Low-solubility particles and a Trojan-horse type mechanism of toxicity: The case of cobalt oxide on human lung cells

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages 1-18

  Ortega, Richard ^a,b   Bresson, Carole ^c   Darolles, Carine ^c   Gautier, Céline ^c   Roudeau, Stéphane ^a,b   Perrin, Laura ^a,b   Janin, Myriam ^c,e   Floriani, Magali ^d   Aloin, Valérie ^c   Carmona, Asuncion ^a,b   Malard, Véronique ^c  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b CENTRE D ETUDES NUCLÉAIRES DE BORDEAUX GRADIGNAN   (France)

^c DIF   (France)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^e CEA DEN DPC SEARS Laboratoire d'Analyse en Soutien aux Exploitants ^*  (France)

Author keywords

Cobalt oxide; Endocytosis; ICP MS; Intracellular solubilization; Lung cells; Lysosome; Particles; PIXE; Toxicity

Indexed keywords

CLATHRIN; COBALT; COBALT CHLORIDE; COBALT OXIDE; METAL OXIDE; UNCLASSIFIED DRUG; ZINC; ADENOSINE TRIPHOSPHATE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; NANOPARTICLE; OXIDE;

ARTICLE; CELL NUCLEUS; CELLULAR SECRETION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENDOCYTOSIS; HUMAN; HUMAN CELL; INTERNALIZATION; LUNG ALVEOLUS CELL; LYSOSOME; MASS SPECTROMETRY; PARTICLE SIZE; PH; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; SOLUBILITY; SOLUBILIZATION; CELL FRACTIONATION; CELL LINE; CELL SURVIVAL; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; LUNG; METABOLISM; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY;

ADENOSINE TRIPHOSPHATE; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; COBALT; CYTOPLASM; HUMANS; INDICATORS AND REAGENTS; LUNG; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; OXIDES; PARTICLE SIZE; SUBCELLULAR FRACTIONS; ZINC;

EID: 84899120670     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-11-14     Document Type: Article

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