Reduced colitis-associated colon cancer in fat-1 (n-3 fatty acid desaturase) transgenic mice

Cancer Research

Volumn 68, Issue 10, 2008, Pages 3985-3991

  Jia, Qian ^a   Lupton, Joanne R ^a   Smith, Roger ^b   Weeks, Brad R ^b   Callaway, Evelyn ^a   Davidson, Laurie A ^a   Kim, Wooki ^a   Fan, Yang Yi ^a   Yang, Peiying ^c   Newman, Robert A ^c   Kang, Jing X ^d   McMurray, David N ^a   Chapkin, Robert S ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; CD3 ANTIGEN; CD4 ANTIGEN; DEXTRAN DERIVATIVE; DEXTRAN SODIUM SULFATE; GENE PRODUCT; ICOSANOID; N 3 FATTY ACID DESATURASE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; ACYL COENZYME A DESATURASE; ANTINEOPLASTIC AGENT; PHOSPHOLIPID; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER PREVENTION; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COUNT; COLITIS; COLON ADENOCARCINOMA; COLON CANCER; COLON ULCER; CONTROLLED STUDY; FAT 1 GENE; GENE; INFLAMMATION; LAMINA PROPRIA; LYMPHOID ORGAN; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COLON TUMOR; GENETICS; LYMPHOCYTE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD3; ANTIGENS, CD4; ANTINEOPLASTIC AGENTS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; COLITIS; COLONIC NEOPLASMS; FATTY ACID DESATURASES; FATTY ACIDS, UNSATURATED; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHOLIPIDS;

EID: 45549085184     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6251     Document Type: Article

References (45)

1. Mudter J, Neurath MF. Mucosal T cells: mediators or guardians of inflammatory bowel disease? Curr Opin Gastroenterol 2003;19:343-9.
2. Itzkowitz SH, Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role in inflammation. Am J Physiol 2004;287:G7-17.
3. Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347:417-29.
4. Rubin DT, Kavitt RT. Surveillance for cancer and dysplasia in inflammatory bowel disease. Gastroenterol Clin North Am 2006;35:581-604.
5. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics 2007. CA Cancer J Clin 2007;57:43-66.
6. Stenson WF, Cort D, Rodgers J, et al. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med 1992;116:609-14.
7. Belluzzi A, Boschi S, Brignola C, Munarini A, Cariani G, Miglio F. Polyunsaturated fatty acids and inflammatory bowel disease. Am J Clin Nutr 2000;71:339-42S.
8. Davidson LA, Nguyen DV, Hokanson RM, et al. Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Res 2004;64:6797-804.
9. Prescott SM, Stenson WF. Fish oil fix. Nat Med 2005;11:596-8.
10. Hudert CA, Weylandt KH, Lu Y, et al. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci U S A 2006;103:11276-81.
11. Reddy BS. Chemoprevention of colon cancer by dietary fatty acids. Cancer Metastasis Rev 1994;13:285-302.
12. Anti M, Giancarlo M, Armelao F, et al. Effect of ω-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology 1992;103:883-91.
13. Anti M, Armelao F, Marra G, et al. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology 1994;107:1709-18.
14. Chang WC, Chapkin RS, Lupton JR. Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 1997;18:721-30.
15. Cheng J, Ogawa K, Kuriki K, et al. Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors. Cancer Lett 2003;193:17-24.
16. Whelan J, McEntee MF. Dietary (n-6) PUFA and intestinal tumorigenesis. J Nutr 2004;134:3421-6S.
17. Hong MY, Lupton JR, Morris JS, et al. Dietary fish oil reduces DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation. Cancer Epidemiol Biomarkers Prev 2000;9:819-26.
18. Courtney ED, Mathews S, Finlayson C, et al. Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas. Int J Colorectal Dis 2007;22:765-76.
19. Spector AA. Essentiality of fatty acids. Lipids 1999;34:S1-3.
20. Kang ZB, Ge Y, Che Z, et al. Adenoviral gene transfer of Caenorhabditis elegans n-3 fatty acid desaturase optimizes fatty acid composition in mammalian cells. Proc Natl Acad Sci U S A 2001;98:4050-4.
21. Kang JX, Wang J, Wu L, Kang ZB. Fat-1 mice convert n-6 to n-3 fatty acids. Nature 2004;427:504.
22. Cooper HS, Murthy S, Kido K, Yoshitake H, Flanigan A. Dysplasia and cancer in dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, β-catenin and p53 expression and the role of inflammation. Carcinogenesis 2000;21:757-68.
23. Seril DN, Liao J, Yang GY, Yang CS. Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 2003;24:353-62.
24. Okayasu I, Ohkusa T, Kajiura K, Kanno J, Sakamoto S. Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut 1996;39:87-92.
25. Greten FR, Eckmann L, Greten TF, et al. Ikkβ links inflammation and tumoringenesis in a mouse model of colitis-associated cancer. Cell 2004;118:285-96.
26. Ma DW, Finnell RH, Davidson LA, et al. Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. Cancer Res 2005;65:887-97.
27. Gavriel Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
28. +/-) mouse. Immunology 2005;114:554-64.
29. 2+ accumulation in colonocytes. Am J Physiol Gastrointest Liver Physiol 2007;293:G935-43.
30. Zhang P, Kim W, Zhou RL, et al. Dietary fish oil inhibits antigen-specific Th1 cell development by suppression of clonal expansion. J Nutr 2006;136:2391-8.
31. Yang P, Chan D, Felix E, et al. Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids. Prostaglandins Leukot Essent Fatty Acids 2006;75:385-95.
32. Fan YY, Ly LH, Barhoumi R, McMurray DN, Chapkin RS. Dietary docosahexaenoic acid suppresses T-cell protein kinase C-θ lipid raft recruitment and interleukin-2 production. J Immunol 2004;173:6151-60.
33. Melgar S, Karlsson A., Michaelsson E. Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. Am J Physiol Gastrointest Liver Physiol 2005;288:G1328-38.
34. Buchanan FG, DuBois RN. Connecting Cox-2 and Wnt in cancer. Cancer Cell 2006;9:6-8.
35. Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 2006;3:390-407.
36. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002;20:495-549.
37. Chapkin RS, McMurray DN, Lupton JR. Colon cancer, fatty acids and anti-inflammatory compounds. Curr Opin Gastroenterol 2007;23:48-54.
38. Chapkin RS, Davidson LA, Ly L, Weeks BR, Lupton JR, McMurray DN. Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer. J Nutr 2007;137:200S-4S.
39. Bedi A, Pasricha PJ, Akhtar AJ, et al. Inhibition of apoptosis during development of colorectal cancer. Cancer Res 1995;55:1811-6.
40. Ancrile B, Lim KH, Counter CM. Oncogenic ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev 2007;21:1714-9.
41. Smith WL. Cyclooxygenases, peroxide tone and the allure of fish oil. Curr Opin Cell Biol 2005;17:174-82.
42. Turner D, Zlotkin SH, Shah PS, Griffiths AM. ω3 fatty acids ( fish oil) for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2007;2:1-17.
43. Mudter J, Neurath MF. Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications. Gut 2007;56:293-303.
44. Nowak J, Weylandt KH, Habbel P, et al. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis 2007;28:1991-5.
45. Hegazi RA, Saad RS, Mady H, Matarese LE, O'Keefe S, Kandil HM. Dietary fatty acids modulate chronic colitis, colitis-associated colon neoplasia and COX-2 expression in IL-10 knockout mice. Nutrition 2006;22:275-82.