Challenges on the toxicological predictions of engineered nanoparticles

NanoImpact

Volumn 8, Issue , 2017, Pages 59-72

  Ribeiro, A R ^a,b,c   Leite, P E ^c,j   Falagan Lotsch, P ^c,k   Benetti, F ^d   Micheletti, C ^d   Budtz, H C ^e   Jacobsen, N R ^e   Lisboa Filho, P N ^b,f   Rocha, L A ^b,f   Kuhnel D ^g   Hristozov, D ^h   Granjeiro, J M ^b,c,i  

^a Inst Ciencias Exatas e da Natureza   (Brazil)

^b Brazilian Branch of the Institute of Biotribocorrosion and Nanomedicine (IBTN Br)   (Brazil)

^c INSTITUTO NACIONAL DE METROLOGIA   (Brazil)

^d European Centre for the Sustainable Impact of Nanotechnology   (Italy)

^e NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^f SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^g HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^h CA' FOSCARI UNIVERSITY OF VENICE   (Italy)

ⁱ FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^j FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^k UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

more..

Author keywords

Engineered nanoparticles; Hazard; Human health effects; Limitations; Toxicology

Indexed keywords

BIOCOMPATIBILITY; BIOLOGY; COPPER OXIDES; DIAGNOSTIC PRODUCTS; GOLD COMPOUNDS; HAZARDS; HEALTH RISKS; II-VI SEMICONDUCTORS; NANOPARTICLES; RISK ASSESSMENT; RISK MANAGEMENT; SAFETY ENGINEERING; TITANIUM DIOXIDE; TITANIUM OXIDES; ZINC OXIDE;

BIOLOGICAL INTERACTIONS; DIAGNOSTIC APPLICATIONS; ENGINEERED NANOPARTICLES; HUMAN HEALTH EFFECTS; LIMITATIONS; PHYSICOCHEMICAL CHARACTERISTICS; TITANIUM DIOXIDES (TIO2); TOXICOLOGY;

CONSUMER PRODUCTS;

EID: 85027418073     PISSN: None     EISSN: 24520748     Source Type: Journal    
DOI: 10.1016/j.impact.2017.07.006     Document Type: Article

References (159)

1. Agarwal, K., Sharma, A., Talukder, G., Clastogenic effects of copper sulphate on the bone marrow chromosomes of mice in vivo. Mutat. Res. 243 (1990), 1–6.
2. 2 nanoparticles in cell culture medium. Colloids Surf. B: Biointerfaces 68 (2009), 83–87, 10.1016/j.colsurfb.2008.09.014.
3. Annangi, B., Hernández, A., Creus, A., Marcos, R., A comprehensive study of the harmful effects of ZnO nanoparticles using Drosophila melanogaster as an in vivo model. J. Hazard. Mater. 296 (2015), 166–174, 10.1016/j.jhazmat.2015.04.053.
4. Arts, J., Hadi, M., Irfan, M.A., Keene, A.M., A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping). Regul. Toxicol. Pharmacol. 71 (2015), S1–S27, 10.1016/j.yrtph.2015.03.007.
5. Aschberger, K., Micheletti, C., Sokull-Klüttgen, B., Christensen, F.M., Analysis of currently available data for characterising the risk of engineered nanomaterials to the environment and human health-lessons learned from four case studies. Environ. Int. 37 (2011), 1143–1156, 10.1016/j.envint.2011.02.005.
6. Baan, R., Straif, K., Grosse, Y., Secretan, B., El Ghissassi, F., Cogliano, V., Carcinogenicity of carbon black, titanium dioxide, and talc. Lancet Oncol. 7 (2006), 295–296, 10.1016/S1470-2045(06)70651-9.
7. Balasubramanian, S.K., Jittiwat, J., Manikandan, J., Ong, C.-N., Yu, L.E., Ong, W.-Y., Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats. Biomaterials 31 (2010), 2034–2042, 10.1016/j.biomaterials.2009.11.079.
8. Becker, H., Herzberg, F., Schulte, A., Kolossa-Gehring, M., The carcinogenic potential of nanomaterials, their release from products and options for regulating them. Int. J. Hyg. Environ. Health 214 (2011), 231–238, 10.1016/j.ijheh.2010.11.004.
9. Bermudez, E., Mangum, J.B., Wong, B.A., Asgharian, B., Hext, P.M., Warheit, D.B. et al., Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol. Sci. 77 (2004), 347–357, 10.1093/toxsci/kfh019.
10. Bhunya, S.P., Jena, G.B., Clastogenic effects of copper sulphate in chick in vivo test system. Mutat. Res. 367 (1996), 57–63.
11. Bitounis, D., Pourchez, J., Forest, V., Boudard, D., Cottier, M., Klein, J.-P., Detection and Analysis of Nanoparticles in Patients: A Critical Review of the Status quo of Clinical Nanotoxicology. 2015, 1–43, 10.1016/j.biomaterials.2015.10.061.
12. Boffetta, P., Soutar, A., Cherrie, J.W., Granath, F., Andersen, A., Anttila, A. et al., Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer Causes Control 15 (2004), 697–706, 10.1023/B:CACO.0000036188.23970.22.
13. Bogart, L.K., Pourroy, G., Murphy, C.J., Puntes, V., Pellegrino, T., Rosenblum, D. et al., Nanoparticles for imaging, sensing, and therapeutic intervention. ACS Nano 8 (2014), 3107–3122, 10.1021/nn500962q.
14. Böhme, S., Stärk, H.-J., Kühnel, D., Reemtsma, T., Exploring LA-ICP-MS as a quantitative imaging technique to study nanoparticle uptake in Daphnia magna and zebrafish (Danio rerio) embryos. Anal. Bioanal. Chem. 407 (2015), 5477–5485, 10.1007/s00216-015-8720-4.
15. Bondarenko, O., Ivask, A., Käkinen, A., Kahru, A., Sub-toxic effects of CuO nanoparticles on bacteria: kinetics, role of Cu ions and possible mechanisms of action. Environ. Pollut. 169 (2012), 81–89, 10.1016/j.envpol.2012.05.009.
16. Bondarenko, O., Juganson, K., Ivask, A., Kasemets, K., Mortimer, M., Kahru, A., Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review. Arch. Toxicol. 87 (2013), 1181–1200, 10.1007/s00204-013-1079-4.
17. Borkow, G., Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections. 2014, Springer, Cham.
18. 2 nanotoxicity. J. Nanopart. Res. 11 (2008), 1361–1374, 10.1007/s11051-008-9523-8.
19. Buly, R.L., Huo, M.H., Salvati, E., Brien, W., Bansal, M., Titanium wear debris in failed cemented total hip arthroplasty. An analysis of 71 cases. J. Arthroplast. 7 (1992), 315–323.
20. Buzea, C., Pacheco, I.I., Robbie, K., Nanomaterials and nanoparticles: sources and toxicity. Biointerphases, 2, 2007, MR17, 10.1116/1.2815690.
21. Capon et al., Perceptions of risk from nanotechnology and trust in stakeholders: a cross sectional study of public, academic, government and business attitudes. BMC Public Health 15 (2015), 424–437.
22. Caracciolo, G., Farokhzad, O.C., Mahmoudi, M., Biological identity of nanoparticles in vivo: clinical implications of the protein corona. Trends Biotechnol., 2016, 1–8, 10.1016/j.tibtech.2016.08.011.
23. Chen, Z., Meng, H., Xing, G., Chen, C., Zhao, Y., Jia, G. et al., Acute toxicological effects of copper nanoparticles in vivo. Toxicol. Lett. 163 (2006), 109–120, 10.1016/j.toxlet.2005.10.003.
24. Chen, Q., Smith, J.M., Park, J., Kim, K., Ho, D., Rasool, H.I., 3D motion of DNA-Au nanoconjugates in graphene liquid cell electron microscopy. Nano Lett. 13 (2013), 4556–4561, 10.1021/nl402694n.
25. Chen, R., Hu, Bin, Liu, Y., Xu, J., Yang, G., Xu, D. et al., Beyond PM2.5: The Role of Ultrafine Particles on Adverse Health Effects of Air Pollution. 2016, 1–43, 10.1016/j.bbagen.2016.03.019.
26. Chia, S.L., Tay, C.Y., Setyawati, M.I., Leong, D.T., Biomimicry 3D gastrointestinal spheroid platform for the assessment of toxicity and inflammatory effects of zinc oxide nanoparticles. Small 11 (2014), 702–712, 10.1002/smll.201401915.
27. 2 nanoparticles: their outcome and effects. J. Nanopart. Res., 15, 2013, 1492, 10.1007/s11051-013-1492-x.
28. Cho, Wan-Seob, Duffin, Rodger, Thielbeer, Frank, Bradley, Mark, Megson, Ian L., MacNee, William, Poland, Craig A., Lang Tran, C., Donaldson, Ken, Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles. Toxicol. Sci. 126 (2012), 469–477.
29. Choi, S.-J., Choy, J.-H., Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction. IJN 9:Suppl. 2 (2014), 261–269, 10.2147/IJN.S57920.
30. Chueh, P.J., Liang, R.-Y., Lee, Y.-H., Zeng, Z.-M., Chuang, S.-M., Differential cytotoxic effects of gold nanoparticles in different mammalian cell lines. J. Hazard. Mater. 264 (2014), 303–312, 10.1016/j.jhazmat.2013.11.031.
31. Chusueia, Charles C., Wub, Chi-Heng, Mallavarapua, Shravan, Houc, Fang Yao Stephen, Hsud, Chen-Ming, Winiarze, Jeffrey G., Aronstamb, Robert S., Huangb, Yue-Wern, Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties. Chem. Biol. Interact. 206 (2013), 319–326, 10.1016/j.cbi.2013.09.020.
32. Cioffi, N., Ditaranto, N., Torsi, L., Picca, R.A., Sabbatini, L., Valentini, A. et al., Analytical characterization of bioactive fluoropolymer ultra-thin coatings modified by copper nanoparticles. Anal. Bioanal. Chem. 381 (2005), 607–616, 10.1007/s00216-004-2761-4.
33. Collins, A.R., Annangi, B., Rubio, L., Marcos, R., Dorn, M., Merker, C. et al., High throughput toxicity screening and intracellular detection of nanomaterials. WIREs Nanomed. Nanobiotechnol., 2016, 10.1002/wnan.1413.
34. Connor, E.E., Mwamuka, J., Gole, A., Murphy, C.J., Wyatt, M.D., Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1 (2005), 325–327, 10.1002/smll.200400093.
35. Cronholm, P., Karlsson, H.L., Hedberg, J., Lowe, T.A., Winnberg, L., Elihn, K. et al., Intracellular uptake and toxicity of Ag and CuO nanoparticles: a comparison between nanoparticles and their corresponding metal ions. Small 9 (2013), 970–982, 10.1002/smll.201201069.
36. Crosera, Matteo, Prodi, Andrea, Mauro, Marcella, Pelin, Marco, Florio, Chiara, Bellomo, Francesca, Adami, Gianpiero, Apostoli, Pietro, De Palma, Giuseppe, Bovenzi, Massimo, Campanini, Marco, Filon, Francesca Larese, Titanium dioxide nanoparticle penetration into the skin and effects on HaCaT cells. Int. J. Environ. Res. Public Health 12 (2015), 9282–9297, 10.3390/ijerph120809282.
37. de Jong, W.H., Hagens, W.I., Krystek, P., Burger, M.C., Sips, A.J.A.M., Geertsma, R.E., Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29 (2008), 1912–1919, 10.1016/j.biomaterials.2007.12.037.
38. De Olivera, J.V.D., Boufleur, L.A., Dos Santos, C.E.I., Dias, J.F., Squeff, C.H., Silva, G.R.G. et al., Occupational genotoxicity among copper smelters. Toxicol. Ind. Health 28 (2012), 789–795, 10.1177/0748233711422735.
39. Dekkers, S., Oomen, A.G., Bleeker, E.A.J., Vandebriel, R.J., Micheletti, C., Cabellos, J. et al., Towards a nanospecific approach for risk assessment. Regul. Toxicol. Pharmacol. 80 (2016), 46–59, 10.1016/j.yrtph.2016.05.037.
40. Dell'Orco, D., Lundqvist, M., Oslakovic, C., Cedervall, T., Linse, S., Modeling the time evolution of the nanoparticle-protein corona in a body fluid. PLoS One, 5, 2010, e10949, 10.1371/journal.pone.0010949.
41. DeLoid, G.M., Cohen, J.M., Pyrgiotakis, G., Demokritou, P., Preparation, Characterization, and in Vitro Dosimetry of Dispersed, Engineered Nanomaterials. Nat. Protoc. 12 (2017), 355–371, 10.1038/nprot.2016.172.
42. Dreaden, E.C., Alkilany, A.M., Huang, X., Murphy, C.J., El-Sayed, M.A., The golden age: gold nanoparticles for biomedicine. Chem. Soc. Rev. 41 (2012), 2740–2779, 10.1039/c1cs15237h.
43. Dreaden, E.C., Austin, L.A., Mackey, M.A., El-Sayed, M.A., Size matters: gold nanoparticles in targeted cancer drug delivery. Ther. Deliv. 3 (2012), 457–478, 10.4155/tde.12.21.
44. Emond, C., Kouassi, S., Schuster, F., Development of an integrative program of nanosafety: promote the coordination between industries and risk assessor. J. Phys. Conf. Ser., 429, 2013, 012070, 10.1088/1742-6596/429/1/012070.
45. Eshed, M., Lellouche, J., Matalon, S., Gedanken, A., Banin, E., Sonochemical coatings of ZnO and CuO nanoparticles inhibit Streptococcus mutans biofilm formation on teeth model. Langmuir 28 (2012), 12288–12295, 10.1021/la301432a.
46. Evans, J.E., Jungjohann, K.L., Browning, N.D., Arslan, I., Controlled growth of nanoparticles from solution with in situ liquid transmission electron microscopy. Nano Lett. 11 (2011), 2809–2813, 10.1021/nl201166k.
47. Foroozandeh, P., Aziz, A.A., Merging worlds of nanomaterials and biological environment: factors governing protein corona formation on nanoparticles and its biological consequences. Nanoscale Res. Lett., 10, 2015, 221, 10.1186/s11671-015-0922-3.
48. Fujisawa, S., Atsumi, T., Kadoma, Y., Sakagami, H., Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity. Toxicology 177 (2002), 39–54.
49. Goodman, C.M., McCusker, C.D., Yilmaz, T., Rotello, V.M., Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug. Chem. 15 (2004), 897–900, 10.1021/bc049951i.
50. Grassian, V.H., O'Shaughnessy, P.T., Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ. Health, 2007, 10.2307/4133174.
51. Grobe et al., Federal Office of Public Health (Bern, Swiss), Risk Dialogue Foundation (St. Gallen, Swiss), (eds.) Report: Nanotechnologies From the Consumers' Point of View, 2012.
52. Grzincic, E.M., Yang, J.A., Drnevich, J., Falagan-Lotsch, P., Murphy, C.J., Global transcriptomic analysis of model human cell lines exposed to surface-modified gold nanoparticles: the effect of surface chemistry. Nanoscale, 2014, 10.1039/c4nr05166a.
53. Guadagnini, R., Halamoda Kenzaoui, B., Cartwright, L., Pojana, G., Magdolenova, Z., Bilaničová, D. et al., Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests. Nanotoxicology, 2013, 10.3109/17435390.2013.829590.
54. Han, S.G., Lee, J.S., Ahn, K., Kim, Y.S., Kim, J.K., Lee, J.H. et al., Size-dependent clearance of gold nanoparticles from lungs of Sprague–Dawley rats after short-term inhalation exposure. Arch. Toxicol. 89 (2015), 1083–1094, 10.1007/s00204-014-1292-9.
55. Hassellöv, M., Readman, J.W., Ranville, J.F., Tiede, K., Nanoparticle analysis and characterization methodologies in environmental risk assessment of engineered nanoparticles. Ecotoxicology 17 (2008), 344–361, 10.1007/s10646-008-0225-x.
56. He, X., Aker, W.G., Fu, P.P., Hwang, H.M., Toxicity of engineered metal oxide nanomaterials mediated by nano–bio–eco–interactions: a review and perspective. Environ. Sci. Nano 2 (2015), 564–582, 10.1039/c5en00094g.
57. Heng, B.C., Zhao, X., Tan, E.C., Khamis, N., Assodani, A., Xiong, S. et al., Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles. Arch. Toxicol. 85 (2011), 1517–1528, 10.1007/s00204-011-0722-1.
58. Hext, P.M., Tomenson, J.A., Thompson, P., Titanium dioxide: inhalation toxicology and epidemiology. Ann. Occup. Hyg. 49 (2005), 461–472, 10.1093/annhyg/mei012.
59. Hodson, Laura, Methner, Mark Zumwalde, Ralph, D., Approaches to Safe Nanotechnology: Managing the Health and Safety Concerns Associated with Engineered Nanomaterials. 2009, NIOSH, 1–104.
60. Hristozov, D., Malsch, I., Hazards and risks of engineered nanoparticles for the environment and human health. Sustainability 1 (2009), 1161–1194, 10.3390/su1041161.
61. Hristozov, D.R., Gottardo, S., Critto, A., Marcomini, A., Risk assessment of engineered nanomaterials: a review of available data and approaches from a regulatory perspective. Nanotoxicology 6 (2012), 880–898, 10.3109/17435390.2011.626534.
62. Hristozov, D.R., Zabeo, A., Foran, C., Isigonis, P., Critto, A., Marcomini, A. et al., A weight of evidence approach for hazard screening of engineered nanomaterials. Nanotoxicology 8 (2014), 72–87, 10.3109/17435390.2012.750695.
63. Janer, G., del Molino, E.M., Fernández-Rosas, E., Fernández, A., Vázquez-Campos, S., Cell uptake and oral absorption of titanium dioxide nanoparticles. Toxicol. Lett. 228 (2014), 103–110, 10.1016/j.toxlet.2014.04.014.
64. Jemec, A., Kahru, A., Potthoff, A., Drobne, D., Heinlaan, M., Böhme, S., Geppert, M., Novak, S., Schirmer, K., Rekulapally, R., Singh, S., Aruoja, V., Sihtmäe, M., Juganson, K., Käkinen, A., Kühnel, D., An interlaboratory comparison of nanosilver characterisation and hazard identification: harmonising techniques for high quality data. Environ. Int. 87:2016 (2016), 20–32, 10.1016/j.envint.2015.10.014.
65. 2 and ZnO nanoparticles released from sunscreens into outdoor swimming pools. J. Hazard. Mater., 2016, 1–30, 10.1016/j.jhazmat.2016.05.099.
66. Karlsson, H.L., Gustafsson, J., Cronholm, P., Möller, L., Size-dependent toxicity of metal oxide particles–a comparison between nano- and micrometer size. Toxicol. Lett. 188 (2009), 112–118, 10.1016/j.toxlet.2009.03.014.
67. 2 to yeast Saccharomyces cerevisiae. Toxicol. in Vitro 23 (2009), 1116–1122, 10.1016/j.tiv.2009.05.015.
68. Khan, M.S., Vishakante, G.D., Siddaramaiah, H., Gold nanoparticles: a paradigm shift in biomedical applications. Adv. Colloid Interf. Sci., 2013, 1–15, 10.1016/j.cis.2013.06.003.
69. Khang, D., Lee, Y.K., Choi, E.-J., Webster, T.J., Kim, S.-H., Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity. IJN, 2014, 97, 10.2147/IJN.S72998.
70. Kim, J.A., Åberg, C., Salvati, A., Dawson, K.A., Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population. Nat. Nanotechnol. 7 (2011), 62–68, 10.1038/nnano.2011.191.
71. Kühnel, D., Marquardt, C., Nau, K., Krug, H.F., Paul, F., Steinbach, C., Environmental benefits and concerns on safety: communicating latest results on nanotechnology safety research—the project DaNa2.0. Environ. Sci. Pollut. Res., 2016, 1–6, 10.1007/s11356-016-6217-0.
72. Kumar, A., Kumar, P., Anandan, A., Fernandes, T.F., Ayoko, G.A., Biskos, G., Engineered nanomaterials: knowledge gaps in fate, exposure, toxicity, and future directions. J. Nanomater. 2014 (2014), 1–16, 10.1155/2014/130198.
73. Lademann, J., Weigmann, H.J., Rickmeyer, C., Barthelmes, H., Schaefer, H., Mueller, G. et al., Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Physiol. 12 (1999), 247–256, 10.1159/000066249.
74. Landsiedel, R., Ma-Hock, L., Kroll, A., Hahn, D., Schnekenburger, J., Wiench, K. et al., Testing metal-oxide nanomaterials for human safety. Adv. Mater. Weinheim 22 (2010), 2601–2627, 10.1002/adma.200902658.
75. Landsiedel, R., Fabian, E., Ma-Hock, L., Wohlleben, W., Wiench, K., Oesch, F. et al., Toxico-/biokinetics of nanomaterials. Arch. Toxicol. 86 (2012), 1021–1060, 10.1007/s00204-012-0858-7.
76. Laney, A.S., McCauley, L.A., Schubauer-Berigan, M.K., Workshop summary: epidemiologic design strategies for studies of nanomaterial workers. J. Occup. Environ. Med. 53 (2011), S87–90, 10.1097/JOM.0b013e31821b1af5.
77. Lanone, S., Rogerieux, F., Geys, J., Dupont, A., Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines. Part. Fibre Toxicol., 2009.
78. Lapresta-Fernández, A., Salinas-Castillo, A., de la Llana, S.A., Costa-Fernández, J.M., Domínguez-Meister, S., Cecchini, R. et al., A general perspective of the characterization and quantification of nanoparticles: imaging, spectroscopic, and separation techniques. Crit. Rev. Solid State Mater. Sci. 39 (2014), 423–458, 10.1080/10408436.2014.899890.
79. Liao, H.-G., Niu, K., Zheng, H., Observation of growth of metal nanoparticles. Chem. Commun. 49 (2013), 11720–11728, 10.1039/c3cc47473a.
80. Lin, W., Xu, Y., Huang, C.-C., Ma, Y., Shannon, K.B., Chen, D.-R. et al., Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells. J. Nanopart. Res. 11 (2008), 25–39, 10.1007/s11051-008-9419-7.
81. Liu, Z., Wu, Y., Guo, Z., Liu, Y., Shen, Y., Zhou, P. et al., Effects of internalized gold nanoparticles with respect to cytotoxicity and invasion activity in lung cancer cells. PLoS One, 9, 2014, e99175, 10.1371/journal.pone.0099175.
82. Lozano, O., Mejia, J., Piret, J.P., Saout, C., How does the deposited dose of oxide nanomaterials evolve in an in vitro assay?. J. Phys. Conf. Ser., 429, 2013, 012013, 10.1088/1742-6596/429/1/012013.
83. Margarethe, H.-A., David, W.G., Heinrich, H., Nanoparticles in medicine: current challenges facing inorganic nanoparticle toxicity assessments and standardizations. Nanomedicine 11 (2015), 1689–1694, 10.1016/j.nano.2015.05.005.
84. Magaye, R., Zhao, J., Bowman, L., Ding, M., Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles. Exp. Ther. Med. 4 (2012), 551–561, 10.3892/etm.2012.656.
85. Magdolenova, Z., Bilaničová, D., Pojana, G., Fjellsbø, L.M., Hudecova, A., Hasplova, K. et al., Impact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity. J. Environ. Monit. 14 (2012), 455–464, 10.1039/c2em10746e.
86. Martirosyan, A., Schneider, Y.-J., Engineered Nanomaterials in food: implications for food safety and consumer health. IJERPH 11 (2014), 5720–5750, 10.3390/ijerph110605720.
87. Medina-Reyes, E.I., Bucio-López, L., Freyre-Fonseca, V., Sánchez-Pérez, Y., García-Cuéllar, C.M., Morales-Bárcenas, R. et al., Cell cycle synchronization reveals greater G2/M-phase accumulation of lung epithelial cells exposed to titanium dioxide nanoparticles. Environ. Sci. Pollut. Res. 22 (2014), 3976–3982, 10.1007/s11356-014-3871-y.
88. 2 P25. J. Nanopart. Res., 16, 2014, 2228, 10.1007/s11051-013-2228-7.
89. Misra, S.K., Nuseibeh, S., Dybowska, A., Berhanu, D., Tetley, T.D., Valsami-Jones, E., Comparative study using spheres, rods and spindle-shaped nanoplatelets on dispersion stability, dissolution and toxicity of CuO nanomaterials. Nanotoxicology 8 (2014), 422–432, 10.3109/17435390.2013.796017.
90. Monopoli, M.P., Åberg, C., Salvati, A., Dawson, K.A., Biomolecular coronas provide the biological identity of nanosized materials. Nat. Nanotechnol. 7 (2012), 779–786, 10.1038/nnano.2012.207.
91. Monteiro-Riviere, N.A., Wiench, K., Landsiedel, R., Schulte, S., Inman, A.O., Riviere, J.E., Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicol. Sci. 123 (2011), 264–280, 10.1093/toxsci/kfr148.
92. Morimoto, Y., Kobayashi, N., Shinohara, N., Myojo, T., Tanaka, I., Nakanishi, J., Hazard assessments of manufactured nanomaterials. J. Occup. Health 52 (2010), 325–334.
93. Murphy, C.J., Sau, T.K., Gole, A.M., Orendorff, C.J., Gao, J., Gou, L. et al., Anisotropic metal nanoparticles: synthesis, assembly, and optical applications. J. Phys. Chem. B 109 (2005), 13857–13870, 10.1021/jp0516846.
94. Murphy, C.J., Gole, A.M., Stone, J.W., Sisco, P.N., Alkilany, A.M., Goldsmith, E.C. et al., Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc. Chem. Res. 41 (2008), 1721–1730, 10.1021/ar800035u.
95. National Institute for Occupational Safety and Health, Occupational Exposure to Titanium Dioxide. 2011.
96. Oberdörster, G., Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J. Intern. Med. 267 (2010), 89–105, 10.1111/j.1365-2796.2009.02187.x.
97. Oberdörster, G., Finkelstein, J.N., Johnston, C., Gelein, R., Cox, C., Baggs, R. et al., Acute pulmonary effects of ultrafine particles in rats and mice. Res. Rep. Health Eff. Inst., 2000, 5–74 (disc. 75–86).
98. Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K. et al., Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part. Fibre Toxicol., 2, 2005, 8, 10.1186/1743-8977-2-8.
99. Ong, K.J., MacCormack, T.J., Clark, R.J., Ede, J.D., Ortega, V.A., Felix, L.C. et al., Widespread nanoparticle-assay interference: implications for nanotoxicity testing. PLoS One, 9, 2014, e90650, 10.1371/journal.pone.0090650.
100. Oomen, A.G., Bos, P.M.J., Fernandes, T.F., Hund-Rinke, K., Boraschi, D., Byrne, H.J. et al., Concern-driven integrated approaches to nanomaterial testing and assessment – report of the NanoSafety Cluster Working Group 10. Nanotoxicology, 2000, 1–15, 10.3109/17435390.2013.802387.
101. Organisation for Economic Co-operation and Development, Guidance on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials. No. 36. ENV/JM/MONO(2012)40. Series on the Safety of Manufactured Nanomaterials, 2012, OECD Environment, Health and Safety Publications, Paris, France.
102. Ortega, R., Bresson, C., Darolles, C., Gautier, C., Roudeau, S., Perrin, L. et al., Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells. Part. Fibre Toxicol., 11, 2014, 14, 10.1186/1743-8977-11-14.
103. Orts-Gil, G., Natte, K., Österle, W., Multi-parametric reference nanomaterials for toxicology: state of the art, future challenges and potential candidates. RSC Adv. 3 (2013), 18202–18215, 10.1039/c3ra42112k.
104. Pan, Y., Neuss, S., Leifert, A., Fischler, M., Wen, F., Simon, U. et al., Size-dependent cytotoxicity of gold nanoparticles. Small 3 (2007), 1941–1949, 10.1002/smll.200700378.
105. Park, J., Park, H., Ercius, P., Pegoraro, A.F., Xu, C., Kim, J.W. et al., Direct observation of wet biological samples by Graphene liquid cell transmission electron microscopy. Nano Lett. 15 (2015), 4737–4744, 10.1021/acs.nanolett.5b01636.
106. Pelaz, B., Charron, G., Pfeiffer, C., Zhao, Y., De La Fuente, J.M., Liang, X.-J. et al., Interfacing engineered nanoparticles with biological systems: anticipating adverse Nano-bio interactions. Small 9 (2012), 1573–1584, 10.1002/smll.201201229.
107. Petersen, E.J., Diamond, S.A., Kennedy, A.J., Goss, G.G., Ho, K., Lead, J. et al., Adapting OECD aquatic toxicity tests for use with manufactured nanomaterials: key issues and consensus recommendations. Environ. Sci. Technol. 49 (2015), 9532–9547, 10.1021/acs.est.5b00997.
108. Pettitt, M.E., Lead, J.R., Minimum physicochemical characterisation requirements for nanomaterial regulation. Environ. Int. 52 (2013), 41–50, 10.1016/j.envint.2012.11.009.
109. Piret, J.-P., Bondarenko, O.M., Boyles, M.S.P., Himly, M., Ribeiro, A.R., Benetti, F. et al., Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles. Arch. Toxicol., 2016, 1–16, 10.1007/s00204-016-1897-2.
110. Rahman, M.M., Lee, J.K., Jeong, J., Seo, Y.R., Usage of nanoparticles with their potential toxicity assessment and regulatory guidelines. Toxicol. Environ. Health Sci. 5 (2013), 49–54, 10.1007/s13530-013-0156-7.
111. Ribeiro, A.R., Gemini-Piperni, S., Travassos, R., Lemgruber, L., Silva, R.C., Rossi, A.L. et al., Trojan-like internalization of anatase titanium dioxide nanoparticles by human osteoblast cells. Sci Rep, 6, 2016, 23615, 10.1038/srep23615.
112. Rivera-Gil, P., Jimenez De Aberasturi, D., Wulf, V., Pelaz, B., Del Pino, P., Zhao, Y. et al., The challenge to relate the physicochemical properties of colloidal nanoparticles to their cytotoxicity. Acc. Chem. Res. 46 (2013), 743–749, 10.1021/ar300039j.
113. Roebben, G., Ramirez-Garcia, S., Hackley, V.A., Roesslein, M., Klaessig, F., Kestens, V. et al., Interlaboratory comparison of size and surface charge measurements on nanoparticles prior to biological impact assessment. J. Nanopart. Res. 13 (2011), 2675–2687, 10.1007/s11051-011-0423-y.
114. SCENIHR/002/05, Modified Opinion (After Public Consultation) on the Appropriateness of Existing Methodologies to Assess the Potential Risks Associated with Engineered and Adventitious Products of Nanotechnologies. 2006, 1–79.
115. Saptarshi, S.R., Duschl, A., Lopata, A.L., Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle. J. Nanobiotechnol., 11, 2013, 26, 10.1186/1477-3155-11-26.
116. Saptarshi, S.R., Feltis, B.N., Wright, P.F., Lopata, A.L., Investigating the immunomodulatory nature of zinc oxide nanoparticles at sub-cytotoxic levels in vitro and after intranasal instillation in vivo. J. Nanobiotechnol., 13, 2015, 6, 10.1186/s12951-015-0067-7.
117. Schulte, P.A., Murashov, V., Zumwalde, R., Kuempel, E.D., Geraci, C.L., Occupational exposure limits for nanomaterials: state of the art. J. Nanopart. Res. 12 (2010), 1971–1987, 10.1007/s11051-010-0008-1.
118. Schulte, P.A., Geraci, C.L., Murashov, V., Kuempel, E.D., Zumwalde, R.D., Castranova, V. et al., Occupational safety and health criteria for responsible development of nanotechnology. J. Nanopart. Res., 16, 2013, 2153, 10.1007/s11051-013-2153-9.
119. Schulz, J., Hohenberg, H., Pflücker, F., Gärtner, E., Will, T., Pfeiffer, S. et al., Distribution of sunscreens on skin. Adv. Drug Deliv. Rev. 54 (2002), S157–S163, 10.1016/S0169-409X(02)00120-5.
120. Schwirn, K., Tietjen, L., Beer, I., Why are nanomaterials different and how can they be appropriately regulated under REACH?. Environ. Sci. Eur., 26, 2014, 4, 10.1186/2190-4715-26-4.
121. Seaton, A., Tran, L., Aitken, R., Donaldson, K., Nanoparticles, human health hazard and regulation. J. R. Soc. Interface 7:Suppl. 1 (2010), S119–29, 10.1098/rsif.2009.0252.focus.
122. Senut, M.C., Zhang, Y., Liu, F., Sen, A., Ruden, D.M., Mao, G., Size-dependent toxicity of gold nanoparticles on human embryonic stem cells and their neural derivatives. Small 12:5 (2016), 631–646, 10.1002/smll.201502346 (3).
123. 2-NP) through various routes of exposure: a review. Biol. Trace Elem. Res. 172 (2015), 1–36, 10.1007/s12011-015-0550-x.
124. Shi, H., Magaye, R., Castranova, V., Zhao, J., Titanium dioxide nanoparticles: a review of current toxicological data. Part. Fibre Toxicol., 10, 2013, 15, 10.1186/1743-8977-10-15.
125. Shukla, Ravi, Bansal, Vipul, Chaudhary, Minakshi, Basu, Atanu, Ramesh, A., Bhonde, R., Sastry, Murali, Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Am. Chem. Soc., 2005, 10.1021/la0513712.
126. Simkó, M., Nosske, D., Kreyling, W., Metrics, dose, and dose concept: the need for a proper dose concept in the risk assessment of nanoparticles. IJERPH 11 (2014), 4026–4048, 10.3390/ijerph110404026.
127. Smijs, T., Pavel, Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness. NSA, 2011, 95-18, 10.2147/NSA.S19419.
128. Sonavane, G., Tomoda, K., Makino, K., Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids Surf. B: Biointerfaces 66 (2008), 274–280, 10.1016/j.colsurfb.2008.07.004.
129. Song, W., Zhang, J., Guo, J., Zhang, J., Ding, F., Li, L. et al., Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles. Toxicol. Lett. 199 (2010), 389–397, 10.1016/j.toxlet.2010.10.003.
130. Souza, V.G.L., Fernando, A.L., Nanoparticles in food packaging: biodegradability and potential migration to food—a review. Food Packag. Shelf Life 8 (2016), 63–70, 10.1016/j.fpsl.2016.04.001.
131. Sperling, R.A., Rivera-Gil, P., Zhang, F., Zanella, M., Parak, W.J., Biological applications of gold nanoparticles. Chem. Soc. Rev. 37 (2008), 1896–1908, 10.1039/b712170a.
132. Stefaniak, A.B., Hackley, V.A., Roebben, G., Ehara, K., Hankin, S., Postek, M.T. et al., Nanoscale reference materials for environmental, health and safety measurements: needs, gaps and opportunities. Nanotoxicology 7 (2013), 1325–1337, 10.3109/17435390.2012.739664.
133. Steiling, W., Bascompta, M., Carthew, P., Catalano, G., Corea, N., D'Haese, A. et al., Principle considerations for the risk assessment of sprayed consumer products. Toxicol. Lett. 227 (2014), 41–49, 10.1016/j.toxlet.2014.03.005.
134. Stone, V., Pozzi-Mucelli, S., Tran, L., Aschberger, K., Sabella, S., Vogel, U. et al., ITS-NANO - Prioritising nanosafety research to develop a stakeholder driven intelligent testing strategy. Part. Fibre Toxicol. 11 (2014), 1–11, 10.1186/1743-8977-11-9.
135. Studer, A.M., Limbach, L.K., Van Duc, L., Krumeich, F., Athanassiou, E.K., Gerber, L.C. et al., Nanoparticle cytotoxicity depends on intracellular solubility: comparison of stabilized copper metal and degradable copper oxide nanoparticles. Toxicol. Lett. 197 (2010), 169–174, 10.1016/j.toxlet.2010.05.012.
136. Sung, J.H., Ji, J.H., Park, J.D., Song, M.Y., Song, K.S., Ryu, H.R. et al., Subchronic inhalation toxicity of gold nanoparticles. Part. Fibre Toxicol., 8, 2011, 1, 10.1186/1743-8977-8-16.
137. Suttiponparnit, K., Jiang, J., Sahu, M., Suvachittanont, S., Charinpanitkul, T., Biswas, P., Role of surface area, primary particle size, and crystal phase on titanium dioxide nanoparticle dispersion properties. Nanoscale Res. Lett., 6, 2010, 27, 10.1007/s11671-010-9772-1.
138. Takeuchi, M.T., Kojima, M., Luetzow, M., State of the art on the initiatives and activities relevant to risk assessment and risk management of nanotechnologies in the food and agriculture sectors. Food Res. Int. 64 (2014), 976–981, 10.1016/j.foodres.2014.03.022.
139. Thompson, C.M., Suh, M., Mittal, L., Wikoff, D.S., Welsh, B., Proctor, D.M., Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul. Toxicol. Pharmacol. 80 (2016), 60–70, 10.1016/j.yrtph.2016.05.031.
140. Turner, M., Golovko, V.B., Vaughan, O.P.H., Abdulkin, P., Berenguer-Murcia, A., Tikhov, M.S. et al., Selective oxidation with dioxygen by gold nanoparticle catalysts derived from 55-atom clusters. Nature 454 (2008), 981–983, 10.1038/nature07194.
141. Ulusoy, M., Lavrentieva, A., Walter, J.-G., Sambale, F., Green, M., Stahl, F. et al., Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures. Toxicol. Res. 5 (2016), 126–135, 10.1039/C5TX00236B.
142. Vance, M.E., Kuiken, T., Vejerano, E.P., McGinnis, S.P., Hochella, M.F. Jr., Rejeski, D. et al., Nanotechnology in the real world: redeveloping the nanomaterial consumer products inventory. Beilstein J. Nanotechnol. 6 (2015), 1769–1780, 10.3762/bjnano.6.181.
143. Verma, A., Stellacci, F., Effect of surface properties on nanoparticle “cell interactions”. Small 6 (2010), 12–21, 10.1002/smll.200901158.
144. Vinardell, M., Mitjans, M., Antitumor activities of metal oxide nanoparticles. Nanomaterials 5 (2015), 1004–1021, 10.3390/nano5021004.
145. Walkey, C.D., Chan, W.C.W., Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment. Chem. Soc. Rev. 41 (2012), 2780–2799, 10.1039/c1cs15233e.
146. Wang, Z., Li, N., Zhao, J., White, J.C., Qu, P., Xing, B., CuO nanoparticle interaction with human epithelial cells: cellular uptake, location, export, and genotoxicity. Chem. Res. Toxicol. 25 (2012), 1512–1521, 10.1021/tx3002093.
147. Wang, C., Qiao, Q., Klie, R.F., Shokuhfar, T., High resolution in-situ study of reactions in graphene liquid cells. Microsc. Microanal. 20 (2014), 1520–1521, 10.1017/S1431927614009337.
148. Wang, C., Qiao, Q., Shokuhfar, T., Klie, R.F., High-resolution electron microscopy and spectroscopy of ferritin in biocompatible graphene liquid cells and graphene sandwiches. Adv. Mater. 26 (2014), 3410–3414, 10.1002/adma.201306069.
149. Wang, Y., Cui, H., Zhou, J., Li, F., Wang, J., Chen, M. et al., Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environ. Sci. Pollut. Res. 22 (2014), 5519–5530, 10.1007/s11356-014-3717-7.
150. 2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicol. Sci. 91 (2006), 227–236.
151. Weir, A., Westerhoff, P., Fabricius, L., Hristovski, K., von Goetz, N., Titanium dioxide nanoparticles in food and personal care products. Environ. Sci. Technol. 46 (2012), 2242–2250, 10.1021/es204168d.
152. Wongrakpanich, A., Mudunkotuwa, I.A., Geary, S.M., Morris, A.S., Mapuskar, K.A., Spitz, D.R. et al., Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells. Environ. Sci. Nano 3 (2016), 365–374.
153. Wright, K.J., Barbosa, S.V., Araki, K., Spångberg, L., In vitro antimicrobial and cytotoxic effects of Kri 1 paste and zinc oxide-eugenol used in primary tooth pulpectomies. Pediatr. Dent., 1994.
154. Xu, M., Li, J., Iwai, H., Mei, Q., Fujita, D., Su, H. et al., Formation of nano-bio-complex as nanomaterials dispersed in a biological solution for understanding nanobiological interactions. Nat. Sci. Rep., 2, 2012, 406, 10.1038/srep00406.
155. Yang, S.T., Liu, J.H., Wang, J., Yuan, Y., Cao, A., Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment. J. Nanosci. Nanotechnol. 10 (2010), 8638–8645, 10.1166/jnn.2010.2491.
156. Yuk, J.M., Park, J., Ercius, P., Kim, K., Hellebusch, D.J., High-resolution EM of colloidal nanocrystal growth using graphene liquid cells. Science, 2012, 10.1126/science.1217654.
157. Yuk, J.M., Park, J., Ercius, P., Kim, K., Hellebusch, D.J., Crommie, M.F. et al., High-resolution EM of colloidal nanocrystal growth using graphene liquid cells. Science 336 (2012), 61–64, 10.1126/science.1217654.
158. Zhang, H., Gilbert, B., Huang, F., Banfield, J.F., Water-driven structure transformation in nanoparticles at room temperature. Nature 424 (2003), 1025–1029, 10.1038/nature01845.
159. Zhang, Haiyuan, Ji, Zhaoxia, Xia, Tian, Meng, Huan, Low-Kam, Cecile, Liu, Rong, Pokhrel, Suman, Lin, Sijie, Wang, Xiang, Liao, Yu-Pei, Wang, Meiying, Li, Linjiang et al., Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano 6:5 (2012), 4349–4368, 10.1021/nn3010087.