Primary habitual abortions are associated with high frequency of Factor V Leiden mutation

Fertility and Sterility

Volumn 74, Issue 5, 2000, Pages 987-991

  Wramsby, M L ^a   Sten Linder, M ^a   Bremme, K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Leiden mutation; MTHFR mutation C677T; Primary recurrent abortions; Prothrombin polymorphism G20210A

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RECURRENT ABORTION; RISK FACTOR;

ABORTION, HABITUAL; ADULT; CASE-CONTROL STUDIES; FACTOR V; FEMALE; GENE FREQUENCY; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; PROTHROMBIN;

EID: 0033754115     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(00)01545-4     Document Type: Article

References (22)

1. Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion
2. Multiples of the median: An alternative method for reporting antiphospholipid antibodies in women with recurrent pregnancy loss
3. Prospective evaluation of the prevalence of haemostasis abnormalities in unexplained primary early recurrent miscarriages
4. Prevalence of prothrombin G20210A, factor V G1691A (Leiden), and methyleneterahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele specific PCR
5. The factor V Leiden mutation is not a common cause of recurrent miscarriage
6. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses
7. Hypercoagulable state in white patients with early first trimester recurrent pregnancy loss
8. Factor V Leiden and factor II G20210A mutations in patients with recurrent abortion
9. Thrombophilic polymorphisms are common in women with fetal loss without apparent cause
10. Genetic risk factor for unexplained recurrent early pregnancy loss
11. A woman with five consecutive fetal deaths: Case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages
12. Special report. The Second International Anti-Cardiolipin Standardization Workshop, the Kingston Anti-Phospholipid antibody study (KAPS) group
13. A rapid screening method for the factor V Arg506-Gln mutation
14. A common genetic variation in the 3'-untranslated region of the PT gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
15. The mutation Ala677- Val in the methylene tetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
16. The Euro-team early pregnancy (ETEP) protocol for recurrent miscarriage
17. Prevalence of the prothrombin gene variant (nt20210A) in venous thrombosis and arterial disease
18. Prevalence of 20210A allele of the prothrombin gene in venous thromboembolism patients
19. Arg 506-Gln mutation in factor V and risk of thrombosis during pregnancy
20. Activated protein C resistance (factor V Leiden) associated with thrombosis in pregnancy
21. The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss
22. Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction