42. Affinity purification of sequence-specific DNA binding proteins
43. Tricine-sodium dodecyl sulfate-polyacryamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
44. A yeast gene that is essential for release from glucose repression encodes a protein kinase
45. Expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias
46. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
47. The high mobility group protein HMGI(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene
48. Immunoglobulin gene transcription is activated by downstream sequence elements
49. Endocytosis, recycling, and degradation of the insulin receptor
50. Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor
51. Specific recognition of cruciform DNA by nuclear protein HMG1
52. DNA recognition and bending
53. Transcription initiation from a poly(dA) tract
54. DNA sequences of two yeast promoter-up mutants
55. Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast
56. The structure of an oligo(dA) oligo (dT) tract and its biological implications
57. Synthetic DNA bending sequences increase the rate of in vitro transcription initiation at the Escherichia coli lac promoter
58. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein
59. The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters
60. Alternative processing of mRNA's coding for human HMGI and HMGY proteins
61. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome