Promyelocytic Leukemia Protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor α (TNFα) and interferon α (IFNα)

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23356-23367

  Cheng, Xiwen ^a,b   Liu, Yu ^a,b   Chu, Hao ^c   Kao, Hung Ying ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c Case Western Reserve University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELL DEATH; DISEASES; ENDOTHELIAL CELLS; MACROPHAGES; PROTEINS; TRANSCRIPTION; TUMORS;

INTERFERON ALPHAS; NEGATIVE REGULATORS; NETWORK FORMATION; PROMYELOCYTIC LEUKEMIA PROTEINS; SIGNAL TRANSDUCERS; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSORS; VASCULAR ENDOTHELIUM;

GLYCOPROTEINS;

ALPHA INTERFERON; BETA1 INTEGRIN; PROMYELOCYTIC LEUKEMIA PROTEIN; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTEGRIN BETA1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

EID: 84863610896     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.340505     Document Type: Article

References (58)

1. Crowder, C., Dahle, Ø., Davis, R. E., Gabrielsen, O. S., and Rudikoff, S. (2005) PML mediates IFN-α-induced apoptosis in myeloma by regulating TRAIL induction. Blood 105, 1280-1287 (Pubitemid 40170904)
2. Kakizuka, A., Miller, W. H., Jr., Umesono, K., Warrell, R. P., Jr., Frankel, S. R., Murty, V. V., Dmitrovsky, E., and Evans, R. M. (1991) Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 66, 663-674 (Pubitemid 121001702)
3. de Thé, H., Lavau, C., Marchio, A., Chomienne, C., Degos, L., and Dejean, A. (1991) The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66, 675-684 (Pubitemid 121001703)
4. Everett, R. D. (2001) DNA viruses and viral proteins that interact with PML nuclear bodies. Oncogene 20, 7266-7273
5. Negorev, D., and Maul, G. G. (2001) Cellular proteins localized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot. Oncogene 20, 7234-7242 (Pubitemid 33105012)
6. Lehembre, F., Müller, S., Pandolfi, P. P., and Dejean, A. (2001) Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene 20, 1-9 (Pubitemid 32142332)
7. Bernardi, R., Guernah, I., Jin, D., Grisendi, S., Alimonti, A., Teruya-Feldstein, J., Cordon-Cardo, C., Simon, M. C., Rafii, S., and Pandolfi, P. P. (2006) PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR. Nature 442, 779-785 (Pubitemid 44258904)
8. Terris, B., Baldin, V., Dubois, S., Degott, C., Flejou, J. F., Hénin, D., and Dejean, A. (1995)PMLnuclear bodies are general targets for inflammation and cell proliferation. Cancer Res. 55, 1590-1597
9. Gao, C., Cheng, X., Lam, M., Liu, Y., Liu, Q., Chang, K. S., and Kao, H. Y. (2008) Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies. Mol. Biol. Cell 19, 3020-3027
10. Reineke, E. L., and Kao, H. Y. (2009) Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies. Int. J. Biol. Sci. 5, 366-376
11. Aggarwal, B. B. (2003) Signaling pathways of the TNF superfamily: a double-edged sword. Nature Reviews. Immunology 3, 745-756
12. Sen, G. C. (2001) Viruses and interferons. Annu. Rev. Microbiol. 55, 255-281
13. Locksley, R. M., Killeen, N., and Lenardo, M. J. (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501 (Pubitemid 32201945)
14. Borden, E. C., Sen, G. C., Uze, G., Silverman, R. H., Ransohoff, R. M., Foster, G. R., and Stark, G. R. (2007) Interferons at age 50: past, current and future impact on biomedicine. Nature Reviews. Drug Discovery 6, 975-990 (Pubitemid 350201788)
15. Albini, A., Tosetti, F., Benelli, R., and Noonan, D. M. (2005) Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res. 65, 10637-10641 (Pubitemid 41713327)
16. Bergers, G., and Benjamin, L. E. (2003) Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer 3, 401-410 (Pubitemid 37328844)
17. Folkman, J. (2006) Angiogenesis. Annu. Rev. Med. 57, 1-18
18. Medina, J., Arroyo, A. G., Sánchez-Madrid, F., and Moreno-Otero, R. (2004) Angiogenesis in chronic inflammatory liver disease. Hepatology 39, 1185-1195 (Pubitemid 38569038)
19. Leibovich, S. J., Polverini, P. J., Shepard, H. M., Wiseman, D. M., Shively, V., and Nuseir, N. (1987) Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α. Nature 329, 630-632 (Pubitemid 17140112)
20. Rosenbaum, J. T., Howes, E. L., Jr., Rubin, R. M., and Samples, J. R. (1988) Ocular inflammatory effects of intravitreally-injected tumor necrosis factor. Am. J. Pathol. 133, 47-53
21. Sunderkötter, C., Roth, J., and Sorg, C. (1990) Immunohistochemical detection of bFGF and TNF-α in the course of inflammatory angiogenesis in the mouse cornea. Am. J. Pathol. 137, 511-515 (Pubitemid 20280980)
22. Cheng, X., and Kao, H. Y. (2009) G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor α-mediated transcriptional regulation. J. Biol. Chem. 284, 36395-36404
23. Mottet, D., Bellahcène, A., Pirotte, S., Waltregny, D., Deroanne, C., Lamour, V., Lidereau, R., and Castronovo, V. (2007) Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis. Circ. Res. 101, 1237-1246 (Pubitemid 350294640)
24. Team, R. D. C. (2009) R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, Austria
25. Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., Hornik, K., Hothorn, T., Huber, W., Iacus, S., Irizarry, R., Leisch, F., Li, C., Maechler, M., Rossini, A. J., Sawitzki, G., Smith, C., Smyth, G., Tierney, L., Yang, J. Y., and Zhang, J. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80
26. Du P, Kibbe, W. A., and Lin, S. M. (2008) lumi: a pipeline for processing Illumina microarray. Bioinformatics 24, 1547-1548 (Pubitemid 351911712)
27. Du P, Kibbe, W. A., and Lin, S. M. (2007) nuID: a universal naming scheme of oligonucleotides for illumina, affymetrix, and other microarrays. Biol. Direct 2, 16
28. Lin, S. M., Du P, Huber, W., and Kibbe, W. A. (2008) Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res. 36, e11
29. Smyth, G. K. (2005) Bioinformatics and Computational Biology Solutions using R and Bioconductor, Vol. 420, pp. 397-420
30. Feng, G., Du P, Krett, N. L., Tessel, M., Rosen, S., Kibbe, W. A., and Lin, S. M. (2010) A collection of bioconductor methods to visualize gene-list annotations. BMC Res. Notes 3, 10
31. Avraamides, C. J., Garmy-Susini, B., and Varner, J. A. (2008) Integrins in angiogenesis and lymphangiogenesis. Nature Reviews Cancer 8, 604-617
32. Miele, M. E., Bennett, C. F., Miller, B. E., and Welch, D. R. (1994) Enhanced metastatic ability of TNF-α-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides. Exp. Cell Res. 214, 231-241 (Pubitemid 24302397)
33. Nakao, S., Kuwano, T., Ishibashi, T., Kuwano, M., and Ono, M. (2003) Synergistic effect of TNF-α in soluble VCAM-1-induced angiogenesis through α4 integrins. J. Immunol. 170, 5704-5711 (Pubitemid 36617863)
34. Stadler, M., Chelbi-Alix, M. K., Koken, M. H., Venturini, L., Lee, C., Saïb, A., Quignon, F., Pelicano, L., Guillemin, M. C., and Schindler, C. (1995) Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene 11, 2565-2573 (Pubitemid 26023824)
35. Caporali, A., Pani, E., Horrevoets, A. J., Kraenkel, N., Oikawa, A., Sala- Newby, G. B., Meloni, M., Cristofaro, B., Graiani, G., Leroyer, A. S., Boulanger, C. M., Spinetti, G., Yoon, S. O., Madeddu, P., and Emanueli, C. (2008) Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles. Circ. Res. 103, e15-e26
36. Breau, M. A., Dahmani, A., Broders-Bondon, F., Thiery, J. P., and Dufour, S. (2009) β1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells. Development 136, 2791-2801
37. Reineke, E. L., Liu, Y., and Kao, H. Y. (2010) Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulinlike growth factor-1. J. Biol. Chem. 285, 9485-9492
38. Hehlgans, T., and Pfeffer, K. (2005) The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115, 1-20 (Pubitemid 40598088)
39. Mathew, S. J., Haubert, D., Krönke, M., and Leptin, M. (2009) Looking beyond death: a morphogenetic role for the TNF signaling pathway. J. Cell Sci. 122, 1939-1946
40. Mbow, M. L., and Sarisky, R. T. (2004) What is disrupting IFN-α's antiviral activity? Trends Biotechnol. 22, 395-399 (Pubitemid 38993222)
41. Takaoka, A., Tanaka, N., Mitani, Y., Miyazaki, T., Fujii, H., Sato, M., Kovarik, P., Decker, T., Schlessinger, J., and Taniguchi, T. (1999) Proteintyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling. EMBO J. 18, 2480-2488 (Pubitemid 29228484)
42. Uddin, S., Lekmine, F., Sharma, N., Majchrzak, B., Mayer, I., Young, P. R., Bokoch, G. M., Fish, E. N., and Platanias, L. C. (2000) The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon α-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J. Biol. Chem. 275, 27634-27640
43. Wong, L. H., Sim, H., Chatterjee-Kishore, M., Hatzinisiriou, I., Devenish, R. J., Stark, G., and Ralph, S. J. (2002) Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1. J. Biol. Chem. 277, 19408-19417 (Pubitemid 34967449)
44. Mahboubi, K., and Pober, J. S. (2002) Activation of signal transducer and activator of transcription 1 (STAT1) is not sufficient for the induction of STAT1-dependent genes in endothelial cells. Comparison of interferon-γand oncostatin M. J. Biol. Chem. 277, 8012-8021 (Pubitemid 34968253)
45. de Totero, D., Meazza, R., Capaia, M., Fabbi, M., Azzarone, B., Balleari, E., Gobbi, M., Cutrona, G., Ferrarini, M., and Ferrini, S. (2008) The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways. Blood 111, 517-524
46. Wang, S., and El-Deiry, W. S. (2003) TRAIL and apoptosis induction by TNF-family death receptors. Oncogene 22, 8628-8633 (Pubitemid 38019198)
47. Caraglia, M., Abbruzzese, A., Leardi, A., Pepe, S., Budillon, A., Baldassare, G., Selleri, C., Lorenzo, S. D., Fabbrocini, A., Giuberti, G., Vitale, G., Lupoli, G., Bianco, A. R., and Tagliaferri, P. (1999) Interferon-α induces apoptosis in human KB cells through a stress-dependent mitogen-activated protein kinase pathway that is antagonized by epidermal growth factor. Cell Death Differ. 6, 773-780 (Pubitemid 29425388)
48. Karin, M. (2006) Nuclear factor-κB in cancer development and progression. Nature 441, 431-436
49. Gambaryan, S., Kobsar, A., Rukoyatkina, N., Herterich, S., Geiger, J., Smolenski, A., Lohmann, S. M., and Walter, U. (2010) Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFκB-IκB complex. J. Biol. Chem. 285, 18352-18363
50. Dougan, M., Li, D., Neuberg, D., Mihm, M., Googe, P., Wong, K. K., and Dranoff, G. (2011) A dual role for the immune response in a mouse model of inflammation-associated lung cancer. J. Clin. Invest. 121, 2436-2446
51. Pradhan, M., Bembinster, L. A., Baumgarten, S. C., and Frasor, J. (2010) Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{κ}B cooperativity at adjacent response elements. J. Biol. Chem. 285, 31100-31106
52. Wu, W. S., Xu, Z. X., Hittelman, W. N., Salomoni, P., Pandolfi, P. P., and Chang, K. S. (2003) Promyelocytic leukemia protein sensitizes tumor necrosis factor α-induced apoptosis by inhibiting the NF-κB survival pathway. J. Biol. Chem. 278, 12294-12304 (Pubitemid 36800212)
53. Rego, E. M., Wang, Z. G., Peruzzi, D., He, L. Z., Cordon-Cardo, C., and Pandolfi, P. P. (2001) Role of promyelocytic leukemia (PML) protein in tumor suppression. J. Exp. Med. 193, 521-529 (Pubitemid 32524482)
54. Reineke, E. L., and Kao, H. Y. (2009) PML: An emerging tumor suppressor and a target with therapeutic potential. Cancer Ther. 7, 219-226
55. Battle, T. E., Lynch, R. A., and Frank, D. A. (2006) Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res. 66, 3649-3657
56. Huang, S., Bucana, C. D., Van Arsdall, M., and Fidler, I. J. (2002) Stat1 negatively regulates angiogenesis, tumorigenicity, and metastasis of tumor cells. Oncogene 21, 2504-2512 (Pubitemid 34438103)
57. Hu, Y., Hu, X., Boumsell, L., and Ivashkiv, L. B. (2008) IFN-γ and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways. J. Immunol. 180, 8057-8065
58. Xie, B., Zhao, J., Kitagawa, M., Durbin, J., Madri, J. A., Guan, J. L., and Fu, X. Y. (2001) Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J. Biol. Chem. 276, 19512-19523