Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis

Journal of Biological Chemistry

Volumn 292, Issue 24, 2017, Pages 10048-10060

  Hsu, Kuo Sheng ^a   Zhao, Xuan ^a   Cheng, Xiwen ^a   Guan, Dongyin ^a   Mahabeleshwar, Ganapati H ^a   Liu, Yu ^a   Borden, Ernest ^b   Jain, Mukesh K ^a   Kao, Hung Ying ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FEEDBACK; MOLECULAR BIOLOGY; PROTEINS;

ANGIOSTATIC ACTIVITIES; ANTI-ANGIOGENIC ACTIVITY; FEEDFORWARD LOOPS; INTERFERON ALPHAS; NEGATIVE FEEDBACK LOOP; NETWORK FORMATION; PROTEIN MODIFICATIONS; TUMOR SUPPRESSOR PROTEINS;

ENDOTHELIAL CELLS;

ALPHA INTERFERON; MATRIGEL; PROMYELOCYTIC LEUKEMIA PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; PML PROTEIN, HUMAN; PML PROTEIN, MOUSE; PROTEINASE; RECOMBINANT PROTEIN; STAT1 PROTEIN, HUMAN; STAT1 PROTEIN, MOUSE; STAT2 PROTEIN, HUMAN; STAT2 PROTEIN, MOUSE; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; UBIQUITIN THIOLESTERASE; USP18 PROTEIN, HUMAN; USP18 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL MIGRATION; COHORT ANALYSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROVASCULATURE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN ISGYLATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATOR GENE; REGULATORY MECHANISM; UBIQUITINATION; AGONISTS; ANGIOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PROTEIN PROCESSING; RNA INTERFERENCE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ANIMALS; CELL LINE; CELLS, CULTURED; ENDOPEPTIDASES; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERFERON-ALPHA; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; RNA INTERFERENCE; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; UBIQUITIN THIOLESTERASE;

EID: 85020888579     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.771071     Document Type: Article

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