Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions

Journal of Thrombosis and Haemostasis

Volumn 12, Issue 11, 2014, Pages 1906-1917

  Srikanthan, S ^a,b   Li, W ^a,b   Silverstein, R L ^a,b,c   Mcintyre, T M ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

CD36 protein; Cell derived microparticles; Exosomes; Platelets; Thrombosis

Indexed keywords

CD36 ANTIGEN; CHLORIDE; CHOLESTEROL; COLLAGEN; FERRIC CHLORIDE; FERRIC ION; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYUBIQUITIN; PROTEASOME;

ANIMAL; BLOOD; C57BL MOUSE; CAROTID ARTERY DISEASES; CHEMICALLY INDUCED; DISEASE MODEL; EXOSOME; FOAM CELL; HUMAN; MEMBRANE MICROPARTICLE; METABOLISM; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOSIS; TIME; UBIQUITINATION;

ANIMALS; ANTIGENS, CD36; BLOOD PLATELETS; CAROTID ARTERY DISEASES; CELL-DERIVED MICROPARTICLES; CHLORIDES; CHOLESTEROL; COLLAGEN; DISEASE MODELS, ANIMAL; EXOSOMES; FERRIC COMPOUNDS; FOAM CELLS; HUMANS; LIPOPROTEINS, LDL; MICE, INBRED C57BL; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET TRANSFUSION; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIGNAL TRANSDUCTION; THROMBOCYTOPENIA; THROMBOSIS; TIME FACTORS; UBIQUITINATION;

EID: 84916633753     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12712     Document Type: Article

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