MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 36, 2017, Pages E7450-E7459

  Liu, Shuzhen ^a   Liu, Hua ^a,b   Johnston, Andrea ^a   Hanna Addams, Sarah ^a   Reynoso, Eduardo ^a   Xiang, Yougui ^a   Wang, Zhigao ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Amyloid like; Disulfide bond; MLKL; Necroptosis; Polymer

Indexed keywords

AMYLOID; CONGO RED; CYSTEINE; MIXED LINEAGE KINASE; POLYMER; PROTEINASE K; AMYLOID PROTEIN; DISULFIDE; MLKL PROTEIN, HUMAN; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISULFIDE BOND; ELECTRON MICROSCOPY; FIBER; HUMAN; HUMAN CELL; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; ANIMAL; APOPTOSIS; CHEMICALLY INDUCED; DRUG EFFECT; HELA CELL LINE; HT-29 CELL LINE; METABOLISM; MOUSE; NECROSIS; TUMOR CELL LINE;

AMYLOID; AMYLOIDOGENIC PROTEINS; ANIMALS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; DISULFIDES; HELA CELLS; HT29 CELLS; HUMANS; MICE; NECROSIS; POLYMERS; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85029218179     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1707531114     Document Type: Article

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