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Volumn 23, Issue 7, 2017, Pages 636-650

Exosomes as Reconfigurable Therapeutic Systems

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; DOXORUBICIN; NANOPARTICLE; POLYMER; RECOMBINANT INTERLEUKIN 10; DRUG CARRIER;

EID: 85021094586     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2017.05.003     Document Type: Review
Times cited : (177)

References (100)
  • 1
    • 84971298295 scopus 로고    scopus 로고
    • From structures to functions: insights into exosomes as promising drug delivery vehicles
    • Ren, J., et al. From structures to functions: insights into exosomes as promising drug delivery vehicles. Biomater. Sci. 4 (2016), 910–921.
    • (2016) Biomater. Sci. , vol.4 , pp. 910-921
    • Ren, J.1
  • 2
    • 84922762082 scopus 로고    scopus 로고
    • Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy
    • Kourembanas, S., Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu. Rev. Physiol. 77 (2015), 13–27.
    • (2015) Annu. Rev. Physiol. , vol.77 , pp. 13-27
    • Kourembanas, S.1
  • 3
    • 84886738545 scopus 로고    scopus 로고
    • Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies
    • Record, M., et al. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim. Biophys. Acta 1841 (2014), 108–120.
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 108-120
    • Record, M.1
  • 4
    • 84937238964 scopus 로고    scopus 로고
    • Proteomics profiling of cholangiocarcinoma exosomes: a potential role of oncogenic protein transferring in cancer progression
    • Dutta, S., et al. Proteomics profiling of cholangiocarcinoma exosomes: a potential role of oncogenic protein transferring in cancer progression. Biochim. Biophys. Acta 1852 (2015), 1989–1999.
    • (2015) Biochim. Biophys. Acta , vol.1852 , pp. 1989-1999
    • Dutta, S.1
  • 5
    • 84911390789 scopus 로고    scopus 로고
    • Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways
    • Ung, T.H., et al. Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways. Cancer Sci. 105 (2014), 1384–1392.
    • (2014) Cancer Sci. , vol.105 , pp. 1384-1392
    • Ung, T.H.1
  • 6
    • 84867369513 scopus 로고    scopus 로고
    • MicroRNAs are exported from malignant cells in customized particles
    • Palma, J., et al. MicroRNAs are exported from malignant cells in customized particles. Nucleic Acids Res. 40 (2012), 9125–9138.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 9125-9138
    • Palma, J.1
  • 7
    • 84959513695 scopus 로고    scopus 로고
    • Cells release subpopulations of exosomes with distinct molecular and biological properties
    • Willms, E., et al. Cells release subpopulations of exosomes with distinct molecular and biological properties. Sci. Rep., 6, 2016, 22519.
    • (2016) Sci. Rep. , vol.6 , pp. 22519
    • Willms, E.1
  • 8
    • 24644485206 scopus 로고    scopus 로고
    • Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
    • Segura, E., et al. Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol. Dis. 35 (2005), 89–93.
    • (2005) Blood Cells Mol. Dis. , vol.35 , pp. 89-93
    • Segura, E.1
  • 9
    • 84924364810 scopus 로고    scopus 로고
    • Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning
    • Kilpinen, L., et al. Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning. J. Extracell. Vesicles 2 (2013), 1–15.
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 1-15
    • Kilpinen, L.1
  • 10
    • 85013156831 scopus 로고    scopus 로고
    • Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
    • de Jong, O.G., et al. Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. J. Extracell. Vesicles 1 (2012), 1–12.
    • (2012) J. Extracell. Vesicles , vol.1 , pp. 1-12
    • de Jong, O.G.1
  • 11
    • 84876927914 scopus 로고    scopus 로고
    • Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
    • Kucharzewska, P., et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 7312–7317.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 7312-7317
    • Kucharzewska, P.1
  • 12
    • 84935026792 scopus 로고    scopus 로고
    • Exosome delivered anticancer drugs across the blood–brain barrier for brain cancer therapy in Danio rerio
    • Yang, T., et al. Exosome delivered anticancer drugs across the blood–brain barrier for brain cancer therapy in Danio rerio. Pharm. Res. 32 (2015), 2003–2014.
    • (2015) Pharm. Res. , vol.32 , pp. 2003-2014
    • Yang, T.1
  • 13
    • 70349542520 scopus 로고    scopus 로고
    • Nanoparticles evading the reticuloendothelial system: role of the supported bilayer
    • Li, S.-D., Huang, L., Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. Biochim. Biophys. Acta 1788 (2009), 2259–2266.
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 2259-2266
    • Li, S.-D.1    Huang, L.2
  • 14
    • 84940956193 scopus 로고    scopus 로고
    • Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity
    • Maeda, H., Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity. Adv. Drug Deliv. Rev. 91 (2015), 3–6.
    • (2015) Adv. Drug Deliv. Rev. , vol.91 , pp. 3-6
    • Maeda, H.1
  • 15
    • 84880641214 scopus 로고    scopus 로고
    • Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles
    • Ayala, V., et al. Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles. J. Nanopart. Res., 15, 2013, 1874.
    • (2013) J. Nanopart. Res. , vol.15 , pp. 1874
    • Ayala, V.1
  • 16
    • 79952008706 scopus 로고    scopus 로고
    • The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles
    • Xiao, K., et al. The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials 32 (2011), 3435–3446.
    • (2011) Biomaterials , vol.32 , pp. 3435-3446
    • Xiao, K.1
  • 17
    • 84930413971 scopus 로고    scopus 로고
    • A TRP channel senses lysosome neutralization by pathogens to trigger their expulsion
    • Miao, Y., et al. A TRP channel senses lysosome neutralization by pathogens to trigger their expulsion. Cell 161 (2015), 1306–1319.
    • (2015) Cell , vol.161 , pp. 1306-1319
    • Miao, Y.1
  • 18
    • 84947431830 scopus 로고    scopus 로고
    • Exosome secretion by the parasitic protozoan Leishmania within the sand fly midgut
    • Atayde, V.D., et al. Exosome secretion by the parasitic protozoan Leishmania within the sand fly midgut. Cell Rep. 13 (2015), 957–967.
    • (2015) Cell Rep. , vol.13 , pp. 957-967
    • Atayde, V.D.1
  • 19
    • 84916633753 scopus 로고    scopus 로고
    • Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions
    • Srikanthan, S., et al. Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions. J. Thromb. Haemost. 12 (2014), 1906–1917.
    • (2014) J. Thromb. Haemost. , vol.12 , pp. 1906-1917
    • Srikanthan, S.1
  • 20
    • 84870239895 scopus 로고    scopus 로고
    • Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
    • Lee, C., et al. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 126 (2012), 2601–2611.
    • (2012) Circulation , vol.126 , pp. 2601-2611
    • Lee, C.1
  • 21
    • 84879976839 scopus 로고    scopus 로고
    • Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis
    • Salomon, C., et al. Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. PLoS One, 8, 2013, e68451.
    • (2013) PLoS One , vol.8 , pp. e68451
    • Salomon, C.1
  • 22
    • 84929649938 scopus 로고    scopus 로고
    • Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction
    • Kang, K., et al. Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction. Stem Cells Int., 2015, 2015, 659890.
    • (2015) Stem Cells Int. , vol.2015 , pp. 659890
    • Kang, K.1
  • 23
    • 84987643662 scopus 로고    scopus 로고
    • Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts
    • Hu, L., et al. Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci. Rep., 6, 2016, 32993.
    • (2016) Sci. Rep. , vol.6 , pp. 32993
    • Hu, L.1
  • 24
    • 84936766922 scopus 로고    scopus 로고
    • Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
    • Nakamura, Y., et al. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Lett. 589 (2015), 1257–1265.
    • (2015) FEBS Lett. , vol.589 , pp. 1257-1265
    • Nakamura, Y.1
  • 25
    • 84938697816 scopus 로고    scopus 로고
    • Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
    • Baglio, S.R., et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res. Ther., 6, 2015, 127.
    • (2015) Stem Cell Res. Ther. , vol.6 , pp. 127
    • Baglio, S.R.1
  • 26
    • 85014769465 scopus 로고    scopus 로고
    • Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection
    • Smith, V.L., et al. Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection. Sci. Rep., 7, 2017, 43578.
    • (2017) Sci. Rep. , vol.7 , pp. 43578
    • Smith, V.L.1
  • 27
    • 85016255446 scopus 로고    scopus 로고
    • Human pericardial fluid contains exosomes enriched with cardiovascular-expressed microRNAs and promotes therapeutic angiogenesis
    • Beltrami, C., et al. Human pericardial fluid contains exosomes enriched with cardiovascular-expressed microRNAs and promotes therapeutic angiogenesis. Mol. Ther. 25 (2017), 679–693.
    • (2017) Mol. Ther. , vol.25 , pp. 679-693
    • Beltrami, C.1
  • 28
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    • Lai, R.C., et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 4 (2010), 214–222.
    • (2010) Stem Cell Res. , vol.4 , pp. 214-222
    • Lai, R.C.1
  • 29
    • 70349658478 scopus 로고    scopus 로고
    • Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1
    • Sarkar, A., et al. Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PLoS One, 4, 2009, e7140.
    • (2009) PLoS One , vol.4 , pp. e7140
    • Sarkar, A.1
  • 30
    • 51349124857 scopus 로고    scopus 로고
    • Human tumor nanoparticles induce apoptosis of pancreatic cancer cells
    • Ristorcelli, E., et al. Human tumor nanoparticles induce apoptosis of pancreatic cancer cells. FASEB J. 22 (2008), 3358–3369.
    • (2008) FASEB J. , vol.22 , pp. 3358-3369
    • Ristorcelli, E.1
  • 32
    • 84861228574 scopus 로고    scopus 로고
    • Extracellular vesicles – vehicles that spread cancer genes
    • Rak, J., Guha, A., Extracellular vesicles – vehicles that spread cancer genes. Bioessays 34 (2012), 489–497.
    • (2012) Bioessays , vol.34 , pp. 489-497
    • Rak, J.1    Guha, A.2
  • 33
    • 84930170395 scopus 로고    scopus 로고
    • Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
    • Costa-Silva, B., et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17 (2015), 816–826.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 816-826
    • Costa-Silva, B.1
  • 34
    • 84875520481 scopus 로고    scopus 로고
    • Dynamics of exosome internalization and trafficking
    • Tian, T., et al. Dynamics of exosome internalization and trafficking. J. Cell Physiol. 228 (2013), 1487–1495.
    • (2013) J. Cell Physiol. , vol.228 , pp. 1487-1495
    • Tian, T.1
  • 35
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • Tian, Y., et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 35 (2014), 2383–2390.
    • (2014) Biomaterials , vol.35 , pp. 2383-2390
    • Tian, Y.1
  • 36
    • 80053574021 scopus 로고    scopus 로고
    • Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
    • Zhuang, X., et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol. Ther. 19 (2011), 1769–1779.
    • (2011) Mol. Ther. , vol.19 , pp. 1769-1779
    • Zhuang, X.1
  • 37
    • 84951831545 scopus 로고    scopus 로고
    • Bovine milk-derived exosomes for drug delivery
    • Munagala, R., et al. Bovine milk-derived exosomes for drug delivery. Cancer Lett. 371 (2016), 48–61.
    • (2016) Cancer Lett. , vol.371 , pp. 48-61
    • Munagala, R.1
  • 38
    • 84966389357 scopus 로고    scopus 로고
    • Human plasma platelet-derived exosomes: effects of aspirin
    • Goetzl, E.J., et al. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 30 (2016), 2058–2063.
    • (2016) FASEB J. , vol.30 , pp. 2058-2063
    • Goetzl, E.J.1
  • 39
    • 20844458756 scopus 로고    scopus 로고
    • Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis
    • Kim, S.-H., et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J. Immunol. 174 (2005), 6440–6448.
    • (2005) J. Immunol. , vol.174 , pp. 6440-6448
    • Kim, S.-H.1
  • 40
    • 84930803061 scopus 로고    scopus 로고
    • Vascular smooth muscle cell calcification is mediated by regulated exosome secretion
    • Kapustin, A.N., et al. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circ. Res. 116 (2015), 1312–1323.
    • (2015) Circ. Res. , vol.116 , pp. 1312-1323
    • Kapustin, A.N.1
  • 41
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes
    • Zitvogel, L., et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. 4 (1998), 594–600.
    • (1998) Nat. Med. , vol.4 , pp. 594-600
    • Zitvogel, L.1
  • 42
    • 84896071176 scopus 로고    scopus 로고
    • Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration
    • Shimbo, K., et al. Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. Biochem. Biophys. Res. Commun. 445 (2014), 381–387.
    • (2014) Biochem. Biophys. Res. Commun. , vol.445 , pp. 381-387
    • Shimbo, K.1
  • 43
    • 84946912433 scopus 로고    scopus 로고
    • Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
    • Peng, D., et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature 527 (2015), 249–253.
    • (2015) Nature , vol.527 , pp. 249-253
    • Peng, D.1
  • 44
    • 84887249207 scopus 로고    scopus 로고
    • Synthetic nucleic acids delivered by exosomes: a potential therapeutic for gene related metabolic brain diseases
    • Liu, R., et al. Synthetic nucleic acids delivered by exosomes: a potential therapeutic for gene related metabolic brain diseases. Metab. Brain Dis. 28 (2013), 551–562.
    • (2013) Metab. Brain Dis. , vol.28 , pp. 551-562
    • Liu, R.1
  • 45
    • 84874980515 scopus 로고    scopus 로고
    • Exosomes for targeted siRNA delivery across biological barriers
    • EL Andaloussi, S., et al. Exosomes for targeted siRNA delivery across biological barriers. Adv. Drug Deliv. Rev 65 (2013), 391–397.
    • (2013) Adv. Drug Deliv. Rev , vol.65 , pp. 391-397
    • EL Andaloussi, S.1
  • 46
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti, L., et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29 (2011), 341–345.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1
  • 47
    • 63849165317 scopus 로고    scopus 로고
    • Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism
    • Qazi, K.R., et al. Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism. Blood 113 (2009), 2673–2683.
    • (2009) Blood , vol.113 , pp. 2673-2683
    • Qazi, K.R.1
  • 48
    • 84880049306 scopus 로고    scopus 로고
    • Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes
    • Gehrmann, U., et al. Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes. Cancer Res. 73 (2013), 3865–3876.
    • (2013) Cancer Res. , vol.73 , pp. 3865-3876
    • Gehrmann, U.1
  • 49
    • 84959091629 scopus 로고    scopus 로고
    • Exosome-associated AAV vector as a robust and convenient neuroscience tool
    • Hudry, E., et al. Exosome-associated AAV vector as a robust and convenient neuroscience tool. Gene Ther. 4 (2016), 380–392.
    • (2016) Gene Ther. , vol.4 , pp. 380-392
    • Hudry, E.1
  • 50
    • 84959440540 scopus 로고    scopus 로고
    • Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
    • Kim, M.S., et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine 12 (2015), 655–664.
    • (2015) Nanomedicine , vol.12 , pp. 655-664
    • Kim, M.S.1
  • 51
    • 84939253225 scopus 로고    scopus 로고
    • Exosomes in development, metastasis and drug resistance of breast cancer
    • Yu, D.D., et al. Exosomes in development, metastasis and drug resistance of breast cancer. Cancer Sci. 106 (2015), 959–964.
    • (2015) Cancer Sci. , vol.106 , pp. 959-964
    • Yu, D.D.1
  • 52
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of Immune Responses by Extracellular Vesicules
    • Robbins, P.D., Morelli, A.E., Regulation of Immune Responses by Extracellular Vesicules. Nat. Immunol. 14 (2014), 195–208.
    • (2014) Nat. Immunol. , vol.14 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 53
    • 84902187969 scopus 로고    scopus 로고
    • Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells
    • Roma-Rodrigues, C., et al. Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells. Biomed. Res. Int., 2014, 2014, 179486.
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 179486
    • Roma-Rodrigues, C.1
  • 54
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado, H., et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18 (2012), 883–891.
    • (2012) Nat. Med. , vol.18 , pp. 883-891
    • Peinado, H.1
  • 55
    • 84944705108 scopus 로고    scopus 로고
    • Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222
    • Yu, D.D., et al. Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222. Tumor Biol. 37 (2015), 3227–3235.
    • (2015) Tumor Biol. , vol.37 , pp. 3227-3235
    • Yu, D.D.1
  • 56
    • 70350542786 scopus 로고    scopus 로고
    • Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance
    • Deng, Z., et al. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Diabetes 58 (2009), 2498–2505.
    • (2009) Diabetes , vol.58 , pp. 2498-2505
    • Deng, Z.1
  • 57
    • 84951787560 scopus 로고    scopus 로고
    • Biobanking of exosomes in the era of precision medicine: are we there yet?
    • Mora, E.M., et al. Biobanking of exosomes in the era of precision medicine: are we there yet?. Int. J. Mol. Sci. 17 (2015), 1–13.
    • (2015) Int. J. Mol. Sci. , vol.17 , pp. 1-13
    • Mora, E.M.1
  • 58
    • 85164370727 scopus 로고    scopus 로고
    • Advanced therapy medicinal products: current and future perspectives
    • Hanna, E., et al. Advanced therapy medicinal products: current and future perspectives. J. Mark. Access Health Policy, 4, 2016, 31036.
    • (2016) J. Mark. Access Health Policy , vol.4 , pp. 31036
    • Hanna, E.1
  • 59
    • 84876729225 scopus 로고    scopus 로고
    • Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection
    • Takahashi, Y., et al. Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. J. Biotechnol. 165 (2013), 77–84.
    • (2013) J. Biotechnol. , vol.165 , pp. 77-84
    • Takahashi, Y.1
  • 60
    • 84930645405 scopus 로고    scopus 로고
    • Biodistribution and function of extracellular miRNA-155 in mice
    • Bala, S., et al. Biodistribution and function of extracellular miRNA-155 in mice. Sci. Rep., 5, 2015, 10721.
    • (2015) Sci. Rep. , vol.5 , pp. 10721
    • Bala, S.1
  • 61
    • 84978136466 scopus 로고    scopus 로고
    • Exosomal cancer immunotherapy is independent of MHC molecules on exosomes
    • Hiltbrunner, S., et al. Exosomal cancer immunotherapy is independent of MHC molecules on exosomes. Oncotarget 7 (2016), 38707–38717.
    • (2016) Oncotarget , vol.7 , pp. 38707-38717
    • Hiltbrunner, S.1
  • 62
    • 85028828913 scopus 로고    scopus 로고
    • Exosomes: mechanisms of uptake
    • McKelvey, K.J., et al. Exosomes: mechanisms of uptake. J. Circ. Biomarkers, 4, 2015, 1.
    • (2015) J. Circ. Biomarkers , vol.4 , pp. 1
    • McKelvey, K.J.1
  • 63
    • 84947723880 scopus 로고    scopus 로고
    • Tumour exosome integrins determine organotropic metastasis
    • Hoshino, A., et al. Tumour exosome integrins determine organotropic metastasis. Nature 527 (2015), 329–335.
    • (2015) Nature , vol.527 , pp. 329-335
    • Hoshino, A.1
  • 64
    • 84906785653 scopus 로고    scopus 로고
    • Nanovesicles engineered from ES cells for enhanced cell proliferation
    • Jeong, D., et al. Nanovesicles engineered from ES cells for enhanced cell proliferation. Biomaterials 35 (2014), 9302–9310.
    • (2014) Biomaterials , vol.35 , pp. 9302-9310
    • Jeong, D.1
  • 65
    • 84895520502 scopus 로고    scopus 로고
    • Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers
    • Jo, W., et al. Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers. Lab Chip 14 (2014), 1261–1269.
    • (2014) Lab Chip , vol.14 , pp. 1261-1269
    • Jo, W.1
  • 66
    • 84884935709 scopus 로고    scopus 로고
    • Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors
    • Jang, S.C., et al. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano 7 (2013), 7698–7710.
    • (2013) ACS Nano , vol.7 , pp. 7698-7710
    • Jang, S.C.1
  • 67
    • 84959489986 scopus 로고    scopus 로고
    • Engineering hybrid exosomes by membrane fusion with liposomes
    • Sato, Y.T., et al. Engineering hybrid exosomes by membrane fusion with liposomes. Sci. Rep., 6, 2016, 21933.
    • (2016) Sci. Rep. , vol.6 , pp. 21933
    • Sato, Y.T.1
  • 68
    • 84963680481 scopus 로고    scopus 로고
    • An injectable nanoparticle generator enhances delivery of cancer therapeutics
    • Xu, R., et al. An injectable nanoparticle generator enhances delivery of cancer therapeutics. Nat. Biotechol. 34 (2016), 414–418.
    • (2016) Nat. Biotechol. , vol.34 , pp. 414-418
    • Xu, R.1
  • 69
    • 84947485811 scopus 로고    scopus 로고
    • Multistage vector (MSV) therapeutics
    • Wolfram, J., et al. Multistage vector (MSV) therapeutics. J. Control. Release 219 (2015), 406–415.
    • (2015) J. Control. Release , vol.219 , pp. 406-415
    • Wolfram, J.1
  • 70
    • 84963680481 scopus 로고    scopus 로고
    • An injectable nanoparticle generator enhances delivery of cancer therapeutics
    • Xu, R., et al. An injectable nanoparticle generator enhances delivery of cancer therapeutics. Nat. Biotechol. 34 (2016), 414–418.
    • (2016) Nat. Biotechol. , vol.34 , pp. 414-418
    • Xu, R.1
  • 71
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • Harding, C., et al. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97 (1983), 329–339.
    • (1983) J. Cell Biol. , vol.97 , pp. 329-339
    • Harding, C.1
  • 72
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan, B.T., et al. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 101 (1985), 942–948.
    • (1985) J. Cell Biol. , vol.101 , pp. 942-948
    • Pan, B.T.1
  • 73
    • 0019874126 scopus 로고
    • Exfoliation of membrane ecto-enzymes in the form of micro-vesicles
    • Trams, E.G., et al. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim. Biophys. Acta 645 (1981), 63–70.
    • (1981) Biochim. Biophys. Acta , vol.645 , pp. 63-70
    • Trams, E.G.1
  • 74
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular Interactions of exosomes and other extracellular vesicles
    • Colombo, M., et al. Biogenesis, secretion, and intercellular Interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30 (2014), 255–289.
    • (2014) Annu. Rev. Cell Dev. Biol. , vol.30 , pp. 255-289
    • Colombo, M.1
  • 75
    • 0036697166 scopus 로고    scopus 로고
    • Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body
    • Babst, M., et al. Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev. Cell 3 (2002), 283–289.
    • (2002) Dev. Cell , vol.3 , pp. 283-289
    • Babst, M.1
  • 76
    • 69249223795 scopus 로고    scopus 로고
    • MHC II In dendritic cells is targeted to lysosomes or t cell-induced exosomes via distinct multivesicular body pathways
    • Buschow, S.I., et al. MHC II In dendritic cells is targeted to lysosomes or t cell-induced exosomes via distinct multivesicular body pathways. Traffic 10 (2009), 1528–1542.
    • (2009) Traffic , vol.10 , pp. 1528-1542
    • Buschow, S.I.1
  • 77
    • 80053208877 scopus 로고    scopus 로고
    • Proteolipidic composition of exosomes changes during reticulocyte maturation
    • Carayon, K., et al. Proteolipidic composition of exosomes changes during reticulocyte maturation. J. Biol. Chem. 286 (2011), 34426–34439.
    • (2011) J. Biol. Chem. , vol.286 , pp. 34426-34439
    • Carayon, K.1
  • 78
    • 0029989258 scopus 로고    scopus 로고
    • B lymphocytes secrete antigen-presenting vesicles
    • Raposo, G., et al. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183 (1996), 1161–1172.
    • (1996) J. Exp. Med. , vol.183 , pp. 1161-1172
    • Raposo, G.1
  • 79
    • 85027933779 scopus 로고    scopus 로고
    • Exosomes: immune properties and potential clinical implementations
    • Chaput, N., Théry, C., Exosomes: immune properties and potential clinical implementations. Semin. Immunopathol. 33 (2011), 419–440.
    • (2011) Semin. Immunopathol. , vol.33 , pp. 419-440
    • Chaput, N.1    Théry, C.2
  • 80
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H., et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9 (2007), 654–659.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1
  • 81
    • 84949310102 scopus 로고    scopus 로고
    • Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
    • Liu, Y., et al. Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse. Sci. Rep., 5, 2015, 17543.
    • (2015) Sci. Rep. , vol.5 , pp. 17543
    • Liu, Y.1
  • 82
    • 14844325736 scopus 로고    scopus 로고
    • Exosomes: a new delivery system for tumor antigens in cancer immunotherapy
    • Cho, J.A., et al. Exosomes: a new delivery system for tumor antigens in cancer immunotherapy. Int. J. Cancer 114 (2005), 613–622.
    • (2005) Int. J. Cancer , vol.114 , pp. 613-622
    • Cho, J.A.1
  • 83
    • 84978492523 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL)-armed exosomes deliver pro-apoptotic signals to tumor site
    • Rivoltini, L., et al. TNF-related apoptosis-inducing ligand (TRAIL)-armed exosomes deliver pro-apoptotic signals to tumor site. Clin. Cancer Res. 22 (2016), 3499–3512.
    • (2016) Clin. Cancer Res. , vol.22 , pp. 3499-3512
    • Rivoltini, L.1
  • 84
    • 24644464140 scopus 로고    scopus 로고
    • Exosome display technology: applications to the development of new diagnostics and therapeutics
    • Delcayre, A., et al. Exosome display technology: applications to the development of new diagnostics and therapeutics. Blood Cells Mol. Dis. 35 (2005), 158–168.
    • (2005) Blood Cells Mol. Dis. , vol.35 , pp. 158-168
    • Delcayre, A.1
  • 85
    • 79960959598 scopus 로고    scopus 로고
    • Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy
    • Rountree, R.B., et al. Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy. Cancer Res. 71 (2011), 5235–5244.
    • (2011) Cancer Res. , vol.71 , pp. 5235-5244
    • Rountree, R.B.1
  • 86
    • 84908051875 scopus 로고    scopus 로고
    • Surface functionalization of exosomes using click chemistry
    • Smyth, T., et al. Surface functionalization of exosomes using click chemistry. Bioconjug. Chem. 25 (2014), 1777–1784.
    • (2014) Bioconjug. Chem. , vol.25 , pp. 1777-1784
    • Smyth, T.1
  • 87
    • 84923174611 scopus 로고    scopus 로고
    • Sorting it out: regulation of exosome loading
    • Villarroya-beltri, C., et al. Sorting it out: regulation of exosome loading. Semin. Cancer Biol. 28 (2014), 3–13.
    • (2014) Semin. Cancer Biol. , vol.28 , pp. 3-13
    • Villarroya-beltri, C.1
  • 88
    • 84890238215 scopus 로고    scopus 로고
    • Exosome secretion is enhanced by invadopodia and drives invasive behavior
    • Hoshino, D., et al. Exosome secretion is enhanced by invadopodia and drives invasive behavior. Cell Rep. 5 (2013), 1159–1168.
    • (2013) Cell Rep. , vol.5 , pp. 1159-1168
    • Hoshino, D.1
  • 89
    • 75449112263 scopus 로고    scopus 로고
    • Aiming for invadopodia: organizing polarized delivery at sites of invasion
    • Caldieri, G., Buccione, R., Aiming for invadopodia: organizing polarized delivery at sites of invasion. Trends Cell Biol. 20 (2010), 64–70.
    • (2010) Trends Cell Biol. , vol.20 , pp. 64-70
    • Caldieri, G.1    Buccione, R.2
  • 90
    • 84979980416 scopus 로고    scopus 로고
    • Cortactin promotes exosome secretion by controlling branched actin dynamics
    • Sinha, S., et al. Cortactin promotes exosome secretion by controlling branched actin dynamics. J. Cell Biol. 214 (2016), 197–213.
    • (2016) J. Cell Biol. , vol.214 , pp. 197-213
    • Sinha, S.1
  • 91
    • 84979995706 scopus 로고    scopus 로고
    • Cortactin enhances exosome secretion without altering cargo
    • Gangoda, L., Mathivanan, S., Cortactin enhances exosome secretion without altering cargo. J. Cell Biol. 214 (2016), 129–131.
    • (2016) J. Cell Biol. , vol.214 , pp. 129-131
    • Gangoda, L.1    Mathivanan, S.2
  • 92
    • 84862618600 scopus 로고    scopus 로고
    • Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers
    • D'Souza-Schorey, C., Clancy, J.W., Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes. Dev. 26 (2012), 1287–1299.
    • (2012) Genes. Dev. , vol.26 , pp. 1287-1299
    • D'Souza-Schorey, C.1    Clancy, J.W.2
  • 93
    • 70450170492 scopus 로고    scopus 로고
    • ARF6-regulated shedding of tumor cell derived plasma membrane microvesicles
    • Muralidharan-Chari, V., et al. ARF6-regulated shedding of tumor cell derived plasma membrane microvesicles. Curr. Biol. 19 (2009), 1875–1885.
    • (2009) Curr. Biol. , vol.19 , pp. 1875-1885
    • Muralidharan-Chari, V.1
  • 94
    • 77952365658 scopus 로고    scopus 로고
    • Microvesicles: mediators of extracellular communication during cancer progression
    • Muralidharan-Chari, V., et al. Microvesicles: mediators of extracellular communication during cancer progression. J. Cell Sci. 123 (2010), 1603–1611.
    • (2010) J. Cell Sci. , vol.123 , pp. 1603-1611
    • Muralidharan-Chari, V.1
  • 95
    • 84926072728 scopus 로고    scopus 로고
    • Organizing polarized delivery of exosomes at synapses
    • Mittelbrunn, M., et al. Organizing polarized delivery of exosomes at synapses. Traffic 16 (2015), 327–337.
    • (2015) Traffic , vol.16 , pp. 327-337
    • Mittelbrunn, M.1
  • 96
    • 20444486130 scopus 로고    scopus 로고
    • The activation of exocytotic sites by the formation of phosphatidylinositol 4, 5-bisphosphate microdomains at syntaxin clusters
    • Aoyagi, K., et al. The activation of exocytotic sites by the formation of phosphatidylinositol 4, 5-bisphosphate microdomains at syntaxin clusters. J. Biol. Chem. 280 (2005), 17346–17352.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17346-17352
    • Aoyagi, K.1
  • 97
    • 84927648644 scopus 로고    scopus 로고
    • PI(4,5)P-binding effector proteins for vesicle exocytosis
    • Martin, T.F., PI(4,5)P-binding effector proteins for vesicle exocytosis. Biochim. Biophys. Acta 1851 (2015), 785–793.
    • (2015) Biochim. Biophys. Acta , vol.1851 , pp. 785-793
    • Martin, T.F.1
  • 98
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial
    • Escudier, B., et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J. Transl. Med., 3, 2005, 10.
    • (2005) J. Transl. Med. , vol.3 , pp. 10
    • Escudier, B.1
  • 99
    • 18144369346 scopus 로고    scopus 로고
    • A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
    • Morse, M.A., et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med., 3, 2005, 9.
    • (2005) J. Transl. Med. , vol.3 , pp. 9
    • Morse, M.A.1
  • 100
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai, S., et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol. Ther. 16 (2008), 782–790.
    • (2008) Mol. Ther. , vol.16 , pp. 782-790
    • Dai, S.1


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