Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1

Cellular and Molecular Life Sciences

Volumn 74, Issue 22, 2017, Pages 4209-4229

  Geithe, Christiane ^a   Protze, Jonas ^b   Kreuchwig, Franziska ^b,c   Krause, Gerd ^b   Krautwurst, Dietmar ^a  

^a DEUTSCHE FORSCHUNGSANSTALT FÜR LEBENSMITTELCHEMIE   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

GPCR; Molecular modeling; Ortholog; Site directed mutagenesis; Structure function study

Indexed keywords

CARVONE; OR1A1 RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG; OLFACTORY RECEPTOR; OR1A1 PROTEIN, HUMAN; OR1A2 PROTEIN, HUMAN; TERPENE;

ANOSMIA; ARTICLE; BINDING SITE; CARAWAY; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENANTIOSELECTIVITY; HEK293 CELL LINE; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MOLECULAR CLONING; MOLECULAR DOCKING; MUTAGENESIS; ORTHOLOGY; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BOVINE; CHEMISTRY; CLASSIFICATION; DNA SEQUENCE; GENETICS; METABOLISM; MOUSE; OLFACTORY RECEPTOR; PHYLOGENY; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATTLE; CLONING, MOLECULAR; HEK293 CELLS; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; MONOTERPENES; MUTAGENESIS, SITE-DIRECTED; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ODORANT; SEQUENCE ANALYSIS, DNA; STEREOISOMERISM;

EID: 85021288676     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-017-2576-z     Document Type: Article

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