Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

EMBO Journal

Volumn 23, Issue 13, 2004, Pages 2608-2619

  Michels, Annemieke A ^a   Fraldi, Alessandro ^b   Li, Qintong ^c   Adamson, Todd E ^c   Bonnet, François ^a   Nguyen, Van Trung ^a   Sedore, Stanley C ^c   Price, Jason P ^c   Price, David H ^c   Lania, Luigi ^b   Bensaude, Olivier ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

HEXIM1; MAQ1; P TEFb; RNA polymerase II; Transcription

Indexed keywords

CYCLIN DEPENDENT KINASE 9; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PROTEIN HEXIM1; RNA BINDING PROTEIN; SMALL NUCLEAR RNA; TRANSCRIPTION ELONGATION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CHROMATIN; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CYCLIN-DEPENDENT KINASE 9; CYCLINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ESCHERICHIA COLI; GLUTATHIONE TRANSFERASE; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA, SMALL NUCLEAR; RNA-BINDING PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 3342967685     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600275     Document Type: Article

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