The factor V Leiden mutation is not a common cause of recurrent miscarriage

Journal of Reproductive Immunology

Volumn 34, Issue 3, 1997, Pages 217-223

  Dizon Townson, Donna S ^a   Kinney, Sonja ^a   Ware Branch, D ^a   Ward, Kenneth ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Factor V Leiden mutation; Recurrent miscarriage; Thrombosis

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; DNA;

ADULT; ALLELE; ARTICLE; CONTINGENCY TABLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EXON; FEMALE; FERTILITY; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; PATIENT REFERRAL; PLACENTA DISORDER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT ABORTION; SPONTANEOUS ABORTION; THROMBOSIS;

EID: 0030797916     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0378(97)00039-9     Document Type: Article

References (23)

1. Alarcon-Segovia, D., Deleze, M., Oria, C.V., Anchez-Guerrero, J., Gomez-Pacheco, L., Cabiedes, J., et al., 1989. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective study of 500 consecutive cases. Medicine 68, 353-363.
2. Amer, L., Kisiel, W., Searles, R.P., Williams, R.C., 1990. Impairment of the protein C anticoagulant pathway in a patient with systemic lupus erythematosus anticardiolipin antibodies and thrombosis. Thromb. Res. 57, 247-258.
3. Asherson, R.A., Khamashta, M.A., Ordi-Ros, J., Derksen, R.H., Machin, S.J., Barquinero, J., et al., 1989. The primary antiphospholipid syndrome: Major clinical and serological features. Medicine 68, 366-374.
4. Bertina, R.M., Koeleman, B.P.C., Koster, T., Rosendaal, F.R., Dirven, R.J., de Ronde, H., van der Velden, P.A., Reitsma, P.H., 1994. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369, 64-67.
5. Branch, D.W., Silver, R.M., Blackwell, J.L., Reading, J.C., Scott, J.R., 1992. Outcome of treated pregnancies in women with antiphospholipid syndrome: An update of the Utah experience. Obstet. Gynecol. 80, 614-620.
6. Branch, D.W., Rodgers, G.M., 1993. Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: A possible mechanism of thrombosis. Am. J. Obstet. Gynecol. 168, 206-210.
7. Braulke, I., Pruggmayer, M., Melloh, P., Hinney, B., Kostering, H., Gunther, E., 1993. Factor XII (Hagmen) deficiency in women with habitual abortions: New subpopulation of recurrent aborters?. Fertil. Steril. 59, 98-101.
8. Cariou, R., Tobelem, G., Soria, C., Caen, J., 1986. Inhibition of protein C activation by endothelial cells in the presence of lupus anticoagulant. New Engl. J. Med. 314, 119.
9. DeWolf, F., Carreras, L.O., Moerman, P., Vermylen, P., Van Assche, A., Renaer, M., 1982. Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss and a lupus anticoagulant. Am. J. Obstet. Gynecol. 142, 829-834.
10. Dizon-Townson, D., Nelson, L., Easton, K., Ward, K., 1996. The factor V Leiden mutation may predispose women to severe preeclampsia. Am. J. Obstet. Gynecol. 175, 902-905.
11. Dizon-Townson, D., Meline, L., Nelson, L., Ward, K., 1997. Fetal carriers of the factor V Leiden mutation are prone to spontaneous miscarriage and placental infarction. Am. J. Obstet. Gynecol. (in press).
12. Grandone, E., Margaglione, M., Colaizzo, D., dAddedda, M., Cappucci, G., Vecchione, G., Scianname, N., Pavone, G., Di Minno, G., 1997. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb. Haemost. 77, 822-824.
13. Hanley, J.A., Lippman-Hand, A., 1983. If nothing goes wrong, is everything all right?. J. Am. Med. Assoc. 249, 1743-1745.
14. Kalafatis, M., Rand, M.D., Mann, K.G., 1994. The mechanism of inactivation of human factor V and human factor Va by activated protein C. J. Biol. Chem. 269, 31869-31880.
15. Khamashta, M.A., Harris, E.N., Gharavi, A.E., et al., 1988. Immune mediated mechanism for thrombosis: Antiphospholipid antibody binding to platelet membranes. Ann. Rheum. Dis. 47, 849-854.
16. Metz, J., Kloss, M., O'Malley, C.J., Rockman, S.P., De Rosa, L., Doig, R., McGrath, K.M. Prevalence of factor V Leiden is not increased in women with recurrent miscarriage. Clin. Appl. Thromb./Hemost. 3, 137-140.
17. Out, H.J., Kooijman, C.D., Bruinse, H.W., Derksen, R.H.W.M., 1991. Histo-pathological findings from patients with intrauterine fetal death and antiphospholipid antibodies. Eur. J. Obstet. Gynecol. 41, 179-186.
18. Peaceman, A.M., Rehnberg, K., 1992. The immunoglobulin G fraction from plasma containing antiphospholipid antibodies causes increased placental thromboxane production. Am. J. Obstet. Gynecol. 167, 1543-1547.
19. Peaceman, A.M., Rehnberg, K., 1993. The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production. Am. J. Obstet. Gynecol. 169, 1403-1406.
20. Rai, R., Regan, L., Hadley, E., Dave, M., Cohen, H., 1996. Second-trimester pregnancy loss is associated with activated protein C resistance. Br. J. Haematol. 92, 489-490.
21. Rossi, E., Gatti, L., Guarneri, D., Finotto, Lobardi, A., Preda, L., 1992. Functional protein S in women with lupus anticoagulant inhibitor. Thromb. Res. 65, 253-262.
22. Soulier, J.P., Boffa, M.C., 1980. Avortements a repetition, thromboses et anticoagulant circulant antithromboplastine: trois observations. Nouv. Presse Med. 9, 859.
23. Tannebaum, S.H., Finko, R., Cines, D.B., 1986. Antibody and immune complexes induce tissue factor production by endothelial cells. J. Immunol. 137, 1532-1537.