Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

Immunity

Volumn 46, Issue 6, 2017, Pages 1030-1044.e8

  Varol, Diana ^a   Mildner, Alexander ^a   Blank, Thomas ^b   Shemer, Anat ^a   Barashi, Neta ^a   Yona, Simon ^a   David, Eyal ^a   Boura Halfon, Sigalit ^a   Segal Hayoun, Yifat ^a   Chappell Maor, Louise ^a   Keren Shaul, Hadas ^a   Leshkowitz, Dena ^a   Hornstein, Eran ^a   Fuhrmann, Martin ^c   Amit, Ido ^a   Maggio, Nicola ^d   Prinz, Marco ^b   Jung, Steffen ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF FREIBURG   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

development; dicer; DNA damage; endotoxin; hippocampus; long term potentiation; LPS; LTP; microglia; microRNA; mutagenesis

Indexed keywords

CD14 ANTIGEN; CD40 ANTIGEN; CD74 ANTIGEN; CDC25A PROTEIN; CDC34 PROTEIN; CDK1 PROTEIN; CKS1B PROTEIN; CRE RECOMBINASE; DICER; ENDOTOXIN; FIBRONECTIN; FIBRONECTIN 1; FTL1 PROTEIN; GENOMIC DNA; HEME OXYGENASE 1; MICRORNA; MICRORNA 126A 3P; MYELOID DIFFERENTIATION FACTOR 88; PEROXIREDOXIN 1; PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SECONDARY LYMPHOID TISSUE CHEMOKINE; TAMOXIFEN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 2; TRANSCRIPTOME; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; RIBONUCLEASE III;

ADULT; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL ACTIVATION; CELL DENSITY; CEREBELLUM; COMET ASSAY; CONTROLLED STUDY; DENDRITE; DNA DAMAGE; DNA REPAIR; ENZYME DEFICIENCY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GENOME; HIPPOCAMPUS; MACROPHAGE; MALE; MICROGLIA; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; SPINAL CORD; STEADY STATE; SYNAPTIC TRANSMISSION; UPREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; EMBRYOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MOTOR ACTIVITY; NERVE CELL PLASTICITY; NEWBORN; PHYSIOLOGY; THREE DIMENSIONAL IMAGING; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DNA REPAIR; FEMALE; HIPPOCAMPUS; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MICRORNAS; MOTOR ACTIVITY; NEURONAL PLASTICITY; NEURONS; RIBONUCLEASE III;

EID: 85029668222     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.05.003     Document Type: Article

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