One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

Cell Research

Volumn 27, Issue 7, 2017, Pages 933-945

  Zuo, Erwei ^a   Cai, Yi Jun ^a   Li, Kui ^a   Wei, Yu ^a,b,c   Wang, Bang An ^b   Sun, Yidi ^e   Liu, Zhen ^a,g   Liu, Jiwei ^a   Hu, Xinde ^a   Wei, Wei ^a,d   Huo, Xiaona ^a   Shi, Linyu ^a,f   Tang, Cheng ^a,g   Liang, Dan ^b   Wang, Yan ^a   Nie, Yan Hong ^a   Zhang, Chen Chen ^a   Yao, Xuan ^a,g   Wang, Xing ^a,g   Zhou, Changyang ^a,g   Ying, Wenqin ^a   Wang, Qifang ^a   Chen, Ren Chao ^a   Shen, Qi ^a   Xu, Guo Liang ^b   Li, Jinsong ^b   Sun, Qiang ^a   Xiong, Zhi Qi ^a   Yang, Hui ^a   more..

^a Shenzhen Fundamental Research Institutions   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c SHANGHAI UNIVERSITY   (China)

^d GUANGXI UNIVERSITY   (China)

^e Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^f SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^g INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARNTL PROTEIN, MOUSE; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; ENDONUCLEASE; GUIDE RNA; MEMBRANE PROTEIN; MESSENGER RNA; PRRT2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR ARNTL;

ANIMAL; C57BL MOUSE; CRISPR CAS SYSTEM; CYTOLOGY; EMBRYOLOGY; EXON; GENE EDITING; GENE KNOCKOUT; GENETICS; HAPLORHINI; KNOCKOUT MOUSE; MAMMALIAN EMBRYO; MOSAICISM; MOUSE; OOCYTE RETRIEVAL; PHENOTYPE; PROCEDURES; WHOLE GENOME SEQUENCING; Y CHROMOSOME; ZYGOTE;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; BACTERIAL PROTEINS; CRISPR-CAS SYSTEMS; EMBRYO, MAMMALIAN; ENDONUCLEASES; EXONS; GENE EDITING; GENE KNOCKOUT TECHNIQUES; HAPLORHINI; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOSAICISM; OOCYTE RETRIEVAL; PHENOTYPE; RNA, GUIDE; RNA, MESSENGER; WHOLE GENOME SEQUENCING; Y CHROMOSOME; ZYGOTE;

EID: 85021819967     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2017.81     Document Type: Article

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