Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes

NeuroToxicology

Volumn 40, Issue , 2014, Pages 75-85

  Mack, Cina M ^a   Lin, Bryant J ^b   Turner, James D ^c   Johnstone, Andrew F M ^a   Burgoon, Lyle D ^a   Shafer, Timothy J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b Durham Technical Community College   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Chemical fingerprinting; In vitro; Neurotoxicity screening

Indexed keywords

BICUCULLINE; CARBARIL; CHLORPYRIFOS; CYCLONITE; DELTAMETHRIN; DOMOIC ACID; FIPRONIL; FLUOXETINE; GLYPHOSATE; LINDANE; MUSCIMOL; NICOTINE; PARACETAMOL; PHTHALIC ACID DIMETHYL ESTER; PICROTOXIN; VERAPAMIL;

ACCURACY; ANIMAL CELL; ARTICLE; BRAIN CELL CULTURE; CONTROLLED STUDY; FEMALE; NERVE CELL NETWORK; NERVE CELL STIMULATION; NERVE POTENTIAL; NEUROTOXICITY; NONHUMAN; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT; SUPPORT VECTOR MACHINE;

CHEMICAL FINGERPRINTING; IN VITRO; NEUROTOXICITY SCREENING;

ACETAMINOPHEN; ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DATA INTERPRETATION, STATISTICAL; FLUOXETINE; GABA ANTAGONISTS; KAINIC ACID; MICROELECTRODES; MUSCIMOL; NERVE NET; NEURONS; NICOTINE; PESTICIDES; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, LONG-EVANS; VERAPAMIL;

EID: 84890847189     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.11.008     Document Type: Article

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