Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss

Blood Coagulation and Fibrinolysis

Volumn 20, Issue 2, 2009, Pages 134-140

  Ivanov, Petar D ^a   Komsa Penkova, Regina S ^a   Konova, Emiliana I ^a   Kovacheva, Katia S ^a   Simeonova, Maria N ^a   Popov, Jordan D ^a  

^a MEDICAL UNIVERSITY PLEVEN   (Bulgaria)

Author keywords

Inherited thrombophilia; Recurrent embryonic loss; Recurrent postembryonic pregnancy loss

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

ADULT; ARTICLE; CONTROLLED STUDY; EMBRYO DEATH; EMBRYO DEVELOPMENT; FEMALE; FETUS WASTAGE; FIRST TRIMESTER PREGNANCY; GENE MUTATION; GESTATION PERIOD; HUMAN; MAJOR CLINICAL STUDY; PLACENTA; PREGNANCY DISORDER; PREVALENCE; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; SPONTANEOUS ABORTION; THROMBOPHILIA;

ADOLESCENT; ADULT; AGED; EMBRYO LOSS; FACTOR V; FEMALE; GENETIC DISEASES, INBORN; GESTATIONAL AGE; HUMANS; MIDDLE AGED; MUTATION, MISSENSE; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PROSPECTIVE STUDIES; PROTHROMBIN; THROMBOPHILIA;

EID: 62349092403     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32832545f3     Document Type: Article

References (53)

1. Porter TF, Scott JR. Evidence-based care of recurrent miscarriage. Baillaires Best Pract Res Clin Obstet Gynaecol 2005; 19:85-101.
2. Regan L, Rai R. Epidemiology and the medical causes of miscarriage. Baillaires Best Pract Res Clin Obstet Gynaecol 2000; 14:839-854.
3. Kutteh WH, Triplett DA. Thrombophilias and recurrent pregnancy loss. Semin Reprod Med 2006; 24:54-66.
4. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999; 340:9-13.
5. Kist WJ, Janssen NG, Kalk JJ, Hague WM, Dekker GA, de Vries JI. Thrombophilias and adverse pregnancy outcome: a confounded problem. Thromb Haemost 2008; 99:77-85.
6. Meinardi JR, Middeldorp S, de Kam PJ, Koopman MM, van Pampus EC, Hamulyák K, et al. Increased risk for fetal loss in carriers of the factor V Leiden mutation. Ann Intern Med 1999; 130:736-739.
7. Paidas MJ, Ku De-Hui W, Langhoff-Roos J, Arkel YS. Inherited thrombophilias and adverse pregnancy outcome: screening and management. Semin Perinatol 2005; 29:150-163.
8. Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haem 1984; 52:176-182.
9. Lockwood CJ. Inherited thrombophilias in pregnant patients. Prenat Neonat Med 2002; 99:333-341.
10. Corash L. Laboratory evaluation of haemostasis. In: Laros Jr R, editor. Blood disorders in pregnancy. Philadelphia: Lea & Febiger; 1986. pp. 125-149.
11. Comp PC, Thurnau GR, Welsh J, Esmon CT. Functional and immunologic protein S levels are decreased during pregnancy. Blood 1986; 68: 881-885.
12. Arciniegas E, Neves CY, Candelle D, Cardier JE. Thrombin and its protease-activated receptor-1 (PAR1) participate in the endothelial-mesenchymal transdifferentiation process. DNA Cell Biol 2004; 23:815-825.
13. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85:1504-1508.
14. Kutteh WH, Park VM, Deitcher SR. Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss. Fertil Steril 1999; 71:1048-1053.
15. Rai R, Shlebak A, Cohen H, Backos M, Holmes Z, Marriott K, Regan L. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod 2001; 16:961-965.
16. Dizon-Townson DS, Kinney S, Branch DW, Ward K. The factor V Leiden mutation is not a common cause of recurrent miscarriage. J Reprod Immunol 1997; 34:217-223.
17. Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361:901-908.
18. Brenner B. Inherited thrombophilia and fetal loss. Curr Opin Hematol 2000; 7:290-295.
19. Pickering W, Marriott K, Regan L. 20210G>A prothrombin gene mutation: prevalence in a recurrent miscarriage population. Clin Appl Thromb Hemost 2001; 7:25-28.
20. Roque H, Paidas M, Funai F, Kuczynski E, Lockwood CJ. Maternal thrombophilias are not associated with early pregnancy loss. Thromb Haemost 2004; 81:290-295.
21. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 39-untranslated region of the PT gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698-3703.
22. Lockwood CJ. Inherited thrombophilias in pregnant patients: detection and treatment paradigm. Obstet Gynecol 2002; 89:333-341.
23. Wramsby ML, Sten-Linder M, Bremme K. Primary habitual abortions are associated with high frequency of factor V Leiden mutation. Fertil Sterilt 2000; 74:987-991.
24. Jaslow CR, Carney J, Fong S, Norman L, Ke RW, Kutteh WH. Etiology of recurrent pregnancy loss. Fertil Steril 2006; 86:8472-8478.
25. Ivanov P, Komsa-Penkova R, Kovacheva K, Ivanov Y, Stoyanova A, Ivanov I, et al. Impact of genetic factors on pulmonary embolism: early onset and recurrent incidences. Lung 2008; 186:27-36.
26. Bland JM, Altman DG. Statistics notes. The odds ratio. BMJ 2000; 320:1468.
27. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 38:175-191.
28. Spina V, Aleandri V, Morini F. The impact of the factor V Leiden mutation on pregnancy. Hum Reprod Update 2000; 6:301-306.
29. Grandone E, Margaglione M, Colaizzo D, d'Addedda M, Cappucci G, Vecchione G, et al. Factor V Leiden is associated with repeated and recurrent fetal losses. Thromb Haemost 1997; 77:822-824.
30. Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM. Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia. Am J Obstet Gynecol 2001; 185:153-157.
31. Infante-Rivard C, Rivard GE, Yotov WV, Génin E, Guiguet M, Weinberg C, et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med 2002; 347:19-25.
32. Langhoff-Roos J, Paidas MJ, Ku DH, et al. Inherited thrombophilias and early pregnancy loss. In: Mor G, editor. Immunology of pregnancy. Eurekah.com 2005 and Springer Science & Business Media; 2006. pp. 229-243.
33. Balasch J, Reverter JC, Fábregues F, Tàssies D, Rafel M, Creus M, et al. First-trimester repeated abortion is not associated with activated protein C resistance. Hum Reprod 1997; 12:1094-1097.
34. Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss. A meta-analysis. Arch Intern Med 2004; 164:558-563.
35. Robertson L, Wu O, Langhorne P, Clark P, Twaddle S, Lowe GD, et al. Thrombophilia in pregnancy: a sytematic review. Br J Haematol 2006; 132:171-196.
36. Younis JS, Brenner B, Ohel G, Tal J, Lanir N, Ben-Ami M. Activated protein C resistance and factor V Leiden mutation can be associated with first- as well as second-trimester recurrent pregnancy loss. Am J Reprod Immunol 2000; 43:31-35.
37. Reznikoff-Etiévan MF, Cayol V, Carbonne B, Robert A, Coulet F, Milliez J. Factor V Leiden and G20210A prothrombin mutations are risk factors for very early recurrent miscarriage. BJOG 2001; 108:1251-1254.
38. Bauduer F, Lacombe D. Factor V Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase 677T, and population genetics. Mol Genet Metab 2005; 86:91-99.
39. Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haemost 1984; 52:176-182.
40. Clark P, Brennand J, Conkie JA, McCall F, Greer IA, Walker ID. Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thromb Haemost 1998; 79:1166-1170.
41. Sood R, Weiler H. Embryogenesis and gene targeting of coagulation factors in mice. Best Pract Res Clin Haematol 2003; 16:169-181.
42. Duga S, Asselta R, Tenchini ML. Molecules in focus, coagulation factor V. Intern J Biochem Cell Biol 2004; 36:1393-1399.
43. Adachi T. Protein S and congenital protein S deficiency: the most frequent congenital thrombophilia in Japanese. Curr Drug Targets 2005; 6: 585-592.
44. Faught W, Garner P, Jones G, Ivey B. Changes in protein C and protein S levels in normal pregnancy. Am J Obstet Gynecol 1995; 172:147-150.
45. Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE. Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia. Nat Genet 2001; 28:389-392.
46. Griffin CT, Srinivasan Y, Zheng Y, Huang W, Shaun R, Coughlin A. Role for thrombin receptor signaling in endothelial cells during embryonic development. Science 2001; 293:1666-1670.
47. Archiniegas E, Neves CY, Candelle D, Cardier JE. Thrombin and its protease-activated receptor-1 (PAR1) participate in the endothelial-mesenchymal transdifferentiation process. DNA Cell Biol 2004; 23: 815-825.
48. Burton GJ, Jauniaux E, Watson AL. Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. Am J Obstet Gynecol 1999; 181:718-724.
49. Jauniaux E, Pahal G, Gervy C, Gulbis B. Blood biochemistry and endocrinology in the human fetus between 11 and 17 weeks of gestation. Reprod Biomed Online 2000; 1:38-44.
50. Jivraj S, Rai R, Underwood J, Regan L. Genetic thrombophilic mutations among couples with recurrent miscarriage. Human Reprod 2006; 21:1161-1165.
51. Brenner B, Hoffman R, Blumenfeld Z, Weiner Z, Younis JS. Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. Thromb Haemost 2000; 83:693-697.
52. Younis JS, Ohel G, Brenner B, Haddad S, Lanir N, Ben-Ami M. The effect of thrombophylaxis on pregnancy outcome in patients with recurrent pregnancy loss associated with factor V Leiden mutation. BJOG 2000; 107:415-419.
53. Dolitzky M, Inbal A, Segal Y, Weiss A, Brenner B, Carp H. A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages. Fertil Steril 2006; 86:362-366.