Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

Molecular Cell

Volumn 67, Issue 6, 2017, Pages 1013-1025.e9

  Porter, Joshua R ^a   Fisher, Brian E ^a   Baranello, Laura ^a   Liu, Julia C ^b,c   Kambach, Diane M ^a   Nie, Zuqin ^a   Koh, Woo Seuk ^a   Luo, Ji ^a   Stommel, Jayne M ^a   Levens, David ^a   Batchelor, Eric ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES   (United States)

Author keywords

apoptosis; cell cycle; DNA damage; MYC; p53; transcriptome

Indexed keywords

MYC PROTEIN; PROTEIN P53; TRANSCRIPTOME; MESSENGER RNA; MYC PROTEIN, HUMAN; PROTEIN BINDING; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL FATE; CELLULAR STRESS RESPONSE; DNA DAMAGE RESPONSE; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; NONHUMAN; RNA SEQUENCE; STRESS; TRANSCRIPTION INITIATION; TRANSCRIPTOMICS; UNFOLDED PROTEIN RESPONSE; UPREGULATION; BINDING SITE; BIOSYNTHESIS; BREAST TUMOR; CELL CYCLE CHECKPOINT; CRISPR CAS SYSTEM; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; PROMOTER REGION; RNA INTERFERENCE; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; TIME FACTOR;

APOPTOSIS; BINDING SITES; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; CRISPR-CAS SYSTEMS; DNA BREAKS, DOUBLE-STRANDED; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; MCF-7 CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, MESSENGER; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTOME; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85028503624     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.07.028     Document Type: Article

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