Met activation is required for early cytoprotection after ischemic kidney injury

Journal of the American Society of Nephrology

Volumn 25, Issue 2, 2014, Pages 329-337

  Mason, Sherene ^a   Hader, Carlos ^b   Marlier, Arnaud ^b   Moeckel, Gilbert ^c   Cantley, Lloyd G ^b  

^a Section of Nephrology   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c School of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN KINASE B; S6 KINASE; SCATTER FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE DELETION; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ACUTE KIDNEY INJURY; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; GENE KNOCKDOWN TECHNIQUES; KIDNEY; KIDNEY TUBULES, PROXIMAL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SPECIFICITY; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR PROTEIN-TYROSINE KINASES; REPERFUSION INJURY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION;

EID: 84893513477     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013050473     Document Type: Article

References (45)

1. Brezis M, Rosen S: Hypoxia of the renal medulla-its implications for disease. N Engl J Med 332:647-655, 1995
2. Brezis M, Shanley P, Silva P, Spokes K, Lear S, Epstein FH, Rosen S: Disparate mechanisms for hypoxic cell injury in different nephron segments. Studies in the isolated perfused rat kidney. J Clin Invest 76:1796-1806, 1985
3. Chou SY, Porush JG, Faubert PF: Renal medullary circulation: Hormonal control. Kidney Int 37:1-13, 1990
4. Bonventre JV: Mechanisms of ischemic acute renal failure. Kidney Int 43:1160-1178, 1993
5. Havasi A, Borkan SC: Apoptosis and acute kidney injury. Kidney Int 80:29-40, 2011
6. Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 121:4210-4221, 2011
7. Devarajan P: Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 17:1503-1520, 2006
8. Mizuno S, Nakamura T: Prevention of neutrophil extravasation by hepatocyte growth factor leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys. Am J Pathol 166:1895-1905, 2005
9. Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG: Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 22:317-326, 2011
10. Guo JK, Cantley LG: Cellular maintenance and repair of the kidney. Annu Rev Physiol 72:357-376, 2010
11. Cantley LG, Barros EJ, Gandhi M, Rauchman M, Nigam SK: Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells. Am J Physiol 267:F271-F280, 1994
12. Cantley LG, Cantley LC: Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase. J Am Soc Nephrol 5:1872-1881, 1995
13. Liu ZX, Nickel CH, Cantley LG: HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. Am J Physiol Renal Physiol 281:F62-F70, 2001
14. Matsumoto K, Nakamura T: Emerging multipotent aspects of hepatocyte growth factor. J Biochem 119:591-600, 1996
15. Joannidis M, Spokes K, Nakamura T, Faletto D, Cantley LG: Regional expression of hepatocyte growth factor/c-met in experimental renal hypertrophy and hyperplasia. Am J Physiol 267:F231-F236, 1994
16. Ishibashi K, Sasaki S, Sakamoto H, Hoshino Y, Nakamura T, Marumo F: Expressions of receptor gene for hepatocyte growth factor in kidney after unilateral nephrectomy and renal injury. Biochem Biophys Res Commun 187:1454-1459, 1992
17. Kawaida K, Matsumoto K, Shimazu H, Nakamura T: Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice. Proc Natl Acad Sci U S A 91:4357-4361, 1994
18. Rabkin R, Fervenza F, Tsao T, Sibley R, Friedlaender M, Hsu F, Lassman C, Hausmann M, Huie P, Schwall RH: Hepatocyte growth factor receptor in acute tubular necrosis. J Am Soc Nephrol 12:531-540, 2001
19. Liu Y, Sun AM, Dworkin LD: Hepatocyte growth factor protects renal epithelial cells from apoptotic cell death. Biochem Biophys Res Commun 246:821-826, 1998
20. Mizuno S, Matsumoto K, Nakamura T: Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int 59:1304-1314, 2001
21. Yo Y, Morishita R, Nakamura S, Tomita N, Yamamoto K, Moriguchi A, Matsumoto K, Nakamura T, Higaki J, Ogihara T: Potential role of hepatocyte growth factor in the maintenance of renal structure: Antiapoptotic action of HGF on epithelial cells. Kidney Int 54:1128-1138, 1998
22. Fiaschi-Taesch NM, Santos S, Reddy V, Van Why SK, Philbrick WF, Ortega A, Esbrit P, Orloff JJ, Garcia-Ocaña A: Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: The efficacy of parathyroid hormone-related protein and hepatocyte growth factor. J Am Soc Nephrol 15:112-125, 2004
23. Dai C, Yang J, Liu Y: Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice. J Am Soc Nephrol 13:411-422, 2002
24. Borowiak M, Garratt AN, Wüstefeld T, Strehle M, Trautwein C, Birchmeier C: Metprovidesessential signalsforliver regeneration. Proc Natl Acad Sci U S A 101:10608-10613, 2004
25. Huh CG, Factor VM, Sánchez A, Uchida K, Conner EA, Thorgeirsson SS: Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 101:4477-4482, 2004
26. Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG, Ishibe S: Deletion of the Metreceptor inthe collecting duct decreases renal repair following ureteral obstruction. Kidney Int 76:868-876, 2009
27. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110:341-350, 2002
28. Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W: Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol 149:1419-1432, 2000
29. Cantley LC: The phosphoinositide 3-kinase pathway. Science 296:1655-1657, 2002
30. Kiley SC, Thornhill BA, Tang SS, Ingelfinger JR, Chevalier RL: Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. Kidney Int 63:33-42, 2003
31. Korsmeyer SJ: BCL-2 gene family and the regulation of programmed cell death. Cancer Res 59 [Suppl]: 1693s-1700s, 1999
32. Liu Y: Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms. Am J Physiol 277:F624-F633, 1999
33. Ishibe S, Karihaloo A, Ma H, Zhang J, Marlier A, Mitobe M, Togawa A, Schmitt R, Czyczk J, Kashgarian M, Geller DS, Thorgeirsson SS, Cantley LG: Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 136:337-345, 2009
34. Schumer M, Colombel MC, Sawczuk IS, Gobé G, Connor J, O'Toole KM, Olsson CA, Wise GJ, Buttyan R: Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol 140:831-838, 1992
35. Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S: The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int 73:430-445, 2008
36. Xie L, Zheng X, Qin J, Chen Z, Jin Y, Ding W: Role of PI3-kinase/Akt signalling pathway in renal function and cell proliferation after renal ischaemia/reperfusion injury in mice. Nephrology (Carlton) 11:207-212, 2006
37. Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR: Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A 98:247-252, 2001
38. Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J: PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370:71-75, 1994
39. Lieberthal W, Fuhro R, Andry CC, Rennke H, Abernathy VE, Koh JS, Valeri R, Levine JS: Rapamycin impairs recoveryfrom acuterenal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 281:F693-F706, 2001
40. Weng QP, Andrabi K, Klippel A, Kozlowski MT, Williams LT, Avruch J: Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci U S A 92:5744-5748, 1995
41. Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH: G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol 287:C281-C291, 2004
42. Pallet N, Thervet E, Le Corre D, Knebelmann B, Nusbaum P, Tomkiewicz C, Meria P, Flinois JP, Beaune P, Legendre C, Anglicheau D: Rapamycin inhibits human renal epithelial cell proliferation: Effect on cyclin D3 mRNA expression and stability. Kidney Int 67:2422-2433, 2005
43. Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 124:471-484, 2006
44. Schmitt R, Marlier A, Cantley LG: Zag expression during aging suppresses proliferation after kidney injury. J Am Soc Nephrol 19:2375-2383, 2008
45. Chen J, Chen JK, Harris RC: Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Kidney Int 82:45-52, 2012