Inhibition of P-TEFb (CDK9/cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

Molecular Cell

Volumn 12, Issue 4, 2003, Pages 971-982

  Yik, Jasper H N ^a   Chen, Ruichuan ^a   Nishimura, Rieko ^a   Jennings, Jennifer L ^b   Link, Andrew J ^b   Zhou, Qiang ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN T1; HEXAMETHYLENEBISACETAMIDE; SYNAPSIN I; TRANSCRIPTION FACTOR;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL STIMULATION; CONTROLLED STUDY; DISSOCIATION; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRUS INHIBITION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0242361319     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00388-5     Document Type: Article

References (34)

1. Brummelkamp T.R., Bernards R., Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:2002;550-553.
2. Casse C., Giannoni F., Nguyen V.T., Dubois M.-F., Bensaude O. The transcriptional inhibitors, actinomycin D and alpha-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain. J. Biol. Chem. 274:1999;16097-16106.
3. Chao S.-H., Price D.H. Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. J. Biol. Chem. 276:2001;31793-31799.
4. Chen D., Fong Y., Zhou Q. Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription. Proc. Natl. Acad. Sci. USA. 96:1999;2728-2733.
5. Dahmus M.E. Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271:1996;19009-19012.
6. Fong Y.W., Zhou Q. Stimulatory effect of splicing factors on transcriptional elongation. Nature. 414:2001;929-933.
7. Ghatpande S., Goswami S., Mathew S., Rong G., Cai L., Shafiq S., Siddiqui M.A. Identification of a novel cardiac lineage-associated protein (cCLP-1). a candidate regulator of cardiogenesis Dev. Biol. 208:1999;210-221.
8. Harper J.W. Cyclin dependent kinase inhibitors. Cancer Surv. 29:1997;91-107.
9. Huang F., Wagner M., Siddiqui M.A. Structure, expression, and functional characterization of the mouse CLP-1 gene. Gene. 292:2002;245-259.
10. Komarnitsky P., Cho E.J., Buratowski S. Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev. 14:2000;2452-2460.
11. Liou L.Y., Herrmann C.H., Rice A.P. Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function. J. Virol. 76:2002;10579-10587.
12. Marks P.A., Richon V.M., Rifkind R.A. Cell cycle regulatory proteins are targets for induced differentiation of transformed cells. molecular and clinical studies employing hybrid polar compounds Int. J. Hematol. 63:1996;1-17.
13. Michels A.A., Nguyen V.T., Fraldi A., Labas V., Edwards M., Bonnet F., Lania L., Bensaude O. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. Mol. Cell. Biol. 23:2003;4859-4869.
14. Murphy S., Di Liegro C., Melli M. The in vitro transcription of the 7SK RNA gene by RNA polymerase III is dependent only on the presence of an upstream promoter. Cell. 51:1987;81-87.
15. Nguyen V.T., Kiss T., Michels A.A., Bensaude O. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature. 414:2001;322-325.
16. Ouchida R., Kusuhara M., Shimizu N., Hisada T., Makino Y., Morimoto C., Handa H., Ohsuzu F., Tanaka H. Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells. 8:2003;95-107.
17. Peng J., Zhu Y., Milton J.T., Price D.H. Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 12:1998;755-762.
18. Price D.H. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol. Cell. Biol. 20:2000;2629-2634.
19. Riedl T., Egly J.M. Phosphorylation in transcription. the CTD and more Gene Expr. 9:2000;3-13.
20. Russo A.A., Tong L., Lee J.O., Jeffrey P.D., Pavletich N.P. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature. 395:1998;237-243.
21. Sanders S.L., Jennings J., Canutescu A., Link A.J., Weil P.A. Proteomics of the eukaryotic transcription machinery. identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry Mol. Cell. Biol. 22:2002;4723-4738.
22. Sano M., Abdellatif M., Oh H., Xie M., Bagella L., Giordano A., Michael L.H., DeMayo F.J., Schneider M.D. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat. Med. 8:2002;1310-1317.
23. Schroeder S.C., Schwer B., Shuman S., Bentley D. Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes Dev. 14:2000;2435-2440.
24. Shim E.Y., Walker A.K., Shi Y., Blackwell T.K. CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev. 16:2002;2135-2146.
25. Valerie K., Delers A., Bruck C., Thiriart C., Rosenberg H., Debouck C., Rosenberg M. Activation of human immunodeficiency virus type 1 by DNA damage in human cells. Nature. 333:1988;78-81.
26. Wada T., Takagi T., Yamaguchi Y., Watanabe D., Handa H. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J. 17:1998;7395-7403.
27. Wei P., Garber M.E., Fang S.M., Fischer W.H., Jones K.A. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell. 92:1998;451-462.
28. Yamaguchi Y., Takagi T., Wada T., Yano K., Furuya A., Sugimoto S., Hasegawa J., Handa H. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell. 97:1999;41-51.
29. Yang X., Gold M.O., Tang D.N., Lewis D.E., Aguilar-Cordova E., Rice A.P., Herrmann C.H. TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. Proc. Natl. Acad. Sci. USA. 94:1997;12331-12336.
30. Yang Z., Zhu Q., Luo K., Zhou Q. The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature. 414:2001;317-322.
31. Zhou Q., Sharp P.A. Novel mechanism and factor for regulation by HIV-1 Tat. EMBO J. 14:1995;321-328.
32. Zhou Q., Chen D., Pierstorff E., Luo K. Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages. EMBO J. 17:1998;3681-3691.
33. Zhu Y., Pe'ery T., Peng J., Ramanathan Y., Marshall N., Marshall T., Amendt B., Mathews M.B., Price D.H. Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev. 11:1997;2622-2632.
34. Zieve G., Benecke B.J., Penman S. Synthesis of two classes of small RNA species in vivo and in vitro. Biochem. 16:1977;4520-4525.