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Volumn 7, Issue 1, 2017, Pages

Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1;

EID: 85023766140     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-05667-5     Document Type: Article
Times cited : (30)

References (66)
  • 1
    • 33745829699 scopus 로고    scopus 로고
    • Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: A population-based study
    • Bagshaw, S. M. et al. Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study. Crit Care 9, R700-9 (2005).
    • (2005) Crit Care , vol.9 , pp. R700-R709
    • Bagshaw, S.M.1
  • 2
    • 45249111128 scopus 로고    scopus 로고
    • The risk of acute renal failure in patients with chronic kidney disease
    • Hsu, C. Y. et al. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int 74, 101-7 (2008).
    • (2008) Kidney Int , vol.74 , pp. 101-107
    • Hsu, C.Y.1
  • 3
    • 66149168705 scopus 로고    scopus 로고
    • Acute kidney injury predicts outcomes of non-critically ill patients
    • Barrantes, F. et al. Acute kidney injury predicts outcomes of non-critically ill patients. Mayo Clin Proc 84, 410-6 (2009).
    • (2009) Mayo Clin Proc , vol.84 , pp. 410-416
    • Barrantes, F.1
  • 4
    • 33644874086 scopus 로고    scopus 로고
    • Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    • Chertow, G. M., Burdick, E., Honour, M., Bonventre, J. V. & Bates, D. W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 16, 3365-70 (2005).
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3365-3370
    • Chertow, G.M.1    Burdick, E.2    Honour, M.3    Bonventre, J.V.4    Bates, D.W.5
  • 5
    • 4344692876 scopus 로고    scopus 로고
    • Spectrum of acute renal failure in the intensive care unit: The PICARD experience
    • Mehta, R. L. et al. Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66, 1613-21 (2004).
    • (2004) Kidney Int , vol.66 , pp. 1613-1621
    • Mehta, R.L.1
  • 6
    • 0036229529 scopus 로고    scopus 로고
    • Protective effect of insulin on ischemic renal injury in diabetes mellitus
    • Melin, J., Hellberg, O., Larsson, E., Zezina, L. & Fellstrom, B. C. Protective effect of insulin on ischemic renal injury in diabetes mellitus. Kidney Int 61, 1383-92 (2002).
    • (2002) Kidney Int , vol.61 , pp. 1383-1392
    • Melin, J.1    Hellberg, O.2    Larsson, E.3    Zezina, L.4    Fellstrom, B.C.5
  • 7
    • 36049031874 scopus 로고    scopus 로고
    • Delayed recovery of renal regional blood flow in diabetic mice subjected to acute ischemic kidney injury
    • Shi, H., Patschan, D., Epstein, T., Goligorsky, M. S. & Winaver, J. Delayed recovery of renal regional blood flow in diabetic mice subjected to acute ischemic kidney injury. Am J Physiol Renal Physiol 293, F1512-7 (2007).
    • (2007) Am J Physiol Renal Physiol , vol.293 , pp. F1512-F1517
    • Shi, H.1    Patschan, D.2    Epstein, T.3    Goligorsky, M.S.4    Winaver, J.5
  • 8
    • 84920270340 scopus 로고    scopus 로고
    • Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury
    • Peng, J. et al. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int 87, 137-50 (2015).
    • (2015) Kidney Int , vol.87 , pp. 137-150
    • Peng, J.1
  • 9
    • 84964683444 scopus 로고    scopus 로고
    • Autophagy in acute kidney injury
    • Kaushal, G. P. & Shah, S. V. Autophagy in acute kidney injury. Kidney Int 89, 779-91 (2016).
    • (2016) Kidney Int , vol.89 , pp. 779-791
    • Kaushal, G.P.1    Shah, S.V.2
  • 10
    • 84977484264 scopus 로고    scopus 로고
    • Autophagy in kidney disease and aging: Lessons from rodent models
    • Lenoir, O., Tharaux, P. L. & Huber, T. B. Autophagy in kidney disease and aging: lessons from rodent models. Kidney Int 90, 950-964 (2016).
    • (2016) Kidney Int , vol.90 , pp. 950-964
    • Lenoir, O.1    Tharaux, P.L.2    Huber, T.B.3
  • 11
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima, N. & Komatsu, M. Autophagy: renovation of cells and tissues. Cell 147, 728-41 (2011).
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 12
    • 77951169411 scopus 로고    scopus 로고
    • Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
    • Hartleben, B. et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 120, 1084-96 (2010).
    • (2010) J Clin Invest , vol.120 , pp. 1084-1096
    • Hartleben, B.1
  • 13
    • 79955626606 scopus 로고    scopus 로고
    • Autophagy protects the proximal tubule from degeneration and acute ischemic injury
    • Kimura, T. et al. Autophagy protects the proximal tubule from degeneration and acute ischemic injury. J Am Soc Nephrol 22, 902-13 (2011).
    • (2011) J Am Soc Nephrol , vol.22 , pp. 902-913
    • Kimura, T.1
  • 14
    • 84942250072 scopus 로고    scopus 로고
    • Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
    • Lenoir, O. et al. Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy 11, 1130-45 (2015).
    • (2015) Autophagy , vol.11 , pp. 1130-1145
    • Lenoir, O.1
  • 15
    • 84962429971 scopus 로고    scopus 로고
    • Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy
    • Tagawa, A. et al. Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy. Diabetes 65, 755-67 (2016).
    • (2016) Diabetes , vol.65 , pp. 755-767
    • Tagawa, A.1
  • 16
    • 39149113436 scopus 로고    scopus 로고
    • Participation of autophagy in renal ischemia/reperfusion injury
    • Suzuki, C. et al. Participation of autophagy in renal ischemia/reperfusion injury. Biochem Biophys Res Commun 368, 100-6 (2008).
    • (2008) Biochem Biophys Res Commun , vol.368 , pp. 100-106
    • Suzuki, C.1
  • 17
    • 77749264299 scopus 로고    scopus 로고
    • Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury
    • Jiang, M., Liu, K., Luo, J. & Dong, Z. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Am J Pathol 176, 1181-92 (2010).
    • (2010) Am J Pathol , vol.176 , pp. 1181-1192
    • Jiang, M.1    Liu, K.2    Luo, J.3    Dong, Z.4
  • 18
    • 84862635122 scopus 로고    scopus 로고
    • Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury
    • Liu, S. et al. Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy 8, 826-37 (2012).
    • (2012) Autophagy , vol.8 , pp. 826-837
    • Liu, S.1
  • 19
    • 84893494111 scopus 로고    scopus 로고
    • New autophagy reporter mice reveal dynamics of proximal tubular autophagy
    • Li, L., Wang, Z. V., Hill, J. A. & Lin, F. New autophagy reporter mice reveal dynamics of proximal tubular autophagy. J Am Soc Nephrol 25, 305-15 (2014).
    • (2014) J Am Soc Nephrol , vol.25 , pp. 305-315
    • Li, L.1    Wang, Z.V.2    Hill, J.A.3    Lin, F.4
  • 20
    • 84870580153 scopus 로고    scopus 로고
    • Autophagy in proximal tubules protects against acute kidney injury
    • Jiang, M. et al. Autophagy in proximal tubules protects against acute kidney injury. Kidney Int 82, 1271-83 (2012).
    • (2012) Kidney Int , vol.82 , pp. 1271-1283
    • Jiang, M.1
  • 21
    • 78650848689 scopus 로고    scopus 로고
    • The emerging role of autophagy in the pathophysiology of diabetes mellitus
    • Gonzalez, C. D. et al. The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy 7, 2-11 (2011).
    • (2011) Autophagy , vol.7 , pp. 2-11
    • Gonzalez, C.D.1
  • 22
    • 84938791685 scopus 로고    scopus 로고
    • Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats
    • Murase, H. et al. Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats. Cardiovasc Diabetol 14, 103 (2015).
    • (2015) Cardiovasc Diabetol , vol.14 , pp. 103
    • Murase, H.1
  • 23
    • 81555225308 scopus 로고    scopus 로고
    • Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: A model of type 2 diabetes
    • Kitada, M. et al. Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes. Exp Diabetes Res 2011, 908185 (2011).
    • (2011) Exp Diabetes Res , vol.2011 , pp. 908185
    • Kitada, M.1
  • 24
    • 84876117324 scopus 로고    scopus 로고
    • Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury
    • Fang, L. et al. Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One 8, e60546 (2013).
    • (2013) PLoS One , vol.8 , pp. e60546
    • Fang, L.1
  • 25
    • 84939877617 scopus 로고    scopus 로고
    • Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice
    • Xiao, T. et al. Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice. Mol Cell Biochem 394, 145-54 (2014).
    • (2014) Mol Cell Biochem , vol.394 , pp. 145-154
    • Xiao, T.1
  • 26
    • 84887070613 scopus 로고    scopus 로고
    • Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions
    • Yamahara, K. et al. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J Am Soc Nephrol 24, 1769-81 (2013).
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1769-1781
    • Yamahara, K.1
  • 27
    • 0033227045 scopus 로고    scopus 로고
    • Examination of the pathogenesis of diabetic nephropathy in OLETF rats
    • Kawano, K., Mori, S., Hirashima, T., Man, Z. W. & Natori, T. Examination of the pathogenesis of diabetic nephropathy in OLETF rats. J Vet Med Sci 61, 1219-28 (1999).
    • (1999) J Vet Med Sci , vol.61 , pp. 1219-1228
    • Kawano, K.1    Mori, S.2    Hirashima, T.3    Man, Z.W.4    Natori, T.5
  • 28
    • 84875648399 scopus 로고    scopus 로고
    • Renoprotective effect of pioglitazone by the prevention of glomerular hyperfiltration through the possible restoration of altered macula densa signaling in rats with type 2 diabetic nephropathy
    • Asakura, J. et al. Renoprotective effect of pioglitazone by the prevention of glomerular hyperfiltration through the possible restoration of altered macula densa signaling in rats with type 2 diabetic nephropathy. Nephron Exp Nephrol 122, 83-94 (2012).
    • (2012) Nephron Exp Nephrol , vol.122 , pp. 83-94
    • Asakura, J.1
  • 29
    • 78650835776 scopus 로고    scopus 로고
    • Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging
    • Shinmura, K. et al. Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging. J Mol Cell Cardiol 50, 117-27 (2011).
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 117-127
    • Shinmura, K.1
  • 30
    • 84874523611 scopus 로고    scopus 로고
    • Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway
    • Kanamori, H. et al. Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway. Am J Pathol 182, 701-13 (2013).
    • (2013) Am J Pathol , vol.182 , pp. 701-713
    • Kanamori, H.1
  • 31
    • 84899526452 scopus 로고    scopus 로고
    • Restriction of food intake prevents postinfarction heart failure by enhancing autophagy in the surviving cardiomyocytes
    • Watanabe, T. et al. Restriction of food intake prevents postinfarction heart failure by enhancing autophagy in the surviving cardiomyocytes. Am J Pathol 184, 1384-94 (2014).
    • (2014) Am J Pathol , vol.184 , pp. 1384-1394
    • Watanabe, T.1
  • 32
    • 0034789534 scopus 로고    scopus 로고
    • Rapamycin impairs recovery from acute renal failure: Role of cell-cycle arrest and apoptosis of tubular cells
    • Lieberthal, W. et al. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 281, F693-706 (2001).
    • (2001) Am J Physiol Renal Physiol , vol.281 , pp. F693-706
    • Lieberthal, W.1
  • 33
    • 84963543125 scopus 로고    scopus 로고
    • Renoprotective Effects of DNAse-I Treatment in a Rat Model of Ischemia/Reperfusion-Induced Acute Kidney Injury
    • Peer, V., Abu Hamad, R., Berman, S. & Efrati, S. Renoprotective Effects of DNAse-I Treatment in a Rat Model of Ischemia/Reperfusion-Induced Acute Kidney Injury. Am J Nephrol 43, 195-205 (2016).
    • (2016) Am J Nephrol , vol.43 , pp. 195-205
    • Peer, V.1    Abu Hamad, R.2    Berman, S.3    Efrati, S.4
  • 34
    • 85006337587 scopus 로고    scopus 로고
    • MiR-182-5p Inhibition Ameliorates Ischemic Acute Kidney Injury
    • Wilflingseder, J. et al. miR-182-5p Inhibition Ameliorates Ischemic Acute Kidney Injury. Am J Pathol 187, 70-79 (2017).
    • (2017) Am J Pathol , vol.187 , pp. 70-79
    • Wilflingseder, J.1
  • 35
    • 59249105964 scopus 로고    scopus 로고
    • Monitoring autophagic degradation of p62/SQSTM1
    • Bjorkoy, G. et al. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol 452, 181-97 (2009).
    • (2009) Methods Enzymol , vol.452 , pp. 181-197
    • Bjorkoy, G.1
  • 36
    • 36249011527 scopus 로고    scopus 로고
    • Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy
    • Chien, C. T., Shyue, S. K. & Lai, M. K. Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy. Transplantation 84, 1183-90 (2007).
    • (2007) Transplantation , vol.84 , pp. 1183-1190
    • Chien, C.T.1    Shyue, S.K.2    Lai, M.K.3
  • 37
    • 84877344747 scopus 로고    scopus 로고
    • Immunohistochemical analysis of macroautophagy: Recommendations and limitations
    • Martinet, W., Schrijvers, D. M., Timmermans, J. P., Bult, H. & De Meyer, G. R. Immunohistochemical analysis of macroautophagy: recommendations and limitations. Autophagy 9, 386-402 (2013).
    • (2013) Autophagy , vol.9 , pp. 386-402
    • Martinet, W.1    Schrijvers, D.M.2    Timmermans, J.P.3    Bult, H.4    De Meyer, G.R.5
  • 38
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan, D. F. et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331, 456-61 (2011).
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1
  • 39
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim, J., Kundu, M., Viollet, B. & Guan, K. L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13, 132-41 (2011).
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 40
    • 26844574330 scopus 로고    scopus 로고
    • Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177
    • Mount, P. F. et al. Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177. Am J Physiol Renal Physiol 289, F1103-15 (2005).
    • (2005) Am J Physiol Renal Physiol , vol.289 , pp. F1103-F1115
    • Mount, P.F.1
  • 41
    • 55549096745 scopus 로고    scopus 로고
    • SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
    • Lan, F., Cacicedo, J. M., Ruderman, N. & Ido, Y. C. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 283, 27628-35 (2008).
    • (2008) J Biol Chem , vol.283 , pp. 27628-27635
    • Lan, F.1    Cacicedo, J.M.2    Ruderman, N.3    Ido, Y.C.4
  • 42
    • 84887415137 scopus 로고    scopus 로고
    • Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
    • Hasegawa, K. et al. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med 19, 1496-503 (2013).
    • (2013) Nat Med , vol.19 , pp. 1496-1503
    • Hasegawa, K.1
  • 43
    • 82755172456 scopus 로고    scopus 로고
    • Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia
    • Seo-Mayer, P. W. et al. Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia. Am J Physiol Renal Physiol 301, F1346-57 (2011).
    • (2011) Am J Physiol Renal Physiol , vol.301 , pp. F1346-F1357
    • Seo-Mayer, P.W.1
  • 44
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki, K., Zhu, T. & Guan, K. L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-90 (2003).
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 45
    • 79551601710 scopus 로고    scopus 로고
    • Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
    • Kitada, M., Kume, S., Imaizumi, N. & Koya, D. Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway. Diabetes 60, 634-43 (2011).
    • (2011) Diabetes , vol.60 , pp. 634-643
    • Kitada, M.1    Kume, S.2    Imaizumi, N.3    Koya, D.4
  • 46
    • 33846854690 scopus 로고    scopus 로고
    • A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy
    • Lee, M. J. et al. A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol 292, F617-27 (2007).
    • (2007) Am J Physiol Renal Physiol , vol.292 , pp. F617-F627
    • Lee, M.J.1
  • 47
    • 33646828975 scopus 로고    scopus 로고
    • Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
    • Horman, S. et al. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem 281, 5335-40 (2006).
    • (2006) J Biol Chem , vol.281 , pp. 5335-5340
    • Horman, S.1
  • 48
    • 84893513477 scopus 로고    scopus 로고
    • Met activation is required for early cytoprotection after ischemic kidney injury
    • Mason, S., Hader, C., Marlier, A., Moeckel, G. & Cantley, L. G. Met activation is required for early cytoprotection after ischemic kidney injury. J Am Soc Nephrol 25, 329-37 (2014).
    • (2014) J Am Soc Nephrol , vol.25 , pp. 329-337
    • Mason, S.1    Hader, C.2    Marlier, A.3    Moeckel, G.4    Cantley, L.G.5
  • 49
    • 84934435476 scopus 로고    scopus 로고
    • Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy
    • Cheng, H., Fan, X., Lawson, W. E., Paueksakon, P. & Harris, R. C. Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy. Kidney Int 88, 85-94 (2015).
    • (2015) Kidney Int , vol.88 , pp. 85-94
    • Cheng, H.1    Fan, X.2    Lawson, W.E.3    Paueksakon, P.4    Harris, R.C.5
  • 50
    • 23944491271 scopus 로고    scopus 로고
    • Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
    • Chen, J. K., Chen, J., Neilson, E. G. & Harris, R. C. Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol 16, 1384-91 (2005).
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1384-1391
    • Chen, J.K.1    Chen, J.2    Neilson, E.G.3    Harris, R.C.4
  • 51
    • 84903957218 scopus 로고    scopus 로고
    • MTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress
    • Grahammer, F. et al. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci USA 111, E2817-26 (2014).
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E2817-E2826
    • Grahammer, F.1
  • 52
    • 0032991434 scopus 로고    scopus 로고
    • Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability
    • Kramer, A. A. et al. Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int 55, 2362-7 (1999).
    • (1999) Kidney Int , vol.55 , pp. 2362-2367
    • Kramer, A.A.1
  • 53
    • 68049109462 scopus 로고    scopus 로고
    • Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats
    • Choi, D. E. et al. Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats. Am J Physiol Renal Physiol 297, F362-70 (2009).
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F362-F370
    • Choi, D.E.1
  • 54
    • 68049136123 scopus 로고    scopus 로고
    • SiRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury
    • Molitoris, B. A. et al. siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury. J Am Soc Nephrol 20, 1754-64 (2009).
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1754-1764
    • Molitoris, B.A.1
  • 55
    • 84922873973 scopus 로고    scopus 로고
    • Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury
    • Ying, Y., Kim, J., Westphal, S. N., Long, K. E. & Padanilam, B. J. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. J Am Soc Nephrol 25, 2707-16 (2014).
    • (2014) J Am Soc Nephrol , vol.25 , pp. 2707-2716
    • Ying, Y.1    Kim, J.2    Westphal, S.N.3    Long, K.E.4    Padanilam, B.J.5
  • 56
    • 84887471307 scopus 로고    scopus 로고
    • Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress
    • Kimura, T. et al. Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress. Autophagy 9, 1876-86 (2013).
    • (2013) Autophagy , vol.9 , pp. 1876-1886
    • Kimura, T.1
  • 57
    • 36649004040 scopus 로고    scopus 로고
    • The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney
    • Plotnikov, E. Y. et al. The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney. Kidney Int 72, 1493-502 (2007).
    • (2007) Kidney Int , vol.72 , pp. 1493-1502
    • Plotnikov, E.Y.1
  • 58
    • 84922952894 scopus 로고    scopus 로고
    • Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers
    • Decleves, A. E., Sharma, K. & Satriano, J. Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers. Nephron Exp Nephrol (2014).
    • (2014) Nephron Exp Nephrol
    • Decleves, A.E.1    Sharma, K.2    Satriano, J.3
  • 59
    • 77954599053 scopus 로고    scopus 로고
    • P62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    • Jain, A. et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 285, 22576-91 (2010).
    • (2010) J Biol Chem , vol.285 , pp. 22576-22591
    • Jain, A.1
  • 60
    • 67651124846 scopus 로고    scopus 로고
    • Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice
    • Liu, M. et al. Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int 76, 277-85 (2009).
    • (2009) Kidney Int , vol.76 , pp. 277-285
    • Liu, M.1
  • 61
    • 84891533000 scopus 로고    scopus 로고
    • Increased protein aggregation in Zucker diabetic fatty rat brain: Identification of key mechanistic targets and the therapeutic application of hydrogen sulfide
    • Talaei, F. et al. Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide. BMC Cell Biol 15, 1 (2014).
    • (2014) BMC Cell Biol , vol.15 , pp. 1
    • Talaei, F.1
  • 62
    • 85017181827 scopus 로고    scopus 로고
    • Liraglutide relieves myocardial damage by promoting autophagy via AMPK-mTOR signaling pathway in zucker diabetic fatty rat
    • Zhang, Y. et al. Liraglutide relieves myocardial damage by promoting autophagy via AMPK-mTOR signaling pathway in zucker diabetic fatty rat. Mol Cell Endocrinol 448, 98-107 (2017).
    • (2017) Mol Cell Endocrinol , vol.448 , pp. 98-107
    • Zhang, Y.1
  • 63
    • 84927142810 scopus 로고    scopus 로고
    • Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis
    • Nepal, S. et al. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis. Oncotarget 6, 7166-81 (2015).
    • (2015) Oncotarget , vol.6 , pp. 7166-7181
    • Nepal, S.1
  • 64
    • 84908259384 scopus 로고    scopus 로고
    • Leptin modulates autophagy in human CD4 + CD25-conventional T cells
    • Cassano, S. et al. Leptin modulates autophagy in human CD4 + CD25-conventional T cells. Metabolism 63, 1272-9 (2014).
    • (2014) Metabolism , vol.63 , pp. 1272-1279
    • Cassano, S.1
  • 65
    • 80052421842 scopus 로고    scopus 로고
    • Neuroendocrine regulation of autophagy by leptin
    • Malik, S. A. et al. Neuroendocrine regulation of autophagy by leptin. Cell Cycle 10, 2917-23 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 2917-2923
    • Malik, S.A.1
  • 66
    • 84959158349 scopus 로고    scopus 로고
    • Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling
    • Fetterman, J. L. et al. Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis 247, 207-17 (2016).
    • (2016) Atherosclerosis , vol.247 , pp. 207-217
    • Fetterman, J.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.