High-Throughput screening of chemical effects on steroidogenesis using H295R human adrenocortical carcinoma cells

Toxicological Sciences

Volumn 150, Issue 2, 2016, Pages 323-332

  Karmaus, Agnes L ^a   Toole, Colleen M ^b   Filer, Dayne L ^a   Lewis, Kenneth C ^c   Martin, Matthew T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b CYPROTEX DISCOVERY LTD   (United Kingdom)

^c OpAns LLC   (United States)

Author keywords

H295R cells; High throughput screening; Steroidogenesis; ToxCast

Indexed keywords

ANDROGEN; CYTOCHROME P450 17; CYTOCHROME P450 17 A1; ENVIRONMENTAL CHEMICAL; ESTRADIOL; ESTROGEN; FORSKOLIN; GESTAGEN; GLUCOCORTICOID; IMIDAZOLE; STEROID HORMONE; TESTOSTERONE; TRIAZOLE; UNCLASSIFIED DRUG; ENDOCRINE DISRUPTOR; HORMONE; STEROID;

ADRENAL CORTEX CARCINOMA; ARTICLE; CARCINOMA CELL; CONCENTRATION RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HORMONE DETERMINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; QUANTITATIVE ANALYSIS; STEROIDOGENESIS; TANDEM MASS SPECTROMETRY; BIOSYNTHESIS; CELL CULTURE TECHNIQUE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; MAXIMUM TOLERATED DOSE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADRENOCORTICAL CARCINOMA; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; HIGH-THROUGHPUT SCREENING ASSAYS; HORMONES; HUMANS; MAXIMUM TOLERATED DOSE; STEROIDS; TANDEM MASS SPECTROMETRY;

EID: 84964755424     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw002     Document Type: Article

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