Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses

Fertility and Sterility

Volumn 93, Issue 4, 2010, Pages 1234-1243

  Jaslow, Carolyn R ^a   Carney, Judi L ^a   Kutteh, William H ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Fertility Associates of Memphis   (United States)

Author keywords

antiphospholipid antibodies; evidence based; miscarriages; Recurrent pregnancy loss; thrombophilias

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; CARDIOLIPIN ANTIBODY; GLUCOSE; HOMOCYSTEINE; LUPUS ANTICOAGULANT; PROTEIN C; PROTEIN S; PROTHROMBIN; THYROTROPIN;

ADULT; ARTICLE; BLOOD TESTIS BARRIER; CHROMOSOME ABERRATION; COHORT ANALYSIS; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; HYSTEROGRAPHY; HYSTEROSALPINGOGRAPHY; HYSTEROSCOPY; IMMUNOLOGICAL PROCEDURES; INFECTION; KARYOTYPING; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PRIVATE PRACTICE; RECURRENT ABORTION; RETROSPECTIVE STUDY; SPONTANEOUS ABORTION; UTERUS MALFORMATION;

ABORTION, HABITUAL; ADULT; BLOOD GLUCOSE; COHORT STUDIES; DIAGNOSTIC TESTS, ROUTINE; FEMALE; HUMANS; KARYOTYPING; MALE; MIDDLE AGED; PREGNANCY; RETROSPECTIVE STUDIES; RISK FACTORS; THYROTROPIN;

EID: 77049098595     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.01.166     Document Type: Article

References (58)

1. Stephenson M., and Kutteh W.H. Evaluation and management of recurrent early pregnancy loss. Clin Obstet Gynecol 50 (2007) 132-145
2. Christiansen O.B., Nielsen H.S., Kolte A., and Pedersen A.T. Research methodology and epidemiology of relevance in recurrent pregnancy loss. Semin Reprod Med 24 (2006) 5-16
3. Martinelli I., Taioli E., Cetin I., Marinoni A., Gerosa S., Villa M.V., et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 343 (2000) 1015-1018
4. George L., Mills J.L., Johansson A.L., Nordmark A., Olander B., Granath F., et al. Plasma folate levels and risk of spontaneous abortion. JAMA 288 (2002) 1867-1873
5. Anselmo J., Cao D., Karrison T., Weiss R.E., and Refetoff S. Fetal loss associated with excess thyroid exposure. JAMA 292 (2004) 691-695
6. Donders G.G.G., Van Bulck B., Caudron J., Londers L., Vereecken A., and Spitz B. Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion. Am J Obstet Gynecol 183 (2000) 431-437
7. Jauniaux E., Farquharson R.G., Christiansen O.B., and Exalto N. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum Reprod 21 (2006) 2216-2222
8. Stephenson M.D. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril 66 (1996) 24-29
9. Clifford K., Rai R., and Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod 12 (1997) 387-389
10. Salim R., Regan L., Woelfer B., Backos M., and Jurkovic D. A comparative study of the morphology of congenital uterine anomalies in women with and without a history of recurrent first trimester miscarriage. Hum Reprod 18 (2003) 162-166
11. Sullivan A.E., Silver R.M., LaCoursiere D.Y., Porter T.F., and Branch D.W. Recurrent fetal aneuploidy and recurrent miscarriage. Obstet Gynecol 104 (2004) 784-788
12. Daya S. Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta-analysis of controlled trials. Br J Obstet Gynecol 96 (1989) 275-280
13. Bussen S., Sütterlin M., and Steck T. Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion. Hum Reprod 14 (1999) 18-20
14. Hirahara F., Andoh N., Sawai K., Hirabuki T., Uemura T., and Minaguchi H. Hyperprolactinemic recurrent miscarriage and results of randomized bromocriptine treatment trials. Fertil Steril 70 (1998) 246-252
15. Sanson B.J., Friederich P.W., Simioni P., Zanardi S., Hilsman M.V., Girolami A., et al. The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women. Thromb Haemost 75 (1996) 387-388
16. Preston F.E., Rosendaal F.R., Walker I.D., Briët E., Berntorp E., Conard J., et al. Increased fetal loss in women with heritable thrombophilia. Lancet 348 (1996) 913-916
17. Sarig G., Younis J.S., Hoffman R., Lanir N., Blumenfeld Z., and Brenner B. Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril 77 (2002) 342-347
18. Yetman D.L., and Kutteh W.H. Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies. Fertil Steril 66 (1996) 540-546
19. Krabbendam I., Franx A., Bots M.L., Fijnheer R., and Bruinse H.W. Thrombophilias and recurrent pregnancy loss: a critical appraisal of the literature. Eur J Obstet Gynecol Reprod Biol 118 (2005) 143-153
20. Kovalevsky G., Gracia C.R., Berlin J.A., Sammel M.D., and Barnhart K.T. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss. Arch Intern Med 164 (2004) 558-563
21. Nelen W.L.D.M., Blom H.J., Steegers E.A.P., Den Heijer M., and Eskes T.K.A.B. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril 74 (2000) 1196-1199
22. Mtiraoui N., Zammiti W., Ghazouani L., Jmili Braham N., Saidi S., Finan R.R., et al. Methylenetetrahydrofolate reductase C667T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses. Reproduction 131 (2006) 395-401
23. Penta M., Lukic A., Conte M.P., Chiarini F., Fioriti D., Longhi C., et al. Infectious agents in tissues from spontaneous abortions in the first trimester of pregnancy. New Microbiol 26 (2003) 329-337
24. Wassertheil-Smoller S. Biostatistics and epidemiology: a primer for health professionals (1990), Springer Verlag, New York
25. Hook E.B., Healy N.P., and Willey A.M. How much difference does chromosome banding make?. Ann Hum Genet 53 (1989) 237-242
26. Branch D.W., Silver R., Pierangeli S., van Leeuwen I., and Harris E.N. Antiphospholipid antibodies other than lupus anticoagulant and anticardiolipin antibodies in women with recurrent pregnancy loss, fertile controls, and antiphospholipid syndrome. Obstet Gynecol 89 (1997) 549-555
27. Gerhardt A., Scharf R.E., Beckmann M.W., Struve S., Bender H.G., Pillny M., et al. Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. N Engl J Med 342 (2000) 374-380
28. Krause M., Sonntag B., Klamroth R., Heinecke A., Scholz C., Langer C., et al. Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage. Results of a multicentre case-control study. Thromb Haemost 93 (2005) 867-871
29. Hollowell J.G., Staehling N.W., Flanders W.D., Hannon W.H., Gunter E.W., Spencer C.A., et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87 (2002) 489-499
30. Samra Z., Soffer Y., and Pansky M. Prevalence of genital chlamydia and mycoplasma infection in couples attending a male infertility clinic. Eur J Epidemiol 10 (1994) 69-73
31. Shepard M.K., and Senturia Y.D. Comparison of serum progesterone and endometrial biopsy for confirmation of ovulation and evaluation of luteal function. Fertil Steril 28 (1977) 541-548
32. Biller B.M.K., Luciano A., Crosignani P.G., Molitch M., Olive D., Rebar R., et al. Guidelines for the diagnosis and treatment of hyperprolactinemia. J Reprod Med 44 (1999) 1075-1084
33. Stephenson M.D., Awartani K.A., and Robinson W.P. Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case-control study. Hum Reprod 17 (2002) 446-451
34. Ogasawara M., Aoki K., Okada S., and Suzumori K. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 73 (2000) 300-304
35. Carp H., Toder V., Aviram A., Daniely M., Mashiach S., and Barkai G. Karyotype of the abortus in recurrent miscarriage. Fertil Steril 75 (2001) 678-682
36. Nybo Andersen A.-M., Wohlfahrt J., Christens P., Olsen J., and Melbye M. Maternal age and fetal loss: population based register linkage study. Br Med J 320 (2000) 1708-1712
37. Stray-Pedersen B., and Stray-Pedersen S. Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am J Obstet Gynecol 148 (1984) 140-146
38. Clifford K., Rai R., Watson H., and Regan L. An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Hum Reprod 9 (1994) l328-l332
39. Harger J.H., Archer D.F., Marchese S.G., Muracca-Clemens M., and Garver K.L. Etiology of recurrent pregnancy losses and outcome of subsequent pregnancies. Obstet Gynecol 62 (1983) 574-581
40. Rey E., Kahn S.R., David M., and Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361 (2003) 901-908
41. Katsuragawa H., Kanzaki H., Inoue T., Hirano T., Mori T., and Rote N.S. Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion. Biol Reprod 56 (1997) 50-58
42. Franklin R.D., and Kutteh W.H. Effects of unfractionated and low molecular weight heparin on antiphospholipid antibody binding in vitro. Obstet Gynecol 101 (2003) 455-462
43. Franklin R.D., and Kutteh W.H. Antiphospholipid antibodies (APA) and recurrent pregnancy loss: treating a unique APA positive population. Hum Reprod 17 (2002) 2981-2985
44. Noble L.S., Kutteh W.H., Lashey N., Franklin R.D., and Herrada J. Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective, multicenter, controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin. Fertil Steril 83 (2005) 684-690
45. Kutteh W.H., Park V.M., and Deitcher S.R. Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss. Fertil Steril 71 (1999) 1048-1053
46. Boushey C.J., Beresford S.A., Omenn G.S., and Motulsky A.G. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274 (1995) 1049-1057
47. Di Simone N., Maggiano N., Caliandro D., Riccardi P., Evangelista A., Carducci B., et al. Homocysteine induces trophoblast cell death with apoptotic features. Biol Reprod 69 (2003) 1129-1134
48. Kirke P.N., Mills J.L., Molloy A.M., Brody L.C., O'Leary V.B., Daly L., et al. Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study. Br Med J 328 (2004) 1535-1536
49. Botto L.D., and Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151 (2000) 862-877
50. Callejón G., Mayor-Olea A., Jiménez A.J., Gaitán M.J., Palomares A.R., Martínez F., et al. Genotypes of the C677T and A1298C polymorphisms of the MTHFR gene as a cause of human spontaneous embryo loss. Hum Reprod 22 (2007) 3249-3254
51. Gürbüz B., Yalti S., Fiçicioǧlu C., Ozden S., Yildirim G., and Sayar C. Basal hormone levels in women with recurrent pregnancy loss. Gynecol Endocrinol 17 (2003) 317-321
52. Haas D.M., and Ramsey P.S. Progestogen for preventing miscarriage. Cochrane Database Syst Rev 2 (2008) CD003511
53. Folkeringa N., Brouwer J.L., Korteweg F.J., Veeger N.J., Erwich J.J., Holm J.P., et al. Reduction of high fetal loss rate by anticoagulant treatment during pregnancy in antithrombin, protein C or protein S deficient women. Br J Haematol 136 (2007) 656-661
54. Wilcox A.J., Baird D.D., and Weinberg C.R. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 340 (1999) 1796-1799
55. Piccinni M.P., Beloni L., Livi C., Maggi E., Scarselli G., and Romagnani S. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 4 (1998) 1020-1024
56. Cnattingius S., Signorello L.B., Annerén G., Clausson B., Ekbom A., Ljunger E., et al. Caffeine intake and the risk of first-trimester spontaneous abortion. N Engl J Med 343 (2000) 1839-1845
57. Ness R.B., Grisso J.A., Hirschinger N., Markovic N., Shaw L.M., Day N.L., et al. Cocaine and tobacco use and the risk of spontaneous abortion. N Engl J Med 340 (1999) 333-339
58. Carson S.A., and Branch D.W. Management of recurrent early pregnancy loss. Am Coll Obstet Gynecol Pract Bull 24 (2001) 1-12