메뉴 건너뛰기




Volumn 14, Issue 1, 2012, Pages 39-50

Can Factor v Leiden and prothrombin G20210A testing in women with recurrent pregnancy loss result in improved pregnancy outcomes?: Results from a targeted evidence-based review

Author keywords

F2 G20210A; F5 G1691A; Factor V Leiden; habitual abortion; prothrombin; recurrent pregnancy loss; systematic review; thrombophilia

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

EID: 85027918258     PISSN: 10983600     EISSN: 15300366     Source Type: Journal    
DOI: 10.1038/gim.0b013e31822e575b     Document Type: Review
Times cited : (39)

References (140)
  • 1
    • 48449103651 scopus 로고    scopus 로고
    • Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications
    • Christiansen OB, Steffensen R, Nielsen HS, Varming K. Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications. Gynecol Obstet Invest 2008;66:257-267.
    • (2008) Gynecol Obstet Invest , vol.66 , pp. 257-267
    • Christiansen, O.B.1    Steffensen, R.2    Nielsen, H.S.3    Varming, K.4
  • 2
    • 41649103961 scopus 로고    scopus 로고
    • Genetics of pregnancy loss
    • DOI 10.1097/GRF.0b013e318161719c, PII 0000308120080300000010
    • Warren JE, Silver RM. Genetics of pregnancy loss. Clin Obstet Gynecol 2008;51:84-95. (Pubitemid 351640165)
    • (2008) Clinical Obstetrics and Gynecology , vol.51 , Issue.1 , pp. 84-95
    • Warren, J.E.1    Silver, R.M.2
  • 3
    • 77950543791 scopus 로고    scopus 로고
    • Factor v Leiden thrombophilia
    • Accessed 3 June 2009
    • Kujovich JL. Factor V Leiden thrombophilia. GENEReviews, 1999. http://www. ncbi.nlm.nih.gov/bookshelf/br.fcgibook-gene&part factor-v-leiden. Accessed 3 June 2009.
    • (1999) GENEReviews
    • Kujovich, J.L.1
  • 4
    • 85028103241 scopus 로고    scopus 로고
    • Prothrombin thrombophilia
    • Accessed 3 June 2009
    • Kujovich JL. Prothrombin thrombophilia. GENEReviews, 2006. http://www.ncbi. nlm.nih.gov/bookshelf/br.fcgibook-gene&part ptt. Accessed 3 June 2009.
    • (2006) GENEReviews
    • Kujovich, J.L.1
  • 5
    • 84921705962 scopus 로고    scopus 로고
    • Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant
    • Empson M, Lassere M, Craig J, Scott J. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev 2005:CD002859.
    • (2005) Cochrane Database Syst Rev
    • Empson, M.1    Lassere, M.2    Craig, J.3    Scott, J.4
  • 6
    • 34250373350 scopus 로고    scopus 로고
    • An overview of methods for detection of factor V Leiden and the prothrombin G20210A mutations
    • DOI 10.1111/j.1751-553X.2007.00892.x
    • Cooper PC, Rezende SM. An overview of methods for detection of factor V Leiden and the prothrombin G20210A mutations. Int J Lab Hematol 2007;29:153-162. (Pubitemid 46911156)
    • (2007) International Journal of Laboratory Hematology , vol.29 , Issue.3 , pp. 153-162
    • Cooper, P.C.1    Rezende, S.M.2
  • 8
    • 0028810738 scopus 로고
    • World distribution of factor v Leiden
    • Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995;346:1133-1134.
    • (1995) Lancet , vol.346 , pp. 1133-1134
    • Rees, D.C.1    Cox, M.2    Clegg, J.B.3
  • 9
    • 58149260397 scopus 로고    scopus 로고
    • Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey 1991-1994
    • Chang MH, Lindegren ML, Butler MA, et al. Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Am J Epidemiol 2009;169:54-66.
    • (2009) Am J Epidemiol , vol.169 , pp. 54-66
    • Chang, M.H.1    Lindegren, M.L.2    Butler, M.A.3
  • 10
    • 0034965498 scopus 로고    scopus 로고
    • Population genetics of factor V Leiden in Europe
    • DOI 10.1006/bcmd.2001.0388
    • Lucotte G, Mercier G. Population genetics of factor V Leiden in Europe. Blood Cells Mol Dis 2001;27:362-367. (Pubitemid 32547831)
    • (2001) Blood Cells, Molecules, and Diseases , vol.27 , Issue.2 , pp. 362-367
    • Lucotte, G.1    Mercier, G.2
  • 11
    • 31144472110 scopus 로고    scopus 로고
    • Thrombophilias and recurrent pregnancy loss
    • Kutteh WH, Triplett DA. Thrombophilias and recurrent pregnancy loss. Semin Reprod Med 2006;24:54-66.
    • (2006) Semin Reprod Med , vol.24 , pp. 54-66
    • Kutteh, W.H.1    Triplett, D.A.2
  • 12
    • 45949094478 scopus 로고    scopus 로고
    • Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0761
    • Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133(6 Suppl):844S-886S. (Pubitemid 351892978)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Bates, S.M.1    Greer, I.A.2    Pabinger, I.3    Sofaer, S.4    Hirsh, J.5
  • 13
    • 58149083101 scopus 로고    scopus 로고
    • Screening and treatment for heritable thrombophilia in pregnancy failure: Inconsistencies among UK early pregnancy units
    • Norrie G, Farquharson RG, Greaves M. Screening and treatment for heritable thrombophilia in pregnancy failure: inconsistencies among UK early pregnancy units. Br J Haematol 2009;144:241-244.
    • (2009) Br J Haematol , vol.144 , pp. 241-244
    • Norrie, G.1    Farquharson, R.G.2    Greaves, M.3
  • 16
    • 59849108152 scopus 로고    scopus 로고
    • The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: Methods of the EGAPP Working Group
    • Teutsch SM, Bradley LA, Palomaki GE, et al. The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group. Genet Med 2009;11:3-14.
    • (2009) Genet Med , vol.11 , pp. 3-14
    • Teutsch, S.M.1    Bradley, L.A.2    Palomaki, G.E.3
  • 17
    • 63449095084 scopus 로고    scopus 로고
    • Systematic reviews of genetic association studies
    • Human Genome Epidemiology Network
    • Sagoo GS, Little J, Higgins JP. Systematic reviews of genetic association studies. Human Genome Epidemiology Network. PLoS Med 2009;6:e28.
    • (2009) PLoS Med , vol.6
    • Sagoo, G.S.1    Little, J.2    Higgins, J.P.3
  • 21
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634. (Pubitemid 27387172)
    • (1997) British Medical Journal , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 23
    • 69149107727 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 2009;151:W65-W94.
    • (2009) Ann Intern Med , vol.151
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3
  • 24
    • 58749117148 scopus 로고    scopus 로고
    • STrengthening the REporting of Genetic Association studies (STREGA): An extension of the STROBE Statement
    • Little J, Higgins JP, Ioannidis JP, et al. STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. Ann Intern Med 2009;150:206-215.
    • (2009) Ann Intern Med , vol.150 , pp. 206-215
    • Little, J.1    Higgins, J.P.2    Ioannidis, J.P.3
  • 26
    • 77950428407 scopus 로고    scopus 로고
    • Analytic validity of genetic tests to identify factor v Leiden and prothrombin G20210A
    • Emadi A, Crim MT, Brotman DJ, et al. Analytic validity of genetic tests to identify factor V Leiden and prothrombin G20210A. Am J Hematol 2010;85:264-270.
    • (2010) Am J Hematol , vol.85 , pp. 264-270
    • Emadi, A.1    Crim, M.T.2    Brotman, D.J.3
  • 28
    • 13844309340 scopus 로고    scopus 로고
    • Multilaboratory testing in thrombophilia through the United Kingdom National External Quality Assessment Scheme (Blood Coagulation) Quality Assurance Program
    • DOI 10.1055/s-2005-863807
    • Jennings I, Kitchen S, Woods TA, Preston FE. Multilaboratory testing in thrombophilia through the United Kingdom National External Quality Assessment Scheme (Blood Coagulation) Quality Assurance Program. Semin Thromb Hemost 2005;31:66-72. (Pubitemid 40262139)
    • (2005) Seminars in Thrombosis and Hemostasis , vol.31 , Issue.1 , pp. 66-72
    • Jennings, I.1    Kitchen, S.2    Woods, T.A.L.3    Preston, F.E.4
  • 29
    • 64149116384 scopus 로고    scopus 로고
    • European external quality control study on the competence of laboratories to recognize rare sequence variants resulting in unusual genotyping results
    • Meki-Zay J, Klein CL, Gancberg D, Schimmel HG, Dux L. European external quality control study on the competence of laboratories to recognize rare sequence variants resulting in unusual genotyping results. Clin Chem 2009;55:739-747.
    • (2009) Clin Chem , vol.55 , pp. 739-747
    • Meki-Zay, J.1    Klein, C.L.2    Gancberg, D.3    Schimmel, H.G.4    Dux, L.5
  • 30
    • 23444443881 scopus 로고    scopus 로고
    • Performance of clinical laboratories for DNA analyses to detect thrombophilia mutations [12]
    • DOI 10.1373/clinchem.2005.049981
    • Tripodi A, Chantarangkul V, Menegatti M, Tagliabue L, Peyvandi F. Performance of clinical laboratories for DNA analyses to detect thrombophilia mutations. Clin Chem 2005;51:1310-1311. (Pubitemid 43079432)
    • (2005) Clinical Chemistry , vol.51 , Issue.7 , pp. 1310-1311
    • Tripodi, A.1    Chantarangkul, V.2    Menegatti, M.3    Tagliabue, L.4    Peyvandi, F.5
  • 32
    • 85205835567 scopus 로고    scopus 로고
    • K033612 510(k) Substantial Equivalence Determination Decision Summary, Factor II (Prothrombin) G20210A (LightCycler), Roche Diagnostics Corp Accessed 9 June 2009
    • K033612: 510(k) Substantial Equivalence Determination Decision Summary, Factor II (Prothrombin) G20210A (LightCycler), Roche Diagnostics Corp., 2003. United States Food and Drug Administartion (FDA) Releasable 510(k) Database. http://www.accessdata.fda.gov/cdrh-docs/pdf3/K033612.pdf. Accessed 9 June 2009.
    • (2003) United States Food and Drug Administartion (FDA) Releasable 510(k) Database
  • 33
    • 85205844369 scopus 로고    scopus 로고
    • K060564 510. (k) Summary for (INFINITI™ F5/F2/MTHFR), Auto-Genomics Inc Accessed 9 June 2009
    • K060564: 510. (k) Summary for (INFINITI™ F5/F2/MTHFR), Auto-Genomics Inc. 2007. US FDA Releasable 510. (k) Database. http://www.accessdata.fda.gov/cdrh-docs/pdf6/K060564.pdf. Accessed 9 June 2009.
    • (2007) US FDA Releasable 510. (K) Database
  • 34
    • 85205844369 scopus 로고    scopus 로고
    • K070597 510(k) Summary (Verigene System F5/F2/MTHFR), Nanosphere Inc Accessed 9 June 2009
    • K070597: 510(k) Summary (Verigene System F5/F2/MTHFR), Nanosphere Inc. 2007. US FDA Releasable 510(k) Database. http://www.accessdata.fda.gov/cdrh- docs/pdf7/K070597.pdf. Accessed 9 June 2009.
    • (2007) US FDA Releasable 510(k) Database
  • 35
    • 85205854540 scopus 로고    scopus 로고
    • K082118 510. (k) Summary (Xpert HemosIL Factor II & Factor V), Cepheid Inc. Accessed 17 June 2010
    • K082118: 510. (k) Summary (Xpert HemosIL Factor II & Factor V), Cepheid Inc., 2009. US FDA Releasable 510. (k) Database. http://www.accessdata. fda. gov/cdrh-docs/pdf7/K070597.pdf. Accessed 17 June 2010.
    • (2009) US FDA Releasable 510. (K) Database
  • 36
    • 85205846605 scopus 로고    scopus 로고
    • K093974: 510(k) Summary (eSensor Factor II-Factor V-MTHFR), Osmetech Molecular Diagnostics Accessed 17 June 2010
    • K093974: 510(k) Summary (eSensor Factor II-Factor V-MTHFR), Osmetech Molecular Diagnostics, 2010. US FDA Releasable 510(k) Database. http://www.accessdata.fda.gov/cdrh-docs/pdf9/K093974.pdf. Accessed 17 June 2010.
    • (2010) US FDA Releasable 510(k) Database
  • 37
    • 77950452071 scopus 로고    scopus 로고
    • Evidence Report/Technology Assessment No. 180 (Prepared by Johns Hopkins University Evidence Based Practice Center under contract no. HHSA 290-2007-10061-1). AHRQ Publication No. 09-E011 Rockville, MD: Agency for Healthcare Research and Quality
    • Segal JB, Brotman DJ, Emadi A, et al. Outcomes of genetic testing in adults with a history of venous thromboembolism. Evidence Report/Technology Assessment No. 180 (Prepared by Johns Hopkins University Evidence Based Practice Center under contract no. HHSA 290-2007-10061-1). AHRQ Publication No. 09-E011, 2009. Rockville, MD: Agency for Healthcare Research and Quality.
    • (2009) Outcomes of Genetic Testing in Adults with A History of Venous Thromboembolism
    • Segal, J.B.1    Brotman, D.J.2    Emadi, A.3
  • 42
    • 22944466378 scopus 로고    scopus 로고
    • The role of factor V Leiden in maternal health and the outcome of pregnancy
    • DOI 10.2174/1389450054546024
    • Calderwood CJ, Greer IA. The role of factor V Leiden in maternal health and the outcome of pregnancy. Curr Drug Targets 2005;6:567-576. (Pubitemid 41051861)
    • (2005) Current Drug Targets , vol.6 , Issue.5 , pp. 567-576
    • Calderwood, C.J.1    Greer, I.A.2
  • 43
    • 0037443934 scopus 로고    scopus 로고
    • Thrombophilic disorders and fetal loss: A meta-analysis
    • DOI 10.1016/S0140-6736(03)12771-7
    • Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003;361:901-908. (Pubitemid 36335814)
    • (2003) Lancet , vol.361 , Issue.9361 , pp. 901-908
    • Rey, E.1    Kahn, S.R.2    David, M.3    Shrier, I.4
  • 44
    • 1842637313 scopus 로고    scopus 로고
    • The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: A meta-analysis
    • Dudding TE, Attia J. The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis. Thromb Haemost 2004;91:700-711. (Pubitemid 38477450)
    • (2004) Thrombosis and Haemostasis , vol.91 , Issue.4 , pp. 700-711
    • Dudding, T.E.1    Attia, J.2
  • 45
    • 1542287296 scopus 로고    scopus 로고
    • Evaluation of the Association between Hereditary Thrombophilias and Recurrent Pregnancy Loss: A Meta-analysis
    • DOI 10.1001/archinte.164.5.558
    • Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Intern Med 2004;164:558-563. (Pubitemid 38314453)
    • (2004) Archives of Internal Medicine , vol.164 , Issue.5 , pp. 558-563
    • Kovalevsky, G.1    Gracia, C.R.2    Berlin, J.A.3    Sammel, M.D.4    Barnhart, K.T.5
  • 47
    • 33646268182 scopus 로고    scopus 로고
    • Screening for thrombophilia in high-risk situations: Systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study
    • Wu O, Robertson L, Twaddle S, et al. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess 2006;10:1-110.
    • (2006) Health Technol Assess , vol.10 , pp. 1-110
    • Wu, O.1    Robertson, L.2    Twaddle, S.3
  • 49
    • 77955027422 scopus 로고    scopus 로고
    • The association of factor v leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: A systematic review and meta-analysis of prospective cohort studies
    • Rodger MA, Betancourt MT, Clark P, et al. The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PLoS Med 2010;7:e1000292.
    • (2010) PLoS Med , vol.7
    • Rodger, M.A.1    Betancourt, M.T.2    Clark, P.3
  • 51
  • 52
    • 34548303853 scopus 로고    scopus 로고
    • Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: Data from the southeast of Turkey
    • DOI 10.1007/s00277-007-0327-1
    • Altintas A, Pasa S, Akdeniz N, et al. Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey. Ann Hematol 2007;86:727-731. (Pubitemid 47337935)
    • (2007) Annals of Hematology , vol.86 , Issue.10 , pp. 727-731
    • Altintas, A.1    Pasa, S.2    Akdeniz, N.3    Cil, T.4    Yurt, M.5    Ayyildiz, O.6    Batun, S.7    Isi, H.8
  • 53
    • 71149106417 scopus 로고    scopus 로고
    • Thrombophilia investigation in Malaysian women with recurrent pregnancy loss
    • Ayadurai T, Muniandy S, Omar SZ. Thrombophilia investigation in Malaysian women with recurrent pregnancy loss. J Obstet Gynaecol Res 2009;35: 1061-1068.
    • (2009) J Obstet Gynaecol Res , vol.35 , pp. 1061-1068
    • Ayadurai, T.1    Muniandy, S.2    Omar, S.Z.3
  • 55
    • 33644534467 scopus 로고    scopus 로고
    • Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion
    • Behjati R, Modarressi MH, Jeddi-Tehrani M, et al. Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion. Ann Hematol 2006;85:268-271.
    • (2006) Ann Hematol , vol.85 , pp. 268-271
    • Behjati, R.1    Modarressi, M.H.2    Jeddi-Tehrani, M.3
  • 56
    • 37549053718 scopus 로고    scopus 로고
    • Recurrent abortions in Asian Indians: No role of factor v Leiden Hong Kong/Cambridge mutation and MTHFR polymorphism
    • Biswas A, Choudhry P, Mittal A, et al. Recurrent abortions in Asian Indians: no role of factor V Leiden Hong Kong/Cambridge mutation and MTHFR polymorphism. Clin Appl Thromb Hemost 2008;14:102-104.
    • (2008) Clin Appl Thromb Hemost , vol.14 , pp. 102-104
    • Biswas, A.1    Choudhry, P.2    Mittal, A.3
  • 59
    • 33645056805 scopus 로고    scopus 로고
    • Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage
    • Coulam CB, Jeyendran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage. Am J Reprod Immunol 2006;55:360-368.
    • (2006) Am J Reprod Immunol , vol.55 , pp. 360-368
    • Coulam, C.B.1    Jeyendran, R.S.2    Fishel, L.A.3    Roussev, R.4
  • 60
  • 61
    • 0033766424 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme DD genotype, angiotensin type 1 receptor CC genotype, and hyperhomocysteinemia increase first-trimester fetal-loss susceptibility
    • Fatini C, Gensini F, Battaglini B, et al. Angiotensin-converting enzyme DD genotype, angiotensin type 1 receptor CC genotype, and hyperhomocysteinemia increase first-trimester fetal-loss susceptibility. Blood Coagul Fibrinolysis 2000;11: 657-662.
    • (2000) Blood Coagul Fibrinolysis , vol.11 , pp. 657-662
    • Fatini, C.1    Gensini, F.2    Battaglini, B.3
  • 62
    • 0036893569 scopus 로고    scopus 로고
    • Prevalence of factor V G1691A (Factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population
    • DOI 10.1002/ajh.10223
    • Finan RR, Tamim H, Ameen G, Sharida HE, Rashid M, Almawi WY. Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population. Am J Hematol 2002;71: 300-305. (Pubitemid 35396947)
    • (2002) American Journal of Hematology , vol.71 , Issue.4 , pp. 300-305
    • Finan, R.R.1    Tamim, H.2    Ameen, G.3    Sharida, H.E.4    Rashid, M.5    Almawi, W.Y.6
  • 64
    • 38949103023 scopus 로고    scopus 로고
    • Factor V Leiden mutation: A treatable etiology for sporadic and recurrent pregnancy loss
    • DOI 10.1016/j.fertnstert.2007.03.011, PII S0015028207005468
    • Glueck CJ, Gogenini S, Munjal J, Tracy T, Pranikoff J, Wang P. Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss. Fertil Steril 2008;89:410-416. (Pubitemid 351215410)
    • (2008) Fertility and Sterility , vol.89 , Issue.2 , pp. 410-416
    • Glueck, C.J.1    Gogenini, S.2    Munjal, J.3    Tracy, T.4    Pranikoff, J.5    Wang, P.6
  • 69
    • 0038300096 scopus 로고    scopus 로고
    • Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage
    • DOI 10.1016/S0015-0282(02)04958-0
    • Hohlagschwandtner M, Unfried G, Heinze G, Huber JC, Nagele F, Tempfer C. Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage. Fertil Steril 2003;79:1141-1148. (Pubitemid 36547852)
    • (2003) Fertility and Sterility , vol.79 , Issue.5 , pp. 1141-1148
    • Hohlagschwandtner, M.1    Unfried, G.2    Heinze, G.3    Huber, J.C.4    Nagele, F.5    Tempfer, C.6
  • 71
    • 77955713196 scopus 로고    scopus 로고
    • Association between factor v Leiden mutation and poor pregnancy outcomes among Palestinian women
    • Hussein AS, Darwish H, Shelbayeh K. Association between factor V Leiden mutation and poor pregnancy outcomes among Palestinian women. Thromb Res 2010;126:e78-e82.
    • (2010) Thromb Res , vol.126
    • Hussein, A.S.1    Darwish, H.2    Shelbayeh, K.3
  • 73
    • 77049098595 scopus 로고    scopus 로고
    • Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses
    • Jaslow CR, Carney JL, Kutteh WH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil Steril 2010;93:1234-1243.
    • (2010) Fertil Steril , vol.93 , pp. 1234-1243
    • Jaslow, C.R.1    Carney, J.L.2    Kutteh, W.H.3
  • 76
    • 0033153189 scopus 로고    scopus 로고
    • Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss
    • DOI 10.1016/S0015-0282(99)00133-8, PII S0015028299001338
    • Kutteh WH, Park VM, Deitcher SR. Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss. Fertil Steril 1999;71:1048-1053. (Pubitemid 29252494)
    • (1999) Fertility and Sterility , vol.71 , Issue.6 , pp. 1048-1053
    • Park, V.M.1
  • 77
    • 24344439224 scopus 로고    scopus 로고
    • Association between adverse pregnancy outcomes and maternal factor V G1691A (Leiden) and prothrombin G20210A genotypes in women with a history of recurrent idiopathic miscarriages
    • DOI 10.1002/ajh.20419
    • Mahjoub T, Mtiraoui N, Tamim H, et al. Association between adverse pregnancy outcomes and maternal factor V G1691A (Leiden) and prothrombin G20210A genotypes in women with a history of recurrent idiopathic miscarriages. Am J Hematol 2005;80:12-19. (Pubitemid 41254262)
    • (2005) American Journal of Hematology , vol.80 , Issue.1 , pp. 12-19
    • Mahjoub, T.1    Mtiraoui, N.2    Tamim, H.3    Hizem, S.4    Finan, R.R.5    Nsiri, B.6    Almawi, W.Y.7
  • 78
    • 0036227458 scopus 로고    scopus 로고
    • Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia
    • DOI 10.1016/S0029-7844(02)01938-5, PII S0029784402019385
    • Many A, Elad R, Yaron Y, Eldor A, Lessing JB, Kupferminc MJ. Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. Obstet Gynecol 2002;99(5 Pt 1):684-687. (Pubitemid 34442440)
    • (2002) Obstetrics and Gynecology , vol.99 , Issue.5 , pp. 684-687
    • Many, A.1    Elad, R.2    Yaron, Y.3    Eldor, A.4    Lessing, J.B.5    Kupferminc, M.J.6
  • 80
    • 77954925938 scopus 로고    scopus 로고
    • Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population
    • Mitic G, Kovac M, Povazan L, et al. Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population. Clin Appl Thromb Hemost 2010;16:435-439.
    • (2010) Clin Appl Thromb Hemost , vol.16 , pp. 435-439
    • Mitic, G.1    Kovac, M.2    Povazan, L.3
  • 84
    • 75649091533 scopus 로고    scopus 로고
    • MTHFR C677T and factor v Leiden in recurrent pregnancy loss: A study among an endogamous group in North India
    • Mukhopadhyay R, Saraswathy KN, Ghosh PK. MTHFR C677T and factor V Leiden in recurrent pregnancy loss: a study among an endogamous group in North India. Genet Test Mol Biomarkers 2009;13:861-865.
    • (2009) Genet Test Mol Biomarkers , vol.13 , pp. 861-865
    • Mukhopadhyay, R.1    Saraswathy, K.N.2    Ghosh, P.K.3
  • 87
    • 59049101057 scopus 로고    scopus 로고
    • Inherited thrombophilias and unexplained pregnancy loss: An incident case-control study
    • Pasquier E, Bohec C, Mottier D, et al. Inherited thrombophilias and unexplained pregnancy loss: an incident case-control study. J Thromb Haemost 2009;7: 306-311.
    • (2009) J Thromb Haemost , vol.7 , pp. 306-311
    • Pasquier, E.1    Bohec, C.2    Mottier, D.3
  • 90
    • 0035017316 scopus 로고    scopus 로고
    • Factor V leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage
    • Rai R, Shlebak A, Cohen H , et al. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod 2001;16:961-965. (Pubitemid 32451834)
    • (2001) Human Reproduction , vol.16 , Issue.5 , pp. 961-965
    • Rai, R.1    Shlebak, A.2    Cohen, H.3    Backos, M.4    Holmes, Z.5    Marriott, K.6    Regan, L.7
  • 94
    • 0032837985 scopus 로고    scopus 로고
    • High prevalence of activated protein c resistance due to factor V Leiden mutation in cases of intrauterine fetal death
    • DOI 10.1002/(SICI)1520-6661(199909/10)8:5<228::AID-MFM6>3.0.CO;2-2
    • Rothbart H, Ohel G, Younis J, Lanir N, Brenner B. High prevalence of activated protein C resistance due to factor V leiden mutation in cases of intrauterine fetal death. J Matern Fetal Med 1999;8:228-230. (Pubitemid 29383354)
    • (1999) Journal of Maternal-Fetal Medicine , vol.8 , Issue.5 , pp. 228-230
    • Rothbart, H.1    Ohel, G.2    Younis, J.3    Lanir, N.4    Brenner, B.5
  • 95
    • 0036149892 scopus 로고    scopus 로고
    • Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage
    • DOI 10.1016/S0015-0282(01)02971-5, PII S0015028201029715
    • Sarig G, Younis JS, Hoffman R, Lanir N, Blumenfeld Z, Brenner B. Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril 2002;77:342-347. (Pubitemid 34086913)
    • (2002) Fertility and Sterility , vol.77 , Issue.2 , pp. 342-347
    • Sarig, G.1    Younis, J.S.2    Hoffman, R.3    Lanir, N.4    Blumenfeld, Z.5    Brenner, B.6
  • 98
    • 0032852675 scopus 로고    scopus 로고
    • Factor V Leiden and factor II G20210A mutations in patients with recurrent abortion
    • DOI 10.1093/humrep/14.10.2448
    • Souza SS, Ferriani RA, Pontes AG, Zago MA, Franco RF. Factor V leiden and factor II G20210A mutations in patients with recurrent abortion. Hum Reprod 1999;14:2448-2450. (Pubitemid 29473908)
    • (1999) Human Reproduction , vol.14 , Issue.10 , pp. 2448-2450
    • Souza, S.S.1    Ferriani, R.A.2    Pontes, A.G.3    Zago, M.A.4    Franco, R.F.5
  • 100
    • 0033040275 scopus 로고    scopus 로고
    • A possible role for activated protein C resistance in patients with first and second trimester pregnancy failure
    • DOI 10.1093/humrep/14.6.1624
    • Tal J, Schliamser LM, Leibovitz Z, Ohel G, Attias D. A possible role for activated protein C resistance in patients with first and second trimester pregnancy failure. Hum Reprod 1999;14:1624-1627. (Pubitemid 29265463)
    • (1999) Human Reproduction , vol.14 , Issue.6 , pp. 1624-1627
    • Tal, J.1    Mschliamser, L.2    Leibovitz, Z.3    Ohel, G.4    Attias, D.5
  • 101
    • 51649112961 scopus 로고    scopus 로고
    • Paternal thrombophilic gene mutations are not associated with recurrent miscarriage
    • Toth B, Vocke F, Rogenhofer N, et al. Paternal thrombophilic gene mutations are not associated with recurrent miscarriage. Am J Reprod Immunol 2008;60:325-332.
    • (2008) Am J Reprod Immunol , vol.60 , pp. 325-332
    • Toth, B.1    Vocke, F.2    Rogenhofer, N.3
  • 102
    • 58149140519 scopus 로고    scopus 로고
    • Thrombophilic dimension of recurrent fetal loss in Indian patients
    • Vora S, Shetty S, Ghosh K. Thrombophilic dimension of recurrent fetal loss in Indian patients. Blood Coagul Fibrinolysis 2008;19:581-584.
    • (2008) Blood Coagul Fibrinolysis , vol.19 , pp. 581-584
    • Vora, S.1    Shetty, S.2    Ghosh, K.3
  • 105
    • 0033754115 scopus 로고    scopus 로고
    • Primary habitual abortions are associated with high frequency of factor v Leiden mutation
    • Wramsby ML, Sten-Linder M, Bremme K. Primary habitual abortions are associated with high frequency of factor V Leiden mutation. Fertil Steril 2000;74: 987-991.
    • (2000) Fertil Steril , vol.74 , pp. 987-991
    • Wramsby, M.L.1    Sten-Linder, M.2    Bremme, K.3
  • 106
    • 0033973640 scopus 로고    scopus 로고
    • Activated protein C resistance and factor V Leiden mutation can be associated with first- as well as second-trimester recurrent pregnancy loss
    • Younis JS, Brenner B, Ohel G, Tal J, Lanir N, Ben-Ami M. Activated protein C resistance and factor V Leiden mutation can be associated with first-as well as secondtrimester recurrent pregnancy loss. Am J Reprod Immunol 2000;43: 31-35. (Pubitemid 30083855)
    • (2000) American Journal of Reproductive Immunology , vol.43 , Issue.1 , pp. 31-35
    • Younis, J.S.1    Brenner, B.2    Ohel, G.3    Tal, J.4    Lanir, N.5    Ben-Ami, M.6
  • 108
    • 33645736601 scopus 로고    scopus 로고
    • Association of factor v gene polymorphisms (Leiden; Cambridge; Hong Kong and HR2 haplotype) with recurrent idiopathic pregnancy loss in Tunisia. A case-control study
    • Zammiti W, Mtiraoui N, Mercier E, et al. Association of factor V gene polymorphisms (Leiden; Cambridge; Hong Kong and HR2 haplotype) with recurrent idiopathic pregnancy loss in Tunisia. A case-control study. Thromb Haemost 2006;95:612-617.
    • (2006) Thromb Haemost , vol.95 , pp. 612-617
    • Zammiti, W.1    Mtiraoui, N.2    Mercier, E.3
  • 111
    • 0033934949 scopus 로고    scopus 로고
    • Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis
    • Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56: 455-463. (Pubitemid 30422636)
    • (2000) Biometrics , vol.56 , Issue.2 , pp. 455-463
    • Duval, S.1    Tweedie, R.2
  • 112
    • 0033768987 scopus 로고    scopus 로고
    • High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss
    • Kupferminc MJ, Peri H, Zwang E, Yaron Y, Wolman I, Eldor A. High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss. Acta Obstet Gynecol Scand 2000;79:963-967.
    • (2000) Acta Obstet Gynecol Scand , vol.79 , pp. 963-967
    • Kupferminc, M.J.1    Peri, H.2    Zwang, E.3    Yaron, Y.4    Wolman, I.5    Eldor, A.6
  • 113
    • 0035144589 scopus 로고    scopus 로고
    • G20210A prothrombin gene mutation: Prevalence in a recurrent miscarriage population
    • Pickering W, Marriott K, Regan L. G20210A prothrombin gene mutation: prevalence in a recurrent miscarriage population. Clin Appl Thromb Hemost 2001;7:25-28. (Pubitemid 32112598)
    • (2001) Clinical and Applied Thrombosis/Hemostasis , vol.7 , Issue.1 , pp. 25-28
    • Pickering, W.1    Marriott, K.2    Regan, L.3
  • 114
    • 73949097566 scopus 로고    scopus 로고
    • A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss
    • Yenicesu GI, Cetin M, Ozdemir O, et al. A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss. Am J Reprod Immunol 2010;63:126-136.
    • (2010) Am J Reprod Immunol , vol.63 , pp. 126-136
    • Yenicesu, G.I.1    Cetin, M.2    Ozdemir, O.3
  • 116
    • 65549083856 scopus 로고    scopus 로고
    • Pregnancy outcome in women with factor v Leiden and recurrent miscarriage
    • Jivraj S, Makris M, Saravelos S, Li TC. Pregnancy outcome in women with factor V Leiden and recurrent miscarriage. BJOG 2009;116:995-998.
    • (2009) BJOG , vol.116 , pp. 995-998
    • Jivraj, S.1    Makris, M.2    Saravelos, S.3    Li, T.C.4
  • 117
    • 78649495650 scopus 로고    scopus 로고
    • Hereditary thrombophilia and recurrent pregnancy loss: A retrospective cohort study of pregnancy outcome and obstetric complications
    • Lund M, Nielsen HS, Hviid TV, Steffensen R, Nyboe Andersen A, Christiansen OB. Hereditary thrombophilia and recurrent pregnancy loss: a retrospective cohort study of pregnancy outcome and obstetric complications. Hum Reprod 2010;25:2978-2984.
    • (2010) Hum Reprod , vol.25 , pp. 2978-2984
    • Lund, M.1    Nielsen, H.S.2    Hviid, T.V.3    Steffensen, R.4    Nyboe Andersen, A.5    Christiansen, O.B.6
  • 118
    • 0036177333 scopus 로고    scopus 로고
    • Factor V Leiden and recurrent miscarriage - Prospective outcome of untreated pregnancies
    • Rai R, Backos M, Elgaddal S, Shlebak A, Regan L. Factor V Leiden and recurrent miscarriage-prospective outcome of untreated pregnancies. Hum Reprod 2002;17:442-445. (Pubitemid 34168455)
    • (2002) Human Reproduction , vol.17 , Issue.2 , pp. 442-445
    • Rai, R.1    Backos, M.2    Elgaddal, S.3    Shlebak, A.4    Regan, L.5
  • 119
    • 77951714717 scopus 로고    scopus 로고
    • SPIN (Scottish Pregnancy Intervention) study: A multicenter randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage
    • Scottish Pregnancy Intervention Study (SPIN) collaborators
    • Clark P, Walker ID, Langhorne P, et al.; Scottish Pregnancy Intervention Study (SPIN) collaborators. SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. Blood 2010;115:4162-4167.
    • (2010) Blood , vol.115 , pp. 4162-4167
    • Clark, P.1    Walker, I.D.2    Langhorne, P.3
  • 122
    • 33645578365 scopus 로고    scopus 로고
    • Activated protein C resistance-in the absence of factor v Leiden-and pregnancy
    • Lindqvist PG, Svensson P, Dahlb̈k B. Activated protein C resistance-in the absence of factor V Leiden-and pregnancy. J Thromb Haemost 2006;4: 361-366.
    • (2006) J Thromb Haemost , vol.4 , pp. 361-366
    • Lindqvist, P.G.1    Svensson, P.2    Dahlb̈k, B.3
  • 124
    • 74049108191 scopus 로고    scopus 로고
    • Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women
    • Said JM, Higgins JR, Moses EK, et al. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. Obstet Gynecol 2010;115: 5-13.
    • (2010) Obstet Gynecol , vol.115 , pp. 5-13
    • Said, J.M.1    Higgins, J.R.2    Moses, E.K.3
  • 125
    • 74049117037 scopus 로고    scopus 로고
    • Prothrombin gene G20210A mutation and obstetric complications
    • Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (NICHD MFMU) Network
    • Silver RM, Zhao Y, Spong CY, et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (NICHD MFMU) Network. Prothrombin gene G20210A mutation and obstetric complications. Obstet Gynecol 2010;115:14-20.
    • (2010) Obstet Gynecol , vol.115 , pp. 14-20
    • Silver, R.M.1    Zhao, Y.2    Spong, C.Y.3
  • 126
    • 37349028049 scopus 로고    scopus 로고
    • The GOAL study: A prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes
    • DOI 10.1111/j.1365-2141.2007.06902.x
    • Clark P, Walker ID, Govan L, Wu O, Greer IA. The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes. Br J Haematol 2008;140:236-240. (Pubitemid 350284489)
    • (2008) British Journal of Haematology , vol.140 , Issue.2 , pp. 236-240
    • Clark, P.1    Walker, I.D.2    Govan, L.3    Wu, O.4    Greer, I.A.5
  • 127
    • 0032710956 scopus 로고    scopus 로고
    • A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage
    • DOI 10.1093/humrep/14.11.2868
    • Brigham SA, Conlon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum Reprod 1999;14:2868-2871. (Pubitemid 29520709)
    • (1999) Human Reproduction , vol.14 , Issue.11 , pp. 2868-2871
    • Brigham, S.A.1    Conlon, C.2    Farquharson, R.G.3
  • 128
    • 0030939856 scopus 로고    scopus 로고
    • Future pregnancy outcome in unexplained recurrent first trimester miscarriage
    • DOI 10.1093/humrep/12.2.387
    • Clifford K, Rai R, Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod 1997;12:387-389. (Pubitemid 27129408)
    • (1997) Human Reproduction , vol.12 , Issue.2 , pp. 387-389
    • Clifford, K.1    Rai, R.2    Regan, L.3
  • 129
    • 70249114038 scopus 로고    scopus 로고
    • Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome
    • Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S. Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. Cochrane Database Syst Rev 2009:CD004734.
    • (2009) Cochrane Database Syst Rev
    • Kaandorp, S.1    Di Nisio, M.2    Goddijn, M.3    Middeldorp, S.4
  • 131
    • 77951724860 scopus 로고    scopus 로고
    • Aspirin plus heparin or aspirin alone in women with recurrent miscarriage
    • Kaandorp SP, Goddijn M, van der Post JA, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010;362: 1586-1596.
    • (2010) N Engl J Med , vol.362 , pp. 1586-1596
    • Kaandorp, S.P.1    Goddijn, M.2    Van Der Post, J.A.3
  • 133
    • 77951724860 scopus 로고    scopus 로고
    • Aspirin plus heparin or aspirin alone in women with recurrent miscarriage
    • Kaandorp SP, Goddijn M, van der Post JA, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010;362: 1586-1596.
    • (2010) N Engl J Med , vol.362 , pp. 1586-1596
    • Kaandorp, S.P.1    Goddijn, M.2    Van Der Post, J.A.3
  • 134
    • 77950377251 scopus 로고    scopus 로고
    • Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: A meta-analysis of randomized controlled trials and meta-regression
    • Mak A, Cheung MW, Cheak AA, Ho RC. Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression. Rheumatology (Oxford) 2010;49:281-288.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 281-288
    • Mak, A.1    Cheung, M.W.2    Cheak, A.A.3    Ho, R.C.4
  • 135
    • 74749099242 scopus 로고    scopus 로고
    • Low molecular weight heparin to achieve live birth following unexplained pregnancy loss: A systematic review
    • Mantha S, Bauer KA, Zwicker JI. Low molecular weight heparin to achieve live birth following unexplained pregnancy loss: a systematic review. J Thromb Haemost 2010;8:263-268.
    • (2010) J Thromb Haemost , vol.8 , pp. 263-268
    • Mantha, S.1    Bauer, K.A.2    Zwicker, J.I.3
  • 136
    • 77952981639 scopus 로고    scopus 로고
    • Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: A systematic review and meta-analysis
    • Ziakas PD, Pavlou M, Voulgarelis M. Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: a systematic review and meta-analysis. Obstet Gynecol 2010;115:1256-1262.
    • (2010) Obstet Gynecol , vol.115 , pp. 1256-1262
    • Ziakas, P.D.1    Pavlou, M.2    Voulgarelis, M.3
  • 137
    • 33747878216 scopus 로고    scopus 로고
    • What is the clinical utility of genetic testing?
    • DOI 10.1097/01.gim.0000227935.26763.c6, PII 0012581720060700000008
    • Grosse SD, Khoury MJ. What is the clinical utility of genetic testing? Genet Med 2006;8:448-450. (Pubitemid 44289007)
    • (2006) Genetics in Medicine , vol.8 , Issue.7 , pp. 448-450
    • Grosse, S.D.1    Khoury, M.J.2
  • 138
    • 57349142577 scopus 로고    scopus 로고
    • Venous thromboembolic disease and pregnancy
    • Marik PE, Plante LA. Venous thromboembolic disease and pregnancy. N Engl J Med 2008;359:2025-2033.
    • (2008) N Engl J Med , vol.359 , pp. 2025-2033
    • Marik, P.E.1    Plante, L.A.2
  • 139
    • 70350221025 scopus 로고    scopus 로고
    • Use of Factor v Leiden genetic testing in practice and impact on management
    • Laberge AM, Psaty BM, Hindorff LA, Burke W. Use of Factor V Leiden genetic testing in practice and impact on management. Genet Med 2009;11: 750-756.
    • (2009) Genet Med , vol.11 , pp. 750-756
    • Laberge, A.M.1    Psaty, B.M.2    Hindorff, L.A.3    Burke, W.4
  • 140
    • 79955014016 scopus 로고    scopus 로고
    • Consultative hematology: The pregnant patient pregnancy loss
    • Bates SM. Consultative hematology: the pregnant patient pregnancy loss. Hematology Am Soc Hematol Educ Program 2010;2010:166-172.
    • (2010) Hematology Am Soc Hematol Educ Program , vol.2010 , pp. 166-172
    • Bates, S.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.