Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Nature Communications

Volumn 7, Issue , 2016, Pages

  Young, Andrew L ^a   Challen, Grant A ^a   Birmann, Brenda M ^b   Druley, Todd E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A; PROTEIN; TET2 PROTEIN; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

ALLELE; BLOOD; CELLS AND CELL COMPONENTS; GENE EXPRESSION; GENETIC ANALYSIS; MUTATION;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ARTICLE; BODY FLUID COMPARTMENT; CANCER RISK; CELL CLONE; CLONAL HAEMATOPOIESIS; CLONAL MUTATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENOME ANALYSIS; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INDEL MUTATION; MALIGNANT TRANSFORMATION; MISSENSE MUTATION; MONOCLONAL B CELL LYMPHOCYTOSIS; MUTATION; MUTATIONAL ANALYSIS; NEXT GENERATION SEQUENCING; NONSENSE MUTATION; NORMAL HUMAN; STEM CELL; ACUTE DISEASE; AGED; COHORT ANALYSIS; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; MIDDLE AGED; MYELOID LEUKEMIA; PROCEDURES;

ACUTE DISEASE; AGED; CLONE CELLS; COHORT STUDIES; DNA (CYTOSINE-5-)-METHYLTRANSFERASES; DNA-BINDING PROTEINS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HEMATOPOIESIS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; LEUKEMIA, MYELOID; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS;

EID: 84984598819     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12484     Document Type: Article

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