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Volumn 68, Issue 1, 2008, Pages 202-215

Patterns of chromosomal fragmentation due to uracil-DNA incorporation reveal a novel mechanism of replication-dependent double-stranded breaks

Author keywords

[No Author keywords available]

Indexed keywords

URACIL;

EID: 40549129679     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06149.x     Document Type: Article
Times cited : (36)

References (59)
  • 1
    • 33747332833 scopus 로고    scopus 로고
    • The replication intermediates in Escherichia coli are not the product of DNA processing or uracil excision
    • Amado, L. Kuzminov, A. (2006) The replication intermediates in Escherichia coli are not the product of DNA processing or uracil excision. J Biol Chem 281:22635 22646.
    • (2006) J Biol Chem , vol.281 , pp. 22635-22646
    • Amado, L.1    Kuzminov, A.2
  • 2
    • 0032479993 scopus 로고    scopus 로고
    • A site- and strand-specific DNA break confers asymmetric switching potential in fission yeast
    • Arcangioli, B. (1998) A site- and strand-specific DNA break confers asymmetric switching potential in fission yeast. EMBO J 17:4503 4510.
    • (1998) EMBO J , vol.17 , pp. 4503-4510
    • Arcangioli, B.1
  • 3
    • 0001246049 scopus 로고
    • Derivations and genotypes of some mutant derivatives of Escherichia coli K-12
    • In. Neidhardt, F.C. (ed.). Washington, DC: American Society for Microbiology, pp.
    • Bachmann, B.J. (1987) Derivations and genotypes of some mutant derivatives of Escherichia coli K-12. In Escherichia coli and Salmonella typhimurium. Cellular and Molecular Biology. Neidhardt, F.C. (ed.). Washington, DC:American Society for Microbiology, pp. 1190 1219.
    • (1987) Escherichia Coli and Salmonella Typhimurium. Cellular and Molecular Biology. , pp. 1190-1219
    • Bachmann, B.J.1
  • 4
    • 0016224060 scopus 로고
    • Mechanisms of chromosomal aberration production. III. Chemicals and ionizing radiation
    • Bender, M.A., Griggs, H.G. Bedford, J.S. (1974) Mechanisms of chromosomal aberration production. III. Chemicals and ionizing radiation. Mutat Res 23:197 212.
    • (1974) Mutat Res , vol.23 , pp. 197-212
    • Bender, M.A.1    Griggs, H.G.2    Bedford, J.S.3
  • 5
    • 0035912756 scopus 로고    scopus 로고
    • Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli
    • Blaisdell, J.O. Wallace, S.S. (2001) Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli. Proc Natl Acad Sci USA 98:7426 7430.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7426-7430
    • Blaisdell, J.O.1    Wallace, S.S.2
  • 7
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • Blount, B.C., Mack, M.M., Wehr, C.M., MacGregor, J.T., Hiatt, R.A., Wang, G., et al. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94:3290 3295.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3290-3295
    • Blount, B.C.1    MacK, M.M.2    Wehr, C.M.3    MacGregor, J.T.4    Hiatt, R.A.5    Wang, G.6
  • 8
    • 0016424156 scopus 로고
    • Enzymatic production of deoxyribonucleic acid double-strand breaks after ultraviolet irradiation of Escherichia coli K-12
    • Bonura, T. Smith, K.C. (1975) Enzymatic production of deoxyribonucleic acid double-strand breaks after ultraviolet irradiation of Escherichia coli K-12. J Bacteriol 121:511 517.
    • (1975) J Bacteriol , vol.121 , pp. 511-517
    • Bonura, T.1    Smith, K.C.2
  • 9
    • 33745270776 scopus 로고    scopus 로고
    • Genotyping and mapping with high-density oligonucleotide arrays
    • Borevitz, J. (2006) Genotyping and mapping with high-density oligonucleotide arrays. Methods Mol Biol 323:137 145.
    • (2006) Methods Mol Biol , vol.323 , pp. 137-145
    • Borevitz, J.1
  • 10
    • 0042161840 scopus 로고    scopus 로고
    • Repair of clustered uracil DNA damages in Escherichia coli
    • D'souza, D.I. Harrison, L. (2003) Repair of clustered uracil DNA damages in Escherichia coli. Nucleic Acids Res 31:4573 4581.
    • (2003) Nucleic Acids Res , vol.31 , pp. 4573-4581
    • D'Souza, D.I.1    Harrison, L.2
  • 11
    • 0026064347 scopus 로고
    • Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation
    • Dianov, G.L., Timchenko, T.V., Sinitsina, O.I., Kuzminov, A.V., Medvedev, O.A. Salganik, R.I. (1991) Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol Gen Genet 225:448 452.
    • (1991) Mol Gen Genet , vol.225 , pp. 448-452
    • Dianov, G.L.1    Timchenko, T.V.2    Sinitsina, O.I.3    Kuzminov, A.V.4    Medvedev, O.A.5    Salganik, R.I.6
  • 12
    • 0018718505 scopus 로고
    • Location and characterisation of a new replication origin in the E. coli K12 chromosome
    • Diaz, R., Barnsley, P. Pritchard, R.H. (1979) Location and characterisation of a new replication origin in the E. coli K12 chromosome. Mol Gen Genet 175:151 157.
    • (1979) Mol Gen Genet , vol.175 , pp. 151-157
    • Diaz, R.1    Barnsley, P.2    Pritchard, R.H.3
  • 13
    • 0017881902 scopus 로고
    • Escherichia coli K-12 mutants deficient in uracil-DNA glycosylase
    • Duncan, B.K., Rockstroh, P.A. Warner, H.R. (1978) Escherichia coli K-12 mutants deficient in uracil-DNA glycosylase. J Bacteriol 134:1039 1045.
    • (1978) J Bacteriol , vol.134 , pp. 1039-1045
    • Duncan, B.K.1    Rockstroh, P.A.2    Warner, H.R.3
  • 14
    • 0035906327 scopus 로고    scopus 로고
    • The role of folic acid and vitamin B12 in genomic stability of human cells
    • Fenech, M. (2001) The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat Res 475:57 67.
    • (2001) Mutat Res , vol.475 , pp. 57-67
    • Fenech, M.1
  • 15
    • 0025344222 scopus 로고
    • A sensitive genetic assay for the detection of cytosine deamination: Determination of rate constants and the activation energy
    • Frederico, L.A., Kunkel, T.A. Shaw, B.R. (1990) A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. Biochemistry 29:2532 2537.
    • (1990) Biochemistry , vol.29 , pp. 2532-2537
    • Frederico, L.A.1    Kunkel, T.A.2    Shaw, B.R.3
  • 16
    • 0025953630 scopus 로고
    • ColE1-type vectors with fully repressible replication
    • Gil, D. Bouché, J.-P. (1991) ColE1-type vectors with fully repressible replication. Gene 105:17 22.
    • (1991) Gene , vol.105 , pp. 17-22
    • Gil, D.1    Bouché, J.-P.2
  • 17
    • 0013858652 scopus 로고
    • The U.V. sensitivity of bacteria: Its relation to the DNA replication cycle
    • Hanawalt, P.C. (1966) The U.V. sensitivity of bacteria: its relation to the DNA replication cycle. Photochem Photobiol 5:1 12.
    • (1966) Photochem Photobiol , vol.5 , pp. 1-12
    • Hanawalt, P.C.1
  • 18
    • 0017886373 scopus 로고
    • Escherichia coli mutants deficient in deoxyuridine triphosphatase
    • Hochhauser, S.J. Weiss, B. (1978) Escherichia coli mutants deficient in deoxyuridine triphosphatase. J Bacteriol 134:157 166.
    • (1978) J Bacteriol , vol.134 , pp. 157-166
    • Hochhauser, S.J.1    Weiss, B.2
  • 19
    • 0026303274 scopus 로고
    • The role of DNA double-strand breaks in ionising radiation-induced killing of eukaryotic cells
    • Iliakis, G. (1991) The role of DNA double-strand breaks in ionising radiation-induced killing of eukaryotic cells. Bioessays 13:641 648.
    • (1991) Bioessays , vol.13 , pp. 641-648
    • Iliakis, G.1
  • 20
    • 0032520807 scopus 로고    scopus 로고
    • Artifactual hybridization bands associated with the pulsed field gel electrophoresis of partially digested yeast chromosomes
    • Ira, G., Svetlova, E. Filipski, J. (1998) Artifactual hybridization bands associated with the pulsed field gel electrophoresis of partially digested yeast chromosomes. Anal Biochem 257:224 226.
    • (1998) Anal Biochem , vol.257 , pp. 224-226
    • Ira, G.1    Svetlova, E.2    Filipski, J.3
  • 21
    • 0018721473 scopus 로고
    • Physical characterization of the 'Rac prophage' in E. coli K-12
    • Kaiser, K. Murray, N.E. (1979) Physical characterization of the 'Rac prophage' in E. coli K-12. Mol Gen Genet 175:159 174.
    • (1979) Mol Gen Genet , vol.175 , pp. 159-174
    • Kaiser, K.1    Murray, N.E.2
  • 22
    • 0016813208 scopus 로고
    • Novel mutants of Escherichia coli that accumulate very small DNA replicative intermediates
    • Konrad, E.B. Lehman, I.R. (1975) Novel mutants of Escherichia coli that accumulate very small DNA replicative intermediates. Proc Natl Acad Sci USA 72:2150 2154.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 2150-2154
    • Konrad, E.B.1    Lehman, I.R.2
  • 23
    • 1542616353 scopus 로고    scopus 로고
    • Chromosomal fragmentation in dUTPase-deficient mutants of Escherichia coli and its recombinational repair
    • Kouzminova, E.A. Kuzminov, A. (2004) Chromosomal fragmentation in dUTPase-deficient mutants of Escherichia coli and its recombinational repair. Mol Microbiol 51:1279 1295.
    • (2004) Mol Microbiol , vol.51 , pp. 1279-1295
    • Kouzminova, E.A.1    Kuzminov, A.2
  • 24
    • 28844477965 scopus 로고    scopus 로고
    • Fragmentation of replicating chromosomes triggered by uracil in DNA
    • Kouzminova, E.A. Kuzminov, A. (2006) Fragmentation of replicating chromosomes triggered by uracil in DNA. J Mol Biol 355:20 33.
    • (2006) J Mol Biol , vol.355 , pp. 20-33
    • Kouzminova, E.A.1    Kuzminov, A.2
  • 25
    • 0016371628 scopus 로고
    • In vivo studies of temperature-sensitive recB and recC mutants
    • Kushner, S.R. (1974) In vivo studies of temperature-sensitive recB and recC mutants. J Bacteriol 120:1213 1218.
    • (1974) J Bacteriol , vol.120 , pp. 1213-1218
    • Kushner, S.R.1
  • 26
    • 0028998597 scopus 로고
    • Collapse and repair of replication forks in Escherichia coli
    • Kuzminov, A. (1995) Collapse and repair of replication forks in Escherichia coli. Mol Microbiol 16:373 384.
    • (1995) Mol Microbiol , vol.16 , pp. 373-384
    • Kuzminov, A.1
  • 27
    • 0032715175 scopus 로고    scopus 로고
    • Recombinational repair of DNA damage in Escherichia coli and bacteriophage λ
    • Kuzminov, A. (1999) Recombinational repair of DNA damage in Escherichia coli and bacteriophage λ. Microbiol Mol Biol Rev 63:751 813.
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 751-813
    • Kuzminov, A.1
  • 28
    • 0035902585 scopus 로고    scopus 로고
    • Single-strand interruptions in replicating chromosomes cause double-strand breaks
    • Kuzminov, A. (2001a) Single-strand interruptions in replicating chromosomes cause double-strand breaks. Proc Natl Acad Sci USA 98:8241 8246.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8241-8246
    • Kuzminov, A.1
  • 29
    • 0035902579 scopus 로고    scopus 로고
    • DNA replication meets genetic exchange: Chromosomal damage and its repair by homologous recombination
    • Kuzminov, A. (2001b) DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination. Proc Natl Acad Sci USA 98:8461 8468.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8461-8468
    • Kuzminov, A.1
  • 30
    • 0028176499 scopus 로고
    • κ-sites in combination with RecA protein increase the survival of linear DNA in E. coli by inactivating ExoV activity of RecBCD nuclease
    • Kuzminov, A., Schabtach, E. Stahl, F.W. (1994) κ-sites in combination with RecA protein increase the survival of linear DNA in E. coli by inactivating ExoV activity of RecBCD nuclease. EMBO J 13:2764 2776.
    • (1994) EMBO J , vol.13 , pp. 2764-2776
    • Kuzminov, A.1    Schabtach, E.2    Stahl, F.W.3
  • 31
    • 0031585996 scopus 로고    scopus 로고
    • Study of plasmid replication in Escherichia coli with a combination of 2D gel electrophoresis and electron microscopy
    • Kuzminov, A., Schabtach, E. Stahl, F.W. (1997) Study of plasmid replication in Escherichia coli with a combination of 2D gel electrophoresis and electron microscopy. J Mol Biol 268:1 7.
    • (1997) J Mol Biol , vol.268 , pp. 1-7
    • Kuzminov, A.1    Schabtach, E.2    Stahl, F.W.3
  • 32
    • 33750935665 scopus 로고    scopus 로고
    • Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance
    • Lari, S.U., Chen, C.Y., Vertéssy, B.G., Morré, J. Bennett, S.E. (2006) Quantitative determination of uracil residues in Escherichia coli DNA: contribution of ung, dug, and dut genes to uracil avoidance. DNA Repair 5:1407 1420.
    • (2006) DNA Repair , vol.5 , pp. 1407-1420
    • Lari, S.U.1    Chen, C.Y.2    Vertéssy, B.G.3    Morré, J.4    Bennett, S.E.5
  • 33
    • 0030773261 scopus 로고    scopus 로고
    • Differential induction of chromosomal instability by DNA strand-breaking agents
    • Limoli, C.L., Kaplan, M.I., Phillips, J.W., Adair, G.M. Morgan, W.F. (1997) Differential induction of chromosomal instability by DNA strand-breaking agents. Cancer Res 57:4048 4056.
    • (1997) Cancer Res , vol.57 , pp. 4048-4056
    • Limoli, C.L.1    Kaplan, M.I.2    Phillips, J.W.3    Adair, G.M.4    Morgan, W.F.5
  • 34
    • 0030606152 scopus 로고    scopus 로고
    • Endogenous damage to DNA
    • Lindahl, T. (1996) Endogenous damage to DNA. Philos Trans R Soc Lond B 351:1529 1538.
    • (1996) Philos Trans R Soc Lond B , vol.351 , pp. 1529-1538
    • Lindahl, T.1
  • 35
    • 0035313218 scopus 로고    scopus 로고
    • Endogenous DNA damage and mutation
    • Marnett, L.J. Plastaras, J.P. (2001) Endogenous DNA damage and mutation. Trends Genet 17:214 221.
    • (2001) Trends Genet , vol.17 , pp. 214-221
    • Marnett, L.J.1    Plastaras, J.P.2
  • 36
    • 0025863843 scopus 로고
    • Unidirectional replication as visualized by two-dimensional agarose gel electrophoresis
    • Martín-Parras, L., Hernández, P., Martínez-Robles, M.L. Schvatzman, J.B. (1991) Unidirectional replication as visualized by two-dimensional agarose gel electrophoresis. J Mol Biol 220:843 853.
    • (1991) J Mol Biol , vol.220 , pp. 843-853
    • Martín-Parras, L.1    Hernández, P.2    Martínez-Robles, M.L.3    Schvatzman, J.B.4
  • 37
    • 0031025093 scopus 로고    scopus 로고
    • DNA double-strand breaks caused by replication arrest
    • Michel, B., Ehrlich, S.D. Uzest, M. (1997) DNA double-strand breaks caused by replication arrest. EMBO J 16:430 438.
    • (1997) EMBO J , vol.16 , pp. 430-438
    • Michel, B.1    Ehrlich, S.D.2    Uzest, M.3
  • 39
    • 0037660900 scopus 로고    scopus 로고
    • The role of DNA breaks in genomic instability and tumorigenesis
    • Mills, K.D., Ferguson, D.O. Alt, F.W. (2003) The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev 194:77 95.
    • (2003) Immunol Rev , vol.194 , pp. 77-95
    • Mills, K.D.1    Ferguson, D.O.2    Alt, F.W.3
  • 40
    • 0037356692 scopus 로고    scopus 로고
    • Induction of genome instability by DNA damage in Saccharomyces cerevisiae
    • Myung, K. Kolodner, R. (2003) Induction of genome instability by DNA damage in Saccharomyces cerevisiae. DNA Repair 2:243 258.
    • (2003) DNA Repair , vol.2 , pp. 243-258
    • Myung, K.1    Kolodner, R.2
  • 41
    • 0001744851 scopus 로고    scopus 로고
    • Biosynthesis and conversions of pyrimidines
    • In. Neidhardt, F.C. (ed.). Washington, DC: American Society for Microbiology Press, pp.
    • Neuhard, J. Kelln, R.A. (1996) Biosynthesis and conversions of pyrimidines. In Escherichia Coli and Salmonella. Cellular and Molecular Biology, Vol. 1. Neidhardt, F.C. (ed.) Washington, DC:American Society for Microbiology Press, pp. 580 599.
    • (1996) Escherichia Coli and Salmonella. Cellular and Molecular Biology , vol.1 , pp. 580-599
    • Neuhard, J.1    Kelln, R.A.2
  • 42
    • 0028967533 scopus 로고
    • Sequence specificity for removal of uracil from U:A pairs and U·G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots
    • Nilsen, H., Yazdankhah, S.P., Eftedal, I. Krokan, H.E. (1995) Sequence specificity for removal of uracil from U:A pairs and U·G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots. FEBS Lett 362:205 209.
    • (1995) FEBS Lett , vol.362 , pp. 205-209
    • Nilsen, H.1    Yazdankhah, S.P.2    Eftedal, I.3    Krokan, H.E.4
  • 44
    • 0035893363 scopus 로고    scopus 로고
    • Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    • Pierce, A.J., Hu, P., Han, M., Ellis, N. Jasin, M. (2001b) Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 15:3237 3242.
    • (2001) Genes Dev , vol.15 , pp. 3237-3242
    • Pierce, A.J.1    Hu, P.2    Han, M.3    Ellis, N.4    Jasin, M.5
  • 45
    • 0033822360 scopus 로고    scopus 로고
    • Replication of oriJ-based plasmid DNA during the stringent and relaxed responses of Escherichia coli
    • Potrykus, K., Wróbel, B., Wegrzyn, A. Wegrzyn, G. (2000) Replication of oriJ-based plasmid DNA during the stringent and relaxed responses of Escherichia coli. Plasmid 44:111 126.
    • (2000) Plasmid , vol.44 , pp. 111-126
    • Potrykus, K.1    Wróbel, B.2    Wegrzyn, A.3    Wegrzyn, G.4
  • 46
    • 0023925454 scopus 로고
    • Interactions between deoxyribonucleotide and DNA synthesis
    • Reichard, P. (1988) Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem 57:349 374.
    • (1988) Annu Rev Biochem , vol.57 , pp. 349-374
    • Reichard, P.1
  • 47
    • 0023683926 scopus 로고
    • Role of deoxyuridine incorporation and DNA repair in the expression of human chromosomal fragile sites
    • Reidy, J.A. (1988) Role of deoxyuridine incorporation and DNA repair in the expression of human chromosomal fragile sites. Mutat Res 200:215 220.
    • (1988) Mutat Res , vol.200 , pp. 215-220
    • Reidy, J.A.1
  • 48
    • 0026640795 scopus 로고
    • Evidence that recBC-dependent degradation of duplex DNA in Escherichia coli recD mutants involves DNA unwinding
    • Rinken, R., Thoms, B. Wackernagel, W. (1992) Evidence that recBC-dependent degradation of duplex DNA in Escherichia coli recD mutants involves DNA unwinding. J Bacteriol 174:5424 5429.
    • (1992) J Bacteriol , vol.174 , pp. 5424-5429
    • Rinken, R.1    Thoms, B.2    Wackernagel, W.3
  • 49
    • 0035830497 scopus 로고    scopus 로고
    • Spontaneous DNA damage, genome instability and cancer - When DNA replication escapes control
    • Schär, P. (2001) Spontaneous DNA damage, genome instability and cancer - when DNA replication escapes control. Cell 104:329 332.
    • (2001) Cell , vol.104 , pp. 329-332
    • Schär, P.1
  • 50
    • 0016524524 scopus 로고
    • Genetic and kinetic evidence for different types of postreplication repair in Escherichia coli B
    • Sedgwick, S.G. (1975) Genetic and kinetic evidence for different types of postreplication repair in Escherichia coli B. J Bacteriol 123:154 161.
    • (1975) J Bacteriol , vol.123 , pp. 154-161
    • Sedgwick, S.G.1
  • 51
    • 0017866954 scopus 로고
    • Deoxyuridine triphosphatase of Escherichia coli. Purification, properties, and use as a reagent to reduce uracil incorporation into DNA
    • Shlomai, J. Kornberg, A. (1978) Deoxyuridine triphosphatase of Escherichia coli. Purification, properties, and use as a reagent to reduce uracil incorporation into DNA. J Biol Chem 253:3305 3312.
    • (1978) J Biol Chem , vol.253 , pp. 3305-3312
    • Shlomai, J.1    Kornberg, A.2
  • 52
    • 0002050661 scopus 로고
    • A replicator's view of recombination (and repair)
    • In. Grell, R.F. (ed.). New York, NY: Plenum Press, pp.
    • Skalka, A. (1974) A replicator's view of recombination (and repair). In Mechanisms in Recombination. Grell, R.F. (ed.). New York, NY:Plenum Press, pp. 421 432.
    • (1974) Mechanisms in Recombination. , pp. 421-432
    • Skalka, A.1
  • 53
    • 0000994156 scopus 로고
    • The relationship of repair mechanisms to the induction of chromosome aberrations in eukaryotic cells
    • In. Altmann, H. (ed.). Stuttgart: F.K. Schattauer, pp.
    • Strauss, B.S. (1972) The relationship of repair mechanisms to the induction of chromosome aberrations in eukaryotic cells. In DNA-Repair Mechanisms. Altmann, H. (ed.). Stuttgart:F.K. Schattauer, pp. 151 171.
    • (1972) DNA-Repair Mechanisms. , pp. 151-171
    • Strauss, B.S.1
  • 54
    • 0034124053 scopus 로고    scopus 로고
    • Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff
    • Strumberg, D., Pilon, A.A., Smith, M., Hickey, R., Malkas, L. Pommier, Y. (2000) Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff. Mol Cell Biol 20:3977 3987.
    • (2000) Mol Cell Biol , vol.20 , pp. 3977-3987
    • Strumberg, D.1    Pilon, A.A.2    Smith, M.3    Hickey, R.4    Malkas, L.5    Pommier, Y.6
  • 55
    • 0012670425 scopus 로고
    • Uracil incorporation: A source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome
    • Tye, B.-K., Chien, J., Lehman, I.R., Duncan, B.K. Warner, H.R. (1978) Uracil incorporation: a source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome. Proc Natl Acad Sci USA 75:233 237.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 233-237
    • Tye, B.-K.1    Chien, J.2    Lehman, I.R.3    Duncan, B.K.4    Warner, H.R.5
  • 56
    • 0017740439 scopus 로고
    • Excision repair of uracil incorporated in DNA as a result of a defect in dUTPase
    • Tye, B.-K. Lehman, I.R. (1977) Excision repair of uracil incorporated in DNA as a result of a defect in dUTPase. J Mol Biol 117:293 306.
    • (1977) J Mol Biol , vol.117 , pp. 293-306
    • Tye, B.-K.1    Lehman, I.R.2
  • 57
    • 0013608322 scopus 로고
    • Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA
    • Tye, B.K., Nyman, P.O., Lehman, I.R., Hochhauser, S. Weiss, B. (1977) Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA. Proc Natl Acad Sci USA 74:154 157.
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 154-157
    • Tye, B.K.1    Nyman, P.O.2    Lehman, I.R.3    Hochhauser, S.4    Weiss, B.5
  • 58
    • 0242300088 scopus 로고    scopus 로고
    • Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer
    • Vilenchik, M.M. Knudson, A.G. (2003) Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer. Proc Natl Acad Sci USA 100:12871 12876.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12871-12876
    • Vilenchik, M.M.1    Knudson, A.G.2
  • 59
    • 0019475150 scopus 로고
    • Synthesis and metabolism of uracil-containing deoxyribonucleic acid in Escherichia coli
    • Warner, H.R., Duncan, B.K., Garrett, C. Neuhard, J. (1981) Synthesis and metabolism of uracil-containing deoxyribonucleic acid in Escherichia coli. J Bacteriol 145:687 695.
    • (1981) J Bacteriol , vol.145 , pp. 687-695
    • Warner, H.R.1    Duncan, B.K.2    Garrett, C.3    Neuhard, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.