Genetics of pregnancy loss

Clinical Obstetrics and Gynecology

Volumn 51, Issue 1, 2008, Pages 84-95

  Warren, Jennifer E ^a   Silver, Robert M ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Genetics; Pregnancy loss; Recurrent; Sporadic

Indexed keywords

HLA ANTIGEN; HLA ANTIGEN CLASS 1;

ANTIPHOSPHOLIPID SYNDROME; BACTERIAL INFECTION; BIRTH DEFECT; CHROMOSOME ABERRATION; CYTOGENETICS; DIABETES MELLITUS; GENETIC DISORDER; GENOTYPE; HUMAN; LUTEAL INSUFFICIENCY; MYCOPLASMA; MYOMA; OVARY POLYCYSTIC DISEASE; PREGNANCY; REVIEW; SPIROCHETE; SPONTANEOUS ABORTION; THROMBOPHILIA; THYROID DISEASE; UTERINE CERVIX DISEASE; UTERUS DISEASE; UTERUS MALFORMATION; VIRUS INFECTION; CHROMOSOME ANALYSIS; FEMALE; GENETICS; METHODOLOGY; PRENATAL DIAGNOSIS; RECURRENT ABORTION; X CHROMOSOME INACTIVATION;

ABORTION, HABITUAL; ABORTION, SPONTANEOUS; CHROMOSOME ABERRATIONS; CYTOGENETIC ANALYSIS; FEMALE; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; PREGNANCY; PREIMPLANTATION DIAGNOSIS; X CHROMOSOME INACTIVATION;

EID: 41649103961     PISSN: 00099201     EISSN: None     Source Type: Journal    
DOI: 10.1097/GRF.0b013e318161719c     Document Type: Review

References (19)

1. Miller JF, Williamson E, Glue J, et al. Fetal loss after implantation: a prospective study. Lancet. 1980;2:554-556.
2. Frias AE Jr, Luikenaar RA, Sullivan AE, et al. Poor obstetric outcome in subsequent pregnancies in women with prior fetal death. Obstet Gynecol. 2004;104:521-526.
3. Silver RM, Branch DW. Sporadic and recurrent pregnancy loss. In: Reece AE, Hobbins J, ed. Clinical Obstetrics: The Fetus and the Mother. Oxford: Blackwell Publishing; 2007:143-160.
4. Wapner RJ, Lewis D. Genetics and metabolic causes of stillbirth. Sem Perinat. 2002;26:70-74.
5. Geraedts JPM. Chromosomal anomalies and recurrent miscarriage. Infertil Reprod Med Clin North Am. 1996;7:677-688.
6. Benkhalifa M, Kasakyan S, Clement P, et al. Array comparative genomic hybridization profiling of first-trimester spontaneous abortions that fail to grow in vitro. Prenat Diagnosis. 2005;25:894-900.
7. Byrne J, Warburton D, Kline J, et al. Morphology of early fetal deaths and their chromosomal characteristics. Teratology. 1985;32:297-315.
8. Eiben B, Bartel I, Bahr-Porsch S, et al. Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage. Am J Hum Genet. 1990;47:656-663.
9. Hassold T. A cytogenetic study of repeated spontaneous abortions. Am J Hum Genet. 1980;32:723-730.
10. Tharapel AT, Tharapel SA, Bannerman RM. Recurrent pregnancy losses and parental chromosome abnormalities: a review. Br J Obstet Gynaecol. 1985;92:899-914.
11. Carrell DT, Wilcox AL, Lowy L, et al. Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss. Obstet Gynecol. 2003;101:1229-1235.
12. Shaw-Smith C, Redon R, Rickman L, et al. Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features. J Med Gene. 2004;41:241-248.
13. Chui DH, Waye JS. Hydrops fetalis caused by alpha-thalassemia: an emerging health care problem. Blood. 1998;91:2213-2222.
14. Rey E, Kahn SR, David M, et al. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet. 2003;361:901-908.
15. Warren JE, Silver RM, Dalton J, et al. Collagen 1A1 and transforming growth factor-β polymorphisms in women with cervical insufficiency. Obstet Gynecol. 2007;110:619-624.
16. Robinson WP, Beever C, Brown CJ, et al. Skewed X inactivation and recurrent spontaneous abortion. Semin Reprod Med. 2001;19:175-181.
17. Sullivan AE, Lewis T, Stephenson M, et al. Pregnancy outcome in recurrent miscarriage patients with skewed X chromosome inactivation. Obstet Gynecol. 2003;101:1236-1242.
18. Sierra S, Stephenson M. Genetics of recurrent pregnancy loss. Semin Reprod Med. 2006;24:17-24.
19. Sermon K, Van Steirteghem A, Liebaers I. Preimplantation genetic diagnosis. Lancet. 2004;363:1633-1641.