Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population

Kidney and Blood Pressure Research

Volumn 42, Issue 3, 2017, Pages 483-494

  Lang, Florian ^a   Guelinckx, Isabelle ^b   Lemetais, Guillaume ^b   Melander, Olle ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Danone Research   (France)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Cancer; Chronic kidney disease; Copeptin; Glucocorticoids; Metabolic syndrome; Vasopressin

Indexed keywords

CALCIUM CHANNEL; COPEPTIN; GLUCOCORTICOID; HYDROCORTISONE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM GLUCOSE COTRANSPORTER 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT5; UNCLASSIFIED DRUG; VASOPRESSIN; IMMEDIATE EARLY PROTEIN; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; VASOPRESSIN DERIVATIVE;

ABDOMINAL OBESITY; CELL FUNCTION; CEREBROVASCULAR ACCIDENT; CHRONIC KIDNEY FAILURE; COGNITIVE DEFECT; CORONARY ARTERY DISEASE; CORTICOSTEROID BLOOD LEVEL; DIABETES MELLITUS; DISEASE ASSOCIATION; DRINKING BEHAVIOR; ENZYME ACTIVITY; FIBROSIS; FLUID INTAKE; HEART FAILURE; HUMAN; HYPERTENSION; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INTESTINE ABSORPTION; KIDNEY FAILURE; KIDNEY TUBULE ABSORPTION; MALIGNANT NEOPLASM; MICROALBUMINURIA; MULTIINFARCT DEMENTIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; POPULATION RESEARCH; PREMATURE MORTALITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; REVIEW; RISK FACTOR; SUBOPTIMAL FLUID INTAKE; THROMBOCYTE FUNCTION; TUMOR GROWTH; UPREGULATION; VASOPRESSIN BLOOD LEVEL; VASOPRESSIN RELEASE; DEHYDRATION; DISEASE PREDISPOSITION; GENETICS; HYDRATION STATUS; METABOLISM; PHYSIOLOGY;

DEHYDRATION; DISEASE SUSCEPTIBILITY; GLUCOCORTICOIDS; HUMANS; IMMEDIATE-EARLY PROTEINS; ORGANISM HYDRATION STATUS; PROTEIN-SERINE-THREONINE KINASES; UP-REGULATION; VASOPRESSINS;

EID: 85027171014     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000479640     Document Type: Review

References (111)

1. Danziger J, Zeidel ML: Osmotic homeostasis. Clin J Am Soc Nephrol 2015;10:852-862.
2. Treschan TA, Peters J: The vasopressin system: physiology and clinical strategies. Anesthesiology 2006;105:599-612; quiz 639-540.
3. Ferreira-Pego C, Guelinckx I, Moreno LA, Kavouras SA, Gandy J, Martinez H, Bardosono S, Abdollahi M, Nasseri E, Jarosz A, Babio N, Salas-Salvado J: Total fluid intake and its determinants: cross-sectional surveys among adults in 13 countries worldwide. Eur J Nutr 2015;54:S35-43.
4. Holsboer F, Ising M: Stress hormone regulation: biological role and translation into therapy. Annu Rev Psychol 2010;61:81-109, C101-111.
5. Papadimitriou A, Priftis KN: Regulation of the hypothalamic-pituitary-adrenal axis. Neuroimmunomodulation 2009;16:265-271.
6. Firestone GL, Giampaolo JR, O'Keeffe BA: Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 2003;13:1-12.
7. Lang F, Stournaras C: Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth. Hormones (Athens) 2013;12:160-171.
8. Perrier E, Vergne S, Klein A, Poupin M, Rondeau P, Le Bellego L, Armstrong LE, Lang F, Stookey J, Tack I: Hydration biomarkers in free-living adults with different levels of habitual fluid consumption. Br J Nutr 2013;109:1678-1687.
9. Iglesia I, Guelinckx I, De Miguel-Etayo PM, Gonzalez-Gil EM, Salas-Salvado J, Kavouras SA, Gandy J, Martinez H, Bardosono S, Abdollahi M, Nasseri E, Jarosz A, Ma G, Carmuega E, Thiebaut I, Moreno LA: Total fluid intake of children and adolescents: cross-sectional surveys in 13 countries worldwide. Eur J Nutr 2015;54:S57-67.
10. Guelinckx I, Vecchio M, Perrier ET, Lemetais G: Fluid Intake and Vasopressin: Connecting the Dots. Ann Nutr Metab 2016;68:S6-11.
11. Johnson EC, Munoz CX, Jimenez L, Le Bellego L, Kupchak BR, Kraemer WJ, Casa DJ, Maresh CM, Armstrong LE: Hormonal and Thirst Modulated Maintenance of Fluid Balance in Young Women with Different Levels of Habitual Fluid Consumption. Nutrients 2016;8:pii: E302.
12. Yun CC, Chen Y, Lang F: Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem 2002;277:7676-7683.
13. Bohmer C, Philippin M, Rajamanickam J, Mack A, Broer S, Palmada M, Lang F: Stimulation of the EAAT4 glutamate transporter by SGK protein kinase isoforms and PKB. Biochem Biophys Res Commun 2004;324:1242-1248.
14. Warntges S, Friedrich B, Henke G, Duranton C, Lang PA, Waldegger S, Meyermann R, Kuhl D, Speckmann EJ, Obermuller N, Witzgall R, Mack AF, Wagner HJ, Wagner A, Broer S, Lang F: Cerebral localization and regulation of the cell volume-sensitive serum-and glucocorticoid-dependent kinase SGK1. Pflugers Arch 2002;443:617-624.
15. Neuhofer W: Role of NFAT5 in inflammatory disorders associated with osmotic stress. Curr Genomics 2010;11:584-590.
16. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG: Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest 2009;119:1647-1658.
17. Tasevska I, Enhorning S, Christensson A, Persson M, Nilsson PM, Melander O: Increased Levels of Copeptin, a Surrogate Marker of Arginine Vasopressin, Are Associated with an Increased Risk of Chronic Kidney Disease in a General Population. Am J Nephrol 2016;44:22-28.
18. Enhorning S, Wang TJ, Nilsson PM, Almgren P, Hedblad B, Berglund G, Struck J, Morgenthaler NG, Bergmann A, Lindholm E, Groop L, Lyssenko V, Orho-Melander M, Newton-Cheh C, Melander O: Plasma copeptin and the risk of diabetes mellitus. Circulation 2010;121:2102-2108.
19. Abbasi A, Corpeleijn E, Meijer E, Postmus D, Gansevoort RT, Gans RO, Struck J, Hillege HL, Stolk RP, Navis G, Bakker SJ: Sex differences in the association between plasma copeptin and incident type 2 diabetes: The Prevention of Renal and Vascular Endstage Disease (PREVEND) study. Diabetologia 2012;55:1963-1970.
20. Wannamethee SG, Welsh P, Papacosta O, Lennon L, Whincup PH, Sattar N: Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men. J Clin Endocrinol Metab 2015;100:3332-3339.
21. Roussel R, El Boustany R, Bouby N, Potier L, Fumeron F, Mohammedi K, Balkau B, Tichet J, Bankir L, Marre M, Velho G: Plasma Copeptin, AVP Gene Variants, and Incidence of Type 2 Diabetes in a Cohort From the Community. J Clin Endocrinol Metab 2016;101:2432-2439.
22. Taveau C, Chollet C, Waeckel L, Desposito D, Bichet DG, Arthus MF, Magnan C, Philippe E, Paradis V, Foufelle F, Hainault I, Enhorning S, Velho G, Roussel R, Bankir L, Melander O, Bouby N: Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats. Diabetologia 2015;58:1081-1090.
23. Enhorning S, Struck J, Wirfalt E, Hedblad B, Morgenthaler NG, Melander O: Plasma copeptin, a unifying factor behind the metabolic syndrome. J Clin Endocrinol Metab 2011;96:E1065-1072.
24. Melander O: Vasopressin, from Regulator to Disease Predictor for Diabetes and Cardiometabolic Risk. Ann Nutr Metab 2016;68:S24-28.
25. Enhorning S, Bankir L, Bouby N, Struck J, Hedblad B, Persson M, Morgenthaler NG, Nilsson PM, Melander O: Copeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: The prospective Malmo Diet and Cancer Study cardiovascular cohort. Int J Obes (Lond) 2013;37:598-603.
26. Saleem U, Khaleghi M, Morgenthaler NG, Bergmann A, Struck J, Mosley TH, Jr., Kullo IJ: Plasma carboxyterminal provasopressin (copeptin): A novel marker of insulin resistance and metabolic syndrome. J Clin Endocrinol Metab 2009;94:2558-2564.
27. Tasevska I, Enhorning S, Persson M, Nilsson PM, Melander O: Copeptin predicts coronary artery disease cardiovascular and total mortality. Heart 2016;102:127-132.
28. Enhorning S, Hedblad B, Nilsson PM, Engstrom G, Melander O: Copeptin is an independent predictor of diabetic heart disease and death. Am Heart J 2015;169:549-556, e541.
29. Tufvesson E, Melander O, Minthon L, Persson M, Nilsson PM, Struck J, Nagga K: Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up. Dement Geriatr Cogn Disord 2013;35:67-76.
30. Pikkemaat M, Melander O, Bengtsson Bostrom K: Association between copeptin and declining glomerular filtration rate in people with newly diagnosed diabetes. The Skaraborg Diabetes Register. J Diabetes Complications 2015;29:1062-1065.
31. Ohlsson B, Melander O: Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection. Drug Target Insights 2015;9:21-27.
32. Belting M, Almgren P, Manjer J, Hedblad B, Struck J, Wang TJ, Bergmann A, Melander O: Vasoactive peptides with angiogenesis-regulating activity predict cancer risk in males. Cancer Epidemiol Biomarkers Prev 2012;21:513-522.
33. Lang F, Stournaras C, Alesutan I: Regulation of transport across cell membranes by the serum-and glucocorticoid-inducible kinase SGK1. Mol Membr Biol 2014;31:29-36.
34. Matschke V, Theiss C, Hollmann M, Schulze-Bahr E, Lang F, Seebohm G, Strutz-Seebohm N: NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytes. Front Cell Neurosci 2015;9:387.
35. Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, Lampert A, Grahammer F, Henke G, Just L, Skutella T, Hollmann M, Lang F: Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression. J Physiol 2005;565:391-401.
36. Schmid E, Gu S, Yang W, Munzer P, Schaller M, Lang F, Stournaras C, Shumilina E: Serum-and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation. Am J Physiol Cell Physiol 2013;304:C49-C55.
37. Lang F, Gorlach A, Vallon V: Targeting SGK1 in diabetes. Expert Opin Ther Targets 2009;13:1303-1311.
38. Chen L, Wei TQ, Wang Y, Zhang J, Li H, Wang KJ: Simulated bladder pressure stimulates human bladder smooth muscle cell proliferation via the PI3K/SGK1 signaling pathway. J Urol 2012;188:661-667.
39. Lang F, Perrotti N, Stournaras C: Colorectal carcinoma cells-regulation of survival and growth by SGK1. Int J Biochem Cell Biol 2010;42:1571-1575.
40. Schmidt EM, Gu S, Anagnostopoulou V, Alevizopoulos K, Foller M, Lang F, Stournaras C: Serum-and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor. FEBS J 2012;279:1231-1242.
41. Schmidt EM, Kraemer BF, Borst O, Munzer P, Schonberger T, Schmidt C, Leibrock C, Towhid ST, Seizer P, Kuhl D, Stournaras C, Lindemann S, Gawaz M, Lang F: SGK1 sensitivity of platelet migration. Cell Physiol Biochem 2012;30:259-268.
42. Hua SZ: Mapped! A machinery of degranulation in mast cells. Focus on "Serum-and glucocorticoidinducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation". Am J Physiol Cell Physiol 2013;304:C36-C37.
43. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V: (Patho)physiological significance of the serum-and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006;86:1151-1178.
44. Faresse N, Lagnaz D, Debonneville A, Ismailji A, Maillard M, Fejes-Toth G, Naray-Fejes-Toth A, Staub O: Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype. Am J Physiol Renal Physiol 2012;302:F977-F985.
45. Rotin D, Staub O: Nedd4-2 and the regulation of epithelial sodium transport. Front Physiol 2012;3:212.
46. Soundararajan R, Lu M, Pearce D: Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol 2012;47:349-359.
47. Lang F, Vallon V: Serum-and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport. Clin Exp Nephrol 2012;16:73-80.
48. Lang F, Strutz-Seebohm N, Seebohm G, Lang UE: Significance of SGK1 in the regulation of neuronal function. J Physiol 2010;588:3349-3354.
49. Arroyo JP, Lagnaz D, Ronzaud C, Vazquez N, Ko BS, Moddes L, Ruffieux-Daidie D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O: Nedd4-2 modulates renal Na+-Cl-cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol 2011;22:1707-1719.
50. Pao AC: SGK regulation of renal sodium transport. Curr Opin Nephrol Hypertens 2012;21:534-540.
51. Dynia DW, Steinmetz AG, Kocinsky HS: NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Am J Physiol Renal Physiol 2010;298:F745-F753.
52. He P, Lee SJ, Lin S, Seidler U, Lang F, Fejes-Toth G, Naray-Fejes-Toth A, Yun CC: Serum-and glucocorticoidinduced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell 2011;22:3812-3825.
53. Panchapakesan U, Pollock C, Saad S: Renal epidermal growth factor receptor: its role in sodium and water homeostasis in diabetic nephropathy. Clin Exp Pharmacol Physiol 2011;38:84-88.
54. Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D: Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol 2010;299:F1496-F1506.
55. Pasham V, Rotte A, Gu S, Yang W, Bhandaru M, Rexhepaj R, Pathare G, Lang F: Upregulation of Intestinal NHE3 Following Saline Ingestion. Kidney Blood Press Res 2013;37:48-57.
56. Resch M, Bergler T, Fredersdorf S, Griese DP, Weil J, Kreuzer P, Brunner S, Riegger GA, Luchner A, Endemann DH: Hyperaldosteronism and altered expression of an SGK1-dependent sodium transporter in ZDF rats leads to salt dependence of blood pressure. Hypertens Res 2010;33:1082-1088.
57. Umbach AT, Pathare G, Foller M, Brosens JJ, Artunc F, Lang F: SGK1-dependent salt appetite in pregnant mice. Acta Physiol (Oxf) 2011;202:39-45.
58. Kawarazaki H, Ando K, Shibata S, Muraoka K, Fujita M, Kawarasaki C, Fujita T: Mineralocorticoid receptor-Rac1 activation and oxidative stress play major roles in salt-induced hypertension and kidney injury in prepubertal rats. J Hypertens 2012;30:1977-1985.
59. Nakagaki T, Hirooka Y, Matsukawa R, Nishihara M, Nakano M, Ito K, Hoka S, Sunagawa K: Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res 2012;35:470-476.
60. Rao AD, Sun B, Saxena A, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams JS: Polymorphisms in the serum-and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake. J Hum Hypertens 2013;27:176-180.
61. Nakano M, Hirooka Y, Matsukawa R, Ito K, Sunagawa K: Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res 2013;36:277-284.
62. von Wowern F, Berglund G, Carlson J, Mansson H, Hedblad B, Melander O: Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. Kidney Int 2005;68:2164-2172.
63. Ackermann TF, Boini KM, Beier N, Scholz W, Fuchss T, Lang F: EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem 2011;28:137-146.
64. Salker MS, Christian M, Steel JH, Nautiyal J, Lavery S, Trew G, Webster Z, Al-Sabbagh M, Puchchakayala G, Foller M, Landles C, Sharkey AM, Quenby S, Aplin JD, Regan L, Lang F, Brosens JJ: Deregulation of the serum-and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med 2011;17:1509-1513.
65. Rexhepaj R, Boini KM, Huang DY, Amann K, Artunc F, Wang K, Brosens JJ, Kuhl D, Lang F: Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet. Am J Physiol Regul Integr Comp Physiol 2008;294:R2008-2013.
66. Rexhepaj R, Alesutan I, Gu S, Pelzl L, Eichenmuller M, Pathare G, Foller M, Kuhl D, Lang F: SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D. Pflugers Arch 2011;462:489-494.
67. Di Pietro N, Panel V, Hayes S, Bagattin A, Meruvu S, Pandolfi A, Hugendubler L, Fejes-Toth G, Naray-Fejes-Toth A, Mueller E: Serum-and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1. Mol Endocrinol 2010;24:370-380.
68. Borst O, Schmidt EM, Munzer P, Schonberger T, Towhid ST, Elvers M, Leibrock C, Schmid E, Eylenstein A, Kuhl D, May AE, Gawaz M, Lang F: The serum-and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood 2012;119:251-261.
69. Eylenstein A, Schmidt S, Gu S, Yang W, Schmid E, Schmidt EM, Alesutan I, Szteyn K, Regel I, Shumilina E, Lang F: Transcription factor NF-kappaB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. J Biol Chem 2012;287:2719-2730.
70. Rotte A, Pasham V, Eichenmuller M, Yang W, Bhandaru M, Lang F: Influence of dexamethasone on Na+/H+ exchanger activity in dendritic cells. Cell Physiol Biochem 2011;28:305-314.
71. Dahlberg J, Smith G, Norrving B, Nilsson P, Hedblad B, Engstrom G, Lovkvist H, Carlson J, Lindgren A, Melander O: Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke. J Hypertens 2011;29:884-889.
72. Abbruzzese C, Mattarocci S, Pizzuti L, Mileo AM, Visca P, Antoniani B, Alessandrini G, Facciolo F, Amato R, D'Antona L, Rinaldi M, Felsani A, Perrotti N, Paggi MG: Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas. J Exp Clin Cancer Res 2012;31:4.
73. Szmulewitz RZ, Chung E, Al Ahmadie H, Daniel S, Kocherginsky M, Razmaria A, Zagaja GP, Brendler CB, Stadler WM, Conzen SD: Serum/glucocorticoid-regulated kinase 1 expression in primary human prostate cancers. Prostate 2012;72:157-164.
74. Fagerli UM, Ullrich K, Stuhmer T, Holien T, Kochert K, Holt RU, Bruland O, Chatterjee M, Nogai H, Lenz G, Shaughnessy JD, Jr., Mathas S, Sundan A, Bargou RC, Dorken B, Borset M, Janz M: Serum/glucocorticoidregulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells. Oncogene 2011;30:3198-3206.
75. Lang F, Artunc F, Vallon V: The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr Opin Nephrol Hypertens 2009;18:439-448.
76. Towhid ST, Liu GL, Ackermann TF, Beier N, Scholz W, Fuchss T, Toulany M, Rodemann HP, Lang F: Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683. Cell Physiol Biochem 2013;32:838-848.
77. Baskin R, Sayeski PP: Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1. Cell Signal 2012;24:435-442.
78. Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR: Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. Biochem J 2013;452:499-508.
79. Gu S, Papadopoulou N, Nasir O, Foller M, Alevizopoulos K, Lang F, Stournaras C: Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling. Mol Med 2011;17:48-58.
80. Lang F, Voelkl J: Therapeutic potential of serum and glucocorticoid inducible kinase inhibition. Expert Opin Investig Drugs 2013;22:701-714.
81. Eylenstein A, Gehring EM, Heise N, Shumilina E, Schmidt S, Szteyn K, Munzer P, Nurbaeva MK, Eichenmuller M, Tyan L, Regel I, Foller M, Kuhl D, Soboloff J, Penner R, Lang F: Stimulation of Ca2+-channel Orai1/STIM1 by serum-and glucocorticoid-inducible kinase 1 (SGK1). FASEB J 2011;25:2012-2021.
82. Schmidt S, Schneider S, Yang W, Liu G, Schmidt EM, Schmid E, Mia S, Brucker S, Stournaras C, Wallwiener D, Brosens JJ, Lang F: TGFbeta1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells. Mol Hum Reprod 2014;20:139-147.
83. Amato R, Scumaci D, D'Antona L, Iuliano R, Menniti M, Di Sanzo M, Faniello MC, Colao E, Malatesta P, Zingone A, Agosti V, Costanzo FS, Mileo AM, Paggi MG, Lang F, Cuda G, Lavia P, Perrotti N: Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells. Oncogene 2013;32:4572-4578.
84. Rusai K, Prokai A, Szebeni B, Fekete A, Treszl A, Vannay A, Muller V, Reusz G, Heemann U, Lutz J, Tulassay T, Szabo AJ: Role of serum and glucocorticoid-regulated kinase-1 in the protective effects of erythropoietin during renal ischemia/reperfusion injury. Biochem Pharmacol 2010;79:1173-1181.
85. Ronchi CL, Leich E, Sbiera S, Weismann D, Rosenwald A, Allolio B, Fassnacht M: Single nucleotide polymorphism microarray analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways. Neoplasia 2012;14:206-218.
86. Ronchi CL, Sbiera S, Leich E, Tissier F, Steinhauer S, Deutschbein T, Fassnacht M, Allolio B: Low SGK1 Expression in Human Adrenocortical Tumors Is Associated with ACTH-Independent Glucocorticoid Secretion and Poor Prognosis. J Clin Endocrinol Metab 2012;97:E2251-E2260.
87. Waldegger S, Klingel K, Barth P, Sauter M, Rfer ML, Kandolf R, Lang F: H-SGK serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterology 1999;116:1081-1088.
88. Szebeni B, Vannay A, Sziksz E, Prokai A, Cseh A, Veres G, Dezsofi A, Gyorffy H, Szabo IR, Arato A: Increased expression of serum-and glucocorticoid-regulated kinase-1 in the duodenal mucosa of children with coeliac disease. J Pediatr Gastroenterol Nutr 2010;50:147-153.
89. Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK: Induction of pathogenic T17 cells by inducible salt-sensing kinase SGK1. Nature 2013;496:513-517.
90. Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA: Sodium chloride drives autoimmune disease by the induction of pathogenic T17 cells. Nature 2013;496:518-522.
91. Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J: Serum-and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int 2010;78:668-678.
92. Akhurst RJ, Hata A: Targeting the TGFbeta signalling pathway in disease. Nat Rev Drug Discov 2012;11:790-811.
93. Hong Y, Cao H, Wang Q, Ye J, Sui L, Feng J, Cai X, Song H, Zhang X, Chen X: MiR-22 may Suppress Fibrogenesis by Targeting TGFbetaR I in Cardiac Fibroblasts. Cell Physiol Biochem 2016;40:1345-1353.
94. Guo Y, Dong Z, Shi Y, Wang W, Wang L, Sun J, Sun X, Tian Z, Yao J, Li Z, Cheng J, Tian Y: Sonodynamic Therapy Inhibits Fibrogenesis in Rat Cardiac Fibroblasts Induced by TGF-beta1. Cell Physiol Biochem 2016;40:579-588.
95. Yu F, Yang J, Huang K, Pan X, Chen B, Dong P, Zheng J: The Epigenetically-Regulated microRNA-378a Targets TGF-beta2 in TGF-beta1-Treated Hepatic Stellate Cells. Cell Physiol Biochem 2016;40:183-194.
96. Li X, Han D, Tian Z, Gao B, Fan M, Li C, Li X, Wang Y, Ma S, Cao F: Activation of Cannabinoid Receptor Type II by AM1241 Ameliorates Myocardial Fibrosis via Nrf2-Mediated Inhibition of TGF-beta1/Smad3 Pathway in Myocardial Infarction Mice. Cell Physiol Biochem 2016;39:1521-1536.
97. Zhang F, Dang Y, Li Y, Hao Q, Li R, Qi X: Cardiac Contractility Modulation Attenuate Myocardial Fibrosis by Inhibiting TGF-beta1/Smad3 Signaling Pathway in a Rabbit Model of Chronic Heart Failure. Cell Physiol Biochem 2016;39:294-302.
98. Feger M, Alesutan I, Castor T, Mia S, Musculus K, Voelkl J, Lang F: Inhibitory effect of NH4Cl treatment on renal Tgfss1 signaling following unilateral ureteral obstruction. Cell Physiol Biochem 2015;37:955-964.
99. Shih VF, Tsui R, Caldwell A, Hoffmann A: A single NFkappaB system for both canonical and non-canonical signaling. Cell Res 2011;21:86-102.
100. Stone KP, Kastin AJ, Pan W: NFkB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia. Cell Physiol Biochem 2011;28:115-124.
101. Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P, Kuhl D, Lang F: Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1. J Mol Med (Berl) 2006;84:737-746.
102. Tsai V, Parker WE, Orlova KA, Baybis M, Chi AW, Berg BD, Birnbaum JF, Estevez J, Okochi K, Sarnat HB, Flores-Sarnat L, Aronica E, Crino PB: Fetal brain mTOR signaling activation in tuberous sclerosis complex. Cereb Cortex 2014;24:315-327.
103. Chilukoti RK, Mostertz J, Bukowska A, Aderkast C, Felix SB, Busch M, Volker U, Goette A, Wolke C, Homuth G, Lendeckel U: Effects of irbesartan on gene expression revealed by transcriptome analysis of left atrial tissue in a porcine model of acute rapid pacing in vivo. Int J Cardiol 2013;168:2100-2108.
104. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J: Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler Thromb Vasc Biol 2012;32:1675-1686.
105. Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Bostrom P, Morissette MR, Del Monte F, Begley MJ, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A: Pathological role of serum-and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation 2012;126:2208-2219.
106. Voelkl J, Lin Y, Alesutan I, Ahmed MS, Pasham V, Mia S, Gu S, Feger M, Saxena A, Metzler B, Kuhl D, Pichler BJ, Lang F: Sgk1 sensitivity of Na(+)/H(+) exchanger activity and cardiac remodeling following pressure overload. Basic Res Cardiol 2012;107:236.
107. Walker-Allgaier B, Schaub M, Alesutan I, Voelkl J, Geue S, Munzer P, Rodriguez JM, Kuhl D, Lang F, Gawaz M, Borst O: SGK1 up-regulates Orai1 expression and VSMC migration during neointima formation after arterial injury. Thromb Haemost 2017;117:1002-1005.
108. Borst O, Schaub M, Walker B, Schmid E, Munzer P, Voelkl J, Alesutan I, Rodriguez JM, Vogel S, Schoenberger T, Metzger K, Rath D, Umbach A, Kuhl D, Muller, II, Seizer P, Geisler T, Gawaz M, Lang F: Pivotal role of serum-and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis. Arterioscler Thromb Vasc Biol 2015;35:547-557.
109. Walker B, Schmid E, Russo A, Schmidt EM, Burk O, Munzer P, Velic A, Macek B, Schaller M, Schwab M, Seabra MC, Gawaz M, Lang F, Borst O: Impact of the serum-and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion. J Thromb Haemost 2015;13:1325-1334.
110. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F, Belaiba RS, Gorlach A, Wulff P, Daut J, Dalton ND, Ross J, Jr., Flogel U, Schrader J, Osswald H, Kandolf R, Kuhl D, Lang F: SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. J Mol Med (Berl) 2006;84:396-404.
111. Artunc F, Nasir O, Amann K, Boini KM, Haring HU, Risler T, Lang F: Serum-and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome. Am J Physiol Renal Physiol 2008;295:F1624-1634.