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Volumn 7, Issue 1, 2017, Pages

Short-term treatment with eicosapentaenoic acid improves inflammation and affects colonic differentiation markers and microbiota in patients with ulcerative colitis

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN; FATTY ACID; HES1 PROTEIN, HUMAN; ICOSAPENTAENOIC ACID; IL10 PROTEIN, HUMAN; INTERLEUKIN 10; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 4; SOCS3 PROTEIN, HUMAN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR HES 1;

EID: 85027029052     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-07992-1     Document Type: Article
Times cited : (52)

References (59)
  • 1
    • 84936751961 scopus 로고    scopus 로고
    • Cancers complicating inflammatory bowel disease
    • Beaugerie, L., & Itzkowitz, S. H. Cancers Complicating Inflammatory Bowel Disease. N. Engl. J. Med. 373, 195 (2015
    • (2015) N. Engl. J. Med , vol.373 , pp. 195
    • Beaugerie, L.1    Itzkowitz, S.H.2
  • 2
    • 77951758579 scopus 로고    scopus 로고
    • Guidelines for colorectal cancer screening, and surveillance in moderate, and high risk groups (update from 2002
    • Cairns, S. R., et al. Guidelines for colorectal cancer screening, and surveillance in moderate, and high risk groups (update from 2002). Gut 59, 666-89 (2010
    • (2010) Gut , vol.59 , pp. 666-689
    • Cairns, S.R.1
  • 3
    • 84936845896 scopus 로고    scopus 로고
    • Forty-year analysis of colonoscopic surveillance program for neoplasia in ulcerative colitis: An updated overview
    • Choi, C.-H. R., et al. Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview. Am. J. Gastroenterol. 110, 1022-1034 (2015
    • (2015) Am. J. Gastroenterol , vol.110 , pp. 1022-1034
    • Choi, C.-H.R.1
  • 6
    • 84902205227 scopus 로고    scopus 로고
    • Fecal calprotectin testing can identify ineffective colorectal cancer surveillance procedures in patients with longstanding colitis
    • Mooiweer, E., Fidder, H. H., Siersema, P. D., Laheij, R. J. F., & Oldenburg, B. Fecal calprotectin testing can identify ineffective colorectal cancer surveillance procedures in patients with longstanding colitis. Inflamm. Bowel Dis. 20, 1079-84 (2014
    • (2014) Inflamm. Bowel Dis , vol.20 , pp. 1079-1084
    • Mooiweer, E.1    Fidder, H.H.2    Siersema, P.D.3    Laheij, R.J.F.4    Oldenburg, B.5
  • 7
    • 58649108302 scopus 로고    scopus 로고
    • Il-6, and stat3 are required for survival of intestinal epithelial cells, and development of colitis-associated cancer
    • Grivennikov, S., et al. IL-6, and Stat3 Are Required for Survival of Intestinal Epithelial Cells, and Development of Colitis-Associated Cancer. Cancer Cell 15, 103-113 (2009
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1
  • 8
    • 0035073083 scopus 로고    scopus 로고
    • Interleukin-10-deficient mice, and inflammatory bowel disease associated cancer development
    • Sturlan, S., et al. Interleukin-10-deficient mice, and inflammatory bowel disease associated cancer development. Carcinogenesis 22, 665-71 (2001
    • (2001) Carcinogenesis , vol.22 , pp. 665-671
    • Sturlan, S.1
  • 9
    • 84891736162 scopus 로고    scopus 로고
    • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models, and patients with ulcerative colitis
    • Johansson, M. E. V., et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models, and patients with ulcerative colitis. Gut 63, 281-291 (2014
    • (2014) Gut , vol.63 , pp. 281-291
    • Johansson, M.E.V.1
  • 10
    • 84966293351 scopus 로고    scopus 로고
    • Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
    • Chu, H., et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science 352, 1116-20 (2016
    • (2016) Science , vol.352 , pp. 1116-1120
    • Chu, H.1
  • 11
    • 84863989936 scopus 로고    scopus 로고
    • A bacterial driver-passenger model for colorectal cancer: Beyond the usual suspects
    • Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat. Rev. Microbiol. 10, 575-82 (2012
    • (2012) Nat. Rev. Microbiol , vol.10 , pp. 575-582
    • Tjalsma, H.1    Boleij, A.2    Marchesi, J.R.3    Dutilh, B.E.4
  • 12
    • 84890916350 scopus 로고    scopus 로고
    • New targets for mucosal healing, and therapy in inflammatory bowel diseases
    • Neurath, M. F. New targets for mucosal healing, and therapy in inflammatory bowel diseases. Mucosal Immunol. 7, 6-19 (2014
    • (2014) Mucosal Immunol , vol.7 , pp. 6-19
    • Neurath, M.F.1
  • 13
    • 0036340041 scopus 로고    scopus 로고
    • The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    • Katz, J. P., et al. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129, 2619-28 (2002
    • (2002) Development , vol.129 , pp. 2619-2628
    • Katz, J.P.1
  • 14
    • 84906266448 scopus 로고    scopus 로고
    • Eicosapentaenoic acid free fatty acid prevents, and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling, and gut microbiota
    • Piazzi, G., et al. Eicosapentaenoic acid free fatty acid prevents, and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling, and gut microbiota. Int. J. cancer 135, 2004-13 (2014
    • (2014) Int. J. Cancer , vol.135 , pp. 2004-2013
    • Piazzi, G.1
  • 15
    • 84902142978 scopus 로고    scopus 로고
    • Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response
    • Ghaleb, A. M., Laroui, H., Merlin, D., & Yang, V. W. Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response. Inflamm. Bowel Dis. 20, 811-20 (2014
    • (2014) Inflamm. Bowel Dis , vol.20 , pp. 811-820
    • Ghaleb, A.M.1    Laroui, H.2    Merlin, D.3    Yang, V.W.4
  • 16
    • 84871630781 scopus 로고    scopus 로고
    • Intestinal microbes in inflammatory bowel diseases
    • Suppl
    • Sartor, R. B., & Mazmanian, S. K. Intestinal Microbes in Inflammatory Bowel Diseases. Am. J. Gastroenterol. 1(Suppl.), 15-21 (2012
    • (2012) Am. J. Gastroenterol , vol.1 , pp. 15-21
    • Sartor, R.B.1    Mazmanian, S.K.2
  • 17
    • 34247564971 scopus 로고    scopus 로고
    • 5-Aminosalicylic acid therapy, and the risk of colorectal cancer among patients with inflammatory bowel disease
    • Terdiman, J. P., Steinbuch, M., Blumentals, W. A., Ullman, T. A., & Rubin, D. T. 5-Aminosalicylic acid therapy, and the risk of colorectal cancer among patients with inflammatory bowel disease. Inflamm. Bowel Dis. 13, 367-71 (2007
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 367-371
    • Terdiman, J.P.1    Steinbuch, M.2    Blumentals, W.A.3    Ullman, T.A.4    Rubin, D.T.5
  • 18
    • 84962419838 scopus 로고    scopus 로고
    • Inflammatory networks underlying colorectal cancer
    • Lasry, A., Zinger, A., & Ben-Neriah, Y. Inflammatory networks underlying colorectal cancer. Nat. Immunol. 17, 230-40 (2016
    • (2016) Nat. Immunol , vol.17 , pp. 230-240
    • Lasry, A.1    Zinger, A.2    Ben-Neriah, Y.3
  • 19
    • 33746809138 scopus 로고    scopus 로고
    • Distribution interconversion, and dose response of n-3 fatty acids in humans
    • Arterburn, L. M., Hall, E. B., & Oken, H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr. 83, 1467S-1476S (2006
    • (2006) Am. J. Clin. Nutr , vol.83 , pp. 1467S-1476S
    • Arterburn, L.M.1    Hall, E.B.2    Oken, H.3
  • 20
    • 84857467280 scopus 로고    scopus 로고
    • Epithelial cell-intrinsic notch signaling plays an essential role in the maintenance of gut immune homeostasis
    • Obata, Y., et al. Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J. Immunol. 188, 2427-36 (2012
    • (2012) J. Immunol , vol.188 , pp. 2427-2436
    • Obata, Y.1
  • 21
    • 84966681522 scopus 로고    scopus 로고
    • Gut microbiota, and extreme longevity
    • Biagi, E., et al. Gut Microbiota, and Extreme Longevity. Curr. Biol. 26, 1480-5 (2016
    • (2016) Curr. Biol , vol.26 , pp. 1480-1485
    • Biagi, E.1
  • 22
    • 84955560598 scopus 로고    scopus 로고
    • Potential applications of fish oils rich in omega-3 polyunsaturated fatty acids in the management of gastrointestinal cancer
    • Eltweri, A. M., et al. Potential applications of fish oils rich in omega-3 polyunsaturated fatty acids in the management of gastrointestinal cancer. Clin. Nutr. 36, 65-78 (2017
    • (2017) Clin. Nutr , vol.36 , pp. 65-78
    • Eltweri, A.M.1
  • 23
    • 82455171808 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer in inflammatory bowel disease
    • Subramanian, V., & Logan, R. F. Chemoprevention of colorectal cancer in inflammatory bowel disease. Best Pract. Res. Clin. Gastroenterol. 25, 593-606 (2011
    • (2011) Best Pract. Res. Clin. Gastroenterol , vol.25 , pp. 593-606
    • Subramanian, V.1    Logan, R.F.2
  • 24
    • 33144460914 scopus 로고    scopus 로고
    • Laboratory markers in IBD: Useful magic or unnecessary toys?
    • Vermeire, S., Van Assche, G., & Rutgeerts, P. Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut 55, 426-31 (2006
    • (2006) Gut , vol.55 , pp. 426-431
    • Vermeire, S.1    Van Assche, G.2    Rutgeerts, P.3
  • 25
    • 84952716488 scopus 로고    scopus 로고
    • Correlation between concentrations of fecal calprotectin, and outcomes of patients with ulcerative colitis in a phase 2 trial
    • Sandborn, W. J., et al. Correlation Between Concentrations of Fecal Calprotectin, and Outcomes of Patients With Ulcerative Colitis in a Phase 2 Trial. Gastroenterology 150, 96-102 (2016
    • (2016) Gastroenterology , vol.150 , pp. 96-102
    • Sandborn, W.J.1
  • 26
    • 84930690119 scopus 로고    scopus 로고
    • Marine ?-3 polyunsaturated fatty acids, and risk of colorectal cancer according to microsatellite instability
    • Song, M., et al. Marine ?-3 polyunsaturated fatty acids, and risk of colorectal cancer according to microsatellite instability. J. Natl. Cancer Inst. 107 (2015
    • (2015) J. Natl. Cancer Inst , vol.107
    • Song, M.1
  • 27
    • 78650364506 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice
    • Fini, L., et al. Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice. Clin. Cancer Res. 16, 5703-11 (2010
    • (2010) Clin. Cancer Res , vol.16 , pp. 5703-5711
    • Fini, L.1
  • 28
    • 83555176443 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids for the treatment, and prevention of colorectal cancer
    • Cockbain, A. J., Toogood, G. J., & Hull, M. A. Omega-3 polyunsaturated fatty acids for the treatment, and prevention of colorectal cancer. Gut 61, 135-149 (2012
    • (2012) Gut , vol.61 , pp. 135-149
    • Cockbain, A.J.1    Toogood, G.J.2    Hull, M.A.3
  • 29
    • 59749091374 scopus 로고    scopus 로고
    • Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts
    • Matsunaga, H., et al. Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Inflamm. Bowel Dis. 14, 1348-57 (2008
    • (2008) Inflamm. Bowel Dis , vol.14 , pp. 1348-1357
    • Matsunaga, H.1
  • 30
    • 45549085184 scopus 로고    scopus 로고
    • Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice
    • Jia, Q., et al. Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Res. 68, 3985-91 (2008
    • (2008) Cancer Res , vol.68 , pp. 3985-3991
    • Jia, Q.1
  • 31
    • 84898010808 scopus 로고    scopus 로고
    • Long-term intake of dietary fat, and risk of ulcerative colitis, and Crohn?s disease
    • Ananthakrishnan, A. N., et al. Long-term intake of dietary fat, and risk of ulcerative colitis, and Crohn?s disease. Gut 63, 776-84 (2014
    • (2014) Gut , vol.63 , pp. 776-784
    • Ananthakrishnan, A.N.1
  • 32
    • 4644359644 scopus 로고    scopus 로고
    • Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation, and progression in the rat
    • Davidson, L. A., et al. Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation, and progression in the rat. Cancer Res. 64, 6797-804 (2004
    • (2004) Cancer Res , vol.64 , pp. 6797-6804
    • Davidson, L.A.1
  • 33
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation, and intestinal inflammation
    • Suzuki, A., et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation, and intestinal inflammation. J. Exp. Med. 193, 471-81 (2001
    • (2001) J. Exp. Med , vol.193 , pp. 471-481
    • Suzuki, A.1
  • 34
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • Pickert, G., et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465-72 (2009
    • (2009) J. Exp. Med , vol.206 , pp. 1465-1472
    • Pickert, G.1
  • 35
    • 77149155643 scopus 로고    scopus 로고
    • Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis, and ulcerative colitis-related carcinogenesis
    • Li, Y., et al. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis, and ulcerative colitis-related carcinogenesis. Gut 59, 227-35 (2010
    • (2010) Gut , vol.59 , pp. 227-235
    • Li, Y.1
  • 36
    • 84927734703 scopus 로고    scopus 로고
    • High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission
    • Xu, A. T., et al. High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission. Inflamm. Bowel Dis. 21, 241-50 (2015
    • (2015) Inflamm. Bowel Dis , vol.21 , pp. 241-250
    • Xu, A.T.1
  • 37
    • 84873745079 scopus 로고    scopus 로고
    • Increased suppressor of cytokine signaling-3 expression predicts mucosal relapse in ulcerative colitis
    • Li, Y., et al. Increased suppressor of cytokine signaling-3 expression predicts mucosal relapse in ulcerative colitis. Inflamm. Bowel Dis. 19, 132-40 (2013
    • (2013) Inflamm. Bowel Dis , vol.19 , pp. 132-140
    • Li, Y.1
  • 38
    • 0034234573 scopus 로고    scopus 로고
    • IL-10 gene expression is controlled by the transcription factors Sp1, and Sp3
    • Tone, M., Powell, M. J., Tone, Y., Thompson, S. A., & Waldmann, H. IL-10 gene expression is controlled by the transcription factors Sp1, and Sp3. J. Immunol. 165, 286-91 (2000
    • (2000) J. Immunol , vol.165 , pp. 286-291
    • Tone, M.1    Powell, M.J.2    Tone, Y.3    Thompson, S.A.4    Waldmann, H.5
  • 39
    • 0035958007 scopus 로고    scopus 로고
    • The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages
    • Ma, W., et al. The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages. J. Biol. Chem. 276, 13664-74 (2001
    • (2001) J. Biol. Chem , vol.276 , pp. 13664-13674
    • Ma, W.1
  • 40
    • 65249155995 scopus 로고    scopus 로고
    • Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a
    • Sharma, A., et al. Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proc. Natl. Acad. Sci. USA 106, 5761-6 (2009
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 5761-5766
    • Sharma, A.1
  • 41
    • 0042357098 scopus 로고    scopus 로고
    • Tyrosine phosphorylation disrupts elongin interaction, and accelerates SOCS3 degradation
    • Haan, S., et al. Tyrosine phosphorylation disrupts elongin interaction, and accelerates SOCS3 degradation. J. Biol. Chem. 278, 31972-9 (2003
    • (2003) J. Biol. Chem , vol.278 , pp. 31972-31979
    • Haan, S.1
  • 42
    • 0037462645 scopus 로고    scopus 로고
    • The n-terminal truncated isoform of socs3 translated from an alternative initiation aug codon under stress conditions is stable due to the lack of a major ubiquitination site lys-6
    • Sasaki, A., et al. The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J. Biol. Chem. 278, 2432-6 (2003
    • (2003) J. Biol. Chem , vol.278 , pp. 2432-2436
    • Sasaki, A.1
  • 43
    • 59049088446 scopus 로고    scopus 로고
    • Activation of Notch signaling in human colon adenocarcinoma
    • Reedijk, M., et al. Activation of Notch signaling in human colon adenocarcinoma. Int. J. Oncol. 33, 1223-9 (2008
    • (2008) Int. J. Oncol , vol.33 , pp. 1223-1229
    • Reedijk, M.1
  • 44
    • 0842329848 scopus 로고    scopus 로고
    • Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
    • Zhao, W., et al. Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene 23, 395-402 (2004
    • (2004) Oncogene , vol.23 , pp. 395-402
    • Zhao, W.1
  • 45
    • 80053602776 scopus 로고    scopus 로고
    • Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice
    • Garg, P., et al. Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice. Gastroenterology 141, 1381-92 (2011
    • (2011) Gastroenterology , vol.141 , pp. 1381-1392
    • Garg, P.1
  • 46
    • 84958581411 scopus 로고    scopus 로고
    • Inflammation increases notch1 activity via mmp9, and is counteracted by eicosapentaenoic acid-free fatty acid in colon cancer cells
    • Fazio, C., et al. Inflammation increases NOTCH1 activity via MMP9, and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells. Sci. Rep. 6, 20670 (2016
    • (2016) Sci. Rep , vol.6 , pp. 20670
    • Fazio, C.1
  • 47
    • 85015227110 scopus 로고    scopus 로고
    • Inflammation and notch signaling: A crosstalk with opposite effects on tumorigenesis
    • Fazio, C., & Ricciardiello, L. Inflammation, and Notch signaling: a crosstalk with opposite effects on tumorigenesis. Cell Death Dis. 7, e2515 (2016
    • (2016) Cell Death Dis , vol.7 , pp. e2515
    • Fazio, C.1    Ricciardiello, L.2
  • 48
    • 84891736162 scopus 로고    scopus 로고
    • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models, and patients with ulcerative colitis
    • Johansson, M. E. V., et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models, and patients with ulcerative colitis. Gut 63, 281-91 (2014
    • (2014) Gut , vol.63 , pp. 281-291
    • Johansson, M.E.V.1
  • 49
    • 78650834843 scopus 로고    scopus 로고
    • Altered intestinal epithelial homeostasis in mice with intestinespecific deletion of the Krüppel-like factor 4 gene
    • Ghaleb, A. M., McConnell, B. B., Kaestner, K. H., & Yang, V. W. Altered intestinal epithelial homeostasis in mice with intestinespecific deletion of the Krüppel-like factor 4 gene. Dev. Biol. 349, 310-320 (2011
    • (2011) Dev. Biol , vol.349 , pp. 310-320
    • Ghaleb, A.M.1    McConnell, B.B.2    Kaestner, K.H.3    Yang, V.W.4
  • 50
    • 84880653498 scopus 로고    scopus 로고
    • Il-10 promotes production of intestinal mucus by suppressing protein misfolding, and endoplasmic reticulum stress in goblet cells
    • e9
    • Hasnain, S. Z., et al. IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding, and Endoplasmic Reticulum Stress in Goblet Cells. Gastroenterology 144, 357-368.e9 (2013
    • (2013) Gastroenterology , vol.144 , pp. 357-368
    • Hasnain, S.Z.1
  • 52
    • 80054925355 scopus 로고    scopus 로고
    • Eating for two: How metabolism establishes interspecies interactions in the gut
    • Fischbach, M. A., & Sonnenburg, J. L. Eating for two: how metabolism establishes interspecies interactions in the gut. Cell Host Microbe 10, 336-47 (2011
    • (2011) Cell Host Microbe , vol.10 , pp. 336-347
    • Fischbach, M.A.1    Sonnenburg, J.L.2
  • 53
    • 84946544913 scopus 로고    scopus 로고
    • Clinical application of faecal calprotectin in ulcerative colitis patients
    • Scaioli, E., et al. Clinical application of faecal calprotectin in ulcerative colitis patients. Eur. J. Gastroenterol. Hepatol. 27, 1418-24 (2015
    • (2015) Eur. J. Gastroenterol. Hepatol , vol.27 , pp. 1418-1424
    • Scaioli, E.1
  • 54
    • 0023521441 scopus 로고
    • Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis a randomized study
    • Schroeder, K. W., Tremaine, W. J., & Ilstrup, D. M. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N. Engl. J. Med. 317, 1625-9 (1987
    • (1987) N. Engl. J. Med , vol.317 , pp. 1625-1629
    • Schroeder, K.W.1    Tremaine, W.J.2    Ilstrup, D.M.3
  • 55
    • 0033849872 scopus 로고    scopus 로고
    • A reproducible grading scale for histological assessment of inflammation in ulcerative colitis
    • Geboes, K., et al. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut 47, 404-9 (2000
    • (2000) Gut , vol.47 , pp. 404-409
    • Geboes, K.1
  • 56
    • 84929317850 scopus 로고    scopus 로고
    • Low fecal calprotectin predicts sustained clinical remission in inflammatory bowel disease patients: A plea for deep remission
    • Mooiweer, E., et al. Low fecal calprotectin predicts sustained clinical remission in inflammatory bowel disease patients: a plea for deep remission. J. Crohns. Colitis 9, 50-5 (2015
    • (2015) J. Crohns. Colitis , vol.9 , pp. 50-55
    • Mooiweer, E.1
  • 57
    • 22244437297 scopus 로고    scopus 로고
    • The comparative power of the discriminant methods used in toxicological pathology
    • Holland, T. The comparative power of the discriminant methods used in toxicological pathology. Toxicol. Pathol. 33, 490-4 (2005
    • (2005) Toxicol. Pathol , vol.33 , pp. 490-494
    • Holland, T.1
  • 58
    • 84939482062 scopus 로고    scopus 로고
    • The pharmacokinetic profile of a new gastroresistant capsule preparation of eicosapentaenoic acid as the free fatty acid
    • Scaioli, E., et al. The Pharmacokinetic Profile of a New Gastroresistant Capsule Preparation of Eicosapentaenoic Acid as the Free Fatty Acid. Biomed Res. Int. 2015, 1-8 (2015
    • (2015) Biomed Res. Int , vol.2015 , pp. 1-8
    • Scaioli, E.1


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