First-trimester repeated abortion is not associated with activated protein C resistance

Human Reproduction

Volumn 12, Issue 5, 1997, Pages 1094-1097

  Balasch, Juan ^a   Reverter, Juan C ^a   Fábregues, Francisco ^a   Tàssies, Dolors ^a   Rafel, Montserrat ^a   Creus, Montserrat ^a   Vanrell, Juan A ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Activated protein C resistance; Factor V Leiden; Repeated abortion

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; RECURRENT ABORTION;

EID: 0030940343     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.5.1094     Document Type: Article

References (29)

1. Amiral, J., Grosley, M., Boyer-Neumann, C. et al. (1994) New direct assay of free protein S antigen using two distinct monoclonal antibodies specific for the free form. Blood Coag. Fibrinol., 5, 179-186.
2. Balasch, J., Creus, M., Fábregues, F. et al. (1996) Antiphospholipid antibodies and human reproductive failure. Hum. Reprod., 11, 2310-2315.
3. Bertina, R.M., Broekmans, A.W., van Es-Krommenhoek, C. and van Wijngaarden, A. (1984) The use of a functional and immunological assay for plasma protein C in the study of the heterogeneity of congenital protein C deficiency. Thromb. Haemost., 51, 1-5.
4. Braulke, I., Pruggmayer, M., Melloh, P. et al. (1993) Factor XII (Hageman) deficiency in women with habitual abortion: new subpopulation or recurrent aborters? Fertil. Steril, 59, 98-101.
5. Büttner, J., Borth, R., Boutwell, J.H. et al. (1979) Approved recommendation on quality control in clinical chemistry. Clin. Chim. Acta, 98, F145-162.
6. Christiansen, O.B. (1996) A fresh look at the causes and treatments of recurrent miscarriage, especially its irnmunological aspects. Hum. Reprod. Update, 2, 271-293.
7. Compton, J. (1991) Nucleic acid sequence-based amplification. Nature, 350, 91-92.
8. Gumming, A.M., Tait, R.C., Fildes, S. et al. (1995) Development of resistance to activated protein C during pregnancy. Br. J. Haematol., 90, 725-727.
9. 506 to Gin mutation in factor V as a pathogenic risk factor for venous thrombosis. Thromb. Haemost., 74, 139-148.
10. Dahlbäck, B., Carlsson, M. and Svensson, P.J. (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc. Natl Acad. Sci. USA, 90, 1004-1008.
11. Daya, S. (1994) Issues in the etiology of recurrent spontaneous abortion. Curr. Opin. Obstet. Gynecol., 4, 153-159.
12. Gouault-Heilmann, M. and Leroy-Matheron, C. (1996) Factor V Leiden-dependent APC resistance: improved sensitivity and specificity of the APC resistance test by plasma dilution in factor V-depleted plasma. Thromb. Res., 82, 281-283.
13. Gris, J.C., Schved, J.F., Neveu, S. et al. (1990) Impaired fibrinolytic capacity and early recurrent spontaneous abortion. Br. Med. J., 300, 1500.
14. Grisaru, D., Fait, G. and Eldor, A. (1996) Activated protein C resistance and pregnancy complications. Am. J. Obstet. Gynecol., 174, 801-802.
15. Hellgren, M., Svensson, P.J. and Dahlbäck, B. (1995) Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives. Am. J. Obstet. Gynecol., 173, 210-213.
16. Jorquera, J.I., Montoro, J.M., Fernändez, M.A. and Aznar, J. (1994) Modified test for activated protein X resistance. Lancet, 344, 1162-1163.
17. Jorquera, J.I., Aznar, J., Fernández, M.A. et al. (1996) A modification of the APC resistance test and its application to the study of patients on coumarin therapy. Thromb. Res., 82, 217-224.
18. Kraus, M. and Wagner, C. (1994) Evaluation of APC-sensitivity in normal blood donors using different reagents and instruments. Thromb. Res., 76, 231-236.
19. Mackworth-Young, C. (1990) Antiphospholipid antibodies: more than just a disease marker? Immunol. Today, 11, 60-65.
20. Majerus, P.W. (1994) Bad blood by mutation. Nature, 369, 14-15.
21. Plouffe, L., White, E.W., Tho, S.P. et al. (1992) Etiologic factors of recurrent abortion and subsequent reproductive performance of couples: have we made any progress in the past 10 years? Am. J. Obstet. Gynecol., 167, 313-321.
22. 2-glycoprotein-I in 500 women with recurrent miscarriage: results of a comprehensive screening approach. Hum. Reprod., 10, 2001-2005.
23. Rai, R.S., Clifford, K., Cohen, H. and Regan, L. (1995b) High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Hum. Reprod., 10, 3301-3304.
24. Rai, R., Regan, L., Hadley, E. et al. (1996) Second-trimester pregnancy loss is associated with activated protein C resistance. Br. J. Hematol., 92, 489-490.
25. R factor V Leiden QL; a new genotype assay to detect the factor V Leiden mutation in anticoagulated blood. Fibrinolysis, 10, 31-32.
26. Stephenson, M.D. (1996) Frequency of factors associated with habitual abortion in 197 couples. Fertil. Steril., 66, 24-29.
27. Stomorken, H. (1991) Spontaneous (unexplained) thrombosis: the inherited basis for the thrombohemorragic balance. In Harris, E.N., Exner, T., Hughes, G.R.V. and Asherson, R.A. (eds), Phospholipid-binding antibodies. CRC Press, Boca Raton, pp. 206-217.
28. Stray-Pedersen, B. and Stray-Pedersen, S. (1984) Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am. J. Obstet. Gynecol., 148, 140-146.
29. Tho, P.T., Byrd, J.R. and McDonough, P.G. (1979) Etiologies and subsequent reproductive performance of 100 couples with recurrent abortion. Fertil. Steril., 32, 389-395.