Herpes simplex virus 1-encoded tegument protein vp16 abrogates the production of beta interferon (IFN) by inhibiting NF-κB activation and blocking IFN regulatory factor 3 to recruit its coactivator CBP

Journal of Virology

Volumn 87, Issue 17, 2013, Pages 9788-9801

  Xing, Junji ^a,b,c   Ni, Liwen ^a,b   Wang, Shuai ^a,b   Wang, Kezhen ^a,b   Lin, Rongtuan ^d   Zheng, Chunfu ^a,b  

^a SOOCHOW UNIVERSITY   (China)

^b WUHAN INSTITUTE OF VIROLOGY   (China)

^c UNIVERSITY OF MINNESOTA   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; PROTEIN VP16; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERFERON PRODUCTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SENDAI VIRUS; TRANSACTIVATION; TRANSCRIPTION INITIATION;

ANIMALS; CERCOPITHECUS AETHIOPS; CREB-BINDING PROTEIN; HEK293 CELLS; HELA CELLS; HERPES SIMPLEX VIRUS PROTEIN VMW65; HERPESVIRUS 1, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON-BETA; PROMOTER REGIONS, GENETIC; PROTEIN STRUCTURE, TERTIARY; SENDAI VIRUS; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION; VERO CELLS;

EID: 84883292814     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01440-13     Document Type: Article

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