Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates

Archives of Toxicology

Volumn 92, Issue 1, 2018, Pages 487-500

  Strickland, Jenna D ^a,c   Martin, Matthew T ^b,d   Richard, Ann M ^b   Houck, Keith A ^b   Shafer, Timothy J ^b  

^a AXION BIOSYSTEMS   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d PFIZER INC   (United States)

Author keywords

Microelectrode array; Neurotoxicity screening; ToxCast

Indexed keywords

BICUCULLINE METHIODIDE; BIPHENYL; CHEMICAL COMPOUND; DIMETHYL SULFOXIDE; DRUG; HERBICIDE; LACTATE DEHYDROGENASE; PESTICIDE; PHENOL;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DATA MINING; EVALUATION STUDY; FIRING RATE; IN VITRO STUDY; NERVE CELL NETWORK; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SCREENING; SOFTWARE; STRUCTURE ACTIVITY RELATION; ACTION POTENTIAL; ANIMAL; BRAIN CORTEX; CELL CULTURE TECHNIQUE; CHEMICAL DATABASE; CYTOLOGY; DEVICES; DRUG EFFECT; LONG EVANS RAT; METABOLISM; MICROELECTRODE; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; TOXICITY AND INTOXICATION; TOXICITY TESTING;

ACTION POTENTIALS; ANIMALS; CELL CULTURE TECHNIQUES; CEREBRAL CORTEX; DATA MINING; DATABASES, CHEMICAL; DRUG EVALUATION, PRECLINICAL; L-LACTATE DEHYDROGENASE; MICROELECTRODES; NERVE NET; NEURONS; NEUROTOXICITY SYNDROMES; RATS, LONG-EVANS; TOXICITY TESTS;

EID: 85026505222     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-017-2035-5     Document Type: Article

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