DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

Blood

Volumn 130, Issue 6, 2017, Pages 753-762

  Buscarlet, Manuel ^a   Provost, Sylvie ^b   Zada, Yassamin Feroz ^b   Barhdadi, Amina ^b   Bourgoin, Vincent ^a   Lépine, Guylaine ^a   Mollica, Luigina ^a,c   Szuber, Natasha ^a,c   Dubé, Marie Pierre ^b,c   Busque, Lambert ^a,c  

^a MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^b MONTREAL HEART INSTITUTE   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A; HEMOGLOBIN; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

ADULT; AGED; AGING; ARTICLE; BONE MARROW CELL; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; CORRELATION ANALYSIS; CORRELATIONAL STUDY; EPIGENETICS; FEMALE; GENE SEQUENCE; GENETIC PREDISPOSITION; HEMATOPOIESIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; MIDDLE AGED; MONOCYTE; MUTATOR GENE; NEUTROPHIL COUNT; PREVALENCE; PRIORITY JOURNAL; TELOMERE LENGTH; TET2 GENE; THROMBOCYTE COUNT; VERY ELDERLY; X CHROMOSOME INACTIVATION; AGE; BLOOD CELL COUNT; CELL CLONE; GENETICS; HEMATOLOGIC DISEASE; HIGH THROUGHPUT SEQUENCING; MUTATION; TELOMERE HOMEOSTASIS;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BLOOD CELL COUNT; CLONE CELLS; COHORT STUDIES; DNA (CYTOSINE-5-)-METHYLTRANSFERASES; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIESIS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS; TELOMERE HOMEOSTASIS; X CHROMOSOME INACTIVATION;

EID: 85028042548     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2017-04-777029     Document Type: Article

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