Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations

Regulatory Toxicology and Pharmacology

Volumn 80, Issue , 2016, Pages 60-70

  Thompson, Chad M ^a   Suh, Mina ^b   Mittal, Liz ^a   Wikoff, Daniele S ^c   Welsh, Brian ^c   Proctor, Deborah M ^b  

^a ToxStrategies   (United States)

^b ToxStrategies Inc   (United States)

^c ToxStrategies Inc   (United States)

Author keywords

No significant risk level (NSRL); Risk of bias; Systematic review; Titanium dioxide (TiO2)

Indexed keywords

TITANIUM DIOXIDE; POLLUTANT; TITANIUM;

ARTICLE; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; CARCINOGENICITY; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; CHRONIC INFLAMMATION; CHRONIC TOXICITY; ENVIRONMENTAL EXPOSURE; HUMAN; LUNG ALVEOLUS MACROPHAGE; LUNG BURDEN; LUNG CANCER; NO SIGNIFICANT RISK LEVEL; NONHUMAN; OCCUPATIONAL HAZARD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SYSTEMATIC REVIEW; ADVERSE EFFECTS; ANIMAL; CARCINOGEN TESTING; CHEMICALLY INDUCED; DOSE RESPONSE; EXPOSURE; FEMALE; LUNG NEOPLASMS; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NONLINEAR SYSTEM; OCCUPATIONAL EXPOSURE; POLLUTANT; PROCEDURES; RAT; STATISTICAL MODEL; TOXICITY;

ANIMALS; CARCINOGENICITY TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INHALATION EXPOSURE; LINEAR MODELS; LUNG NEOPLASMS; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NONLINEAR DYNAMICS; OCCUPATIONAL EXPOSURE; RATS; RISK ASSESSMENT; TITANIUM;

EID: 84979642807     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2016.05.031     Document Type: Article

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