Inherited thrombophilia screening in Greek women with recurrent fetal loss

Clinical and Experimental Obstetrics and Gynecology

Volumn 35, Issue 3, 2008, Pages 172-174

  Mougiou, A ^a   Androutsopoulos, G ^a,b   Karakantza, M ^a   Theodori, E ^a   Decavalas, G ^a   Zoumbos, N ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b Medical School ^*  (Greece)

Author keywords

Factor V Leiden; First trimester recurrent fetal loss; Molecular thrombophilic testing; MTHFR C677T; Prothrombin G20210A

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

ADULT; ANAMNESIS; ARTICLE; CHI SQUARE TEST; CONTROLLED STUDY; FEMALE; FETUS WASTAGE; GENE MUTATION; GENOTYPE; GREECE; HUMAN; INHERITANCE; MAJOR CLINICAL STUDY; PREGNANCY; PREGNANCY OUTCOME; PREVALENCE; RECURRENT ABORTION; SCREENING TEST; THROMBOEMBOLISM; THROMBOPHILIA;

ABORTION, HABITUAL; FACTOR V; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GREECE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PREGNANCY; PREVALENCE; PROTHROMBIN; THROMBOPHILIA;

EID: 49949104143     PISSN: 03906663     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Robertson L., Wu O., Langhorne P., Twaddle S., Clark P., Lowe G.D. et al.: "The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Thrombophilia in pregnancy: a systematic review". Br. J. Haematol., 2006, 132, 171.
2. Bonnar J., Green R., Norris L.: "Inherited thrombophilia and pregnancy: the obstetric perspective". Semin. Thromb. Hemost., 1998, 24 (suppl. 1), 49.
3. Hatasaka H.H.: "Recurrent miscarriage: epidemiologic factors, definitions, and incidence". Clin. Obstet. Gynecol., 1994, 37, 625.
4. Salafia C.M., Minior V.K., Pezzullo J.C., Popek E.J., Rosenkrantz T.S., Vintzileos A.M.: "Intrauterine growth restriction in infants of less than thirty-two weeks' gestation: associated placental pathologic features". Am. J. Obstet. Gynecol., 1995, 173, 1049.
5. Brenner B.: "Thrombophilia and pregnancy loss". Thromb. Res., 2002, 108, 197.
6. Wu O., Robertson L., Twaddle S., Lowe G.D., Clark R, G-reaves M. et al.: "Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study". Health Technol. Assess., 2006, 10, 1.
7. Finan R.R., Tamim H., Ameen G., Sharida H.E., Rashid M., Almawi W.Y.: "Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population". Am. J. Hematol., 2002, 71, 300.
8. Reznikoff-Etievan M.F., Cayol V., Carbonne B., Robert A., Coulet F., Milliez J.: "Factor V Leiden and G20210A prothrombin mutations are risk factors for very early recurrent miscarriage". Br. J. Obstet. Gynecol., 2001, 108, 1251.
9. Rai R., Shlebak A., Cohen H., Backos M., Holmes Z., Marriott K., Regan L.: "Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage". Hum. Reprod., 2001, 16, 961.
10. Tal J., Schliamser L.M., Leibovitz Z., Ohel G., Attias D.: "A possible role for activated protein C resistance in patients with first and second trimester pregnancy failure". Hum. Reprod., 1999, 14, 1624.
11. Carp H., Salomon O., Seidman D., Dardik R., Rosenberg N., Inbal A.: "Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss". Hum. Reprod., 2002, 17, 1633.
12. Foka Z.J., Lambropoulos A.F., Saravelos H., Karas G.B., Karavida A., Agorastos T. et al.: "Factor V leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages". Hum. Reprod. 2000, 15, 458.
13. Tormene D., Simioni P., Prandoni P., Luni S., Innella B., Sabbion P., Girolami A.: "The risk of fetal loss in family members of probands with factor V Leiden mutation". Thromb. Haemost., 1999, 82, 1237.
14. Kupferminc M.J., Peti H., Zwang E., Yaron Y., Wolman I., Eldor A.: "High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss". Acta Obstet. Gynecol. Scand., 2000, 79, 963.
15. Pickering W., Marriott K., Regan L.: "G20210A prothrombin gene mutation: prevalence in a recurrent miscarriage population". Clin. Appl. Thromb. Hemost., 2001, 7, 25.
16. Pihusch R., Buchholz T., Lohse P., Rubsamen H., Rogenhofer N., Hasbargen U. et al.: "Thrombophilic gene mutations and recurrent spontaneous abortion: prothrombin mutation increases the risk in the first trimester". Am. J. Reprod. Immunol., 2001, 46, 124.
17. Holmes Z.R., Regan L., Chilcott I., Cohen H.: "The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss". Br. J. Haematol., 1999, 105, 98.
18. Lissak A., Sharon A., Fruchter O., Kassel A., Sanderovitz J., Abramovici H.: "Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss". Am. J. Obstet. Gynecol., 1999, 181, 126.
19. Kutteh W.H., Triplett D.A.: "Thrombophilias and recurrent pregnancy loss". Semin. Reprod. Med., 2006, 24, 54.
20. Coulam C.B., Jeyendran R.S., Fishel L.A., Roussev R.: "Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage". Am. J. Reprod. Immunol., 2006, 55, 360.
21. Brenner B., Hoffman R., Carp H., Dulitsky M., Younis J., LIVE-ENOX Investigators: "Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study". J. Thromb. Haemost., 2005, 3, 227.
22. Bick R.L., Hoppensteadt D.: "Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update". Clin. Appl. Thromb. Hemost., 2005, 11, 1.
23. Karakantza M., Androutsopoulos G., Mougiou A., Sakellaropoulos G., Kourounis G., Decavalas G.: "Inheritance and perinatal consequences of inherited thrombophilia in Greece". Int. J. Gynaecol. Obstet., 2008, 100, 124.