Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA

Structure

Volumn 25, Issue 10, 2017, Pages 1506-1518.e4

  de Vera, Ian Mitchelle S ^a,b   Zheng, Jie ^a   Novick, Scott ^a   Shang, Jinsai ^a   Hughes, Travis S ^a,c   Brust, Richard ^a   Munoz Tello, Paola ^a   Gardner, William J ^a   Marciano, David P ^a   Kong, Xiangming ^a   Griffin, Patrick R ^a   Kojetin, Douglas J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MONTANA   (United States)

Author keywords

allostery; cooperativity; hydrogen deuterium exchange (HDX) mass spectrometry; ligand binding; NMR spectroscopy; nuclear receptor; peroxisome proliferator activated receptor; retinoid X receptor; stabilization; transcription

Indexed keywords

CARBON 13; CELL NUCLEUS RECEPTOR; DNA; HETERODIMER; LIGAND; NUCLEAR RECEPTOR COACTIVATOR 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE; MULTIPROTEIN COMPLEX; NCOA2 PROTEIN, HUMAN; PROTEIN BINDING; RETINOID X RECEPTOR ALPHA;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BIOCHEMICAL ANALYSIS; DEUTERIUM HYDROGEN EXCHANGE; DISPERSION; DNA BINDING; FLUORESCENCE POLARIZATION; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; THERMODYNAMICS; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; GENE EXPRESSION REGULATION; HUMAN; METABOLISM;

BINDING SITES; CARBON-13 MAGNETIC RESONANCE SPECTROSCOPY; DEUTERIUM EXCHANGE MEASUREMENT; DNA; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; MULTIPROTEIN COMPLEXES; NUCLEAR RECEPTOR COACTIVATOR 2; PPAR GAMMA; PROTEIN BINDING; RETINOID X RECEPTOR ALPHA;

EID: 85030458846     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2017.07.019     Document Type: Article

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